hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09237.1
Complex Portal: CPX-16885
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SARS2 | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | 5 | UniProt NCBI |
| PGC | Gastricsin (EC 3.4.23.3) (Pepsinogen C) | 5 | UniProt NCBI |
| MAT2A | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | 5 | UniProt NCBI |
| MAT1A | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | 5 | UniProt NCBI |
| MAT2B | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP704 | 1.20729029075e-08 | 0.6 | MAT1A MAT2A MAT2B | Methylation pathways |
| REAC:R-HSA-156581 | 2.61984124802e-07 | 0.6 | MAT1A MAT2A MAT2B | Methylation |
| GO:0048269 | 9.61200410764e-07 | 0.6 | MAT1A MAT2A MAT2B | methionine adenosyltransferase complex |
| WP:WP3580 | 1.37419225557e-06 | 0.6 | MAT1A MAT2A MAT2B | Methionine de novo and salvage pathway |
| GO:0006556 | 3.84440695359e-06 | 0.6 | MAT1A MAT2A MAT2B | S-adenosylmethionine biosynthetic process |
| CORUM:7191 | 1.36501667663e-05 | 0.4 | MAT2A MAT2B | Methionine adenosyltransferase alpha2 beta-v1 |
| KEGG:00270 | 1.41035814484e-05 | 0.6 | MAT1A MAT2A MAT2B | Cysteine and methionine metabolism |
| WP:WP2525 | 3.15108918412e-05 | 0.6 | MAT1A MAT2A MAT2B | Trans sulfuration one carbon metabolism and related pathways |
| KEGG:01230 | 4.44119474406e-05 | 0.6 | MAT1A MAT2A MAT2B | Biosynthesis of amino acids |
| GO:0046500 | 8.06911104389e-05 | 0.6 | MAT1A MAT2A MAT2B | S-adenosylmethionine metabolic process |
| WP:WP4292 | 0.000211546265436 | 0.4 | MAT1A MAT2B | Methionine metabolism leading to sulfur amino acids and related disorders |
| REAC:R-HSA-156580 | 0.000254380816813 | 0.6 | MAT1A MAT2A MAT2B | Phase II - Conjugation of compounds |
| KEGG:01240 | 0.000360991485359 | 0.6 | MAT1A MAT2A MAT2B | Biosynthesis of cofactors |
| WP:WP241 | 0.00161852668418 | 0.4 | MAT1A MAT2B | One carbon metabolism |
| REAC:R-HSA-211859 | 0.00217510180244 | 0.6 | MAT1A MAT2A MAT2B | Biological oxidations |
| GO:0004478 | 0.00468200720083 | 0.4 | MAT1A MAT2A | methionine adenosyltransferase activity |
| WP:WP3940 | 0.00528162918062 | 0.4 | MAT1A MAT2A | One carbon metabolism and related pathways |
| CORUM:7197 | 0.0498708842806 | 0.2 | MAT1A | Methionine adenosyltransferase alpha1 beta-v1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAT2A | MAT2B | 1.0 | 0.558 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| MAT1A | MAT2B | 0.998 | 0.682 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| MAT2A | MAT1A | 0.996 | 0.734 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PGC | MAT2B | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MAT2A | SARS2 | 0.986 | 0.026 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| MAT2B | SARS2 | 0.022 | 0.094 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes