hu.MAP 3.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Uniprot Annotation Score	Links
AP5S1	AP-5 complex subunit sigma-1 (Adaptor-related protein complex 5 sigma subunit) (Sigma5)	5	UniProt NCBI
ZFYVE26	Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin)	5	UniProt NCBI
AP5Z1	AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5)	5	UniProt NCBI
SPG11	Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein)	5	UniProt NCBI
AP5B1	AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5)	4	UniProt NCBI
AP5M1	AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein)	5	UniProt NCBI
CDC123	Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6602	5.40403185205e-20	0.857142857143	SPG11 AP5Z1 ZFYVE26 AP5B1 AP5S1 AP5M1	AP5-SPG11-SPG15 complex
CORUM:6626	1.92263483365e-12	0.571428571429	AP5M1 AP5Z1 AP5S1 AP5B1	AP5 adaptor complex
GO:0044599	9.2094208532e-10	0.571428571429	AP5M1 AP5Z1 AP5S1 AP5B1	AP-5 adaptor complex
GO:0030119	4.7975405982e-05	0.571428571429	AP5M1 AP5Z1 AP5S1 AP5B1	AP-type membrane coat adaptor complex
HP:0002839	0.000130555487924	0.428571428571	AP5Z1 ZFYVE26 SPG11	Urinary bladder sphincter dysfunction
GO:0005770	0.000480771931868	0.714285714286	AP5M1 AP5Z1 AP5B1 AP5S1 ZFYVE26	late endosome
GO:0030117	0.00202210317171	0.571428571429	AP5M1 AP5Z1 AP5S1 AP5B1	membrane coat
GO:0048475	0.00202210317171	0.571428571429	AP5M1 AP5Z1 AP5S1 AP5B1	coated membrane
HP:0002064	0.00257567372155	0.428571428571	AP5Z1 ZFYVE26 SPG11	Spastic gait
HP:0030890	0.00294725802973	0.428571428571	AP5Z1 ZFYVE26 SPG11	Hyperintensity of cerebral white matter on MRI
HP:0001258	0.00959299491915	0.428571428571	AP5Z1 ZFYVE26 SPG11	Spastic paraplegia
HP:0000020	0.0172483920487	0.428571428571	AP5Z1 ZFYVE26 SPG11	Urinary incontinence
HP:0010550	0.0189708908941	0.428571428571	AP5Z1 ZFYVE26 SPG11	Paraplegia
HP:0001152	0.0283864349721	0.285714285714	ZFYVE26 SPG11	Saccadic smooth pursuit
HP:0031064	0.0292982733881	0.428571428571	AP5Z1 ZFYVE26 SPG11	Impaired continence
HP:0031058	0.0356200251306	0.428571428571	AP5Z1 ZFYVE26 SPG11	Impairment of activities of daily living
HP:0006986	0.0419603197237	0.285714285714	ZFYVE26 SPG11	Upper limb spasticity

Protein 1	Protein 2	Score	ProteomeHD	Evidence
AP5S1	ZFYVE26	0.999	0.148	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP5Z1	SPG11	0.999	0.15	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP5M1	AP5B1	0.999	0.18	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
AP5S1	AP5Z1	0.998	0.334	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP5S1	SPG11	0.998	0.112	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SPG11	AP5M1	0.998	0.202	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
AP5S1	AP5M1	0.998	0.232	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SPG11	AP5B1	0.998	0.268	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
AP5S1	AP5B1	0.998	0.444	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CDC123	AP5B1	0.95	0.042	bioplex_WMM bioplex3_WMM WMM_only
ZFYVE26	AP5M1	0.811	0.174	bioplex3_WMM WMM_only
AP5Z1	AP5M1	0.804	0.102	bioplex3_WMM WMM_only
AP5Z1	AP5B1	0.76	0.554	bioplex3_WMM WMM_only
ZFYVE26	AP5Z1	0.727	0.214	bioplex3_WMM WMM_only
ZFYVE26	SPG11	0.722	0.198	bioplex3_WMM WMM_only
ZFYVE26	AP5B1	0.431	0.188	bioplex3_WMM WMM_only
CDC123	SPG11	0.013	0.036	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CDC123	AP5Z1	0.008	0.02	bioplex_WMM WMM_only