hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09205.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CXCL1 | Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| DIABLO | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP231 | 2.80248370233e-08 | 0.625 | TRAF2 DIABLO TRAF1 BIRC3 TANK | TNF alpha signaling pathway |
| KEGG:04210 | 9.32868870867e-08 | 0.625 | TRAF2 DIABLO TRAF1 BIRC3 HTRA2 | Apoptosis |
| KEGG:04621 | 2.51378764444e-07 | 0.625 | TRAF2 TANK IKBKE CXCL1 BIRC3 | NOD-like receptor signaling pathway |
| REAC:R-HSA-5357905 | 1.05469981253e-06 | 0.5 | TRAF2 IKBKE BIRC3 TRAF1 | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 2.27057596428e-06 | 0.5 | TRAF2 IKBKE BIRC3 TRAF1 | TNF signaling |
| KEGG:04064 | 2.83654365515e-06 | 0.5 | TRAF2 TRAF1 CXCL1 BIRC3 | NF-kappa B signaling pathway |
| WP:WP254 | 3.60336134753e-06 | 0.5 | DIABLO TRAF1 BIRC3 TRAF2 | Apoptosis |
| KEGG:04668 | 5.69084438069e-06 | 0.5 | TRAF2 TRAF1 CXCL1 BIRC3 | TNF signaling pathway |
| GO:0071345 | 7.32928172214e-06 | 0.875 | HTRA2 TANK CXCL1 TRAF2 BIRC3 IKBKE TRAF1 | cellular response to cytokine stimulus |
| GO:0034097 | 1.67514895132e-05 | 0.875 | HTRA2 TANK CXCL1 TRAF2 BIRC3 IKBKE TRAF1 | response to cytokine |
| KEGG:04215 | 1.93441448626e-05 | 0.375 | DIABLO BIRC3 HTRA2 | Apoptosis - multiple species |
| REAC:R-HSA-168164 | 2.05516498559e-05 | 0.5 | TANK IKBKE BIRC3 TRAF2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 2.24415957957e-05 | 0.5 | TANK IKBKE BIRC3 TRAF2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 2.24415957957e-05 | 0.5 | TANK IKBKE BIRC3 TRAF2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-5357786 | 4.61108204583e-05 | 0.375 | TRAF2 BIRC3 IKBKE | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-166016 | 6.93206477654e-05 | 0.5 | TANK IKBKE BIRC3 TRAF2 | Toll Like Receptor 4 (TLR4) Cascade |
| WP:WP2036 | 6.95406701237e-05 | 0.375 | TRAF2 BIRC3 TRAF1 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| CORUM:5210 | 7.17483486175e-05 | 0.25 | TANK TRAF2 | TANK-TRAF2-TRAF3 complex |
| KEGG:05417 | 7.4205437503e-05 | 0.5 | TANK IKBKE CXCL1 TRAF2 | Lipid and atherosclerosis |
| REAC:R-HSA-73887 | 7.88413959175e-05 | 0.5 | TRAF2 IKBKE BIRC3 TRAF1 | Death Receptor Signaling |
| REAC:R-HSA-933541 | 8.31386651542e-05 | 0.375 | TANK IKBKE TRAF2 | TRAF6 mediated IRF7 activation |
| REAC:R-HSA-5357956 | 0.000112766844535 | 0.375 | TRAF2 BIRC3 TRAF1 | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-168898 | 0.000123441958688 | 0.5 | TANK IKBKE BIRC3 TRAF2 | Toll-like Receptor Cascades |
| GO:0019221 | 0.000170744030661 | 0.75 | TANK CXCL1 TRAF2 BIRC3 IKBKE TRAF1 | cytokine-mediated signaling pathway |
| WP:WP5039 | 0.000214361446347 | 0.375 | TANK CXCL1 TRAF2 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| KEGG:04622 | 0.000229110026744 | 0.375 | TANK IKBKE TRAF2 | RIG-I-like receptor signaling pathway |
| WP:WP3865 | 0.000240465496707 | 0.375 | TANK IKBKE TRAF2 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04657 | 0.00038250291155 | 0.375 | TRAF2 CXCL1 IKBKE | IL-17 signaling pathway |
| KEGG:05222 | 0.000533899657075 | 0.375 | TRAF2 BIRC3 TRAF1 | Small cell lung cancer |
| CORUM:5212 | 0.000668735194034 | 0.25 | TANK TRAF2 | Kinase maturation complex 2 |
| WP:WP1772 | 0.00073298842797 | 0.375 | DIABLO BIRC3 HTRA2 | Apoptosis modulation and signaling |
| GO:0035631 | 0.000886327111509 | 0.375 | DIABLO HTRA2 TRAF2 | CD40 receptor complex |
| WP:WP4658 | 0.00109108919451 | 0.375 | TRAF2 BIRC3 TRAF1 | Small cell lung cancer |
| REAC:R-HSA-168928 | 0.00151831565434 | 0.375 | TANK IKBKE TRAF2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0043122 | 0.00169542746879 | 0.625 | TANK TRAF1 IKBKE BIRC3 TRAF2 | regulation of canonical NF-kappaB signal transduction |
| GO:0007166 | 0.00177183690053 | 1.0 | HTRA2 DIABLO TANK CXCL1 TRAF2 BIRC3 IKBKE TRAF1 | cell surface receptor signaling pathway |
| WP:WP5182 | 0.00216982178847 | 0.25 | TRAF2 BIRC3 | Pro survival signaling of neuroprotectin D1 |
| CORUM:6344 | 0.00216982178847 | 0.25 | TRAF2 BIRC3 | TNF-R1-associated signaling complex |
| GO:0035556 | 0.00268170503809 | 1.0 | HTRA2 DIABLO TANK CXCL1 TRAF2 BIRC3 IKBKE TRAF1 | intracellular signal transduction |
| GO:0007249 | 0.00283286321993 | 0.625 | TANK TRAF1 IKBKE BIRC3 TRAF2 | canonical NF-kappaB signal transduction |
| REAC:R-HSA-5676594 | 0.0030606580132 | 0.25 | TRAF2 BIRC3 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| REAC:R-HSA-9013973 | 0.00367178411278 | 0.25 | TANK IKBKE | TICAM1-dependent activation of IRF3/IRF7 |
| KEGG:05167 | 0.00396473051169 | 0.375 | TRAF2 CXCL1 IKBKE | Kaposi sarcoma-associated herpesvirus infection |
| WP:WP2507 | 0.00407177869695 | 0.25 | DIABLO HTRA2 | Nanomaterial induced apoptosis |
| GO:0071310 | 0.00483750130485 | 0.875 | HTRA2 TANK CXCL1 TRAF2 BIRC3 IKBKE TRAF1 | cellular response to organic substance |
| REAC:R-HSA-936964 | 0.00505983974502 | 0.25 | TANK IKBKE | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| WP:WP4950 | 0.0077239395488 | 0.25 | TRAF2 TRAF1 | 16p11 2 distal deletion syndrome |
| REAC:R-HSA-168249 | 0.00836238659736 | 0.625 | TRAF2 TANK IKBKE CXCL1 BIRC3 | Innate Immune System |
| WP:WP5406 | 0.00897861635867 | 0.25 | TRAF2 TRAF1 | 13q12 12 copy number variation |
| WP:WP3941 | 0.0149316061259 | 0.25 | TRAF2 TRAF1 | Oxidative damage response |
| GO:0071356 | 0.0197287134506 | 0.5 | TANK TRAF1 BIRC3 TRAF2 | cellular response to tumor necrosis factor |
| REAC:R-HSA-5213460 | 0.0240813966337 | 0.25 | TRAF2 BIRC3 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.0240813966337 | 0.25 | TRAF2 BIRC3 | Regulation of necroptotic cell death |
| WP:WP2018 | 0.0244633875231 | 0.25 | TRAF2 TRAF1 | RANKL RANK signaling pathway |
| GO:0010033 | 0.0254723846001 | 0.875 | HTRA2 TANK CXCL1 TRAF2 BIRC3 IKBKE TRAF1 | response to organic substance |
| REAC:R-HSA-5357801 | 0.0261261838654 | 0.375 | DIABLO BIRC3 TRAF2 | Programmed Cell Death |
| GO:0009898 | 0.0281979257523 | 0.5 | DIABLO TRAF1 HTRA2 TRAF2 | cytoplasmic side of plasma membrane |
| GO:0097191 | 0.0290088602918 | 0.5 | DIABLO TRAF1 HTRA2 TRAF2 | extrinsic apoptotic signaling pathway |
| GO:0065009 | 0.0291013996482 | 0.875 | HTRA2 DIABLO TANK TRAF2 BIRC3 IKBKE TRAF1 | regulation of molecular function |
| GO:0034612 | 0.0306827893089 | 0.5 | TANK TRAF1 BIRC3 TRAF2 | response to tumor necrosis factor |
| GO:0097190 | 0.0354572655202 | 0.625 | DIABLO TRAF1 IKBKE HTRA2 TRAF2 | apoptotic signaling pathway |
| KEGG:05168 | 0.0396384155032 | 0.375 | TRAF2 BIRC3 IKBKE | Herpes simplex virus 1 infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRAF2 | TRAF1 | 1.0 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF1 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF2 | DIABLO | 0.996 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| HTRA2 | TRAF2 | 0.994 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TANK | DIABLO | 0.993 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CXCL1 | TRAF2 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TRAF1 | DIABLO | 0.986 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HTRA2 | TRAF1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | DIABLO | 0.973 | 0.374 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| BIRC3 | TRAF2 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF1 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | DIABLO | 0.964 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | TANK | 0.952 | 0.096 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CXCL1 | DIABLO | 0.952 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | |
| TRAF1 | IKBKE | 0.796 | bioplex3_WMM WMM_only | |
| HTRA2 | IKBKE | 0.451 | bioplex3_WMM WMM_only | |
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | |
| IKBKE | DIABLO | 0.374 | bioplex3_WMM WMM_only | |
| BIRC3 | HTRA2 | 0.306 | bioplex3_WMM WMM_only | |
| CXCL1 | TANK | 0.043 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes