hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09080.1
Complex Portal: CPX-15420
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LCTL | Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein) | 4 | UniProt NCBI |
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | 5 | UniProt NCBI |
| SMAD3 | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | 5 | UniProt NCBI |
| SMAD9 | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | 5 | UniProt NCBI |
| SMAD5 | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | 5 | UniProt NCBI |
| SEMA4A | Semaphorin-4A (Semaphorin-B) (Sema B) | 5 | UniProt NCBI |
| LEMD3 | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | 5 | UniProt NCBI |
| ZFYVE9 | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP560 | 8.7999408491e-10 | 0.625 | ZFYVE9 SMAD3 SMAD2 SMAD5 SMAD9 | TGF beta receptor signaling |
| WP:WP4816 | 1.1165325657e-09 | 0.625 | ZFYVE9 SMAD3 SMAD2 SMAD5 SMAD9 | TGF beta receptor signaling in skeletal dysplasias |
| KEGG:04350 | 1.81897246823e-08 | 0.625 | ZFYVE9 SMAD3 SMAD2 SMAD5 SMAD9 | TGF-beta signaling pathway |
| CORUM:1827 | 3.92798604902e-08 | 0.375 | SMAD3 SMAD2 ZFYVE9 | PML-SMAD2/3-SARA complex |
| GO:0071141 | 6.44235965654e-08 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | SMAD protein complex |
| GO:0071144 | 6.44235965654e-08 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | heteromeric SMAD protein complex |
| WP:WP4331 | 1.20125766468e-07 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | Neovascularisation processes |
| GO:0007179 | 1.39737087021e-06 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | transforming growth factor beta receptor signaling pathway |
| GO:0070411 | 2.50812007172e-06 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | I-SMAD binding |
| GO:0071560 | 3.11412952668e-06 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | cellular response to transforming growth factor beta stimulus |
| GO:0071559 | 3.71306764666e-06 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | response to transforming growth factor beta |
| WP:WP5353 | 3.80843066597e-06 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | A network map of Macrophage stimulating protein MSP signaling |
| KEGG:04550 | 1.46036227458e-05 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | Signaling pathways regulating pluripotency of stem cells |
| GO:0141091 | 1.52540288285e-05 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | transforming growth factor beta receptor superfamily signaling pathway |
| GO:0007178 | 2.09937557672e-05 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| CORUM:6513 | 2.39226645298e-05 | 0.25 | SMAD2 LEMD3 | MAN1-SMAD2 complex |
| REAC:R-HSA-9006936 | 4.10552092745e-05 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | Signaling by TGFB family members |
| CORUM:2834 | 7.17483486175e-05 | 0.25 | SMAD3 SMAD2 | SMAD4-SMAD2-SMAD3 complex |
| CORUM:2830 | 7.17483486175e-05 | 0.25 | SMAD3 SMAD2 | TIF1gamma-SMAD2-SMAD3 complex |
| WP:WP4535 | 8.21209581065e-05 | 0.375 | SMAD3 SMAD2 LEMD3 | Envelope proteins and their potential roles in EDMD physiopathology |
| WP:WP4879 | 0.000157481549049 | 0.375 | SMAD3 SMAD2 LEMD3 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| REAC:R-HSA-3315487 | 0.000167311042734 | 0.25 | SMAD3 SMAD2 | SMAD2/3 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3311021 | 0.000167311042734 | 0.25 | SMAD3 SMAD2 | SMAD4 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3304347 | 0.000167311042734 | 0.25 | SMAD3 SMAD2 | Loss of Function of SMAD4 in Cancer |
| REAC:R-HSA-3304356 | 0.000334530488176 | 0.25 | SMAD3 SMAD2 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| REAC:R-HSA-3656532 | 0.000334530488176 | 0.25 | SMAD3 SMAD2 | TGFBR1 KD Mutants in Cancer |
| REAC:R-HSA-3656534 | 0.000557398190654 | 0.25 | SMAD3 SMAD2 | Loss of Function of TGFBR1 in Cancer |
| REAC:R-HSA-3304349 | 0.000557398190654 | 0.25 | SMAD3 SMAD2 | Loss of Function of SMAD2/3 in Cancer |
| GO:0071363 | 0.000600611215614 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | cellular response to growth factor stimulus |
| GO:0046332 | 0.000668834683502 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | SMAD binding |
| GO:0070848 | 0.000735403982421 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | response to growth factor |
| GO:0060395 | 0.000828238133244 | 0.5 | SMAD3 SMAD2 SMAD5 SMAD9 | SMAD protein signal transduction |
| REAC:R-HSA-3304351 | 0.000835868410279 | 0.25 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex in Cancer |
| CORUM:2829 | 0.000859567015467 | 0.25 | SMAD3 SMAD2 | RSmad complex |
| WP:WP3876 | 0.00107416462378 | 0.25 | SMAD5 SMAD9 | BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation |
| WP:WP5382 | 0.00157457895347 | 0.25 | SMAD3 SMAD2 | TGF Smad signaling pathway |
| REAC:R-HSA-9823730 | 0.00200443712543 | 0.25 | SMAD3 SMAD2 | Formation of definitive endoderm |
| REAC:R-HSA-9796292 | 0.00200443712543 | 0.25 | SMAD3 SMAD2 | Formation of axial mesoderm |
| HP:0008419 | 0.00225842370351 | 0.25 | SMAD3 SMAD2 | Intervertebral disc degeneration |
| WP:WP3859 | 0.00250295506608 | 0.25 | SMAD3 SMAD2 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition |
| WP:WP3874 | 0.00250295506608 | 0.25 | SMAD3 SMAD2 | Canonical and non canonical TGF B signaling |
| REAC:R-HSA-1502540 | 0.00250486048439 | 0.25 | SMAD3 SMAD2 | Signaling by Activin |
| WP:WP366 | 0.00261051604069 | 0.375 | SMAD3 SMAD2 ZFYVE9 | TGF beta signaling pathway |
| REAC:R-HSA-9754189 | 0.00367178411278 | 0.25 | SMAD3 SMAD2 | Germ layer formation at gastrulation |
| WP:WP5103 | 0.00407177869695 | 0.25 | SMAD3 SMAD2 | Progeria associated lipodystrophy |
| HP:0000987 | 0.0043733297498 | 0.375 | SMAD3 SMAD2 LEMD3 | Atypical scarring of skin |
| GO:0030509 | 0.00441407178313 | 0.5 | LEMD3 SMAD5 SMAD2 SMAD9 | BMP signaling pathway |
| WP:WP2895 | 0.00499769201238 | 0.25 | SMAD5 SMAD9 | Differentiation of white and brown adipocyte |
| GO:0071773 | 0.00504805624577 | 0.5 | LEMD3 SMAD5 SMAD2 SMAD9 | cellular response to BMP stimulus |
| GO:0071772 | 0.00504805624577 | 0.5 | LEMD3 SMAD5 SMAD2 SMAD9 | response to BMP |
| WP:WP3668 | 0.00656300097601 | 0.25 | SMAD3 SMAD2 | Hypothesized pathways in pathogenesis of cardiovascular disease |
| REAC:R-HSA-9617828 | 0.00666866305696 | 0.25 | SMAD3 SMAD2 | FOXO-mediated transcription of cell cycle genes |
| HP:0100718 | 0.00812142628406 | 0.25 | SMAD3 SMAD2 | Uterine rupture |
| HP:0005086 | 0.00812142628406 | 0.25 | SMAD3 SMAD2 | Knee osteoarthritis |
| REAC:R-HSA-1181150 | 0.00849789009901 | 0.25 | SMAD3 SMAD2 | Signaling by NODAL |
| GO:0007167 | 0.008865457517 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | enzyme-linked receptor protein signaling pathway |
| WP:WP2870 | 0.00897861635867 | 0.25 | SMAD3 SMAD2 | Extracellular vesicle mediated signaling in recipient cells |
| KEGG:04144 | 0.0101901500628 | 0.375 | SMAD3 SMAD2 ZFYVE9 | Endocytosis |
| HP:0100699 | 0.0103089116999 | 0.375 | SMAD3 SMAD2 LEMD3 | Scarring |
| WP:WP3850 | 0.0103268762936 | 0.25 | SMAD3 SMAD2 | Factors and pathways affecting insulin like growth factor IGF1 Akt signaling |
| KEGG:05321 | 0.0115899115219 | 0.25 | SMAD3 SMAD2 | Inflammatory bowel disease |
| REAC:R-HSA-2173788 | 0.0140328389809 | 0.25 | SMAD3 SMAD2 | Downregulation of TGF-beta receptor signaling |
| HP:0008843 | 0.014877056319 | 0.25 | SMAD3 SMAD2 | Hip osteoarthritis |
| HP:0005294 | 0.014877056319 | 0.25 | SMAD3 SMAD2 | Arterial dissection |
| GO:0032924 | 0.0156477314671 | 0.375 | SMAD3 SMAD2 LEMD3 | activin receptor signaling pathway |
| REAC:R-HSA-201451 | 0.0166306183768 | 0.25 | SMAD5 SMAD9 | Signaling by BMP |
| REAC:R-HSA-9615017 | 0.0166306183768 | 0.25 | SMAD3 SMAD2 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| WP:WP1971 | 0.0184665051061 | 0.25 | SMAD3 SMAD2 | Integrated cancer pathway |
| REAC:R-HSA-2173795 | 0.0224821270291 | 0.25 | SMAD3 SMAD2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| WP:WP5144 | 0.0255436500108 | 0.25 | SMAD3 SMAD2 | NRP1 triggered signaling pathways in pancreatic cancer |
| WP:WP5352 | 0.0255436500108 | 0.25 | SMAD5 SMAD9 | 10q11 21q11 23 copy number variation syndrome |
| KEGG:05212 | 0.032546331302 | 0.25 | SMAD3 SMAD2 | Pancreatic cancer |
| HP:0031105 | 0.0344027510839 | 0.375 | SMAD3 SMAD2 SEMA4A | Abnormal uterus morphology |
| HP:0200146 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Mucoid extracellular matrix accumulation |
| HP:0004959 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Descending thoracic aorta aneurysm |
| HP:0012180 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Cystic medial necrosis |
| HP:0032079 | 0.0344311064357 | 0.25 | SMAD3 SMAD2 | Medial degeneration |
| REAC:R-HSA-2173796 | 0.0348192347107 | 0.25 | SMAD3 SMAD2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| REAC:R-HSA-9758941 | 0.0367988237757 | 0.25 | SMAD3 SMAD2 | Gastrulation |
| WP:WP5356 | 0.0376097283422 | 0.25 | SMAD3 SMAD2 | Affected pathways in Duchenne muscular dystrophy |
| KEGG:05210 | 0.0381752840247 | 0.25 | SMAD3 SMAD2 | Colorectal cancer |
| HP:0012763 | 0.0384712883781 | 0.25 | SMAD3 SMAD2 | Paroxysmal dyspnea |
| HP:0012432 | 0.0384712883781 | 0.25 | SMAD3 SMAD2 | Chronic fatigue |
| WP:WP5158 | 0.0402976114103 | 0.25 | SMAD3 SMAD2 | Urotensin II mediated signaling pathway |
| WP:WP2324 | 0.0416757621985 | 0.25 | SMAD3 SMAD2 | AGE RAGE pathway |
| HP:0012499 | 0.0427341718023 | 0.25 | SMAD3 SMAD2 | Descending aortic dissection |
| REAC:R-HSA-2173789 | 0.0452582424141 | 0.25 | SMAD3 SMAD2 | TGF-beta receptor signaling activates SMADs |
| KEGG:04933 | 0.0474398326563 | 0.25 | SMAD3 SMAD2 | AGE-RAGE signaling pathway in diabetic complications |
| GO:0071495 | 0.0488155931118 | 0.75 | SMAD5 SMAD2 SMAD3 LEMD3 ZFYVE9 SMAD9 | cellular response to endogenous stimulus |
| CORUM:3199 | 0.0499436884912 | 0.125 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3039 | 0.0499436884912 | 0.125 | SMAD2 | SMAD2-FAST1 complex |
| CORUM:3198 | 0.0499436884912 | 0.125 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3733 | 0.0499436884912 | 0.125 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3729 | 0.0499436884912 | 0.125 | SMAD2 | SKI-SMAD2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SMAD3 | LEMD3 | 0.999 | 0.124 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| SMAD9 | LEMD3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ZFYVE9 | SMAD2 | 0.998 | 0.088 |
mutually_exclusive (Q99717)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SMAD2 | LEMD3 | 0.997 | 0.076 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZFYVE9 | SMAD3 | 0.996 | 0.212 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| SMAD2 | SMAD3 | 0.993 | 0.29 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMAD3 | SMAD9 | 0.989 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SEMA4A | LEMD3 | 0.97 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SMAD5 | LEMD3 | 0.967 | 0.07 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD2 | SMAD9 | 0.965 |
mutually_exclusive (P84022)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LCTL | LEMD3 | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZFYVE9 | LEMD3 | 0.841 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZFYVE9 | SMAD9 | 0.353 |
mutually_exclusive (P84022)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD3 | SMAD5 | 0.206 | 0.2 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD2 | SMAD5 | 0.102 | 0.094 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
Related Complexes