hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09234.1
Complex Portal: CPX-12700
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RC3H2 | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | 5 | UniProt NCBI |
| MARCHF9 | E3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9) | 5 | UniProt NCBI |
| PFDN1 | Prefoldin subunit 1 | 4 | UniProt NCBI |
| MTFR1L | Mitochondrial fission regulator 1-like | 4 | UniProt NCBI |
| TYMS | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | 5 | UniProt NCBI |
| PFDN6 | Prefoldin subunit 6 (Protein Ke2) | 5 | UniProt NCBI |
| KATNB1 | Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) | 5 | UniProt NCBI |
| PFDN4 | Prefoldin subunit 4 (Protein C-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:33 | 1.962985025e-07 | 0.375 | PFDN6 PFDN1 PFDN4 | Prefoldin complex |
| CORUM:112 | 1.962985025e-07 | 0.375 | PFDN6 PFDN1 PFDN4 | Prefoldin complex |
| WP:WP4918 | 1.962985025e-07 | 0.375 | PFDN6 PFDN1 PFDN4 | Cellular proteostasis |
| REAC:R-HSA-389957 | 6.65860913492e-05 | 0.375 | PFDN6 PFDN1 PFDN4 | Prefoldin mediated transfer of substrate to CCT/TriC |
| GO:0016272 | 0.00010757157937 | 0.375 | PFDN6 PFDN1 PFDN4 | prefoldin complex |
| REAC:R-HSA-389958 | 0.000112766844535 | 0.375 | PFDN6 PFDN1 PFDN4 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| GO:1905907 | 0.000886327111509 | 0.375 | PFDN6 PFDN1 PFDN4 | negative regulation of amyloid fibril formation |
| REAC:R-HSA-390466 | 0.00221515749645 | 0.375 | PFDN6 PFDN1 PFDN4 | Chaperonin-mediated protein folding |
| GO:1905906 | 0.00244160521127 | 0.375 | PFDN6 PFDN1 PFDN4 | regulation of amyloid fibril formation |
| REAC:R-HSA-391251 | 0.00281136504087 | 0.375 | PFDN6 PFDN1 PFDN4 | Protein folding |
| GO:1902904 | 0.0100133115528 | 0.5 | PFDN6 PFDN4 PFDN1 KATNB1 | negative regulation of supramolecular fiber organization |
| GO:1990000 | 0.0450022850424 | 0.375 | PFDN6 PFDN1 PFDN4 | amyloid fibril formation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PFDN6 | PFDN4 | 1.0 | 0.948 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PFDN4 | PFDN1 | 1.0 | 0.92 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| PFDN6 | PFDN1 | 0.999 | 0.98 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PFDN4 | MARCHF9 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KATNB1 | PFDN4 | 0.998 | 0.15 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| PFDN4 | RC3H2 | 0.996 | 0.182 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| MTFR1L | PFDN1 | 0.996 | 0.054 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| KATNB1 | PFDN1 | 0.995 | 0.112 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| TYMS | PFDN1 | 0.983 | 0.038 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| PFDN4 | MTFR1L | 0.977 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MARCHF9 | PFDN1 | 0.976 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| RC3H2 | PFDN1 | 0.909 | 0.21 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PFDN4 | TYMS | 0.874 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| RC3H2 | MTFR1L | 0.834 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| PFDN6 | MTFR1L | 0.797 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| KATNB1 | MTFR1L | 0.754 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| PFDN6 | MARCHF9 | 0.716 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TYMS | MTFR1L | 0.685 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| RC3H2 | MARCHF9 | 0.675 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KATNB1 | RC3H2 | 0.529 | 0.164 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PFDN6 | TYMS | 0.485 | 0.054 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| KATNB1 | PFDN6 | 0.477 | 0.174 |
structurally_consistent (Q9NQP4)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| RC3H2 | TYMS | 0.448 | 0.098 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PFDN6 | RC3H2 | 0.279 | 0.208 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MARCHF9 | MTFR1L | 0.218 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KATNB1 | MARCHF9 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KATNB1 | TYMS | 0.179 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MARCHF9 | TYMS | 0.139 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes