hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09129.1
Complex Portal: CPX-12298
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORMDL3 | ORM1-like protein 3 | 5 | UniProt NCBI |
| SLC2A12 | Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12) | 4 | UniProt NCBI |
| ORMDL2 | ORM1-like protein 2 (Adoplin-2) | 5 | UniProt NCBI |
| SLC5A5 | Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Natrium iodide transporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660661 | 0.00573491177379 | 0.5 | ORMDL3 ORMDL2 | Sphingolipid de novo biosynthesis |
| WP:WP2884 | 0.015715675352 | 0.5 | SLC2A12 SLC5A5 | NRF2 pathway |
| GO:0035339 | 0.0168521501606 | 0.5 | ORMDL3 ORMDL2 | SPOTS complex |
| GO:0090156 | 0.0168521501606 | 0.5 | ORMDL3 ORMDL2 | intracellular sphingolipid homeostasis |
| REAC:R-HSA-428157 | 0.0267695204965 | 0.5 | ORMDL3 ORMDL2 | Sphingolipid metabolism |
| GO:1900060 | 0.0280843539964 | 0.5 | ORMDL3 ORMDL2 | negative regulation of ceramide biosynthetic process |
| GO:0017059 | 0.042122686785 | 0.5 | ORMDL3 ORMDL2 | serine C-palmitoyltransferase complex |
| GO:0031211 | 0.042122686785 | 0.5 | ORMDL3 ORMDL2 | endoplasmic reticulum palmitoyltransferase complex |
| GO:0090155 | 0.042122686785 | 0.5 | ORMDL3 ORMDL2 | negative regulation of sphingolipid biosynthetic process |
| HPA:0120233 | 0.0424284218432 | 0.25 | SLC5A5 | choroid plexus; ependymal cells[High] |
| CORUM:6982 | 0.049938562206 | 0.25 | ORMDL3 | ORMDL3-SPTLC1 complex |
| REAC:R-HSA-5619096 | 0.0499436884912 | 0.25 | SLC5A5 | Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ORMDL2 | ORMDL3 | 0.988 | 0.262 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ORMDL3 | SLC2A12 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ORMDL2 | SLC2A12 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SLC5A5 | ORMDL2 | 0.95 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes