hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09231.1

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
KLF15	Krueppel-like factor 15 (Kidney-enriched krueppel-like factor)	5	UniProt NCBI
UBXN11	UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5)	5	UniProt NCBI
TESPA1	Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)	5	UniProt NCBI
COL1A2	Collagen alpha-2(I) chain (Alpha-2 type I collagen)	5	UniProt NCBI
COL3A1	Collagen alpha-1(III) chain	5	UniProt NCBI
COL1A1	Collagen alpha-1(I) chain (Alpha-1 type I collagen)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0025019	1.65494737492e-06	0.5	COL3A1 COL1A2 COL1A1	Arterial rupture
REAC:R-HSA-3000480	4.79564882828e-06	0.5	COL3A1 COL1A2 COL1A1	Scavenging by Class A Receptors
WP:WP453	4.86958082231e-06	0.5	COL3A1 COL1A2 COL1A1	Inflammatory response pathway
REAC:R-HSA-3000170	1.08523688914e-05	0.5	COL3A1 COL1A2 COL1A1	Syndecan interactions
REAC:R-HSA-8874081	1.42587173715e-05	0.5	COL3A1 COL1A2 COL1A1	MET activates PTK2 signaling
REAC:R-HSA-8948216	2.85755298292e-05	0.5	COL3A1 COL1A2 COL1A1	Collagen chain trimerization
REAC:R-HSA-8875878	4.20912658431e-05	0.5	COL3A1 COL1A2 COL1A1	MET promotes cell motility
REAC:R-HSA-2173782	4.60302232639e-05	0.5	COL3A1 COL1A2 COL1A1	Binding and Uptake of Ligands by Scavenger Receptors
HP:0010648	5.22168897407e-05	0.5	COL3A1 COL1A2 COL1A1	Dermal translucency
GO:0005583	6.72425931667e-05	0.5	COL3A1 COL1A2 COL1A1	fibrillar collagen trimer
GO:0098643	6.72425931667e-05	0.5	COL3A1 COL1A2 COL1A1	banded collagen fibril
KEGG:04974	0.000103211468895	0.5	COL3A1 COL1A2 COL1A1	Protein digestion and absorption
HP:0003321	0.000108046320019	0.333333333333	COL1A1 COL1A2	Biconcave flattened vertebrae
HP:0005897	0.000108046320019	0.333333333333	COL1A1 COL1A2	Severe generalized osteoporosis
HP:0005005	0.000108046320019	0.333333333333	COL1A1 COL1A2	Femoral bowing present at birth, straightening with time
HP:0005623	0.000108046320019	0.333333333333	COL1A1 COL1A2	Absent ossification of calvaria
REAC:R-HSA-2022090	0.000113827315454	0.5	COL3A1 COL1A2 COL1A1	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-3000171	0.00012139707053	0.5	COL3A1 COL1A2 COL1A1	Non-integrin membrane-ECM interactions
REAC:R-HSA-1442490	0.000129294318659	0.5	COL3A1 COL1A2 COL1A1	Collagen degradation
HP:0001030	0.000132369077408	0.5	COL3A1 COL1A2 COL1A1	Fragile skin
REAC:R-HSA-1650814	0.000155019643237	0.5	COL3A1 COL1A2 COL1A1	Collagen biosynthesis and modifying enzymes
HP:0001075	0.000160619133799	0.5	COL3A1 COL1A2 COL1A1	Atrophic scars
HP:0000015	0.000160619133799	0.5	COL3A1 COL1A2 COL1A1	Bladder diverticulum
KEGG:05146	0.000201071778007	0.5	COL3A1 COL1A2 COL1A1	Amoebiasis
KEGG:04933	0.000208220726788	0.5	COL3A1 COL1A2 COL1A1	AGE-RAGE signaling pathway in diabetic complications
REAC:R-HSA-3000178	0.000216237937074	0.5	COL3A1 COL1A2 COL1A1	ECM proteoglycans
HP:0006094	0.00022859990461	0.5	COL3A1 COL1A2 COL1A1	Finger joint hypermobility
REAC:R-HSA-216083	0.00027807877525	0.5	COL3A1 COL1A2 COL1A1	Integrin cell surface interactions
KEGG:04611	0.000298275635298	0.5	COL3A1 COL1A2 COL1A1	Platelet activation
HP:0006256	0.000313432690896	0.5	COL3A1 COL1A2 COL1A1	Abnormality of hand joint mobility
GO:0048407	0.000316805542726	0.5	COL3A1 COL1A2 COL1A1	platelet-derived growth factor binding
HP:0006201	0.000324079809263	0.333333333333	COL3A1 COL1A2	Hypermobility of distal interphalangeal joints
REAC:R-HSA-6806834	0.000366552496151	0.5	COL3A1 COL1A2 COL1A1	Signaling by MET
KEGG:04926	0.000399751749456	0.5	COL3A1 COL1A2 COL1A1	Relaxin signaling pathway
REAC:R-HSA-1474290	0.000417052782963	0.5	COL3A1 COL1A2 COL1A1	Collagen formation
HP:0430046	0.000508000048987	0.5	COL3A1 COL1A2 COL1A1	Small joint hypermobilty
HP:0005620	0.000648041335154	0.333333333333	COL3A1 COL1A2	Hypermobility of interphalangeal joints
HP:0003023	0.000648041335154	0.333333333333	COL1A1 COL1A2	Bowing of limbs due to multiple fractures
HP:0030009	0.000648041335154	0.333333333333	COL3A1 COL1A1	Cervical insufficiency
GO:0098644	0.000698569295426	0.5	COL3A1 COL1A2 COL1A1	complex of collagen trimers
HP:0002616	0.000904872598217	0.5	COL3A1 COL1A2 COL1A1	Aortic root aneurysm
REAC:R-HSA-430116	0.000928329318648	0.333333333333	COL1A1 COL1A2	GP1b-IX-V activation signalling
HP:0000974	0.00100321433019	0.5	COL3A1 COL1A2 COL1A1	Hyperextensible skin
REAC:R-HSA-198933	0.00102704788141	0.5	COL3A1 COL1A2 COL1A1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
HP:0000993	0.00107987178333	0.333333333333	COL3A1 COL1A1	Molluscoid pseudotumors
HP:0000362	0.00107987178333	0.333333333333	COL1A1 COL1A2	Otosclerosis
HP:0005758	0.00107987178333	0.333333333333	COL1A1 COL1A2	Basilar impression
REAC:R-HSA-75892	0.00116019984728	0.333333333333	COL1A1 COL1A2	Platelet Adhesion to exposed collagen
WP:WP3967	0.00120604069052	0.333333333333	COL3A1 COL1A1	miR 509 3p alteration of YAP1 ECM axis
REAC:R-HSA-1474228	0.00130420727992	0.5	COL3A1 COL1A2 COL1A1	Degradation of the extracellular matrix
HP:0000987	0.00140289497732	0.5	COL3A1 COL1A2 COL1A1	Atypical scarring of skin
HP:0025487	0.00146741733922	0.5	COL3A1 COL1A2 COL1A1	Abnormal bladder morphology
WP:WP2911	0.00153714048185	0.333333333333	COL3A1 COL1A2	miRNA targets in ECM and membrane receptors
HP:0100823	0.00161951205762	0.333333333333	COL3A1 COL1A1	Genital hernia
HP:0006367	0.00161951205762	0.333333333333	COL1A1 COL1A2	Crumpled long bones
HP:0000139	0.00161951205762	0.333333333333	COL3A1 COL1A1	Uterine prolapse
KEGG:05415	0.00191301809451	0.5	COL3A1 COL1A2 COL1A1	Diabetic cardiomyopathy
REAC:R-HSA-2214320	0.00200991204249	0.333333333333	COL1A1 COL1A2	Anchoring fibril formation
HP:0000923	0.0022669030801	0.333333333333	COL1A1 COL1A2	Beaded ribs
HP:0000444	0.0023115348624	0.5	COL3A1 COL1A2 COL1A1	Convex nasal ridge
HP:0001787	0.00240122360395	0.5	COL3A1 COL1A2 COL1A1	Abnormal delivery
HP:0000963	0.00249319307056	0.5	COL3A1 COL1A2 COL1A1	Thin skin
WP:WP5036	0.00276984458443	0.333333333333	COL1A1 COL1A2	Angiotensin II receptor type 1 pathway
REAC:R-HSA-2243919	0.00309047926945	0.333333333333	COL1A1 COL1A2	Crosslinking of collagen fibrils
HP:0100699	0.00331442935792	0.5	COL3A1 COL1A2 COL1A1	Scarring
GO:0005581	0.00339409783315	0.5	COL3A1 COL1A2 COL1A1	collagen trimer
HP:0008921	0.00388470114881	0.333333333333	COL1A1 COL1A2	Neonatal short-limb short stature
HP:0004947	0.00388470114881	0.333333333333	COL3A1 COL1A1	Arteriovenous fistula
HP:0000592	0.00390912678804	0.5	COL3A1 COL1A2 COL1A1	Blue sclerae
HP:0004334	0.00390912678804	0.5	COL3A1 COL1A2 COL1A1	Dermal atrophy
WP:WP4786	0.0046606239013	0.333333333333	COL1A1 COL1A2	Type I collagen synthesis in the context of osteogenesis imperfecta
HP:0012727	0.00485475790375	0.5	COL3A1 COL1A2 COL1A1	Thoracic aortic aneurysm
HP:0001073	0.00485499013014	0.333333333333	COL3A1 COL1A1	Cigarette-paper scars
HP:0031869	0.00593279372985	0.333333333333	COL1A1 COL1A2	Recurrent joint dislocation
HP:0008628	0.00593279372985	0.333333333333	COL1A1 COL1A2	Abnormality of the stapes
HP:0001634	0.0061081203127	0.5	COL3A1 COL1A2 COL1A1	Mitral valve prolapse
WP:WP3932	0.00666912471972	0.5	COL3A1 COL1A2 COL1A1	Focal adhesion PI3K Akt mTOR signaling pathway
GO:0030020	0.00699636827123	0.5	COL3A1 COL1A2 COL1A1	extracellular matrix structural constituent conferring tensile strength
GO:0005584	0.00702301080125	0.333333333333	COL1A1 COL1A2	collagen type I trimer
HP:0003179	0.00711805296098	0.333333333333	COL1A1 COL1A2	Protrusio acetabuli
HP:0012888	0.00711805296098	0.333333333333	COL3A1 COL1A1	Abnormal uterine cervix morphology
HP:0005294	0.00711805296098	0.333333333333	COL3A1 COL1A1	Arterial dissection
HP:0001027	0.00711805296098	0.333333333333	COL1A1 COL1A2	Soft, doughy skin
WP:WP5373	0.00741608411471	0.333333333333	COL3A1 COL1A1	Role of hypoxia angiogenesis and FGF pathway in OA chondrocyte hypertrophy
HP:0000591	0.0075592305979	0.5	COL3A1 COL1A2 COL1A1	Abnormal sclera morphology
HP:0010547	0.00841070885474	0.333333333333	COL1A1 COL1A2	Muscle flaccidity
REAC:R-HSA-114604	0.00902151290218	0.333333333333	COL1A1 COL1A2	GPVI-mediated activation cascade
REAC:R-HSA-76009	0.00971370123257	0.333333333333	COL1A1 COL1A2	Platelet Aggregation (Plug Formation)
WP:WP5144	0.0108030732892	0.333333333333	COL1A1 COL1A2	NRP1 triggered signaling pathways in pancreatic cancer
HP:0003834	0.011317974846	0.333333333333	COL1A1 COL1A2	Shoulder dislocation
HP:0031654	0.0118805266195	0.5	COL3A1 COL1A2 COL1A1	Abnormal pulmonary valve physiology
HP:0001633	0.0124125846174	0.5	COL3A1 COL1A2 COL1A1	Abnormal mitral valve morphology
HP:0004942	0.0126844263563	0.5	COL3A1 COL1A2 COL1A1	Aortic aneurysm
HP:0001788	0.0129324670968	0.333333333333	COL3A1 COL1A1	Premature rupture of membranes
REAC:R-HSA-1474244	0.0133066815994	0.5	COL3A1 COL1A2 COL1A1	Extracellular matrix organization
HP:0001622	0.0138111776458	0.5	COL3A1 COL1A2 COL1A1	Premature birth
HP:0005474	0.0146541203169	0.333333333333	COL1A1 COL1A2	Decreased calvarial ossification
HP:0002691	0.0146541203169	0.333333333333	COL1A1 COL1A2	Platybasia
HP:0100541	0.0146541203169	0.333333333333	COL1A1 COL1A2	Femoral hernia
HP:0040160	0.0146541203169	0.333333333333	COL1A1 COL1A2	Generalized osteoporosis
HP:0005855	0.0146541203169	0.333333333333	COL1A1 COL1A2	Multiple prenatal fractures
HP:0000978	0.0153102613551	0.5	COL3A1 COL1A2 COL1A1	Bruising susceptibility
HP:0025323	0.0153102613551	0.5	COL3A1 COL1A2 COL1A1	Abnormal arterial physiology
KEGG:04512	0.0158846761267	0.333333333333	COL1A1 COL1A2	ECM-receptor interaction
WP:WP5055	0.0159206501541	0.333333333333	COL1A1 COL1A2	Burn wound healing
GO:0030199	0.0161301339283	0.5	COL3A1 COL1A2 COL1A1	collagen fibril organization
HP:0000703	0.0164828756284	0.333333333333	COL1A1 COL1A2	Dentinogenesis imperfecta
HP:0004452	0.0164828756284	0.333333333333	COL1A1 COL1A2	Abnormality of the middle ear ossicles
WP:WP5158	0.0170615762461	0.333333333333	COL3A1 COL1A1	Urotensin II mediated signaling pathway
HP:0006705	0.0182726158894	0.5	COL3A1 COL1A2 COL1A1	Abnormal atrioventricular valve morphology
HP:0008067	0.019338239817	0.5	COL3A1 COL1A2 COL1A1	Abnormally lax or hyperextensible skin
HP:0010299	0.020461457105	0.333333333333	COL1A1 COL1A2	Abnormal dentin morphology
HP:0008065	0.0266033265904	0.5	COL3A1 COL1A2 COL1A1	Aplasia/Hypoplasia of the skin
HP:0010444	0.0272311241025	0.333333333333	COL1A1 COL1A2	Pulmonary insufficiency
HP:0002617	0.0288997454362	0.5	COL3A1 COL1A2 COL1A1	Vascular dilatation
HP:0004586	0.0297012565438	0.333333333333	COL1A1 COL1A2	Biconcave vertebral bodies
HP:0001591	0.0349615340576	0.333333333333	COL1A1 COL1A2	Bell-shaped thorax
HP:0008609	0.0349615340576	0.333333333333	COL1A1 COL1A2	Abnormal middle ear morphology
HP:0032153	0.037751561683	0.333333333333	COL1A1 COL1A2	Joint subluxation
HP:0005743	0.0406481036194	0.333333333333	COL1A1 COL1A2	Avascular necrosis of the capital femoral epiphysis
HP:0002982	0.0406481036194	0.333333333333	COL1A1 COL1A2	Tibial bowing
MIRNA:hsa-miR-29c-3p	0.0414897534761	0.666666666667	COL1A1 COL3A1 TESPA1 COL1A2	hsa-miR-29c-3p
HP:0010647	0.0435813356909	0.5	COL3A1 COL1A2 COL1A1	Abnormal elasticity of skin
HP:0009124	0.0454639361427	0.5	COL3A1 COL1A2 COL1A1	Abnormal adipose tissue morphology
HP:0011119	0.0461031757991	0.5	COL3A1 COL1A2 COL1A1	Abnormal nasal dorsum morphology
HP:0001933	0.0467483115964	0.5	COL3A1 COL1A2 COL1A1	Subcutaneous hemorrhage

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
COL1A1	COL1A2	0.998	0.616	bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only
TESPA1	COL3A1	0.997		bioplex3_WMM bioplex3_HCT116 WMM_only
KLF15	COL3A1	0.997		bioplex3_WMM bioplex3_HCT116 WMM_only
COL1A1	KLF15	0.974		bioplex3_WMM bioplex3_HCT116 WMM_only
UBXN11	COL1A1	0.972		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
COL1A1	TESPA1	0.962		bioplex3_WMM bioplex3_HCT116 WMM_only
COL1A1	COL3A1	0.94	0.530653061224	bioplex_WMM bioplex3_WMM WMM_only
COL1A2	COL3A1	0.828	0.464	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
KLF15	huMAP3_02820.1 huMAP3_08965.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_13382.1 huMAP3_14070.1 huMAP3_15229.1
UBXN11	huMAP3_02069.1 huMAP3_02141.1 huMAP3_04848.1 huMAP3_09231.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1
TESPA1	huMAP3_02194.1 huMAP3_07657.1 huMAP3_08965.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_14070.1
COL1A2	huMAP3_02069.1 huMAP3_02141.1 huMAP3_06460.1 huMAP3_07562.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1
COL3A1	huMAP3_02820.1 huMAP3_08354.1 huMAP3_08965.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10555.1 huMAP3_10652.1 huMAP3_13382.1 huMAP3_14070.1 huMAP3_15229.1
COL1A1	huMAP3_02069.1 huMAP3_02141.1 huMAP3_06460.1 huMAP3_07562.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09231.1