hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09179.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NPRL2 | GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | 5 | UniProt NCBI |
| ITFG2 | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | 5 | UniProt NCBI |
| NPRL3 | GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) | 5 | UniProt NCBI |
| OGA | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | 5 | UniProt NCBI |
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | 5 | UniProt NCBI |
| DEPDC5 | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 5.68434264714e-10 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | Amino acids regulate mTORC1 |
| CORUM:6215 | 4.67737426163e-09 | 0.5 | NPRL3 NPRL2 DEPDC5 | GATOR1 complex |
| GO:1904262 | 4.58614910437e-08 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | negative regulation of TORC1 signaling |
| GO:0034198 | 5.18929314326e-08 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | cellular response to amino acid starvation |
| GO:1990928 | 6.58565753718e-08 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | response to amino acid starvation |
| REAC:R-HSA-9711097 | 1.28814034961e-07 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | Cellular response to starvation |
| CORUM:6217 | 2.61731336666e-07 | 0.5 | NPRL3 NPRL2 DEPDC5 | GATOR complex |
| GO:0032007 | 2.69643647861e-07 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | negative regulation of TOR signaling |
| HP:0012004 | 5.91234728455e-07 | 0.5 | NPRL3 NPRL2 DEPDC5 | Focal cognitive seizure with deja vu/jamais vu |
| HP:0012005 | 5.91234728455e-07 | 0.5 | NPRL3 NPRL2 DEPDC5 | Deja vu aura |
| HP:0032680 | 5.91234728455e-07 | 0.5 | NPRL3 NPRL2 DEPDC5 | Focal cognitive seizure |
| HP:0008765 | 1.03450143333e-06 | 0.5 | NPRL3 NPRL2 DEPDC5 | Auditory hallucination |
| GO:1903432 | 1.7640596292e-06 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | regulation of TORC1 signaling |
| GO:0038202 | 2.23176181384e-06 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | TORC1 signaling |
| HP:0033346 | 2.48203872664e-06 | 0.5 | NPRL3 NPRL2 DEPDC5 | Psychic epileptic aura |
| HP:0012002 | 2.48203872664e-06 | 0.5 | NPRL3 NPRL2 DEPDC5 | Experiential epileptic aura |
| HP:0002427 | 4.87393142655e-06 | 0.5 | NPRL3 NPRL2 DEPDC5 | Expressive aphasia |
| GO:0009267 | 9.80306376797e-06 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | cellular response to starvation |
| HP:0031951 | 1.07472199296e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | Nocturnal seizures |
| HP:0032046 | 1.07472199296e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | Focal cortical dysplasia |
| HP:0007206 | 1.07472199296e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | Hemimegalencephaly |
| GO:0032006 | 1.20814684781e-05 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | regulation of TOR signaling |
| HP:0002367 | 1.34319552877e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | Visual hallucination |
| GO:1990130 | 1.92180881975e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | GATOR1 complex |
| GO:0042594 | 1.93005700328e-05 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | response to starvation |
| GO:0031929 | 2.07823329526e-05 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | TOR signaling |
| HP:0033348 | 2.85880110041e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | Epileptic aura |
| HP:0011171 | 3.92263544242e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | Simple febrile seizure |
| HP:0002349 | 3.92263544242e-05 | 0.5 | NPRL3 NPRL2 DEPDC5 | Focal aware seizure |
| GO:0031669 | 4.53359177509e-05 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | cellular response to nutrient levels |
| GO:0031668 | 5.96742751786e-05 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | cellular response to extracellular stimulus |
| HP:0032052 | 0.000108046320019 | 0.333333333333 | NPRL3 DEPDC5 | Focal cortical dysplasia type IIa |
| GO:0071496 | 0.000149682230544 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | cellular response to external stimulus |
| HP:0032679 | 0.000176135758605 | 0.5 | NPRL3 NPRL2 DEPDC5 | Focal non-motor seizure |
| GO:0031667 | 0.000213965212858 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | response to nutrient levels |
| HP:0001355 | 0.00022859990461 | 0.5 | NPRL3 NPRL2 DEPDC5 | Megalencephaly |
| GO:0009991 | 0.000273808632875 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | response to extracellular stimulus |
| REAC:R-HSA-2262752 | 0.000309290917502 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.000324464342864 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | Cellular responses to stimuli |
| HP:0031284 | 0.000389229073674 | 0.5 | NPRL3 NPRL2 DEPDC5 | Flushing |
| WP:WP4657 | 0.000439359505343 | 0.5 | NPRL3 NPRL2 DEPDC5 | 22q11 2 copy number variation syndrome |
| CORUM:6753 | 0.000477929626316 | 0.333333333333 | NPRL3 NPRL2 | SOG complex |
| GO:0035859 | 0.000548960443183 | 0.5 | NPRL3 NPRL2 DEPDC5 | Seh1-associated complex |
| HP:0002539 | 0.000611367064879 | 0.5 | NPRL3 NPRL2 DEPDC5 | Cortical dysplasia |
| KEGG:04150 | 0.00103019356944 | 0.5 | NPRL3 NPRL2 DEPDC5 | mTOR signaling pathway |
| HP:0010841 | 0.00105494184562 | 0.5 | NPRL3 NPRL2 DEPDC5 | Multifocal epileptiform discharges |
| HP:0032051 | 0.00107987178333 | 0.333333333333 | NPRL3 DEPDC5 | Focal cortical dysplasia type II |
| HP:0002381 | 0.00278306724781 | 0.5 | NPRL3 NPRL2 DEPDC5 | Aphasia |
| GO:1902532 | 0.00392183535385 | 0.833333333333 | NPRL3 BMT2 DEPDC5 NPRL2 ITFG2 | negative regulation of intracellular signal transduction |
| HP:0002384 | 0.00457065401807 | 0.5 | NPRL3 NPRL2 DEPDC5 | Focal impaired awareness seizure |
| HP:0011185 | 0.00545760584829 | 0.5 | NPRL3 NPRL2 DEPDC5 | EEG with focal epileptiform discharges |
| HP:0003401 | 0.00662835320171 | 0.5 | NPRL3 NPRL2 DEPDC5 | Paresthesia |
| HP:0032892 | 0.00717714082957 | 0.5 | NPRL3 NPRL2 DEPDC5 | Infection-related seizure |
| HP:0002373 | 0.00717714082957 | 0.5 | NPRL3 NPRL2 DEPDC5 | Febrile seizure (within the age range of 3 months to 6 years) |
| HP:0032894 | 0.00717714082957 | 0.5 | NPRL3 NPRL2 DEPDC5 | Seizure precipitated by febrile infection |
| HP:0003829 | 0.00878583114312 | 0.5 | NPRL3 NPRL2 DEPDC5 | Typified by incomplete penetrance |
| HP:0000738 | 0.0103753999201 | 0.5 | NPRL3 NPRL2 DEPDC5 | Hallucinations |
| HP:0012469 | 0.0108621519105 | 0.5 | NPRL3 NPRL2 DEPDC5 | Infantile spasms |
| HP:0000980 | 0.0116202560559 | 0.5 | NPRL3 NPRL2 DEPDC5 | Pallor |
| HP:0002521 | 0.0179262368461 | 0.5 | NPRL3 NPRL2 DEPDC5 | Hypsarrhythmia |
| HP:0033259 | 0.023595733488 | 0.5 | NPRL3 NPRL2 DEPDC5 | Non-motor seizure |
| HP:0011097 | 0.0244307972482 | 0.5 | NPRL3 NPRL2 DEPDC5 | Epileptic spasm |
| HP:0002126 | 0.0270525934689 | 0.5 | NPRL3 NPRL2 DEPDC5 | Polymicrogyria |
| HP:0033747 | 0.0423552755261 | 0.5 | NPRL3 NPRL2 DEPDC5 | Abnormal exteroceptive sensation |
| HP:0011146 | 0.0442030419385 | 0.5 | NPRL3 NPRL2 DEPDC5 | Dialeptic seizure |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NPRL2 | DEPDC5 | 1.0 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NPRL2 | NPRL3 | 0.999 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BMT2 | DEPDC5 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DEPDC5 | NPRL3 | 0.996 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | BMT2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BMT2 | ITFG2 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| OGA | BMT2 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BMT2 | NPRL3 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPRL2 | ITFG2 | 0.978 | 0.15 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DEPDC5 | ITFG2 | 0.959 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ITFG2 | NPRL3 | 0.92 | 0.178 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGA | DEPDC5 | 0.345 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | OGA | 0.254 | 0.05 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGA | NPRL3 | 0.063 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
| OGA | ITFG2 | 0.026 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes