hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09197.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ASPH | Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) | 5 | UniProt NCBI |
| IL2RA | Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) | 5 | UniProt NCBI |
| MCU | Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A) | 5 | UniProt NCBI |
| STEAP3 | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) | 5 | UniProt NCBI |
| SMDT1 | Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial) | 5 | UniProt NCBI |
| MCUB | Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6473 | 4.675933868e-08 | 0.5 | SMDT1 MCU MCUB | mitochondrial calcium uniporter complex |
| REAC:R-HSA-8949664 | 3.94996643825e-06 | 0.5 | SMDT1 MCU MCUB | Processing of SMDT1 |
| REAC:R-HSA-8949215 | 1.08523688914e-05 | 0.5 | SMDT1 MCU MCUB | Mitochondrial calcium ion transport |
| GO:1990246 | 3.84302573496e-05 | 0.5 | SMDT1 MCU MCUB | uniplex complex |
| REAC:R-HSA-382551 | 6.77703888853e-05 | 0.833333333333 | STEAP3 MCUB SMDT1 ASPH MCU | Transport of small molecules |
| GO:0034704 | 9.81259188038e-05 | 0.666666666667 | SMDT1 MCUB ASPH MCU | calcium channel complex |
| GO:0036444 | 0.00042234232358 | 0.5 | SMDT1 MCU MCUB | calcium import into the mitochondrion |
| GO:0006851 | 0.0010743908712 | 0.5 | SMDT1 MCU MCUB | mitochondrial calcium ion transmembrane transport |
| GO:0051560 | 0.00156505859778 | 0.5 | SMDT1 MCU MCUB | mitochondrial calcium ion homeostasis |
| GO:0034703 | 0.00442159197262 | 0.666666666667 | SMDT1 MCUB ASPH MCU | cation channel complex |
| GO:0030001 | 0.0112754825257 | 0.833333333333 | STEAP3 MCUB SMDT1 ASPH MCU | metal ion transport |
| GO:0006874 | 0.0118285149586 | 0.666666666667 | SMDT1 MCUB ASPH MCU | intracellular calcium ion homeostasis |
| GO:0034702 | 0.0121174468054 | 0.666666666667 | SMDT1 MCUB ASPH MCU | monoatomic ion channel complex |
| GO:0055074 | 0.0149614267119 | 0.666666666667 | SMDT1 MCUB ASPH MCU | calcium ion homeostasis |
| WP:WP5356 | 0.0159206501541 | 0.333333333333 | MCUB MCU | Affected pathways in Duchenne muscular dystrophy |
| GO:0070588 | 0.0167421435431 | 0.666666666667 | SMDT1 MCUB ASPH MCU | calcium ion transmembrane transport |
| GO:0006812 | 0.018956843244 | 0.833333333333 | STEAP3 MCUB SMDT1 ASPH MCU | monoatomic cation transport |
| GO:0170036 | 0.0252998897888 | 0.5 | SMDT1 MCU MCUB | import into the mitochondrion |
| HP:0007833 | 0.0322780794397 | 0.333333333333 | ASPH IL2RA | Anterior chamber synechiae |
| GO:0006811 | 0.0394764540724 | 0.833333333333 | STEAP3 MCUB SMDT1 ASPH MCU | monoatomic ion transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STEAP3 | ASPH | 0.992 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM |
| SMDT1 | MCU | 0.992 | 0.408 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| MCUB | ASPH | 0.991 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MCUB | MCU | 0.986 | 0.5 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| SMDT1 | MCUB | 0.986 | 0.15 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| ASPH | MCU | 0.983 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MCUB | IL2RA | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SMDT1 | IL2RA | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SMDT1 | ASPH | 0.959 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MCUB | STEAP3 | 0.814 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only |
| MCU | IL2RA | 0.801 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SMDT1 | STEAP3 | 0.727 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
| STEAP3 | MCU | 0.187 | 0.034 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ASPH | IL2RA | 0.017 | bioplex3_HEK293 WMM_only |
Related Complexes