hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09184.1
Complex Portal: CPX-22533
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLDIP3 | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | 5 | UniProt NCBI |
| NCBP3 | Nuclear cap-binding protein subunit 3 (Protein ELG) | 5 | UniProt NCBI |
| CCDC9B | Coiled-coil domain-containing protein 9B | 3 | UniProt NCBI |
| RSPO1 | R-spondin-1 (Roof plate-specific spondin-1) (hRspo1) | 5 | UniProt NCBI |
| ALYREF | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | 5 | UniProt NCBI |
| THOC6 | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | 5 | UniProt NCBI |
| THOC3 | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | 5 | UniProt NCBI |
| CHTOP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | 5 | UniProt NCBI |
| ALKBH5 | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | 5 | UniProt NCBI |
| C19orf47 | Uncharacterized protein C19orf47 | 3 | UniProt NCBI |
| THOC1 | THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84) | 5 | UniProt NCBI |
| FXR1 | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | 5 | UniProt NCBI |
| FYTTD1 | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | 5 | UniProt NCBI |
| THOC7 | THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0006406 | 1.5601804782e-14 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | mRNA export from nucleus |
| GO:0051028 | 3.58227214801e-14 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | mRNA transport |
| GO:0006405 | 1.72734750701e-13 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | RNA export from nucleus |
| GO:0050658 | 1.49603214602e-12 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | RNA transport |
| GO:0050657 | 1.49603214602e-12 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nucleic acid transport |
| GO:0051236 | 1.93599494196e-12 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | establishment of RNA localization |
| REAC:R-HSA-72187 | 3.31388547325e-12 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 9.00909820465e-12 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | RNA Polymerase II Transcription Termination |
| GO:0006403 | 1.81227107004e-11 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | RNA localization |
| REAC:R-HSA-159236 | 1.9470850034e-11 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| GO:0051168 | 2.06580458135e-11 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nuclear export |
| GO:0015931 | 3.21957429102e-11 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nucleobase-containing compound transport |
| REAC:R-HSA-72202 | 4.69297731885e-11 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | Transport of Mature Transcript to Cytoplasm |
| CORUM:6160 | 3.16769554386e-10 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | hTREX84 complex |
| CORUM:770 | 7.3876470612e-10 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | TREX complex |
| GO:0051169 | 2.72270644814e-09 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nuclear transport |
| GO:0006913 | 2.72270644814e-09 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nucleocytoplasmic transport |
| GO:0000346 | 5.3393134954e-09 | 0.384615384615 | THOC3 THOC7 THOC6 THOC1 CHTOP | transcription export complex |
| GO:0000445 | 2.81924903404e-07 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | THO complex part of transcription export complex |
| GO:0000347 | 2.81924903404e-07 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | THO complex |
| CORUM:774 | 3.08563128138e-07 | 0.230769230769 | THOC7 THOC6 THOC1 | THO complex |
| REAC:R-HSA-72203 | 3.21204104324e-07 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0044417 | 6.57500588447e-07 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | translocation of molecules into host |
| GO:0046784 | 6.57500588447e-07 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | viral mRNA export from host cell nucleus |
| GO:0016607 | 1.47823656785e-06 | 0.615384615385 | FYTTD1 POLDIP3 THOC7 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nuclear speck |
| KEGG:03013 | 8.37779518443e-05 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | Nucleocytoplasmic transport |
| REAC:R-HSA-8953854 | 0.000174737220395 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | Metabolism of RNA |
| CORUM:351 | 0.000277989331641 | 0.307692307692 | THOC3 THOC7 THOC6 THOC1 | Spliceosome |
| GO:0016604 | 0.000822508680251 | 0.615384615385 | FYTTD1 POLDIP3 THOC7 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nuclear body |
| GO:0071705 | 0.00167832635474 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | nitrogen compound transport |
| GO:0046907 | 0.00174780540736 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | intracellular transport |
| REAC:R-HSA-73857 | 0.00544250481316 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | RNA Polymerase II Transcription |
| HPA:0030071 | 0.00770728375556 | 0.846153846154 | CCDC9B POLDIP3 C19orf47 FXR1 THOC3 THOC1 CHTOP NCBP3 FYTTD1 THOC7 ALKBH5 | appendix; lymphoid tissue[>=Low] |
| GO:0071702 | 0.00976664070671 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | organic substance transport |
| REAC:R-HSA-74160 | 0.0123811504483 | 0.538461538462 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 THOC6 CHTOP | Gene expression (Transcription) |
| GO:0051649 | 0.0152974101734 | 0.692307692308 | FYTTD1 POLDIP3 THOC7 THOC3 THOC1 CHTOP NCBP3 THOC6 ALKBH5 | establishment of localization in cell |
| HPA:0460663 | 0.0155833164165 | 0.384615384615 | FXR1 NCBP3 CHTOP FYTTD1 ALKBH5 | skin 1; keratinocytes[High] |
| HPA:0620222 | 0.0187422085158 | 0.769230769231 | CCDC9B POLDIP3 C19orf47 FXR1 THOC3 FYTTD1 CHTOP NCBP3 THOC7 ALKBH5 | vagina; squamous epithelial cells[>=Medium] |
| HPA:0620223 | 0.020871317771 | 0.461538461538 | C19orf47 NCBP3 THOC3 FYTTD1 FXR1 CHTOP | vagina; squamous epithelial cells[High] |
| HPA:0330223 | 0.024076964912 | 0.461538461538 | FYTTD1 POLDIP3 NCBP3 THOC3 FXR1 CHTOP | oral mucosa; squamous epithelial cells[High] |
| HPA:0460662 | 0.0243120846451 | 0.692307692308 | CCDC9B POLDIP3 FXR1 THOC3 FYTTD1 CHTOP NCBP3 THOC7 ALKBH5 | skin 1; keratinocytes[>=Medium] |
| HPA:0340463 | 0.0303700098281 | 0.307692307692 | NCBP3 ALKBH5 POLDIP3 CHTOP | ovary; ovarian stroma cells[High] |
| HPA:0380513 | 0.0318312074022 | 0.461538461538 | FYTTD1 NCBP3 THOC3 CHTOP FXR1 ALKBH5 | placenta; decidual cells[High] |
| HPA:0060103 | 0.0346862806731 | 0.538461538462 | FYTTD1 POLDIP3 NCBP3 THOC3 CHTOP FXR1 ALKBH5 | bronchus; respiratory epithelial cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| THOC6 | THOC1 | 1.0 | 0.902 |
structurally_consistent (Q13769)
|
| THOC7 | THOC1 | 1.0 | 0.55 | |
| THOC3 | THOC1 | 1.0 | 0.326 | |
| THOC3 | THOC7 | 1.0 | 0.1 |
structurally_consistent (Q8NI27)
|
| THOC6 | THOC7 | 1.0 | 0.526 |
structurally_consistent (Q13769)
structurally_consistent (dimer) |
| THOC6 | THOC3 | 1.0 | 0.342 |
structurally_consistent (dimer)
|
| CHTOP | FYTTD1 | 1.0 | 0.086 | |
| THOC6 | NCBP3 | 0.999 | 0.448 | |
| ALYREF | CHTOP | 0.999 | 0.572 | |
| THOC1 | NCBP3 | 0.999 | 0.172 |
mutually_exclusive (P61326)
|
| THOC7 | NCBP3 | 0.999 | 0.14 | |
| CHTOP | THOC1 | 0.998 | 0.286 | |
| THOC1 | FYTTD1 | 0.997 | 0.116 | |
| POLDIP3 | THOC7 | 0.997 | 0.3 |
structurally_consistent (Q86W42)
|
| CHTOP | NCBP3 | 0.997 | 0.208 | |
| ALYREF | NCBP3 | 0.997 | 0.298 | |
| POLDIP3 | THOC1 | 0.997 | 0.526 | |
| FYTTD1 | NCBP3 | 0.996 | 0.114 | |
| CHTOP | THOC7 | 0.996 | 0.252 | |
| RSPO1 | CHTOP | 0.995 | ||
| THOC7 | FYTTD1 | 0.995 | 0.106 | |
| POLDIP3 | ALKBH5 | 0.994 | 0.164 | |
| ALYREF | THOC1 | 0.993 | 0.331 | |
| POLDIP3 | THOC6 | 0.992 | 0.304 |
structurally_consistent (dimer)
|
| CHTOP | FXR1 | 0.991 | 0.178 | |
| POLDIP3 | FYTTD1 | 0.99 | 0.194 | |
| THOC6 | FYTTD1 | 0.985 | 0.248 | |
| THOC3 | ALYREF | 0.984 | 0.246 |
structurally_consistent (dimer)
|
| THOC3 | FYTTD1 | 0.984 | 0.048 | |
| FXR1 | NCBP3 | 0.983 | 0.076 | |
| THOC3 | NCBP3 | 0.98 | 0.108 |
structurally_consistent (dimer)
|
| ALYREF | THOC7 | 0.979 | 0.242 |
structurally_consistent (Q86W42)
|
| ALKBH5 | THOC1 | 0.977 | 0.052 | |
| CHTOP | ALKBH5 | 0.975 | 0.048 | |
| ALKBH5 | NCBP3 | 0.975 | 0.104 | |
| POLDIP3 | ALYREF | 0.974 | 0.484 | |
| POLDIP3 | NCBP3 | 0.973 | 0.184 | |
| THOC6 | CHTOP | 0.972 | 0.146 |
mutually_exclusive (Q96J01)
|
| THOC3 | CHTOP | 0.97 | 0.134 |
mutually_exclusive (Q96A72)
structurally_consistent (dimer) |
| THOC6 | FXR1 | 0.968 | 0.086 | |
| CCDC9B | THOC1 | 0.966 | 0.056 | |
| ALYREF | ALKBH5 | 0.966 | 0.158 | |
| C19orf47 | THOC1 | 0.965 | 0.192 | |
| FXR1 | FYTTD1 | 0.962 | 0.182666666667 | |
| ALYREF | FYTTD1 | 0.962 | 0.13685 | |
| POLDIP3 | CHTOP | 0.96 | 0.322 | |
| C19orf47 | NCBP3 | 0.949 | 0.332 | |
| THOC6 | ALYREF | 0.949 | 0.284 |
structurally_consistent (dimer)
|
| THOC7 | ALKBH5 | 0.939 | 0.062 | |
| THOC7 | CCDC9B | 0.934 | 0.05 | |
| THOC7 | FXR1 | 0.924 | 0.184 | |
| THOC7 | C19orf47 | 0.921 | 0.21 | |
| POLDIP3 | THOC3 | 0.914 | 0.234 |
mutually_exclusive (Q96A72)
|
| THOC6 | C19orf47 | 0.91 | 0.236 | |
| FXR1 | THOC1 | 0.895 | 0.054 | |
| C19orf47 | FYTTD1 | 0.785 | 0.062 | |
| C19orf47 | CCDC9B | 0.781 | 0.08 | |
| THOC3 | CCDC9B | 0.781 | 0.038 | |
| CCDC9B | NCBP3 | 0.781 | 0.08 | |
| THOC6 | CCDC9B | 0.781 | 0.08 | |
| CHTOP | C19orf47 | 0.744 | 0.232 | |
| POLDIP3 | C19orf47 | 0.729 | 0.23 | |
| THOC6 | ALKBH5 | 0.663 | 0.152 | |
| THOC3 | ALKBH5 | 0.662 | 0.034 | |
| ALKBH5 | FYTTD1 | 0.65 | 0.066 | |
| CHTOP | CCDC9B | 0.641 | 0.068 | |
| ALYREF | CCDC9B | 0.641 | 0.088 | |
| CCDC9B | FYTTD1 | 0.641 | 0.044 | |
| POLDIP3 | FXR1 | 0.616 | 0.242 | |
| FXR1 | ALKBH5 | 0.611 | 0.062 | |
| THOC3 | C19orf47 | 0.562 | 0.192 | |
| POLDIP3 | CCDC9B | 0.536 | 0.074 | |
| ALYREF | C19orf47 | 0.412 | 0.256 | |
| CCDC9B | ALKBH5 | 0.248 | 0.072 | |
| C19orf47 | FXR1 | 0.213 | 0.106 | |
| C19orf47 | ALKBH5 | 0.192 | 0.136 | |
| ALYREF | FXR1 | 0.17 | 0.19 | |
| FXR1 | CCDC9B | 0.038 | 0.048 | |
| THOC6 | RSPO1 | 0.038 | ||
| THOC3 | FXR1 | 0.016 | 0.138 | |
| RSPO1 | FXR1 | 0.012 | ||
| THOC3 | RSPO1 | 0.009 | ||
| RSPO1 | ALYREF | 0.004 |
Related Complexes