hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09092.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMG8 | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | 5 | UniProt NCBI |
| SMG1 | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | 5 | UniProt NCBI |
| CIB3 | Calcium and integrin-binding family member 3 (Kinase-interacting protein 3) (KIP 3) | 5 | UniProt NCBI |
| SMG9 | Nonsense-mediated mRNA decay factor SMG9 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-975957 | 0.000335499618459 | 0.75 | SMG8 SMG9 SMG1 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.000335499618459 | 0.75 | SMG8 SMG9 SMG1 | Nonsense-Mediated Decay (NMD) |
| GO:0000184 | 0.00209449363787 | 0.75 | SMG8 SMG9 SMG1 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SMG1 | SMG9 | 0.995 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| SMG8 | SMG9 | 0.969 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| SMG8 | CIB3 | 0.968 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SMG8 | SMG1 | 0.966 | 0.14 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes