hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09238.1

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
TIMELESS	Protein timeless homolog (hTIM)	5	UniProt NCBI
MCM3	DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)	5	UniProt NCBI
GINS1	DNA replication complex GINS protein PSF1 (GINS complex subunit 1)	5	UniProt NCBI
MCM5	DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)	5	UniProt NCBI
CLSPN	Claspin (hClaspin)	5	UniProt NCBI
GINS2	DNA replication complex GINS protein PSF2 (GINS complex subunit 2)	5	UniProt NCBI
GINS4	DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]	5	UniProt NCBI
MCM7	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	5	UniProt NCBI
GINS3	DNA replication complex GINS protein PSF3 (GINS complex subunit 3)	5	UniProt NCBI
TIPIN	TIMELESS-interacting protein	5	UniProt NCBI
CDC45	Cell division control protein 45 homolog (PORC-PI-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-176974	1.69738107152e-12	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	Unwinding of DNA
CORUM:678	3.36110250117e-12	0.5	GINS3 GINS1 GINS2 GINS4	GINS complex
GO:0071162	2.32722490539e-10	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	CMG complex
GO:0031261	3.98884551806e-10	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	DNA replication preinitiation complex
REAC:R-HSA-69190	4.30104656022e-10	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	DNA strand elongation
GO:0000811	1.84188417064e-09	0.5	GINS3 GINS1 GINS2 GINS4	GINS complex
GO:0006261	2.65721538163e-09	0.875	TIMELESS GINS2 TIPIN GINS4 GINS1 CDC45 GINS3	DNA-templated DNA replication
GO:0006268	1.02328314981e-08	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	DNA unwinding involved in DNA replication
GO:0000228	1.14204846201e-08	0.875	TIMELESS GINS2 TIPIN GINS4 GINS1 CDC45 GINS3	nuclear chromosome
GO:0006260	5.34396095629e-08	0.875	TIMELESS GINS2 TIPIN GINS4 GINS1 CDC45 GINS3	DNA replication
REAC:R-HSA-69239	3.84295665702e-07	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	Synthesis of DNA
GO:0032508	6.11859846001e-07	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	DNA duplex unwinding
GO:0032392	1.4351743773e-06	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	DNA geometric change
REAC:R-HSA-69242	1.66077446895e-06	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	S Phase
REAC:R-HSA-69306	2.61423596025e-06	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	DNA Replication
GO:0071103	2.72810863015e-06	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	DNA conformation change
GO:0000076	5.61890325943e-06	0.5	TIMELESS CDC45 CLSPN TIPIN	DNA replication checkpoint signaling
REAC:R-HSA-1640170	4.06216370762e-05	0.75	GINS2 CDC45 GINS4 GINS1 GINS3 CLSPN	Cell Cycle
GO:0033260	7.48923430326e-05	0.5	GINS1 CDC45 TIPIN GINS3	nuclear DNA replication
GO:0044786	0.000120770447162	0.5	GINS1 CDC45 TIPIN GINS3	cell cycle DNA replication
GO:0006259	0.000396845715691	0.875	TIMELESS GINS2 TIPIN GINS4 GINS1 CDC45 GINS3	DNA metabolic process
REAC:R-HSA-69278	0.000645311785686	0.625	GINS3 GINS1 CDC45 GINS2 GINS4	Cell Cycle, Mitotic
GO:0000727	0.000886327111509	0.375	GINS4 GINS2 CDC45	double-strand break repair via break-induced replication
GO:1902969	0.00153551162834	0.375	GINS1 CDC45 GINS3	mitotic DNA replication
REAC:R-HSA-5693607	0.00263138488572	0.375	TIMELESS CLSPN TIPIN	Processing of DNA double-strand break ends
GO:0032993	0.00320293753229	0.875	TIMELESS GINS2 TIPIN GINS4 GINS1 CDC45 GINS3	protein-DNA complex
GO:0140513	0.00521846176444	0.875	TIMELESS GINS2 TIPIN GINS4 GINS1 CDC45 GINS3	nuclear protein-containing complex
REAC:R-HSA-5693567	0.00672088844441	0.375	TIMELESS CLSPN TIPIN	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
REAC:R-HSA-5693538	0.00775010993696	0.375	TIMELESS CLSPN TIPIN	Homology Directed Repair
GO:0031570	0.012426913615	0.5	TIMELESS CDC45 CLSPN TIPIN	DNA integrity checkpoint signaling
REAC:R-HSA-5693532	0.0141950226766	0.375	TIMELESS CLSPN TIPIN	DNA Double-Strand Break Repair
GO:0006974	0.0177166948638	0.75	TIMELESS GINS2 TIPIN GINS4 CDC45 CLSPN	DNA damage response
GO:0005694	0.0263739534621	0.875	TIMELESS GINS2 TIPIN GINS4 GINS1 CDC45 GINS3	chromosome
REAC:R-HSA-176187	0.0348192347107	0.25	CDC45 CLSPN	Activation of ATR in response to replication stress
GO:0043111	0.0393180950424	0.25	TIMELESS TIPIN	replication fork arrest
GO:0031298	0.0393180950424	0.25	TIMELESS TIPIN	replication fork protection complex
GO:0000724	0.0445000722229	0.5	TIMELESS CDC45 GINS2 GINS4	double-strand break repair via homologous recombination
GO:0000725	0.0491838271735	0.5	TIMELESS CDC45 GINS2 GINS4	recombinational repair

Edges

Protein 1	Protein 2	Score	ProteomeHD
GINS2	GINS4	1.0	0.93
GINS3	GINS1	1.0	0.93
TIPIN	TIMELESS	1.0	0.216
GINS2	GINS1	1.0	0.838
GINS2	GINS3	1.0	0.908
GINS4	GINS1	1.0	0.836
GINS4	GINS3	1.0	0.922
MCM3	MCM5	0.999	0.962
MCM5	MCM7	0.998	0.98
GINS4	TIMELESS	0.998	0.204
MCM3	MCM7	0.998	0.986
GINS4	TIPIN	0.997	0.09
CLSPN	GINS4	0.996	0.12
TIPIN	GINS3	0.996	0.084
CLSPN	TIMELESS	0.995	0.124
TIMELESS	CDC45	0.995	0.416
GINS3	TIMELESS	0.995	0.158
TIPIN	MCM7	0.994	0.402
MCM3	GINS4	0.994	0.256
MCM3	GINS3	0.993	0.646
MCM3	TIPIN	0.992	0.236
GINS4	MCM7	0.989	0.59
CLSPN	TIPIN	0.988	0.22
MCM7	TIMELESS	0.988	0.464
GINS3	CDC45	0.984	0.474
MCM3	TIMELESS	0.979	0.342
MCM7	CDC45	0.978	0.49
CLSPN	GINS3	0.978	0.154
GINS1	CDC45	0.976	0.316
TIPIN	MCM5	0.974	0.26
MCM5	TIMELESS	0.967	0.502
MCM3	CLSPN	0.965	0.384
GINS2	MCM5	0.963	0.472
GINS3	MCM5	0.957	0.578
GINS4	MCM5	0.953	0.328
GINS2	TIMELESS	0.952	0.092
GINS2	MCM7	0.939	0.47
CLSPN	MCM7	0.925	0.516
GINS3	MCM7	0.915	0.516
GINS4	CDC45	0.91	0.198
GINS1	TIMELESS	0.908	0.128
TIPIN	GINS1	0.896	0.104
MCM3	GINS2	0.879	0.302
GINS1	MCM5	0.877	0.594
GINS2	CDC45	0.857	0.124
MCM3	GINS1	0.841	0.404
GINS1	MCM7	0.835	0.592
MCM5	CDC45	0.832	0.426
MCM3	CDC45	0.754	0.354
GINS2	TIPIN	0.699	0.098
CLSPN	CDC45	0.694	0.22
TIPIN	CDC45	0.594	0.122
CLSPN	GINS1	0.568	0.074
GINS2	CLSPN	0.401	0.078
CLSPN	MCM5	0.064	0.34

Related Complexes

Genename	Complexes
TIMELESS	huMAP3_06136.1 huMAP3_06417.1 huMAP3_07113.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM3	huMAP3_00154.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS1	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM5	huMAP3_05529.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
CLSPN	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS2	huMAP3_03896.1 huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_13708.1 huMAP3_14758.1
GINS4	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM7	huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS3	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
TIPIN	huMAP3_04079.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
CDC45	huMAP3_06136.1 huMAP3_06278.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09238.1