hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09211.1
Complex Portal: CPX-15892
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | 5 | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | 5 | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | 5 | UniProt NCBI |
| TDP1 | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | 5 | UniProt NCBI |
| CHD1L | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | 5 | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | 5 | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | 5 | UniProt NCBI |
| APLF | Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | 5 | UniProt NCBI |
| RNF146 | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | 5 | UniProt NCBI |
| APTX | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | 5 | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03410 | 4.72636596656e-12 | 0.6 | APTX TDP1 POLB PNKP LIG3 PARP2 | Base excision repair |
| CORUM:5243 | 1.68385473419e-08 | 0.3 | TDP1 PNKP LIG3 | XRCC1-LIG3-PNK-TDP1 complex |
| CORUM:362 | 1.68385473419e-08 | 0.3 | LIG3 PNKP POLB | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| GO:0006281 | 2.16303813366e-08 | 0.9 | XPC PARP2 CHD1L TDP1 LIG3 PNKP APTX POLB APLF | DNA repair |
| REAC:R-HSA-73894 | 4.52590213304e-08 | 0.7 | XPC PARP2 CHD1L TDP1 LIG3 PNKP POLB | DNA Repair |
| WP:WP4752 | 2.95554457269e-07 | 0.4 | LIG3 PARP2 PNKP POLB | Base excision repair |
| WP:WP4946 | 6.07902247067e-07 | 0.5 | XPC LIG3 PARP2 PNKP POLB | DNA repair pathways full network |
| GO:0006974 | 7.59816583603e-07 | 0.9 | XPC PARP2 CHD1L TDP1 LIG3 PNKP APTX POLB APLF | DNA damage response |
| GO:0006259 | 1.32880440525e-06 | 0.9 | XPC PARP2 CHD1L TDP1 LIG3 PNKP APTX POLB APLF | DNA metabolic process |
| REAC:R-HSA-73933 | 1.38352291517e-06 | 0.4 | LIG3 PARP2 PNKP POLB | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5649702 | 1.94746021672e-06 | 0.3 | LIG3 PNKP POLB | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| REAC:R-HSA-73884 | 3.34457823732e-05 | 0.4 | LIG3 PARP2 PNKP POLB | Base Excision Repair |
| REAC:R-HSA-5696399 | 4.77943696984e-05 | 0.4 | XPC LIG3 PARP2 CHD1L | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0140097 | 4.93113793373e-05 | 0.6 | CHD1L APTX TDP1 LIG3 APLF POLB | catalytic activity, acting on DNA |
| REAC:R-HSA-5696398 | 0.000138239115309 | 0.4 | XPC LIG3 PARP2 CHD1L | Nucleotide Excision Repair |
| GO:0033554 | 0.000145983076476 | 0.9 | XPC PARP2 CHD1L TDP1 LIG3 PNKP APTX POLB APLF | cellular response to stress |
| CORUM:1086 | 0.000184411585051 | 0.2 | POLB LIG3 | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| CORUM:1085 | 0.000184411585051 | 0.2 | POLB LIG3 | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| GO:0160002 | 0.0002304395259 | 0.3 | CHD1L PARP2 APLF | ADP-D-ribose modification-dependent protein binding |
| GO:0072572 | 0.0002304395259 | 0.3 | RNF146 PARP2 APLF | poly-ADP-D-ribose binding |
| GO:0006302 | 0.000371213922121 | 0.6 | PARP2 TDP1 POLB APLF LIG3 PNKP | double-strand break repair |
| REAC:R-HSA-110381 | 0.000610250897391 | 0.2 | POLB LIG3 | Resolution of AP sites via the single-nucleotide replacement pathway |
| REAC:R-HSA-5696395 | 0.000630778022304 | 0.3 | XPC PARP2 CHD1L | Formation of Incision Complex in GG-NER |
| WP:WP5114 | 0.00137707513928 | 0.3 | XPC LIG3 CHD1L | Nucleotide excision repair in xeroderma pigmentosum |
| GO:0000012 | 0.00138065085968 | 0.3 | TDP1 APLF APTX | single strand break repair |
| GO:0003684 | 0.00185320096161 | 0.4 | XPC APTX PNKP PARP2 | damaged DNA binding |
| HP:0003380 | 0.00220497806558 | 0.3 | TDP1 APTX LIG3 | Decreased number of peripheral myelinated nerve fibers |
| REAC:R-HSA-110362 | 0.00284368219242 | 0.2 | POLB PARP2 | POLB-Dependent Long Patch Base Excision Repair |
| GO:0006287 | 0.00328700479383 | 0.3 | LIG3 PNKP POLB | base-excision repair, gap-filling |
| GO:0006266 | 0.00328700479383 | 0.3 | LIG3 PNKP APLF | DNA ligation |
| HP:0009830 | 0.00382005685439 | 0.5 | XPC APTX PNKP LIG3 TDP1 | Peripheral neuropathy |
| HP:0003431 | 0.00520371988663 | 0.3 | TDP1 PNKP LIG3 | Decreased motor nerve conduction velocity |
| REAC:R-HSA-5685939 | 0.00557969031297 | 0.2 | PARP2 LIG3 | HDR through MMEJ (alt-NHEJ) |
| HP:0040131 | 0.00582350189537 | 0.3 | TDP1 PNKP LIG3 | Abnormal motor nerve conduction velocity |
| HP:0003124 | 0.00758230982268 | 0.3 | TDP1 PNKP APTX | Hypercholesterolemia |
| GO:0140640 | 0.0135377163474 | 0.6 | CHD1L APTX TDP1 LIG3 APLF POLB | catalytic activity, acting on a nucleic acid |
| HPA:0380511 | 0.0157681713642 | 0.9 | XPC RNF146 PARP2 CHD1L TDP1 LIG3 PNKP POLB APTX | placenta; decidual cells[>=Low] |
| HPA:0301371 | 0.01599841018 | 0.6 | XPC APTX CHD1L PNKP LIG3 PARP2 | lung; alveolar cells type II[>=Low] |
| HP:0007141 | 0.020190644814 | 0.3 | TDP1 PNKP LIG3 | Sensorimotor neuropathy |
| GO:0090734 | 0.0227360626478 | 0.4 | CHD1L APLF PNKP PARP2 | site of DNA damage |
| HPA:0190222 | 0.0241429555459 | 0.9 | XPC RNF146 PARP2 CHD1L TDP1 LIG3 PNKP POLB APTX | esophagus; squamous epithelial cells[>=Medium] |
| HPA:0570792 | 0.0252569044181 | 0.6 | CHD1L APTX TDP1 POLB PNKP LIG3 | testis; round or early spermatids[>=Medium] |
| HPA:0460672 | 0.0254212533736 | 0.8 | XPC APTX RNF146 TDP1 LIG3 PNKP CHD1L POLB | skin 1; melanocytes[>=Medium] |
| HP:0003130 | 0.0284132342749 | 0.3 | TDP1 APTX LIG3 | Abnormal peripheral myelination |
| HP:0000762 | 0.0293393599374 | 0.3 | TDP1 PNKP LIG3 | Decreased nerve conduction velocity |
| REAC:R-HSA-110373 | 0.0302795201711 | 0.2 | POLB PARP2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| HP:0012116 | 0.0322365869344 | 0.3 | TDP1 PNKP APTX | Abnormal circulating albumin concentration |
| HP:0003073 | 0.0322365869344 | 0.3 | TDP1 PNKP APTX | Hypoalbuminemia |
| HP:0040129 | 0.0332426017963 | 0.3 | TDP1 PNKP LIG3 | Abnormal nerve conduction velocity |
| REAC:R-HSA-5693532 | 0.033986572252 | 0.3 | TDP1 PARP2 LIG3 | DNA Double-Strand Break Repair |
| HPA:0301361 | 0.0364546918442 | 0.5 | XPC APTX PNKP LIG3 CHD1L | lung; alveolar cells type I[>=Low] |
| HP:0002495 | 0.0397152677732 | 0.3 | TDP1 PNKP APTX | Impaired vibratory sensation |
| GO:0005654 | 0.042696914045 | 1.0 | XPC RNF146 PARP2 CHD1L TDP1 LIG3 PNKP APTX POLB APLF | nucleoplasm |
| HPA:0630052 | 0.0476573520553 | 0.8 | XPC APTX RNF146 TDP1 LIG3 PNKP CHD1L POLB | cervix; glandular cells[>=Medium] |
| GO:0006950 | 0.0490245907666 | 0.9 | XPC PARP2 CHD1L TDP1 LIG3 PNKP APTX POLB APLF | response to stress |
| CORUM:365 | 0.0499436884912 | 0.1 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:363 | 0.0499436884912 | 0.1 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:212 | 0.0499436884912 | 0.1 | LIG3 | DNA ligase III-XRCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LIG3 | XRCC1 | 1.0 | 0.55 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| POLB | XRCC1 | 0.999 | 0.084 |
mutually_exclusive (P35244)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| POLB | PARP2 | 0.999 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LIG3 | POLB | 0.999 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RNF146 | PARP2 | 0.999 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LIG3 | PNKP | 0.998 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| APLF | XPC | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIG3 | APTX | 0.997 | 0.136 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| APLF | PARP2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| APLF | LIG3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIG3 | TDP1 | 0.996 | 0.0660385964912 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PNKP | POLB | 0.994 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| XPC | PARP2 | 0.993 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PNKP | XRCC1 | 0.993 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| APLF | POLB | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIG3 | PARP2 | 0.991 | 0.076 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| APLF | XRCC1 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| POLB | APTX | 0.99 | 0.134 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RNF146 | CHD1L | 0.988 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| XPC | CHD1L | 0.988 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| POLB | TDP1 | 0.986 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| XPC | RNF146 | 0.984 | 0.182 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LIG3 | XPC | 0.981 | 0.164 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| XPC | POLB | 0.976 | 0.19 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PARP2 | CHD1L | 0.966 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNKP | APTX | 0.958 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| XRCC1 | APTX | 0.951 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| XRCC1 | CHD1L | 0.943 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LIG3 | CHD1L | 0.92 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| XRCC1 | TDP1 | 0.918 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | |
| XRCC1 | PARP2 | 0.908 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| APLF | TDP1 | 0.904 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PNKP | TDP1 | 0.862 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| APLF | CHD1L | 0.818 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| XPC | TDP1 | 0.787 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| TDP1 | PARP2 | 0.785 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| TDP1 | APTX | 0.765 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| PNKP | PARP2 | 0.661 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| XPC | XRCC1 | 0.515 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only | |
| APLF | APTX | 0.353 | bioplex_WMM bioplex3_WMM WMM_only | ||
| LIG3 | RNF146 | 0.345 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| APLF | PNKP | 0.297 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APTX | PARP2 | 0.179 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| XRCC1 | RNF146 | 0.164 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| POLB | CHD1L | 0.115 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| XPC | PNKP | 0.111 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| TDP1 | CHD1L | 0.094 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | |
| XPC | APTX | 0.051 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes