hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09111.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP35 | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | 5 | UniProt NCBI |
| NDC1 | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | 5 | UniProt NCBI |
| NUP155 | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | 5 | UniProt NCBI |
| SENP2 | Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 9.59218740742e-08 | 1.0 | SENP2 NDC1 NUP35 NUP155 | Nucleocytoplasmic transport |
| REAC:R-HSA-2990846 | 2.72176702781e-06 | 1.0 | SENP2 NDC1 NUP35 NUP155 | SUMOylation |
| REAC:R-HSA-9615933 | 2.8370403595e-06 | 0.75 | NDC1 NUP35 NUP155 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-170822 | 4.59102468944e-06 | 0.75 | NDC1 NUP35 NUP155 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 4.59102468944e-06 | 0.75 | NDC1 NUP35 NUP155 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168333 | 5.12049513312e-06 | 0.75 | NDC1 NUP35 NUP155 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168271 | 5.12049513312e-06 | 0.75 | NDC1 NUP35 NUP155 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168274 | 5.12049513312e-06 | 0.75 | NDC1 NUP35 NUP155 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-180746 | 6.29837429836e-06 | 0.75 | NDC1 NUP35 NUP155 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 6.29837429836e-06 | 0.75 | NDC1 NUP35 NUP155 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 6.29837429836e-06 | 0.75 | NDC1 NUP35 NUP155 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-165054 | 6.94957302308e-06 | 0.75 | NDC1 NUP35 NUP155 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-4085377 | 6.94957302308e-06 | 0.75 | NDC1 NUP35 NUP155 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 6.94957302308e-06 | 0.75 | NDC1 NUP35 NUP155 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 7.64413736449e-06 | 0.75 | NDC1 NUP35 NUP155 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 8.38346160394e-06 | 0.75 | NDC1 NUP35 NUP155 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 8.38346160394e-06 | 0.75 | NDC1 NUP35 NUP155 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 9.16893973468e-06 | 0.75 | NDC1 NUP35 NUP155 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 1.08839322026e-05 | 0.75 | NDC1 NUP35 NUP155 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 1.18162330858e-05 | 0.75 | NDC1 NUP35 NUP155 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 1.28002609524e-05 | 0.75 | NDC1 NUP35 NUP155 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 1.38374083551e-05 | 0.75 | NDC1 NUP35 NUP155 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 1.60766305396e-05 | 0.75 | NDC1 NUP35 NUP155 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 1.72814889866e-05 | 0.75 | NDC1 NUP35 NUP155 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 2.27017011202e-05 | 0.75 | NDC1 NUP35 NUP155 | Nuclear Envelope Breakdown |
| REAC:R-HSA-194441 | 2.91499008839e-05 | 0.75 | NDC1 NUP35 NUP155 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 2.91499008839e-05 | 0.75 | NDC1 NUP35 NUP155 | snRNP Assembly |
| WP:WP3998 | 3.1983058296e-05 | 0.75 | NDC1 NUP35 NUP155 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-6784531 | 3.67150180564e-05 | 0.75 | NDC1 NUP35 NUP155 | tRNA processing in the nucleus |
| GO:0005643 | 4.8352616995e-05 | 1.0 | SENP2 NDC1 NUP35 NUP155 | nuclear pore |
| REAC:R-HSA-3371453 | 6.1097260824e-05 | 0.75 | NDC1 NUP35 NUP155 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 6.1097260824e-05 | 0.75 | NDC1 NUP35 NUP155 | Glycolysis |
| REAC:R-HSA-1169408 | 6.40033583955e-05 | 0.75 | NDC1 NUP35 NUP155 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 6.40033583955e-05 | 0.75 | NDC1 NUP35 NUP155 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-2995410 | 6.70000655285e-05 | 0.75 | NDC1 NUP35 NUP155 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-5619102 | 7.65476877178e-05 | 0.75 | NDC1 NUP35 NUP155 | SLC transporter disorders |
| REAC:R-HSA-159236 | 7.65476877178e-05 | 0.75 | NDC1 NUP35 NUP155 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 7.99206750774e-05 | 0.75 | NDC1 NUP35 NUP155 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 8.33911915483e-05 | 0.75 | NDC1 NUP35 NUP155 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 0.000110531761496 | 0.75 | NDC1 NUP35 NUP155 | Glucose metabolism |
| REAC:R-HSA-72202 | 0.000110531761496 | 0.75 | NDC1 NUP35 NUP155 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-3371556 | 0.000138011947324 | 0.75 | NDC1 NUP35 NUP155 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 0.000169699262125 | 0.75 | NDC1 NUP35 NUP155 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-72306 | 0.000219007946647 | 0.75 | NDC1 NUP35 NUP155 | tRNA processing |
| REAC:R-HSA-9610379 | 0.000219007946647 | 0.75 | NDC1 NUP35 NUP155 | HCMV Late Events |
| REAC:R-HSA-9705671 | 0.00031803083943 | 0.75 | NDC1 NUP35 NUP155 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-211000 | 0.000372329018867 | 0.75 | NDC1 NUP35 NUP155 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.000391711563853 | 0.75 | NDC1 NUP35 NUP155 | HCMV Early Events |
| REAC:R-HSA-68875 | 0.00041175394675 | 0.75 | NDC1 NUP35 NUP155 | Mitotic Prophase |
| REAC:R-HSA-162909 | 0.000443078669654 | 0.75 | NDC1 NUP35 NUP155 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.000498740793897 | 0.75 | NDC1 NUP35 NUP155 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 0.000510403660163 | 0.75 | NDC1 NUP35 NUP155 | Influenza Viral RNA Transcription and Replication |
| GO:0017056 | 0.000591522022343 | 0.75 | NDC1 NUP35 NUP155 | structural constituent of nuclear pore |
| REAC:R-HSA-5619115 | 0.000637157683969 | 0.75 | NDC1 NUP35 NUP155 | Disorders of transmembrane transporters |
| REAC:R-HSA-162587 | 0.000650875640662 | 0.75 | NDC1 NUP35 NUP155 | HIV Life Cycle |
| REAC:R-HSA-9609646 | 0.000650875640662 | 0.75 | NDC1 NUP35 NUP155 | HCMV Infection |
| REAC:R-HSA-168255 | 0.000737326259628 | 0.75 | NDC1 NUP35 NUP155 | Influenza Infection |
| REAC:R-HSA-3108232 | 0.000897810107574 | 0.75 | NDC1 NUP35 NUP155 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-913531 | 0.00122110889015 | 0.75 | NDC1 NUP35 NUP155 | Interferon Signaling |
| REAC:R-HSA-9705683 | 0.00151474987795 | 0.75 | NDC1 NUP35 NUP155 | SARS-CoV-2-host interactions |
| KEGG:05014 | 0.00189623846113 | 0.75 | NDC1 NUP35 NUP155 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-162906 | 0.0024623188735 | 0.75 | NDC1 NUP35 NUP155 | HIV Infection |
| REAC:R-HSA-68882 | 0.00252982363853 | 0.75 | NDC1 NUP35 NUP155 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00256403202009 | 0.75 | NDC1 NUP35 NUP155 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-71387 | 0.00382744839761 | 0.75 | NDC1 NUP35 NUP155 | Metabolism of carbohydrates |
| REAC:R-HSA-9694516 | 0.00464100691605 | 0.75 | NDC1 NUP35 NUP155 | SARS-CoV-2 Infection |
| REAC:R-HSA-72203 | 0.00469213914253 | 0.75 | NDC1 NUP35 NUP155 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-597592 | 0.0091733555377 | 1.0 | SENP2 NDC1 NUP35 NUP155 | Post-translational protein modification |
| REAC:R-HSA-9679506 | 0.0120967178818 | 0.75 | NDC1 NUP35 NUP155 | SARS-CoV Infections |
| REAC:R-HSA-68886 | 0.0131851712206 | 0.75 | NDC1 NUP35 NUP155 | M Phase |
| GO:0005635 | 0.0163581002539 | 1.0 | SENP2 NDC1 NUP35 NUP155 | nuclear envelope |
| REAC:R-HSA-69278 | 0.0329329593357 | 0.75 | NDC1 NUP35 NUP155 | Cell Cycle, Mitotic |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | SENP2 NDC1 NUP35 NUP155 | Metabolism of proteins |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDC1 | NUP35 | 0.997 | 0.27 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NUP155 | NUP35 | 0.991 | 0.476 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| NUP155 | NDC1 | 0.986 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| SENP2 | NDC1 | 0.98 | 0.086 | hein_WMM youn_WMM gupta_WMM WMM_only |
| SENP2 | NUP155 | 0.959 | 0.15 | hein_WMM youn_WMM gupta_WMM WMM_only |
| SENP2 | NUP35 | 0.951 | 0.214 | hein_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes