hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09214.1

Complex Portal: CPX-22022

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
CFAP74	Cilia- and flagella-associated protein 74	5	UniProt NCBI
RNF34	E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)	5	UniProt NCBI
UNC119	Protein unc-119 homolog A (Retinal protein 4) (hRG4)	5	UniProt NCBI
UNC119B	Protein unc-119 homolog B	5	UniProt NCBI
SIPA1L2	Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)	4	UniProt NCBI
CYS1	Cystin-1 (Cilia-associated protein)	4	UniProt NCBI
FAM13A	Protein FAM13A	4	UniProt NCBI
GNAT2	Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain)	5	UniProt NCBI
PDE8A	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)	5	UniProt NCBI
LZTS2	Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)	5	UniProt NCBI
RSPRY1	RING finger and SPRY domain-containing protein 1	4	UniProt NCBI
MACIR	Macrophage immunometabolism regulator	5	UniProt NCBI
PSKH2	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2)	5	UniProt NCBI
PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)	5	UniProt NCBI
PALD1	Paladin	4	UniProt NCBI
AVPI1	Arginine vasopressin-induced protein 1 (AVP-induced protein 1)	5	UniProt NCBI
PRKG2	cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII)	5	UniProt NCBI
DENND4C	DENN domain-containing protein 4C	5	UniProt NCBI
NPHP3	Nephrocystin-3	5	UniProt NCBI
SPDEF	SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor)	5	UniProt NCBI
LZTS1	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5624138	8.17971429006e-06	0.142857142857	UNC119B NPHP3 CYS1	Trafficking of myristoylated proteins to the cilium
REAC:R-HSA-5620920	0.0119551195518	0.142857142857	UNC119B NPHP3 CYS1	Cargo trafficking to the periciliary membrane
HP:0004592	0.0349934705793	0.0952380952381	RSPRY1 PRKG2	Thoracic platyspondyly
REAC:R-HSA-418457	0.0412387552064	0.0952380952381	PDE9A PRKG2	cGMP effects

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
UNC119	NPHP3	1.0	0.112	structurally_consistent (dimer)
UNC119	UNC119B	1.0	0.32	structurally_consistent (dimer)
UNC119B	NPHP3	1.0	0.07
LZTS1	LZTS2	0.999	0.136
UNC119	MACIR	0.999	0.092	structurally_consistent (dimer)
PALD1	UNC119	0.999	0.066
UNC119	AVPI1	0.999
PDE9A	UNC119	0.999		structurally_consistent (dimer)
SIPA1L2	LZTS2	0.998	0.192
PDE8A	UNC119	0.998	0.112
UNC119	LZTS1	0.998	0.036
UNC119	PSKH2	0.998		structurally_consistent (dimer)
PALD1	UNC119B	0.997	0.014
PSKH2	UNC119B	0.997		structurally_consistent (Q13432) structurally_consistent (dimer)
UNC119	LZTS2	0.997	0.136
UNC119	SPDEF	0.996
RNF34	UNC119	0.996	0.072	structurally_consistent (dimer)
UNC119B	FAM13A	0.996
UNC119B	LZTS2	0.996	0.03
UNC119	FAM13A	0.995
AVPI1	MACIR	0.995
AVPI1	UNC119B	0.995
SPDEF	MACIR	0.995
RNF34	UNC119B	0.995	0.038
CYS1	UNC119B	0.994
UNC119B	MACIR	0.994	0.056
LZTS1	SIPA1L2	0.988	0.15
UNC119	GNAT2	0.987		structurally_consistent (dimer)
UNC119	CYS1	0.985
UNC119B	SIPA1L2	0.98	0.044	structurally_consistent (dimer)
MACIR	DENND4C	0.978	0.064
UNC119	RSPRY1	0.977	0.122
RSPRY1	UNC119B	0.977	0.068
SPDEF	UNC119B	0.976
UNC119B	GNAT2	0.973
PALD1	MACIR	0.972	0.05
RSPRY1	MACIR	0.971	0.084
UNC119	PRKG2	0.966
UNC119B	LZTS1	0.955	0.04
PDE8A	PDE9A	0.947
PDE9A	PALD1	0.918
PDE9A	LZTS1	0.916
PDE8A	LZTS1	0.912	0.16
PDE9A	NPHP3	0.889
PDE9A	LZTS2	0.868
PDE8A	NPHP3	0.805	0.124
PDE9A	MACIR	0.789		structurally_consistent (Q13432)
NPHP3	LZTS2	0.762	0.235333333333
PALD1	NPHP3	0.74	0.082
UNC119	SIPA1L2	0.72	0.112
PDE8A	LZTS2	0.709	0.222
PDE9A	RSPRY1	0.693
PDE8A	RSPRY1	0.693	0.09
PDE8A	PALD1	0.668	0.046
PDE8A	PRKG2	0.663
PDE8A	MACIR	0.659	0.052
MACIR	NPHP3	0.65	0.128	mutually_exclusive (Q13432)
PDE9A	PRKG2	0.65
PDE9A	UNC119B	0.605
PALD1	LZTS1	0.582	0.072
LZTS1	NPHP3	0.572	0.12
PRKG2	LZTS1	0.572
PDE8A	AVPI1	0.572
AVPI1	PRKG2	0.557
PDE9A	AVPI1	0.557
PDE8A	UNC119B	0.539	0.054
AVPI1	LZTS1	0.53
PALD1	PRKG2	0.495
MACIR	LZTS2	0.47	0.108
PALD1	RSPRY1	0.468	0.036
RNF34	PDE9A	0.46		structurally_consistent (Q13432)
RNF34	PRKG2	0.45
LZTS1	MACIR	0.448	0.09
RSPRY1	LZTS1	0.408	0.118
PDE9A	FAM13A	0.35
PRKG2	FAM13A	0.35
PALD1	AVPI1	0.336
PDE8A	RNF34	0.335	0.068
PRKG2	NPHP3	0.334
PRKG2	LZTS2	0.333
RNF34	AVPI1	0.333
RSPRY1	NPHP3	0.292	0.086
DENND4C	SIPA1L2	0.278	0.126
PALD1	LZTS2	0.268	0.118
PRKG2	MACIR	0.267
FAM13A	MACIR	0.25
FAM13A	SIPA1L2	0.246
FAM13A	DENND4C	0.238
PALD1	FAM13A	0.223
AVPI1	RSPRY1	0.218
RNF34	PALD1	0.216	0.042
RNF34	NPHP3	0.207	0.1	mutually_exclusive (Q13432)
PRKG2	RSPRY1	0.201
MACIR	SIPA1L2	0.201	0.12
RNF34	LZTS2	0.187	0.172
FAM13A	NPHP3	0.187
RNF34	MACIR	0.186	0.074	mutually_exclusive (Q13432)
RNF34	LZTS1	0.172	0.074
AVPI1	LZTS2	0.172
AVPI1	NPHP3	0.172
AVPI1	FAM13A	0.172
LZTS1	FAM13A	0.172
PDE8A	FAM13A	0.172
PRKG2	UNC119B	0.165
FAM13A	LZTS2	0.165
RSPRY1	LZTS2	0.147	0.166
RNF34	FAM13A	0.143
RNF34	SIPA1L2	0.08	0.118
RNF34	DENND4C	0.076	0.088
DENND4C	LZTS2	0.07	0.146
RSPRY1	CFAP74	0.063
RSPRY1	FAM13A	0.059
RNF34	RSPRY1	0.051	0.128
PALD1	DENND4C	0.017	0.038
UNC119B	DENND4C	0.014	0.056
PDE8A	DENND4C	0.014	0.084
LZTS1	DENND4C	0.014	0.074
RSPRY1	SIPA1L2	0.013	0.122
CYS1	SIPA1L2	0.012
PALD1	SIPA1L2	0.004	0.1

Related Complexes

Genename	Complexes
CFAP74	huMAP3_00345.1 huMAP3_00549.1 huMAP3_04280.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_09214.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_12967.1
RNF34	huMAP3_00184.1 huMAP3_00345.1 huMAP3_04280.1 huMAP3_08140.1 huMAP3_08913.1 huMAP3_09214.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_12595.1 huMAP3_13555.1
UNC119	huMAP3_00184.1 huMAP3_00345.1 huMAP3_00471.1 huMAP3_02534.1 huMAP3_04280.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_07508.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1
UNC119B	huMAP3_00345.1 huMAP3_02534.1 huMAP3_04280.1 huMAP3_04431.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1
SIPA1L2	huMAP3_01739.1 huMAP3_06137.1 huMAP3_08140.1 huMAP3_09214.1 huMAP3_10165.1
CYS1	huMAP3_00184.1 huMAP3_00345.1 huMAP3_01767.1 huMAP3_04280.1 huMAP3_05968.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_08388.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_09797.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10348.1 huMAP3_10930.1
FAM13A	huMAP3_01612.1 huMAP3_06615.1 huMAP3_07522.1 huMAP3_07673.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10682.1
GNAT2	huMAP3_02643.1 huMAP3_08140.1 huMAP3_08591.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
PDE8A	huMAP3_00113.1 huMAP3_08140.1 huMAP3_09214.1 huMAP3_11623.1 huMAP3_14850.1
LZTS2	huMAP3_08140.1 huMAP3_09214.1
RSPRY1	huMAP3_00184.1 huMAP3_00345.1 huMAP3_00765.1 huMAP3_02534.1 huMAP3_04280.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11715.1
MACIR	huMAP3_01645.1 huMAP3_02534.1 huMAP3_04751.1 huMAP3_07174.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1
PSKH2	huMAP3_00184.1 huMAP3_00345.1 huMAP3_04280.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1
PDE9A	huMAP3_00184.1 huMAP3_00471.1 huMAP3_04280.1 huMAP3_07463.1 huMAP3_07508.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_11623.1 huMAP3_14850.1
PALD1	huMAP3_00184.1 huMAP3_00345.1 huMAP3_02534.1 huMAP3_04280.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1 huMAP3_13488.1
AVPI1	huMAP3_00184.1 huMAP3_01645.1 huMAP3_01867.1 huMAP3_02534.1 huMAP3_07174.1 huMAP3_07201.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1
PRKG2	huMAP3_00184.1 huMAP3_00471.1 huMAP3_04280.1 huMAP3_07508.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
DENND4C	huMAP3_01645.1 huMAP3_02534.1 huMAP3_04751.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1 huMAP3_12897.1
NPHP3	huMAP3_03977.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_11623.1
SPDEF	huMAP3_00184.1 huMAP3_00345.1 huMAP3_01416.1 huMAP3_02534.1 huMAP3_06451.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_09214.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1
LZTS1	huMAP3_00345.1 huMAP3_04280.1 huMAP3_04431.1 huMAP3_06137.1 huMAP3_07174.1 huMAP3_07463.1 huMAP3_08140.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_10165.1 huMAP3_10266.1 huMAP3_10930.1 huMAP3_11623.1 huMAP3_14850.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09214.1

Complex Portal: CPX-22022