hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09102.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | 5 | UniProt NCBI |
| AGO4 | Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 3.58839967947e-05 | 1.0 | AGO4 AGO3 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-9768778 | 4.78453290596e-05 | 1.0 | AGO4 AGO3 | Regulation of NPAS4 mRNA translation |
| REAC:R-HSA-8948700 | 4.78453290596e-05 | 1.0 | AGO4 AGO3 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-426486 | 6.15154230766e-05 | 1.0 | AGO4 AGO3 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-8943723 | 6.15154230766e-05 | 1.0 | AGO4 AGO3 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-9768759 | 7.68942788458e-05 | 1.0 | AGO4 AGO3 | Regulation of NPAS4 gene expression |
| REAC:R-HSA-8934593 | 0.00023239159829 | 1.0 | AGO4 AGO3 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-203927 | 0.000432316723289 | 1.0 | AGO4 AGO3 | MicroRNA (miRNA) biogenesis |
| REAC:R-HSA-9634815 | 0.000645911942305 | 1.0 | AGO4 AGO3 | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9022692 | 0.000693757271364 | 1.0 | AGO4 AGO3 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 0.00079457421474 | 1.0 | AGO4 AGO3 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-2559585 | 0.000902226205124 | 1.0 | AGO4 AGO3 | Oncogene Induced Senescence |
| REAC:R-HSA-8853884 | 0.00113803532692 | 1.0 | AGO4 AGO3 | Transcriptional Regulation by VENTX |
| REAC:R-HSA-9024446 | 0.00126619245833 | 1.0 | AGO4 AGO3 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 0.00235467369443 | 1.0 | AGO4 AGO3 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-4086398 | 0.00235467369443 | 1.0 | AGO4 AGO3 | Ca2+ pathway |
| REAC:R-HSA-1912408 | 0.00486997099357 | 1.0 | AGO4 AGO3 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5628897 | 0.00526469495831 | 1.0 | AGO4 AGO3 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-8936459 | 0.00539968713673 | 1.0 | AGO4 AGO3 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| REAC:R-HSA-5687128 | 0.0055363880769 | 1.0 | AGO4 AGO3 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912422 | 0.00715287669441 | 1.0 | AGO4 AGO3 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-2559580 | 0.00969038789632 | 1.0 | AGO4 AGO3 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-211000 | 0.0117955823749 | 1.0 | AGO4 AGO3 | Gene Silencing by RNA |
| GO:0070578 | 0.0131096201623 | 1.0 | AGO4 AGO3 | RISC-loading complex |
| REAC:R-HSA-9018519 | 0.0136718027788 | 1.0 | AGO4 AGO3 | Estrogen-dependent gene expression |
| REAC:R-HSA-6807070 | 0.015455750048 | 1.0 | AGO4 AGO3 | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.0156864328845 | 1.0 | AGO4 AGO3 | Beta-catenin independent WNT signaling |
| GO:0010501 | 0.016855225923 | 1.0 | AGO4 AGO3 | RNA secondary structure unwinding |
| GO:0070922 | 0.0210690324038 | 1.0 | AGO4 AGO3 | RISC complex assembly |
| CORUM:1386 | 0.0249718442457 | 0.5 | AGO4 | TTP-AGO4 complex |
| REAC:R-HSA-2559583 | 0.0260158976762 | 1.0 | AGO4 AGO3 | Cellular Senescence |
| REAC:R-HSA-8939211 | 0.0290831250212 | 1.0 | AGO4 AGO3 | ESR-mediated signaling |
| REAC:R-HSA-157118 | 0.0353816208396 | 1.0 | AGO4 AGO3 | Signaling by NOTCH |
| REAC:R-HSA-8878171 | 0.0378576166184 | 1.0 | AGO4 AGO3 | Transcriptional regulation by RUNX1 |
| GO:0016442 | 0.0426062655276 | 1.0 | AGO4 AGO3 | RISC complex |
| GO:0031332 | 0.0426062655276 | 1.0 | AGO4 AGO3 | RNAi effector complex |
| REAC:R-HSA-1257604 | 0.0450002407423 | 1.0 | AGO4 AGO3 | PIP3 activates AKT signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AGO3 | AGO4 | 0.968 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only |
Related Complexes