hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09259.1

Complex Portal: CPX-25340

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
LMNB1	Lamin-B1	5	UniProt NCBI
PDE6D	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)	5	UniProt NCBI
FBXO10	F-box only protein 10	5	UniProt NCBI
TBC1D10A	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha)	5	UniProt NCBI
LMNB2	Lamin-B2	5	UniProt NCBI
UBL3	Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1)	4	UniProt NCBI
RAB28	Ras-related protein Rab-28	5	UniProt NCBI
INPP5E	Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6741	6.1565588648e-05	0.285714285714	PDE6D INPP5E	INPP5E-PDE6D-RPGR complex
REAC:R-HSA-5624958	0.00011430200373	0.285714285714	PDE6D INPP5E	ARL13B-mediated ciliary trafficking of INPP5E
WP:WP4803	0.0036650703234	0.428571428571	PDE6D INPP5E RAB28	Ciliopathies
HP:0002335	0.0129659395038	0.285714285714	PDE6D INPP5E	Agenesis of cerebellar vermis
REAC:R-HSA-5620920	0.0390490515953	0.285714285714	PDE6D INPP5E	Cargo trafficking to the periciliary membrane
WP:WP4656	0.0435709553271	0.285714285714	PDE6D INPP5E	Joubert syndrome
HP:0007973	0.0457644476584	0.285714285714	PDE6D INPP5E	Retinal dysplasia
WP:WP5234	0.0499136541057	0.285714285714	PDE6D INPP5E	Bardet Biedl syndrome

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
UBL3	PDE6D	0.999	0.058	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
LMNB1	LMNB2	0.999	0.636	mutually_exclusive (O43924)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
PDE6D	INPP5E	0.998		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only
PDE6D	FBXO10	0.998			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
PDE6D	RAB28	0.998	0.174	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only
PDE6D	TBC1D10A	0.997	0.06	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
LMNB1	PDE6D	0.978	0.174255319149	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
LMNB2	PDE6D	0.974	0.108	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
INPP5E	RAB28	0.946			bioplex3_WMM WMM_only
TBC1D10A	INPP5E	0.931		mutually_exclusive (O43924)	bioplex3_WMM WMM_only
UBL3	INPP5E	0.923		mutually_exclusive (O43924)	bioplex3_WMM WMM_only
TBC1D10A	RAB28	0.826	0.116	mutually_exclusive (O43924)	bioplex3_WMM WMM_only
FBXO10	TBC1D10A	0.77			bioplex3_WMM WMM_only
FBXO10	INPP5E	0.757			bioplex3_WMM WMM_only
UBL3	FBXO10	0.734			bioplex3_WMM WMM_only
FBXO10	RAB28	0.72			bioplex3_WMM WMM_only
UBL3	TBC1D10A	0.72	0.076	mutually_exclusive (O43924)	bioplex3_WMM WMM_only
UBL3	RAB28	0.527	0.114	mutually_exclusive (O43924)	bioplex3_WMM WMM_only
LMNB2	RAB28	0.287	0.228	mutually_exclusive (O43924)	bioplex3_WMM bioplex3_HCT116 WMM_only
LMNB2	FBXO10	0.251	0.076		bioplex3_HEK293 bioplex3_WMM WMM_only
LMNB2	INPP5E	0.244		mutually_exclusive (O43924)	bioplex3_WMM WMM_only
UBL3	LMNB2	0.213	0.14	mutually_exclusive (O43924)	bioplex_WMM bioplex3_WMM WMM_only
LMNB2	TBC1D10A	0.205	0.086	mutually_exclusive (O43924)	bioplex3_WMM WMM_only
LMNB1	INPP5E	0.159		mutually_exclusive (O43924)	bioplex3_WMM WMM_only
LMNB1	TBC1D10A	0.124	0.190413043478	mutually_exclusive (O43924)	bioplex_WMM bioplex3_WMM WMM_only
LMNB1	RAB28	0.044	0.248413043478	mutually_exclusive (O43924)	bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
UBL3	LMNB1	0.043	0.164	mutually_exclusive (O43924)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
LMNB1	FBXO10	0.023	0.114		bioplex3_HEK293 bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
LMNB1	huMAP3_00325.1 huMAP3_00940.1 huMAP3_03013.1 huMAP3_03501.1 huMAP3_05468.1 huMAP3_07353.1 huMAP3_07977.1 huMAP3_09259.1 huMAP3_09691.1 huMAP3_09748.1 huMAP3_10433.1 huMAP3_10473.1 huMAP3_10492.1 huMAP3_10614.1 huMAP3_13213.1 huMAP3_13519.1
PDE6D	huMAP3_00901.1 huMAP3_03331.1 huMAP3_03636.1 huMAP3_05961.1 huMAP3_07547.1 huMAP3_09259.1 huMAP3_10433.1 huMAP3_10492.1 huMAP3_10614.1 huMAP3_11986.1 huMAP3_12633.1 huMAP3_13233.1 huMAP3_13572.1 huMAP3_15040.1
FBXO10	huMAP3_00901.1 huMAP3_03636.1 huMAP3_05386.1 huMAP3_05961.1 huMAP3_07547.1 huMAP3_08871.1 huMAP3_09259.1 huMAP3_09295.1 huMAP3_10492.1 huMAP3_10560.1 huMAP3_10614.1 huMAP3_12496.1 huMAP3_13572.1 huMAP3_13932.1
TBC1D10A	huMAP3_00901.1 huMAP3_01381.1 huMAP3_03636.1 huMAP3_03697.1 huMAP3_06879.1 huMAP3_07034.1 huMAP3_07547.1 huMAP3_08059.1 huMAP3_09259.1 huMAP3_10492.1 huMAP3_10614.1 huMAP3_11986.1 huMAP3_12633.1 huMAP3_13233.1 huMAP3_13572.1
LMNB2	huMAP3_00325.1 huMAP3_03501.1 huMAP3_09259.1 huMAP3_10433.1 huMAP3_10492.1 huMAP3_10614.1 huMAP3_13519.1
UBL3	huMAP3_00169.1 huMAP3_00901.1 huMAP3_03069.1 huMAP3_03636.1 huMAP3_07812.1 huMAP3_08231.1 huMAP3_08238.1 huMAP3_09259.1 huMAP3_10492.1 huMAP3_10614.1 huMAP3_11660.1 huMAP3_12633.1 huMAP3_13233.1 huMAP3_13572.1 huMAP3_14399.1
RAB28	huMAP3_01964.1 huMAP3_03636.1 huMAP3_09259.1 huMAP3_10492.1 huMAP3_11986.1 huMAP3_12633.1 huMAP3_13233.1 huMAP3_13572.1
INPP5E	huMAP3_00901.1 huMAP3_03331.1 huMAP3_03636.1 huMAP3_05961.1 huMAP3_07547.1 huMAP3_09259.1 huMAP3_10433.1 huMAP3_10492.1 huMAP3_10614.1 huMAP3_11986.1 huMAP3_12633.1 huMAP3_13233.1 huMAP3_13572.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09259.1

Complex Portal: CPX-25340