hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09260.1
Complex Portal: CPX-16685
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORMDL3 | ORM1-like protein 3 | 5 | UniProt NCBI |
| SLC2A12 | Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12) | 4 | UniProt NCBI |
| ORMDL2 | ORM1-like protein 2 (Adoplin-2) | 5 | UniProt NCBI |
| CHST11 | Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660661 | 0.00573491177379 | 0.5 | ORMDL3 ORMDL2 | Sphingolipid de novo biosynthesis |
| GO:0035339 | 0.0168521501606 | 0.5 | ORMDL3 ORMDL2 | SPOTS complex |
| GO:0090156 | 0.0168521501606 | 0.5 | ORMDL3 ORMDL2 | intracellular sphingolipid homeostasis |
| REAC:R-HSA-428157 | 0.0267695204965 | 0.5 | ORMDL3 ORMDL2 | Sphingolipid metabolism |
| GO:1900060 | 0.0280843539964 | 0.5 | ORMDL3 ORMDL2 | negative regulation of ceramide biosynthetic process |
| GO:0017059 | 0.042122686785 | 0.5 | ORMDL3 ORMDL2 | serine C-palmitoyltransferase complex |
| GO:0031211 | 0.042122686785 | 0.5 | ORMDL3 ORMDL2 | endoplasmic reticulum palmitoyltransferase complex |
| GO:0090155 | 0.042122686785 | 0.5 | ORMDL3 ORMDL2 | negative regulation of sphingolipid biosynthetic process |
| CORUM:6982 | 0.049938562206 | 0.25 | ORMDL3 | ORMDL3-SPTLC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ORMDL2 | ORMDL3 | 0.988 | 0.262 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ORMDL3 | SLC2A12 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ORMDL2 | SLC2A12 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CHST11 | SLC2A12 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CHST11 | ORMDL3 | 0.213 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| CHST11 | ORMDL2 | 0.165 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes