hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09088.1

Complex Portal: CPX-13024

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
GYPB	Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b)	5	UniProt NCBI
BZW1	eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf)	5	UniProt NCBI
EIF2B2	Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)	5	UniProt NCBI
EIF2B1	Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha)	5	UniProt NCBI
EIF2B3	Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma)	5	UniProt NCBI
EIF2B4	Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)	5	UniProt NCBI
EXOG	Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)	5	UniProt NCBI
BZW2	eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2)	5	UniProt NCBI
PTAFR	Platelet-activating factor receptor (PAF-R) (PAFr)	5	UniProt NCBI
EIF2B5	Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7292	1.84180722403e-15	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
REAC:R-HSA-72731	3.00907593977e-13	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	Recycling of eIF2:GDP
GO:0005851	1.13455325e-12	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	eukaryotic translation initiation factor 2B complex
CORUM:7291	5.38212907005e-12	0.444444444444	EIF2B2 EIF2B4 EIF2B5 EIF2B3	EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
GO:0006413	1.43485453193e-09	0.777777777778	EIF2B3 EIF2B5 EIF2B2 BZW2 BZW1 EIF2B4 EIF2B1	translational initiation
WP:WP107	3.90843971834e-09	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	Translation factors
GO:0014003	7.00141271396e-09	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	oligodendrocyte development
GO:0048709	3.65797757329e-07	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	oligodendrocyte differentiation
REAC:R-HSA-72613	9.1676686367e-07	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	Eukaryotic Translation Initiation
REAC:R-HSA-72737	9.1676686367e-07	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	Cap-dependent Translation Initiation
GO:0003743	1.22120697132e-06	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	translation initiation factor activity
GO:0021782	2.37926130639e-06	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	glial cell development
GO:0009408	6.11898981566e-06	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to heat
GO:0008135	1.35290192926e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	translation factor activity, RNA binding
GO:0009749	1.67785355241e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to glucose
GO:0034284	1.92708556818e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to monosaccharide
GO:0009746	1.92708556818e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to hexose
HP:0000869	2.18268284959e-05	0.444444444444	EIF2B2 EIF2B4 EIF2B1 EIF2B3	Secondary amenorrhea
GO:0009266	2.68109964568e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to temperature stimulus
GO:0009743	3.04164504441e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to carbohydrate
GO:0090079	3.65405136871e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	translation regulator activity, nucleic acid binding
GO:0010001	5.17342495562e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	glial cell differentiation
KEGG:05168	5.69745212713e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	Herpes simplex virus 1 infection
GO:0050852	5.7789363666e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	T cell receptor signaling pathway
WP:WP5316	6.4359235662e-05	0.444444444444	EIF2B2 EIF2B4 EIF2B5 EIF2B3	Primary ovarian insufficiency
REAC:R-HSA-72766	8.03363746558e-05	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	Translation
GO:0045182	0.000135563471558	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	translation regulator activity
GO:0006412	0.000145014867252	0.777777777778	EIF2B3 EIF2B5 EIF2B2 BZW2 BZW1 EIF2B4 EIF2B1	translation
GO:0043043	0.000178020511892	0.777777777778	EIF2B3 EIF2B5 EIF2B2 BZW2 BZW1 EIF2B4 EIF2B1	peptide biosynthetic process
GO:0050851	0.000193437808234	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	antigen receptor-mediated signaling pathway
GO:0042063	0.00021963178469	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	gliogenesis
GO:0043604	0.000610978561782	0.777777777778	EIF2B3 EIF2B5 EIF2B2 BZW2 BZW1 EIF2B4 EIF2B1	amide biosynthetic process
GO:0006518	0.000671373035736	0.777777777778	EIF2B3 EIF2B5 EIF2B2 BZW2 BZW1 EIF2B4 EIF2B1	peptide metabolic process
GO:0005085	0.00104852376706	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	guanyl-nucleotide exchange factor activity
HP:0000141	0.00111194043176	0.444444444444	EIF2B2 EIF2B4 EIF2B1 EIF2B3	Amenorrhea
GO:0002429	0.00282053658626	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	immune response-activating cell surface receptor signaling pathway
GO:0006446	0.00316270648564	0.444444444444	BZW1 EIF2B5 BZW2 EIF2B2	regulation of translational initiation
GO:0043434	0.00334738121191	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to peptide hormone
GO:0002768	0.00433082653971	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	immune response-regulating cell surface receptor signaling pathway
HP:0002352	0.00457026551821	0.444444444444	EIF2B2 EIF2B4 EIF2B1 EIF2B3	Leukoencephalopathy
GO:0043603	0.00464387181741	0.777777777778	EIF2B3 EIF2B5 EIF2B2 BZW2 BZW1 EIF2B4 EIF2B1	amide metabolic process
GO:0001541	0.00778531456229	0.333333333333	EIF2B2 EIF2B5 EIF2B4	ovarian follicle development
GO:1901652	0.0088969701328	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	response to peptide
HP:0000140	0.0090926165236	0.444444444444	EIF2B2 EIF2B4 EIF2B1 EIF2B3	Abnormality of the menstrual cycle
GO:0006417	0.0116332335811	0.555555555556	BZW1 EIF2B4 EIF2B5 BZW2 EIF2B2	regulation of translation
HP:0030012	0.021175319094	0.444444444444	EIF2B2 EIF2B4 EIF2B1 EIF2B3	Abnormal female reproductive system physiology
GO:0008585	0.0234426873659	0.333333333333	EIF2B2 EIF2B5 EIF2B4	female gonad development
GO:0046545	0.0262477173145	0.333333333333	EIF2B2 EIF2B5 EIF2B4	development of primary female sexual characteristics
GO:0034248	0.0264467978108	0.555555555556	BZW1 EIF2B4 EIF2B5 BZW2 EIF2B2	regulation of amide metabolic process
GO:0002757	0.0272899667719	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	immune response-activating signaling pathway
GO:0002764	0.0358806003362	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	immune response-regulating signaling pathway
GO:0046660	0.0436468140298	0.333333333333	EIF2B2 EIF2B5 EIF2B4	female sex differentiation
GO:0060589	0.0464900850516	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	nucleoside-triphosphatase regulator activity
GO:0030695	0.0464900850516	0.555555555556	EIF2B2 EIF2B4 EIF2B5 EIF2B1 EIF2B3	GTPase regulator activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
EIF2B2	EIF2B5	1.0	0.882	mixed_interface	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B3	EIF2B5	1.0	0.932	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B2	EIF2B3	1.0	0.878	structurally_consistent (Q13144)	bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B4	EIF2B2	1.0	0.38		bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B2	EIF2B1	1.0	0.538		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B5	EIF2B1	1.0	0.57		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B4	EIF2B5	1.0	0.472	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
BZW1	BZW2	0.999	0.286		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM treiber_WMM
EIF2B3	EIF2B1	0.999	0.324		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B4	EIF2B1	0.998	0.094		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EXOG	EIF2B2	0.998	0.028	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EIF2B4	EIF2B3	0.997	0.436	structurally_consistent (dimer)	bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM
BZW1	EIF2B4	0.983	0.11		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
BZW2	EIF2B3	0.979	0.12		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
EIF2B2	PTAFR	0.977		structurally_consistent (Q13144)	bioplex3_WMM bioplex3_HCT116 WMM_only
GYPB	EIF2B4	0.972			bioplex3_HEK293 bioplex ()
GYPB	EIF2B3	0.972			bioplex3_HEK293 bioplex ()
BZW1	EIF2B5	0.972	0.152		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
GYPB	BZW1	0.971			bioplex3_HEK293 bioplex ()
BZW2	EIF2B2	0.971	0.074	structurally_consistent (Q9Y2C4)	bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
GYPB	EIF2B1	0.971			bioplex3_HEK293 bioplex ()
EXOG	EIF2B1	0.97	0.048		bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
EXOG	EIF2B5	0.969	0.044		bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
EIF2B4	PTAFR	0.968		structurally_consistent (Q13144)	bioplex3_WMM bioplex3_HCT116 WMM_only
BZW2	EIF2B5	0.967	0.128		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
BZW1	EIF2B3	0.96	0.282		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
PTAFR	EIF2B5	0.959		structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
EIF2B4	BZW2	0.954	0.094		bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM
BZW2	EXOG	0.946	0.022	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
GYPB	EIF2B2	0.937			bioplex3_HEK293 bioplex ()
BZW1	EIF2B2	0.913	0.208		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
BZW2	EIF2B1	0.912	0.144		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
GYPB	BZW2	0.873			bioplex3_HEK293 bioplex ()
GYPB	EIF2B5	0.862			bioplex3_HEK293 bioplex ()
BZW1	EIF2B1	0.656	0.244		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
EXOG	EIF2B3	0.599	0.046		bioplex_WMM bioplex3_WMM WMM_only
EIF2B4	EXOG	0.461	0.044		bioplex_WMM bioplex3_WMM WMM_only
BZW1	EXOG	0.031	0.046		bioplex_WMM bioplex3_WMM WMM_only
PTAFR	EIF2B1	0.021			bioplex3_WMM bioplex3_HCT116 WMM_only
PTAFR	EIF2B3	0.021		mutually_exclusive (Q13144)	bioplex3_WMM bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
GYPB	huMAP3_00951.1 huMAP3_03018.1 huMAP3_03231.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
BZW1	huMAP3_00951.1 huMAP3_01913.1 huMAP3_03018.1 huMAP3_03231.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_14489.1
EIF2B2	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08680.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EIF2B1	huMAP3_08485.1 huMAP3_08680.1 huMAP3_08968.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1
EIF2B3	huMAP3_03231.1 huMAP3_04876.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_12208.1
EIF2B4	huMAP3_00951.1 huMAP3_03018.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EXOG	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11700.1
BZW2	huMAP3_00951.1 huMAP3_02736.1 huMAP3_04876.1 huMAP3_06722.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
PTAFR	huMAP3_02469.1 huMAP3_02659.1 huMAP3_07141.1 huMAP3_08184.1 huMAP3_08680.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10287.1 huMAP3_10530.1
EIF2B5	huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09399.1 huMAP3_09406.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_11977.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09088.1

Complex Portal: CPX-13024