hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09206.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PAPSS1 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | 5 | UniProt NCBI |
| C8B | Complement component C8 beta chain (Complement component 8 subunit beta) | 5 | UniProt NCBI |
| PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2408550 | 2.04544380615e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se |
| KEGG:00920 | 3.43391458703e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Sulfur metabolism |
| KEGG:00450 | 5.95130368674e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Selenocompound metabolism |
| WP:WP692 | 6.22753219356e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Sulfation biotransformation reaction |
| REAC:R-HSA-174362 | 6.81752388431e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Transport and synthesis of PAPS |
| REAC:R-HSA-156584 | 0.000926675585137 | 0.666666666667 | PAPSS1 PAPSS2 | Cytosolic sulfonation of small molecules |
| GO:0034036 | 0.00140460216025 | 0.666666666667 | PAPSS1 PAPSS2 | purine ribonucleoside bisphosphate biosynthetic process |
| GO:0050428 | 0.00140460216025 | 0.666666666667 | PAPSS1 PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| GO:0004781 | 0.00140460216025 | 0.666666666667 | PAPSS1 PAPSS2 | sulfate adenylyltransferase (ATP) activity |
| GO:0004779 | 0.00140460216025 | 0.666666666667 | PAPSS1 PAPSS2 | sulfate adenylyltransferase activity |
| GO:0000103 | 0.00140460216025 | 0.666666666667 | PAPSS1 PAPSS2 | sulfate assimilation |
| GO:0004020 | 0.00140460216025 | 0.666666666667 | PAPSS1 PAPSS2 | adenylylsulfate kinase activity |
| KEGG:00230 | 0.00361241039138 | 0.666666666667 | PAPSS1 PAPSS2 | Purine metabolism |
| REAC:R-HSA-156580 | 0.0214696523361 | 0.666666666667 | PAPSS1 PAPSS2 | Phase II - Conjugation of compounds |
| REAC:R-HSA-1630316 | 0.0406752460979 | 0.666666666667 | PAPSS1 PAPSS2 | Glycosaminoglycan metabolism |
| REAC:R-HSA-2408522 | 0.041419681818 | 0.666666666667 | PAPSS1 PAPSS2 | Selenoamino acid metabolism |
| REAC:R-HSA-3560796 | 0.0498224659464 | 0.333333333333 | PAPSS2 | Defective PAPSS2 causes SEMD-PA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PAPSS1 | PAPSS2 | 0.999 | 0.074 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PAPSS2 | C8B | 0.964 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PAPSS1 | huMAP3_00514.1 huMAP3_09206.1 |
| C8B | huMAP3_03077.1 huMAP3_07352.1 huMAP3_09206.1 huMAP3_12732.1 |
| PAPSS2 | huMAP3_00514.1 huMAP3_09206.1 huMAP3_14657.1 |