hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09074.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTP4A1 | Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) | 5 | UniProt NCBI |
| FNTB | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | 5 | UniProt NCBI |
| PGGT1B | Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) | 5 | UniProt NCBI |
| DGKZ | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) | 5 | UniProt NCBI |
| NAP1L4 | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | 5 | UniProt NCBI |
| FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:419 | 1.70876175213e-05 | 0.333333333333 | FNTB FNTA | Farnesyltransferase |
| GO:0008318 | 3.84302573496e-05 | 0.5 | FNTB PGGT1B FNTA | protein prenyltransferase activity |
| GO:0018342 | 0.000316805542726 | 0.5 | FNTB PGGT1B FNTA | protein prenylation |
| GO:0097354 | 0.000316805542726 | 0.5 | FNTB PGGT1B FNTA | prenylation |
| GO:0004659 | 0.0010743908712 | 0.5 | FNTB PGGT1B FNTA | prenyltransferase activity |
| KEGG:00900 | 0.00167329519289 | 0.333333333333 | FNTB FNTA | Terpenoid backbone biosynthesis |
| REAC:R-HSA-9648002 | 0.00594265866298 | 0.333333333333 | FNTB FNTA | RAS processing |
| REAC:R-HSA-2514859 | 0.00650743774508 | 0.333333333333 | FNTB FNTA | Inactivation, recovery and regulation of the phototransduction cascade |
| REAC:R-HSA-2514856 | 0.00650743774508 | 0.333333333333 | FNTB FNTA | The phototransduction cascade |
| GO:0004660 | 0.00702301080125 | 0.333333333333 | FNTB FNTA | protein farnesyltransferase activity |
| GO:0004662 | 0.00702301080125 | 0.333333333333 | FNTA PGGT1B | CAAX-protein geranylgeranyltransferase activity |
| GO:0005953 | 0.00702301080125 | 0.333333333333 | FNTA PGGT1B | CAAX-protein geranylgeranyltransferase complex |
| GO:0005965 | 0.00702301080125 | 0.333333333333 | FNTB FNTA | protein farnesyltransferase complex |
| GO:0018343 | 0.0210651876021 | 0.333333333333 | FNTB FNTA | protein farnesylation |
| GO:0016765 | 0.0446883661999 | 0.5 | FNTB PGGT1B FNTA | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FNTA | FNTB | 1.0 | 0.33 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| FNTB | NAP1L4 | 0.999 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FNTA | PGGT1B | 0.999 | 0.34 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| DGKZ | FNTB | 0.992 | 0.156 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PTP4A1 | FNTA | 0.988 | 0.016 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PTP4A1 | FNTB | 0.983 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FNTA | DGKZ | 0.982 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| DGKZ | NAP1L4 | 0.981 | 0.202 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| FNTA | NAP1L4 | 0.972 | 0.13 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| FNTB | PGGT1B | 0.227 | 0.096 | bioplex3_WMM WMM_only |
| PTP4A1 | PGGT1B | 0.189 | 0.12 | bioplex3_WMM WMM_only |
| PTP4A1 | NAP1L4 | 0.032 | 0.214 | bioplex_WMM bioplex3_WMM WMM_only |
| NAP1L4 | PGGT1B | 0.011 | 0.072 | bioplex3_WMM fraction |
Related Complexes