hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09089.1
Complex Portal: CPX-17445
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | 5 | UniProt NCBI |
| UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| THRSP | Thyroid hormone-inducible hepatic protein (Spot 14 protein) (S14) (SPOT14) | 5 | UniProt NCBI |
| UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| OTUB1 | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) | 5 | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061631 | 7.15510962757e-08 | 0.625 | UBE2D1 UBE2D2 UBE2D4 UBE2D3 UBE2E2 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 1.62855460324e-07 | 0.625 | UBE2D1 UBE2D2 UBE2D4 UBE2D3 UBE2E2 | ubiquitin-like protein conjugating enzyme activity |
| KEGG:04120 | 1.6926992291e-07 | 0.625 | UBE2D1 UBE2D2 UBE2D4 UBE2D3 UBE2E2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983168 | 2.82342748503e-07 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 9.65477700289e-07 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | Class I MHC mediated antigen processing & presentation |
| KEGG:03083 | 2.98324067382e-06 | 0.5 | UBE2D1 UBE2D4 UBE2D3 UBE2D2 | Polycomb repressive complex |
| GO:0070936 | 6.97460549517e-06 | 0.625 | UBE2D1 UBE2D2 UBE2D4 UBE2D3 UBE2E2 | protein K48-linked ubiquitination |
| GO:0000209 | 1.36597602434e-05 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | protein polyubiquitination |
| REAC:R-HSA-168927 | 2.21041516255e-05 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 2.59982063947e-05 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | IKK complex recruitment mediated by RIP1 |
| REAC:R-HSA-9705462 | 4.03573329385e-05 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Inactivation of CSF3 (G-CSF) signaling |
| KEGG:04141 | 4.18684039424e-05 | 0.5 | UBE2D1 UBE2D4 UBE2D3 UBE2D2 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-1280218 | 4.73913973479e-05 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | Adaptive Immune System |
| REAC:R-HSA-9674555 | 7.45572658486e-05 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-936440 | 0.000124011659906 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Negative regulators of DDX58/IFIH1 signaling |
| GO:0070647 | 0.000126962382918 | 0.875 | RNF25 UBE2D1 UBE2D4 OTUB1 UBE2D2 UBE2E2 UBE2D3 | protein modification by small protein conjugation or removal |
| KEGG:05131 | 0.000187054370925 | 0.5 | UBE2D1 UBE2D4 UBE2D3 UBE2D2 | Shigellosis |
| GO:0043687 | 0.000200817178726 | 0.875 | RNF25 UBE2D1 UBE2D4 OTUB1 UBE2D2 UBE2E2 UBE2D3 | post-translational protein modification |
| GO:0004842 | 0.000219127801644 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | ubiquitin-protein transferase activity |
| REAC:R-HSA-5357905 | 0.000300178466725 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Regulation of TNFR1 signaling |
| WP:WP183 | 0.000348281985026 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Proteasome degradation |
| GO:0019787 | 0.000350419464195 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | ubiquitin-like protein transferase activity |
| REAC:R-HSA-9033241 | 0.000391615111842 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Peroxisomal protein import |
| GO:0016755 | 0.000430541533747 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | aminoacyltransferase activity |
| REAC:R-HSA-75893 | 0.000529728773758 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | TNF signaling |
| REAC:R-HSA-8866654 | 0.000560745073172 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-1234176 | 0.00089567252269 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-1234174 | 0.00123242662733 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Cellular response to hypoxia |
| REAC:R-HSA-8852135 | 0.00145795819653 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Protein ubiquitination |
| REAC:R-HSA-168928 | 0.00151831565434 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0085020 | 0.00195378579303 | 0.375 | RNF25 UBE2D4 UBE2D3 | protein K6-linked ubiquitination |
| GO:0016567 | 0.00250984376957 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | protein ubiquitination |
| REAC:R-HSA-168164 | 0.00272039056422 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 0.0029043291557 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.0029043291557 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | TRIF(TICAM1)-mediated TLR4 signaling |
| GO:0031625 | 0.00370387665416 | 0.625 | UBE2D1 UBE2D3 UBE2D4 OTUB1 UBE2D2 | ubiquitin protein ligase binding |
| GO:0016746 | 0.00404152463452 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | acyltransferase activity |
| GO:0044389 | 0.00496080448558 | 0.625 | UBE2D1 UBE2D3 UBE2D4 OTUB1 UBE2D2 | ubiquitin-like protein ligase binding |
| GO:0032446 | 0.00540459876835 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | protein modification by small protein conjugation |
| REAC:R-HSA-166016 | 0.00672088844441 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 0.00739626952664 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Death Receptor Signaling |
| REAC:R-HSA-9609507 | 0.00907607024649 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Protein localization |
| REAC:R-HSA-168898 | 0.0103248470282 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Toll-like Receptor Cascades |
| REAC:R-HSA-168256 | 0.0113619114179 | 0.75 | RNF25 UBE2D1 UBE2D3 UBE2D2 UBE2E2 UBE2D4 | Immune System |
| REAC:R-HSA-201451 | 0.0166306183768 | 0.25 | UBE2D1 UBE2D3 | Signaling by BMP |
| GO:0070979 | 0.0175209574744 | 0.375 | UBE2D4 UBE2D3 UBE2E2 | protein K11-linked ubiquitination |
| REAC:R-HSA-2173795 | 0.0224821270291 | 0.25 | UBE2D1 UBE2D3 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| REAC:R-HSA-8866652 | 0.0240813966337 | 0.25 | UBE2D1 UBE2D2 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| REAC:R-HSA-5689896 | 0.0328938418336 | 0.25 | UBE2D1 OTUB1 | Ovarian tumor domain proteases |
| REAC:R-HSA-8951664 | 0.0405199292649 | 0.375 | UBE2D1 UBE2D3 UBE2D2 | Neddylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF25 | UBE2D2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RNF25 | UBE2D3 | 0.998 | 0.064 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 |
mutually_exclusive (Q969T4)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF25 | UBE2D4 | 0.99 |
mutually_exclusive (Q96LR5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBE2E2 | OTUB1 | 0.988 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2E2 | 0.984 | 0.046 |
mutually_exclusive (P61077)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D2 | OTUB1 | 0.982 | 0.246 |
mutually_exclusive (Q96LR5)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| UBE2D1 | THRSP | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D3 | UBE2D2 | 0.975 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D4 | OTUB1 | 0.963 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2D3 | UBE2D4 | 0.909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| RNF25 | OTUB1 | 0.562 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D4 | UBE2E2 | 0.502 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2D1 | 0.388 | 0.308 | bioplex3_WMM youn_WMM WMM_only | |
| UBE2D1 | OTUB1 | 0.259 | 0.272 |
mutually_exclusive (Q969T4)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D1 | UBE2E2 | 0.214 | 0.214 | bioplex3_WMM WMM_only | |
| UBE2D1 | UBE2D4 | 0.214 | bioplex3_WMM WMM_only | ||
| UBE2D3 | UBE2E2 | 0.153 | 0.062 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D2 | UBE2D4 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | ||
| UBE2D2 | UBE2E2 | 0.143 | 0.15 |
mutually_exclusive (Q96FW1)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM WMM_only |
| RNF25 | THRSP | 0.078 | bioplex3_WMM WMM_only | ||
| UBE2D3 | THRSP | 0.076 | bioplex3_WMM WMM_only | ||
| THRSP | OTUB1 | 0.066 | bioplex3_WMM WMM_only | ||
| UBE2D3 | OTUB1 | 0.034 | 0.396 |
structurally_consistent (Q96LR5)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes