hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09250.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TPR | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | 5 | UniProt NCBI |
| CTC1 | CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) | 5 | UniProt NCBI |
| STN1 | CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) | 5 | UniProt NCBI |
| TEN1 | CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6075 | 2.33868713081e-10 | 1.0 | TEN1 CTC1 STN1 | CST complex |
| GO:1990879 | 9.61200410764e-08 | 1.0 | TEN1 CTC1 STN1 | CST complex |
| REAC:R-HSA-174430 | 1.33448212368e-07 | 1.0 | TEN1 CTC1 STN1 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-174411 | 1.21316556698e-06 | 1.0 | TEN1 CTC1 STN1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-174417 | 2.79214721263e-06 | 1.0 | TEN1 CTC1 STN1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 9.7169895894e-06 | 1.0 | TEN1 CTC1 STN1 | Extension of Telomeres |
| GO:0000782 | 2.11464090368e-05 | 1.0 | TEN1 CTC1 STN1 | telomere cap complex |
| GO:0000783 | 2.11464090368e-05 | 1.0 | TEN1 CTC1 STN1 | nuclear telomere cap complex |
| GO:0140445 | 2.74903317479e-05 | 1.0 | TEN1 CTC1 STN1 | chromosome, telomeric repeat region |
| REAC:R-HSA-157579 | 7.54495662236e-05 | 1.0 | TEN1 CTC1 STN1 | Telomere Maintenance |
| GO:0032211 | 0.000127839654632 | 1.0 | TEN1 CTC1 STN1 | negative regulation of telomere maintenance via telomerase |
| REAC:R-HSA-73886 | 0.000155553488805 | 1.0 | TEN1 CTC1 STN1 | Chromosome Maintenance |
| GO:2000279 | 0.000351222630093 | 1.0 | TEN1 CTC1 STN1 | negative regulation of DNA biosynthetic process |
| GO:1904357 | 0.000351222630093 | 1.0 | TEN1 CTC1 STN1 | negative regulation of telomere maintenance via telomere lengthening |
| GO:0016233 | 0.000629105668845 | 1.0 | TEN1 CTC1 STN1 | telomere capping |
| GO:0032205 | 0.000686297093286 | 1.0 | TEN1 CTC1 STN1 | negative regulation of telomere maintenance |
| GO:0042162 | 0.000746852719164 | 1.0 | TEN1 CTC1 STN1 | telomeric DNA binding |
| GO:0032210 | 0.00200169985542 | 1.0 | TEN1 CTC1 STN1 | regulation of telomere maintenance via telomerase |
| GO:1904356 | 0.00328922780564 | 1.0 | TEN1 CTC1 STN1 | regulation of telomere maintenance via telomere lengthening |
| HP:0007763 | 0.00348901893966 | 0.666666666667 | CTC1 STN1 | Retinal telangiectasia |
| GO:0007004 | 0.00460463056777 | 1.0 | TEN1 CTC1 STN1 | telomere maintenance via telomerase |
| GO:0006278 | 0.00460463056777 | 1.0 | TEN1 CTC1 STN1 | RNA-templated DNA biosynthetic process |
| GO:0010833 | 0.00760107672828 | 1.0 | TEN1 CTC1 STN1 | telomere maintenance via telomere lengthening |
| GO:2001251 | 0.0101882437539 | 1.0 | TEN1 CTC1 STN1 | negative regulation of chromosome organization |
| HP:0002216 | 0.0114052550978 | 0.666666666667 | CTC1 STN1 | Premature graying of hair |
| GO:2000278 | 0.0141719388563 | 1.0 | TEN1 CTC1 STN1 | regulation of DNA biosynthetic process |
| GO:0032204 | 0.0155426106421 | 1.0 | TEN1 CTC1 STN1 | regulation of telomere maintenance |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | TEN1 CTC1 STN1 | Cell Cycle |
| GO:0051053 | 0.0219076797621 | 1.0 | TEN1 CTC1 STN1 | negative regulation of DNA metabolic process |
| HP:0005528 | 0.022338444757 | 0.666666666667 | CTC1 STN1 | Bone marrow hypocellularity |
| HP:0002206 | 0.0287391839378 | 0.666666666667 | CTC1 STN1 | Pulmonary fibrosis |
| GO:0000723 | 0.0458676185213 | 1.0 | TEN1 CTC1 STN1 | telomere maintenance |
| GO:0071897 | 0.0458676185213 | 1.0 | TEN1 CTC1 STN1 | DNA biosynthetic process |
| GO:0000781 | 0.0478331772413 | 1.0 | TEN1 CTC1 STN1 | chromosome, telomeric region |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STN1 | TEN1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STN1 | CTC1 | 0.998 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TEN1 | CTC1 | 0.993 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| TPR | TEN1 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TPR | STN1 | 0.195 | 0.13 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TPR | CTC1 | 0.06 | 0.216 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes