hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09126.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDUFAF2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | 5 | UniProt NCBI |
| FAM185A | Protein FAM185A | 2 | UniProt NCBI |
| NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2) (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 0.00167805708824 | 0.666666666667 | NDUFV2 NDUFAF2 | Mitochondrial complex I assembly model OXPHOS system |
| HP:0012748 | 0.00667190161012 | 0.666666666667 | NDUFV2 NDUFAF2 | Focal T2 hyperintense brainstem lesion |
| HP:0007704 | 0.00795970060154 | 0.666666666667 | NDUFV2 NDUFAF2 | Paroxysmal involuntary eye movements |
| HP:0012747 | 0.00936084070842 | 0.666666666667 | NDUFV2 NDUFAF2 | Abnormal brainstem MRI signal intensity |
| HP:0008316 | 0.00936084070842 | 0.666666666667 | NDUFV2 NDUFAF2 | Abnormal mitochondria in muscle tissue |
| REAC:R-HSA-6799198 | 0.0108549519561 | 0.666666666667 | NDUFV2 NDUFAF2 | Complex I biogenesis |
| HP:0000114 | 0.0136509708315 | 0.666666666667 | NDUFV2 NDUFAF2 | Proximal tubulopathy |
| KEGG:04714 | 0.0158142547588 | 0.666666666667 | NDUFV2 NDUFAF2 | Thermogenesis |
| HP:0004366 | 0.0167410266547 | 0.666666666667 | NDUFV2 NDUFAF2 | Abnormality of glycolysis |
| HP:0003542 | 0.0167410266547 | 0.666666666667 | NDUFV2 NDUFAF2 | Increased serum pyruvate |
| HP:0001138 | 0.0173967419879 | 0.666666666667 | NDUFV2 NDUFAF2 | Optic neuropathy |
| HP:0003737 | 0.0180650213362 | 0.666666666667 | NDUFV2 NDUFAF2 | Mitochondrial myopathy |
| HP:0025116 | 0.0208637442425 | 0.666666666667 | NDUFV2 NDUFAF2 | Fetal distress |
| HP:0011013 | 0.0278951902268 | 0.666666666667 | NDUFV2 NDUFAF2 | Abnormal circulating carbohydrate concentration |
| REAC:R-HSA-611105 | 0.0329299631783 | 0.666666666667 | NDUFV2 NDUFAF2 | Respiratory electron transport |
| HP:0003800 | 0.0398445800112 | 0.666666666667 | NDUFV2 NDUFAF2 | Muscle abnormality related to mitochondrial dysfunction |
| REAC:R-HSA-163200 | 0.049233254294 | 0.666666666667 | NDUFV2 NDUFAF2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| HP:0011923 | 0.0493566712329 | 0.666666666667 | NDUFV2 NDUFAF2 | Decreased activity of mitochondrial complex I |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDUFAF2 | NDUFV2 | 0.968 | 0.102 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only |
| FAM185A | NDUFV2 | 0.952 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| NDUFAF2 | FAM185A | 0.079 | 0.07 | bioplex3_WMM WMM_only |
Related Complexes