hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09058.1
Complex Portal: CPX-16753
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UNG | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | 5 | UniProt NCBI |
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 3.91945798564e-08 | 1.0 | CAMK2B CAMK2D CAMK2G | CaMK IV-mediated phosphorylation of CREB |
| REAC:R-HSA-442982 | 1.69843179378e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | Ras activation upon Ca2+ influx through NMDA receptor |
| WP:WP4875 | 1.78287172964e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | Disruption of postsynaptic signaling by CNV |
| REAC:R-HSA-9617324 | 3.1728945598e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-438066 | 3.1728945598e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9620244 | 3.80747347177e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | Long-term potentiation |
| GO:0005954 | 3.84480164306e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | calcium- and calmodulin-dependent protein kinase complex |
| WP:WP4756 | 4.63856714356e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | Renin angiotensin aldosterone system RAAS |
| WP:WP4008 | 6.02300579971e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | NO cGMP PKG mediated neuroprotection |
| REAC:R-HSA-442742 | 7.18567297368e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-3371571 | 8.26352391973e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | HSF1-dependent transactivation |
| REAC:R-HSA-5576892 | 9.44402733683e-07 | 1.0 | CAMK2B CAMK2D CAMK2G | Phase 0 - rapid depolarisation |
| REAC:R-HSA-399719 | 1.07318492464e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 1.07318492464e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| KEGG:04971 | 1.22375439253e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Gastric acid secretion |
| KEGG:04720 | 1.29573994503e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Long-term potentiation |
| KEGG:05031 | 1.52851760973e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Amphetamine addiction |
| REAC:R-HSA-9022692 | 1.70496422375e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Regulation of MECP2 expression and activity |
| REAC:R-HSA-5673000 | 1.89440469306e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | RAF activation |
| REAC:R-HSA-111933 | 1.89440469306e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Calmodulin induced events |
| REAC:R-HSA-111997 | 1.89440469306e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | CaM pathway |
| KEGG:04911 | 2.28180619251e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Insulin secretion |
| REAC:R-HSA-111996 | 2.31434662009e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Ca-dependent events |
| KEGG:05214 | 2.61801737967e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Glioma |
| KEGG:04912 | 2.61801737967e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | GnRH signaling pathway |
| KEGG:04750 | 2.73701816965e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Inflammatory mediator regulation of TRP channels |
| REAC:R-HSA-9656223 | 3.05391101381e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Signaling by RAF1 mutants |
| WP:WP4341 | 3.07824431547e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04713 | 3.24906634499e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Circadian entrainment |
| REAC:R-HSA-1489509 | 3.3315392878e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | DAG and IP3 signaling |
| KEGG:04925 | 3.38635083845e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Aldosterone synthesis and secretion |
| KEGG:04012 | 3.67241243895e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | ErbB signaling pathway |
| REAC:R-HSA-936837 | 3.93625566272e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Ion transport by P-type ATPases |
| REAC:R-HSA-6802955 | 3.93625566272e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 3.93625566272e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Signaling by RAS mutants |
| REAC:R-HSA-6802946 | 3.93625566272e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 3.93625566272e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Signaling downstream of RAS mutants |
| REAC:R-HSA-9609736 | 3.93625566272e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04740 | 4.62629936833e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Olfactory transduction |
| KEGG:04916 | 4.79978559464e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Melanogenesis |
| REAC:R-HSA-5578775 | 4.97397882464e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Ion homeostasis |
| REAC:R-HSA-112043 | 5.35659258038e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | PLC beta mediated events |
| KEGG:04725 | 5.93248714392e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Cholinergic synapse |
| KEGG:04922 | 6.56019280347e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Glucagon signaling pathway |
| WP:WP673 | 6.61367895536e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | ErbB signaling pathway |
| REAC:R-HSA-112040 | 7.56595371871e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | G-protein mediated events |
| KEGG:04066 | 8.19365887109e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | HIF-1 signaling pathway |
| KEGG:04722 | 8.44707100112e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Neurotrophin signaling pathway |
| KEGG:04114 | 9.51295867401e-06 | 1.0 | CAMK2B CAMK2D CAMK2G | Oocyte meiosis |
| REAC:R-HSA-8986944 | 1.09306217585e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Transcriptional Regulation by MECP2 |
| KEGG:04728 | 1.09667742953e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Dopaminergic synapse |
| WP:WP428 | 1.29180684237e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Wnt signaling |
| REAC:R-HSA-6802952 | 1.29342113526e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Signaling by BRAF and RAF1 fusions |
| KEGG:04921 | 1.39434656978e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Oxytocin signaling pathway |
| KEGG:04261 | 1.43040725693e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Adrenergic signaling in cardiomyocytes |
| KEGG:04148 | 1.62006150102e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Efferocytosis |
| KEGG:04934 | 1.65989907892e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Cushing syndrome |
| WP:WP5083 | 1.71942475092e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Neuroinflammation and glutamatergic signaling |
| WP:WP536 | 1.76674836791e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Calcium regulation in cardiac cells |
| KEGG:04217 | 2.18996976196e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Necroptosis |
| REAC:R-HSA-438064 | 2.33842329058e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Post NMDA receptor activation events |
| KEGG:05152 | 2.65416687338e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Tuberculosis |
| REAC:R-HSA-6802957 | 2.66686453773e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Oncogenic MAPK signaling |
| WP:WP289 | 2.83821551935e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Myometrial relaxation and contraction pathways |
| KEGG:04310 | 2.8799444916e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Wnt signaling pathway |
| KEGG:04360 | 3.11817592384e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Axon guidance |
| REAC:R-HSA-877300 | 3.28021305227e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Interferon gamma signaling |
| KEGG:04024 | 3.36919550068e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | cAMP signaling pathway |
| REAC:R-HSA-111885 | 3.549722449e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Opioid Signalling |
| REAC:R-HSA-442755 | 3.83360319167e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Activation of NMDA receptors and postsynaptic events |
| KEGG:04020 | 4.35329755601e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Calcium signaling pathway |
| REAC:R-HSA-3371556 | 4.60862934812e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Cellular response to heat stress |
| REAC:R-HSA-5576891 | 4.60862934812e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Cardiac conduction |
| KEGG:05417 | 4.99333165562e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Lipid and atherosclerosis |
| KEGG:05205 | 5.16258651055e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Proteoglycans in cancer |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | CAMK2B CAMK2D CAMK2G | Diabetic cardiomyopathy |
| KEGG:05012 | 0.00011589966492 | 1.0 | CAMK2B CAMK2D CAMK2G | Parkinson disease |
| REAC:R-HSA-442729 | 0.000143154936711 | 0.666666666667 | CAMK2B CAMK2G | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde |
| REAC:R-HSA-983712 | 0.000144704522421 | 1.0 | CAMK2B CAMK2D CAMK2G | Ion channel transport |
| GO:0004683 | 0.000148024863258 | 1.0 | CAMK2B CAMK2D CAMK2G | calmodulin-dependent protein kinase activity |
| REAC:R-HSA-397014 | 0.000257237760415 | 1.0 | CAMK2B CAMK2D CAMK2G | Muscle contraction |
| REAC:R-HSA-112314 | 0.000300937850546 | 1.0 | CAMK2B CAMK2D CAMK2G | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-913531 | 0.000409665014874 | 1.0 | CAMK2B CAMK2D CAMK2G | Interferon Signaling |
| REAC:R-HSA-418594 | 0.000492377243425 | 1.0 | CAMK2B CAMK2D CAMK2G | G alpha (i) signalling events |
| GO:0043502 | 0.000524430944113 | 1.0 | CAMK2B CAMK2D CAMK2G | regulation of muscle adaptation |
| KEGG:05022 | 0.000613327564103 | 1.0 | CAMK2B CAMK2D CAMK2G | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-112315 | 0.000640971827897 | 1.0 | CAMK2B CAMK2D CAMK2G | Transmission across Chemical Synapses |
| REAC:R-HSA-5673001 | 0.000740957667713 | 1.0 | CAMK2B CAMK2D CAMK2G | RAF/MAP kinase cascade |
| KEGG:05200 | 0.000767224943957 | 1.0 | CAMK2B CAMK2D CAMK2G | Pathways in cancer |
| REAC:R-HSA-5684996 | 0.000783695624229 | 1.0 | CAMK2B CAMK2D CAMK2G | MAPK1/MAPK3 signaling |
| REAC:R-HSA-5683057 | 0.00118616050146 | 1.0 | CAMK2B CAMK2D CAMK2G | MAPK family signaling cascades |
| GO:0043500 | 0.00118621742692 | 1.0 | CAMK2B CAMK2D CAMK2G | muscle adaptation |
| REAC:R-HSA-9006925 | 0.001430872794 | 1.0 | CAMK2B CAMK2D CAMK2G | Intracellular signaling by second messengers |
| REAC:R-HSA-112316 | 0.00203732306248 | 1.0 | CAMK2B CAMK2D CAMK2G | Neuronal System |
| REAC:R-HSA-388396 | 0.00381272507886 | 1.0 | CAMK2B CAMK2D CAMK2G | GPCR downstream signalling |
| REAC:R-HSA-5663202 | 0.00393910426879 | 1.0 | CAMK2B CAMK2D CAMK2G | Diseases of signal transduction by growth factor receptors and second messengers |
| GO:0014733 | 0.00421361424067 | 0.666666666667 | CAMK2B CAMK2G | regulation of skeletal muscle adaptation |
| REAC:R-HSA-372790 | 0.00563898766183 | 1.0 | CAMK2B CAMK2D CAMK2G | Signaling by GPCR |
| GO:0005516 | 0.00851239083773 | 1.0 | CAMK2B CAMK2D CAMK2G | calmodulin binding |
| REAC:R-HSA-382551 | 0.0117092435511 | 1.0 | CAMK2B CAMK2D CAMK2G | Transport of small molecules |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | CAMK2B CAMK2D CAMK2G | Cytokine Signaling in Immune system |
| GO:0043501 | 0.0210651876021 | 0.666666666667 | CAMK2B CAMK2G | skeletal muscle adaptation |
| GO:0090257 | 0.0231134095574 | 1.0 | CAMK2B CAMK2D CAMK2G | regulation of muscle system process |
| REAC:R-HSA-2262752 | 0.0292688889279 | 1.0 | CAMK2B CAMK2D CAMK2G | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0301284815898 | 1.0 | CAMK2B CAMK2D CAMK2G | Cellular responses to stimuli |
| GO:0051924 | 0.0411908979227 | 1.0 | CAMK2B CAMK2D CAMK2G | regulation of calcium ion transport |
| GO:0030666 | 0.0488366704701 | 1.0 | CAMK2B CAMK2D CAMK2G | endocytic vesicle membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAMK2D | CAMK2G | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| CAMK2B | CAMK2D | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | ||
| CAMK2B | CAMK2G | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | ||
| UNG | CAMK2D | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| UNG | CAMK2B | 0.284 | bioplex_WMM bioplex3_WMM WMM_only | ||
| UNG | CAMK2G | 0.275 | 0.034 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes