hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09225.1
Complex Portal: CPX-14774
Confidence: Moderate High  
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLDIP3 | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | 5 | UniProt   NCBI |
| NCBP3 | Nuclear cap-binding protein subunit 3 (Protein ELG) | 5 | UniProt   NCBI |
| THOC6 | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | 5 | UniProt   NCBI |
| RSPO1 | R-spondin-1 (Roof plate-specific spondin-1) (hRspo1) | 5 | UniProt   NCBI |
| DDX39A | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | 5 | UniProt   NCBI |
| ALYREF | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | 5 | UniProt   NCBI |
| THOC3 | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | 5 | UniProt   NCBI |
| THOC2 | THO complex subunit 2 (Tho2) (hTREX120) | 5 | UniProt   NCBI |
| SARNP | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | 5 | UniProt   NCBI |
| CHTOP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | 5 | UniProt   NCBI |
| DDX39B | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | 5 | UniProt   NCBI |
| FYTTD1 | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | 5 | UniProt   NCBI |
| THOC7 | THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30) | 5 | UniProt   NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
|   GO:0006406 | 3.95995798513e-21 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | mRNA export from nucleus |
|   REAC:R-HSA-72187 | 4.27049144781e-21 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | mRNA 3'-end processing |
|   GO:0051028 | 1.11384340881e-20 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | mRNA transport |
|   REAC:R-HSA-73856 | 1.86417988871e-20 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | RNA Polymerase II Transcription Termination |
|   REAC:R-HSA-159236 | 5.78130056178e-20 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | Transport of Mature mRNA derived from an Intron-Containing Transcript |
|   GO:0006405 | 7.85650685482e-20 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | RNA export from nucleus |
|   REAC:R-HSA-72202 | 2.09718890865e-19 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | Transport of Mature Transcript to Cytoplasm |
|   GO:0050657 | 1.13940515077e-18 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | nucleic acid transport |
|   GO:0050658 | 1.13940515077e-18 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | RNA transport |
|   GO:0051236 | 1.56749379097e-18 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | establishment of RNA localization |
|   GO:0006403 | 2.48787372427e-17 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | RNA localization |
|   GO:0051168 | 2.92459796926e-17 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | nuclear export |
|   GO:0015931 | 5.05889581482e-17 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | nucleobase-containing compound transport |
|   GO:0000346 | 4.62542507958e-16 | 0.583333333333 | SARNP THOC3 DDX39B THOC7 CHTOP THOC2 THOC6 | transcription export complex |
|   GO:0051169 | 1.2091003305e-14 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | nuclear transport |
|   GO:0006913 | 1.2091003305e-14 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | nucleocytoplasmic transport |
|   REAC:R-HSA-72203 | 7.90669749456e-14 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | Processing of Capped Intron-Containing Pre-mRNA |
|   CORUM:770 | 1.82045571662e-13 | 0.416666666667 | THOC7 THOC3 DDX39B THOC6 THOC2 | TREX complex |
|   GO:0044417 | 1.49641459906e-10 | 0.416666666667 | THOC7 THOC3 DDX39B THOC6 THOC2 | translocation of molecules into host |
|   GO:0046784 | 1.49641459906e-10 | 0.416666666667 | THOC7 THOC3 DDX39B THOC6 THOC2 | viral mRNA export from host cell nucleus |
|   CORUM:6160 | 2.37469785827e-10 | 0.333333333333 | THOC7 THOC3 THOC6 THOC2 | hTREX84 complex |
|   REAC:R-HSA-8953854 | 7.7925639851e-10 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | Metabolism of RNA |
|   GO:0016607 | 5.14036309143e-09 | 0.75 | POLDIP3 SARNP THOC7 DDX39B THOC6 DDX39A CHTOP FYTTD1 NCBP3 | nuclear speck |
|   REAC:R-HSA-73857 | 1.29006655752e-07 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | RNA Polymerase II Transcription |
|   GO:0071705 | 1.83913951432e-07 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | nitrogen compound transport |
|   GO:0046907 | 1.93517206394e-07 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | intracellular transport |
|   GO:0000445 | 1.9520016395e-07 | 0.333333333333 | THOC7 THOC3 THOC6 THOC2 | THO complex part of transcription export complex |
|   GO:0000347 | 1.9520016395e-07 | 0.333333333333 | THOC7 THOC3 THOC6 THOC2 | THO complex |
|   CORUM:774 | 2.57017958481e-07 | 0.25 | THOC7 THOC6 THOC2 | THO complex |
|   REAC:R-HSA-74160 | 4.45489549754e-07 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A THOC6 FYTTD1 THOC2 CHTOP | Gene expression (Transcription) |
|   KEGG:03013 | 5.65054507562e-07 | 0.416666666667 | THOC7 THOC3 DDX39B THOC6 THOC2 | Nucleocytoplasmic transport |
|   GO:0071702 | 1.68698679103e-06 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | organic substance transport |
|   GO:0051649 | 2.97403288334e-06 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | establishment of localization in cell |
|   CORUM:351 | 3.07405499269e-06 | 0.416666666667 | THOC7 THOC3 DDX39B THOC6 THOC2 | Spliceosome |
|   GO:0016604 | 6.73857883808e-06 | 0.75 | POLDIP3 SARNP THOC7 DDX39B THOC6 DDX39A CHTOP FYTTD1 NCBP3 | nuclear body |
|   GO:0006810 | 0.000104919322528 | 1.0 | POLDIP3 SARNP THOC7 THOC3 DDX39B THOC2 DDX39A NCBP3 FYTTD1 CHTOP RSPO1 THOC6 | transport |
|   GO:0033036 | 0.000119960103189 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | macromolecule localization |
|   HPA:0460643 | 0.000197441141621 | 0.5 | FYTTD1 DDX39B NCBP3 CHTOP THOC2 SARNP | skin 1; Langerhans[High] |
|   GO:0051234 | 0.000313582884475 | 1.0 | POLDIP3 SARNP THOC7 THOC3 DDX39B THOC2 DDX39A NCBP3 FYTTD1 CHTOP RSPO1 THOC6 | establishment of localization |
|   HPA:0470683 | 0.00039856716881 | 0.583333333333 | POLDIP3 SARNP DDX39B CHTOP FYTTD1 THOC2 NCBP3 | skin 2; epidermal cells[High] |
|   HPA:0460663 | 0.00046087489261 | 0.5 | FYTTD1 DDX39B NCBP3 CHTOP THOC2 SARNP | skin 1; keratinocytes[High] |
|   HPA:0620223 | 0.000737970610422 | 0.583333333333 | SARNP THOC3 DDX39B CHTOP FYTTD1 THOC2 NCBP3 | vagina; squamous epithelial cells[High] |
|   HPA:0330223 | 0.000876342772827 | 0.583333333333 | POLDIP3 SARNP THOC3 CHTOP FYTTD1 THOC2 NCBP3 | oral mucosa; squamous epithelial cells[High] |
|   GO:0051701 | 0.00100221860257 | 0.416666666667 | THOC7 THOC3 DDX39B THOC6 THOC2 | biological process involved in interaction with host |
|   GO:0051641 | 0.00109462381825 | 0.916666666667 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 CHTOP THOC2 THOC6 | cellular localization |
|   HPA:0380513 | 0.00122659504032 | 0.583333333333 | SARNP THOC3 DDX39B CHTOP FYTTD1 THOC2 NCBP3 | placenta; decidual cells[High] |
|   HPA:0060103 | 0.00134657257461 | 0.666666666667 | POLDIP3 SARNP THOC3 DDX39B CHTOP FYTTD1 THOC2 NCBP3 | bronchus; respiratory epithelial cells[High] |
|   GO:0051179 | 0.00197652202779 | 1.0 | POLDIP3 SARNP THOC7 THOC3 DDX39B THOC2 DDX39A NCBP3 FYTTD1 CHTOP RSPO1 THOC6 | localization |
|   HPA:0440343 | 0.00228743551542 | 0.5 | FYTTD1 DDX39B NCBP3 CHTOP THOC2 SARNP | skeletal muscle; myocytes[High] |
|   HPA:0610833 | 0.00282896538328 | 0.666666666667 | POLDIP3 SARNP THOC3 DDX39B CHTOP FYTTD1 THOC2 NCBP3 | urinary bladder; urothelial cells[High] |
|   HPA:0050012 | 0.00427058262231 | 0.583333333333 | POLDIP3 SARNP DDX39B THOC7 CHTOP THOC2 NCBP3 | breast; adipocytes[>=Medium] |
|   HPA:0620222 | 0.00539323604483 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 THOC2 CHTOP | vagina; squamous epithelial cells[>=Medium] |
|   KEGG:03040 | 0.00660131488073 | 0.25 | THOC3 THOC2 DDX39B | Spliceosome |
|   HPA:0630223 | 0.00742333163317 | 0.5 | FYTTD1 DDX39B NCBP3 CHTOP THOC2 SARNP | cervix; squamous epithelial cells[High] |
|   HPA:0490693 | 0.00759298751463 | 0.416666666667 | FYTTD1 CHTOP DDX39B NCBP3 THOC2 | smooth muscle; smooth muscle cells[High] |
|   HPA:0460662 | 0.0087870739766 | 0.75 | POLDIP3 SARNP THOC3 DDX39B THOC7 CHTOP FYTTD1 THOC2 NCBP3 | skin 1; keratinocytes[>=Medium] |
|   HPA:0190223 | 0.00896621963176 | 0.583333333333 | SARNP THOC3 DDX39B CHTOP FYTTD1 THOC2 NCBP3 | esophagus; squamous epithelial cells[High] |
|   HPA:0210053 | 0.0093996806627 | 0.583333333333 | POLDIP3 SARNP DDX39B THOC7 CHTOP THOC2 NCBP3 | fallopian tube; glandular cells[High] |
|   HPA:0320103 | 0.0150764166019 | 0.583333333333 | POLDIP3 SARNP THOC3 DDX39B CHTOP THOC2 NCBP3 | nasopharynx; respiratory epithelial cells[High] |
|   GO:0044403 | 0.0155118576058 | 0.416666666667 | THOC7 THOC3 DDX39B THOC6 THOC2 | biological process involved in symbiotic interaction |
|   HPA:0340463 | 0.0206923872087 | 0.333333333333 | POLDIP3 CHTOP NCBP3 THOC2 | ovary; ovarian stroma cells[High] |
|   HPA:0320102 | 0.0229241144182 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 THOC2 CHTOP | nasopharynx; respiratory epithelial cells[>=Medium] |
|   HPA:0500652 | 0.0232729921853 | 0.666666666667 | POLDIP3 SARNP DDX39B THOC7 CHTOP FYTTD1 THOC2 NCBP3 | soft tissue 1; fibroblasts[>=Medium] |
|   GO:0016973 | 0.0278917334495 | 0.25 | POLDIP3 THOC2 SARNP | poly(A)+ mRNA export from nucleus |
|   HPA:0060102 | 0.0310587535007 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 THOC2 CHTOP | bronchus; respiratory epithelial cells[>=Medium] |
|   HPA:0220053 | 0.0345068762131 | 0.666666666667 | POLDIP3 SARNP THOC3 DDX39B THOC7 CHTOP THOC2 NCBP3 | gallbladder; glandular cells[High] |
|   HPA:0600222 | 0.0351238404437 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 THOC2 CHTOP | tonsil; squamous epithelial cells[>=Medium] |
|   HPA:0460641 | 0.0399548215156 | 0.75 | SARNP THOC7 THOC3 DDX39B DDX39A CHTOP FYTTD1 THOC2 NCBP3 | skin 1; Langerhans[>=Low] |
|   HPA:0190222 | 0.0414639049089 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 THOC2 CHTOP | esophagus; squamous epithelial cells[>=Medium] |
|   HPA:0460661 | 0.0422268894731 | 0.833333333333 | POLDIP3 SARNP THOC7 THOC3 DDX39B DDX39A NCBP3 FYTTD1 THOC2 CHTOP | skin 1; keratinocytes[>=Low] |
|   HPA:0470682 | 0.0488252296425 | 0.75 | POLDIP3 SARNP THOC3 DDX39B THOC7 CHTOP FYTTD1 THOC2 NCBP3 | skin 2; epidermal cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
|  THOC3 |  THOC7 | 1.0 | 0.1           |
structurally_consistent (Q8NI27)        
|
|  THOC6 |  THOC3 | 1.0 | 0.342           |
structurally_consistent (dimer)        
|
|  THOC6 |  THOC7 | 1.0 | 0.526           |
structurally_consistent (Q13769)        
structurally_consistent (dimer)         |
|  THOC6 |  THOC2 | 1.0 | 0.874           |          |
|  THOC3 |  THOC2 | 1.0 | 0.46           |
structurally_consistent (dimer)        
|
|  CHTOP |  FYTTD1 | 1.0 | 0.086           |          |
|  THOC2 |  THOC7 | 1.0 | 0.332           |
structurally_consistent (dimer)        
|
|  THOC6 |  NCBP3 | 0.999 | 0.448           |          |
|  THOC2 |  SARNP | 0.999 | 0.344           |
mutually_exclusive (O00148)        
|
|  ALYREF |  CHTOP | 0.999 | 0.572           |          |
|  THOC2 |  DDX39B | 0.999 | 0.458           |
structurally_consistent (dimer)        
|
|  THOC7 |  NCBP3 | 0.999 | 0.14           |          |
|  THOC6 |  DDX39B | 0.999 | 0.408           |          |
|  THOC6 |  SARNP | 0.998 | 0.176           |          |
|  DDX39B |  NCBP3 | 0.998 | 0.208           |          |
|  CHTOP |  SARNP | 0.998 | 0.518           |          |
|  DDX39A |  DDX39B | 0.998 | 0.446           |          |
|  CHTOP |  DDX39B | 0.998 | 0.684           |          |
|  THOC6 |  DDX39A | 0.997 | 0.164           |          |
|  POLDIP3 |  THOC7 | 0.997 | 0.3           |
structurally_consistent (Q86W42)        
|
|  POLDIP3 |  SARNP | 0.997 | 0.408           |          |
|  THOC7 |  SARNP | 0.997 | 0.412           |          |
|  CHTOP |  NCBP3 | 0.997 | 0.208           |          |
|  ALYREF |  NCBP3 | 0.997 | 0.298           |          |
|  DDX39B |  SARNP | 0.997 | 0.736           |          |
|  THOC2 |  FYTTD1 | 0.997 | 0.208           |          |
|  DDX39A |  SARNP | 0.996 | 0.394           |
structurally_consistent (dimer)        
|
|  FYTTD1 |  NCBP3 | 0.996 | 0.114           |          |
|  DDX39B |  THOC7 | 0.996 | 0.242           |          |
|  CHTOP |  THOC7 | 0.996 | 0.252           |          |
|  RSPO1 |  CHTOP | 0.995 |            |          |
|  THOC7 |  FYTTD1 | 0.995 | 0.106           |          |
|  SARNP |  FYTTD1 | 0.995 | 0.262           |          |
|  THOC2 |  NCBP3 | 0.992 | 0.386           |          |
|  THOC3 |  SARNP | 0.992 | 0.1           |          |
|  POLDIP3 |  THOC6 | 0.992 | 0.304           |
structurally_consistent (dimer)        
|
|  CHTOP |  THOC2 | 0.991 | 0.288           |          |
|  SARNP |  NCBP3 | 0.99 | 0.43           |          |
|  POLDIP3 |  FYTTD1 | 0.99 | 0.194           |          |
|  DDX39A |  NCBP3 | 0.99 | 0.086           |
mutually_exclusive (Q96J01)        
|
|  DDX39A |  THOC2 | 0.989 | 0.174           |
mutually_exclusive (Q96J01)        
structurally_consistent (dimer)         |
|  CHTOP |  DDX39A | 0.988 | 0.13           |
mutually_exclusive (Q96J01)        
|
|  ALYREF |  THOC2 | 0.988 | 0.674           |
mutually_exclusive (O00148)        
|
|  THOC3 |  DDX39B | 0.986 | 0.238           |          |
|  THOC6 |  FYTTD1 | 0.985 | 0.248           |          |
|  THOC3 |  ALYREF | 0.984 | 0.246           |
structurally_consistent (dimer)        
|
|  THOC3 |  FYTTD1 | 0.984 | 0.048           |          |
|  ALYREF |  DDX39B | 0.983 | 0.816           |          |
|  THOC3 |  NCBP3 | 0.98 | 0.108           |
structurally_consistent (dimer)        
|
|  ALYREF |  THOC7 | 0.979 | 0.242           |
structurally_consistent (Q86W42)        
|
|  DDX39A |  FYTTD1 | 0.977 | 0.098           |          |
|  POLDIP3 |  THOC2 | 0.975 | 0.562           |          |
|  POLDIP3 |  ALYREF | 0.974 | 0.484           |          |
|  THOC3 |  DDX39A | 0.974 | 0.128           |
structurally_consistent (dimer)        
|
|  POLDIP3 |  NCBP3 | 0.973 | 0.184           |          |
|  DDX39A |  THOC7 | 0.973 | 0.168           |
structurally_consistent (Q8NI27)        
|
|  THOC6 |  CHTOP | 0.972 | 0.146           |
mutually_exclusive (Q96J01)        
|
|  ALYREF |  DDX39A | 0.972 | 0.406           |
structurally_consistent (dimer)        
|
|  THOC3 |  CHTOP | 0.97 | 0.134           |
mutually_exclusive (Q96A72)        
structurally_consistent (dimer)         |
|  ALYREF |  FYTTD1 | 0.962 | 0.13685           |          |
|  ALYREF |  SARNP | 0.962 | 0.62           |
mutually_exclusive (O00148)        
|
|  POLDIP3 |  CHTOP | 0.96 | 0.322           |          |
|  THOC6 |  ALYREF | 0.949 | 0.284           |
structurally_consistent (dimer)        
|
|  DDX39B |  FYTTD1 | 0.937 | 0.09           |          |
|  POLDIP3 |  DDX39B | 0.917 | 0.266           |          |
|  POLDIP3 |  THOC3 | 0.914 | 0.234           |
mutually_exclusive (Q96A72)        
|
|  POLDIP3 |  DDX39A | 0.866 | 0.3           |
structurally_consistent (dimer)        
|
|  THOC6 |  RSPO1 | 0.038 |            |          |
|  THOC3 |  RSPO1 | 0.009 |            |          |
|  RSPO1 |  DDX39B | 0.008 |            |          |
|  RSPO1 |  ALYREF | 0.004 |            |          |
Related Complexes