hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09119.1

Complex Portal: CPX-24521

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
WIPF1	WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)	5	UniProt NCBI
PIK3AP1	Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)	5	UniProt NCBI
WIPF2	WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)	5	UniProt NCBI
SH3PXD2B	SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)	5	UniProt NCBI
WIPF3	WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog)	4	UniProt NCBI
CBLB	E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)	5	UniProt NCBI
NHS	Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein)	5	UniProt NCBI
TNK2	Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)	5	UniProt NCBI
DOK1	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)	5	UniProt NCBI
SEMA6A	Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)	5	UniProt NCBI
ARAP1	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)	5	UniProt NCBI
TNIK	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)	5	UniProt NCBI
WASL	Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)	5	UniProt NCBI
ASAP2	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)	5	UniProt NCBI
NCK1	SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)	5	UniProt NCBI
ARHGEF10L	Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF)	5	UniProt NCBI
NCK2	Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04144	1.35289005533e-07	0.4375	ASAP2 CBLB WIPF3 WASL WIPF2 WIPF1 ARAP1	Endocytosis
REAC:R-HSA-9012999	8.09820217069e-07	0.5	NHS NCK2 WIPF3 ARHGEF10L WASL WIPF2 WIPF1 ARAP1	RHO GTPase cycle
REAC:R-HSA-9013149	3.10809103167e-06	0.375	NHS WIPF3 WASL WIPF2 WIPF1 ARAP1	RAC1 GTPase cycle
REAC:R-HSA-5663213	1.27340308297e-05	0.25	WIPF2 WASL WIPF1 WIPF3	RHO GTPases Activate WASPs and WAVEs
REAC:R-HSA-194315	3.1585464739e-05	0.5	NHS NCK2 WIPF3 ARHGEF10L WASL WIPF2 WIPF1 ARAP1	Signaling by Rho GTPases
REAC:R-HSA-9716542	3.74287771712e-05	0.5	NHS NCK2 WIPF3 ARHGEF10L WASL WIPF2 WIPF1 ARAP1	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
KEGG:05130	4.04419193337e-05	0.3125	WIPF2 WASL WIPF1 NCK2 WIPF3	Pathogenic Escherichia coli infection
REAC:R-HSA-9013148	5.20553039178e-05	0.3125	WIPF2 WASL WIPF1 ARAP1 WIPF3	CDC42 GTPase cycle
REAC:R-HSA-9664407	7.94055959354e-05	0.25	WIPF2 WASL WIPF1 WIPF3	Parasite infection
REAC:R-HSA-9664417	7.94055959354e-05	0.25	WIPF2 WASL WIPF1 WIPF3	Leishmania phagocytosis
REAC:R-HSA-9664422	7.94055959354e-05	0.25	WIPF2 WASL WIPF1 WIPF3	FCGR3A-mediated phagocytosis
REAC:R-HSA-2029482	9.94018508785e-05	0.25	WIPF2 WASL WIPF1 WIPF3	Regulation of actin dynamics for phagocytic cup formation
KEGG:05135	0.000365056922	0.25	WIPF2 WASL WIPF1 WIPF3	Yersinia infection
REAC:R-HSA-2029480	0.000380489790327	0.25	WIPF2 WASL WIPF1 WIPF3	Fcgamma receptor (FCGR) dependent phagocytosis
REAC:R-HSA-162582	0.00267509547333	0.625	NHS WASL PIK3AP1 DOK1 WIPF3 ARHGEF10L NCK2 ARAP1 WIPF2 WIPF1	Signal Transduction
REAC:R-HSA-9658195	0.00350030956112	0.25	WIPF2 WASL WIPF1 WIPF3	Leishmania infection
REAC:R-HSA-9824443	0.00350030956112	0.25	WIPF2 WASL WIPF1 WIPF3	Parasitic Infection Pathways
REAC:R-HSA-8849469	0.0117754515762	0.125	ARAP1 DOK1	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
GO:0030036	0.0345486060113	0.4375	TNIK NCK2 WIPF3 ARHGEF10L WASL WIPF1 ARAP1	actin cytoskeleton organization
GO:0007015	0.0473648356162	0.375	NCK2 WIPF3 ARHGEF10L WASL WIPF1 ARAP1	actin filament organization
CORUM:2513	0.0497620750785	0.0625	WASL	N-WASp homomer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
NCK2	WIPF2	1.0	0.044
NCK1	NCK2	1.0	0.084
NCK1	WIPF2	0.999	0.1
NCK2	WASL	0.999	0.028
ARAP1	NCK2	0.999	0.082
NCK1	WASL	0.999	0.126
WIPF2	WASL	0.999	0.244
PIK3AP1	NCK2	0.998	0.06
NCK2	TNK2	0.998	0.07
WIPF1	WASL	0.997	0.13
NCK1	WIPF1	0.997	0.052
SH3PXD2B	NCK2	0.997	0.03
WIPF3	WASL	0.996
NCK1	PIK3AP1	0.994	0.056
NCK2	WIPF1	0.994	0.04
WIPF1	WIPF2	0.993	0.16
NCK2	WIPF3	0.992
ARHGEF10L	WASL	0.989	0.1
NHS	NCK2	0.988	0.096
NCK2	ASAP2	0.986	0.054
NCK1	TNK2	0.984	0.204
DOK1	NCK2	0.979	0.062
PIK3AP1	WASL	0.977	0.08
NCK1	NHS	0.976	0.15
NCK2	CBLB	0.973	0.03
PIK3AP1	TNK2	0.972	0.106
PIK3AP1	WIPF2	0.972	0.112
ARAP1	TNK2	0.966	0.074
SEMA6A	NCK2	0.965
NCK2	TNIK	0.964	0.128
SH3PXD2B	CBLB	0.964	0.094
NCK1	ARAP1	0.959	0.044
ARAP1	WIPF2	0.958	0.242
ARAP1	WASL	0.954	0.058
NCK1	ASAP2	0.953	0.06
ARAP1	PIK3AP1	0.939	0.042
NCK1	WIPF3	0.933
WIPF1	TNK2	0.928	0.056
WASL	TNK2	0.923	0.108
WIPF2	TNK2	0.914	0.148
SH3PXD2B	TNK2	0.868	0.112
WIPF1	WIPF3	0.785
WIPF2	WIPF3	0.785
ARAP1	ASAP2	0.763	0.102
ARAP1	CBLB	0.626	0.128
PIK3AP1	WIPF1	0.622	0.092
WIPF3	TNK2	0.622
PIK3AP1	WIPF3	0.622
SH3PXD2B	WIPF2	0.618	0.184
WIPF2	ASAP2	0.614	0.258
ARAP1	WIPF1	0.614	0.128
PIK3AP1	ASAP2	0.614	0.068
ARAP1	WIPF3	0.614
WIPF1	ASAP2	0.614	0.092
WIPF3	ASAP2	0.614
TNK2	ASAP2	0.614	0.104
SH3PXD2B	PIK3AP1	0.559	0.038
SH3PXD2B	WASL	0.544	0.144
NCK1	TNIK	0.519	0.052
DOK1	WIPF2	0.513	0.104
DOK1	WIPF1	0.513	0.182
DOK1	CBLB	0.513	0.078
DOK1	PIK3AP1	0.513	0.108
DOK1	TNK2	0.513	0.156
DOK1	WIPF3	0.513
WASL	ASAP2	0.505	0.27
NCK1	SH3PXD2B	0.501	0.07
NHS	TNK2	0.499	0.144
NHS	WIPF2	0.49	0.168
NHS	PIK3AP1	0.49	0.072
NCK1	SEMA6A	0.45
NHS	WASL	0.433	0.22
NHS	ARAP1	0.433	0.196
SH3PXD2B	ARAP1	0.423	0.056
DOK1	WASL	0.378	0.19
DOK1	ARAP1	0.377	0.106
DOK1	TNIK	0.377	0.05
DOK1	ASAP2	0.377	0.072
WIPF2	TNIK	0.363	0.17
DOK1	NCK1	0.339	0.096
SEMA6A	WIPF1	0.324
SEMA6A	WIPF3	0.324
SEMA6A	TNK2	0.324
SEMA6A	WIPF2	0.324
SEMA6A	PIK3AP1	0.324
WIPF1	TNIK	0.3	0.182
WIPF3	TNIK	0.3
ARAP1	TNIK	0.3	0.074
TNIK	ASAP2	0.3	0.044
SH3PXD2B	TNIK	0.299	0.08
CBLB	ASAP2	0.291	0.102
CBLB	WASL	0.291	0.12
CBLB	WIPF3	0.291
CBLB	WIPF1	0.291	0.076
CBLB	TNK2	0.291	0.142
PIK3AP1	CBLB	0.291	0.116
CBLB	WIPF2	0.291	0.064
SH3PXD2B	WIPF1	0.247	0.068
SH3PXD2B	WIPF3	0.247
SEMA6A	ASAP2	0.233
SEMA6A	WASL	0.233
SEMA6A	ARAP1	0.233
WASL	TNIK	0.223	0.176
TNIK	TNK2	0.223	0.054
CBLB	TNIK	0.215	0.048
DOK1	SH3PXD2B	0.215	0.07
SEMA6A	CBLB	0.212
SH3PXD2B	ASAP2	0.205	0.184
PIK3AP1	TNIK	0.202	0.036
NCK1	CBLB	0.188	0.07
DOK1	SEMA6A	0.188
NHS	ASAP2	0.175	0.084
SH3PXD2B	SEMA6A	0.17
SH3PXD2B	NHS	0.131	0.086
DOK1	NHS	0.131	0.108
NHS	TNIK	0.106	0.062
NHS	WIPF3	0.106
NHS	WIPF1	0.106	0.11
NHS	SEMA6A	0.098
SEMA6A	TNIK	0.066
NHS	CBLB	0.046	0.104
PIK3AP1	ARHGEF10L	0.015	0.104
ARHGEF10L	TNIK	0.006	0.094
NCK1	ARHGEF10L	0.005	0.074

Related Complexes

Genename	Complexes
WIPF1	huMAP3_03586.1 huMAP3_05054.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
PIK3AP1	huMAP3_00870.1 huMAP3_05139.1 huMAP3_06440.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
WIPF2	huMAP3_03586.1 huMAP3_05139.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
SH3PXD2B	huMAP3_00870.1 huMAP3_02228.1 huMAP3_07569.1 huMAP3_09119.1 huMAP3_10500.1 huMAP3_14886.1
WIPF3	huMAP3_03586.1 huMAP3_05054.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
CBLB	huMAP3_02228.1 huMAP3_07569.1 huMAP3_07767.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_10500.1 huMAP3_14886.1
NHS	huMAP3_00870.1 huMAP3_01805.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_10500.1 huMAP3_13345.1
TNK2	huMAP3_05139.1 huMAP3_06440.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_12394.1 huMAP3_14886.1
DOK1	huMAP3_00858.1 huMAP3_00870.1 huMAP3_05924.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_10003.1 huMAP3_10500.1 huMAP3_13038.1 huMAP3_13345.1 huMAP3_14886.1 huMAP3_15305.1
SEMA6A	huMAP3_00870.1 huMAP3_01805.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_10500.1
ARAP1	huMAP3_00870.1 huMAP3_06652.1 huMAP3_07569.1 huMAP3_08077.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_10500.1 huMAP3_10870.1 huMAP3_12900.1 huMAP3_15054.1
TNIK	huMAP3_03716.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09757.1
WASL	huMAP3_03586.1 huMAP3_05054.1 huMAP3_07569.1 huMAP3_08336.1 huMAP3_09119.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
ASAP2	huMAP3_07569.1 huMAP3_08747.1 huMAP3_08948.1 huMAP3_09119.1 huMAP3_10500.1 huMAP3_13345.1
NCK1	huMAP3_00870.1 huMAP3_01805.1 huMAP3_05139.1 huMAP3_06440.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
ARHGEF10L	huMAP3_01001.1 huMAP3_03586.1 huMAP3_05054.1 huMAP3_08336.1 huMAP3_09119.1 huMAP3_09549.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_11552.1 huMAP3_11721.1 huMAP3_13598.1 huMAP3_14830.1 huMAP3_15087.1
NCK2	huMAP3_00870.1 huMAP3_01805.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09119.1

Complex Portal: CPX-24521