hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09127.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | 5 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| FNTB | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6710 | 5.12628525639e-06 | 0.5 | CAPN1 CAPNS1 | Calpain 1 |
| GO:0004198 | 6.34131776058e-05 | 0.75 | CAPNS1 CAPN8 CAPN1 | calcium-dependent cysteine-type endopeptidase activity |
| REAC:R-HSA-1474228 | 0.000261669015753 | 0.75 | CAPNS1 CAPN8 CAPN1 | Degradation of the extracellular matrix |
| REAC:R-HSA-8862803 | 0.00214930898727 | 0.5 | CAPN1 CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00214930898727 | 0.5 | CAPN1 CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-1474244 | 0.00270393678592 | 0.75 | CAPNS1 CAPN8 CAPN1 | Extracellular matrix organization |
| REAC:R-HSA-9734009 | 0.00282403231951 | 0.5 | CAPN1 CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| WP:WP185 | 0.00883615359641 | 0.5 | CAPN1 CAPNS1 | Integrin mediated cell adhesion |
| GO:0110158 | 0.0168521501606 | 0.5 | CAPN1 CAPNS1 | calpain complex |
| GO:0004197 | 0.0209740664347 | 0.75 | CAPNS1 CAPN8 CAPN1 | cysteine-type endopeptidase activity |
| REAC:R-HSA-6809371 | 0.022534212454 | 0.5 | CAPN1 CAPNS1 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.0239057396727 | 0.5 | CAPN1 CAPNS1 | Keratinization |
| REAC:R-HSA-9645723 | 0.041644107744 | 0.5 | CAPN1 CAPNS1 | Diseases of programmed cell death |
| CORUM:419 | 0.049938562206 | 0.25 | FNTB | Farnesyltransferase |
| CORUM:6706 | 0.049938562206 | 0.25 | CAPN1 | CAPN1-HSP90AB1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAPN1 | CAPNS1 | 1.0 | 0.604 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CAPN8 | CAPN1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPNS1 | 0.987 | 0.336 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN8 | CAPNS1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPN1 | 0.963 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| FNTB | CAPN1 | 0.958 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FNTB | CAPNS1 | 0.952 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FNTB | CAPN8 | 0.678 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FNTB | CAPN2 | 0.614 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CAPN8 | CAPN2 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes