hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09282.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | 5 | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | 5 | UniProt NCBI |
| SEC23IP | SEC23-interacting protein (p125) | 5 | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | 5 | UniProt NCBI |
| SEC24A | Protein transport protein Sec24A (SEC24-related protein A) | 5 | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030127 | 2.35839012012e-10 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | COPII vesicle coat |
| GO:0090110 | 2.35839012012e-10 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | COPII-coated vesicle cargo loading |
| GO:0030134 | 6.29495494168e-10 | 1.0 | SEC24C SEC23B SEC23A SEC23IP SEC24A SEC24D | COPII-coated ER to Golgi transport vesicle |
| WP:WP1982 | 8.05098708103e-10 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | Sterol regulatory element binding proteins SREBP signaling |
| REAC:R-HSA-204005 | 1.17788247364e-09 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | COPII-mediated vesicle transport |
| GO:0070971 | 3.54959615011e-09 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | endoplasmic reticulum exit site |
| GO:0035459 | 9.1660568716e-09 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | vesicle cargo loading |
| REAC:R-HSA-5694530 | 2.5402076735e-08 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Cargo concentration in the ER |
| REAC:R-HSA-983170 | 2.5402076735e-08 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| GO:0090114 | 3.1045722158e-08 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | COPII-coated vesicle budding |
| KEGG:04141 | 4.00131323611e-08 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-199977 | 9.14976149591e-08 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | ER to Golgi Anterograde Transport |
| GO:0012507 | 9.22826328254e-08 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | ER to Golgi transport vesicle membrane |
| GO:0030120 | 2.25543082344e-07 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | vesicle coat |
| REAC:R-HSA-948021 | 2.32738499526e-07 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-1655829 | 3.32498882377e-07 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0030135 | 5.90196021447e-07 | 1.0 | SEC24C SEC23B SEC23A SEC23IP SEC24A SEC24D | coated vesicle |
| GO:0006900 | 7.53023205866e-07 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | vesicle budding from membrane |
| GO:0030117 | 1.98692887304e-06 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | membrane coat |
| GO:0048475 | 1.98692887304e-06 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | coated membrane |
| REAC:R-HSA-446203 | 2.85376278052e-06 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | Asparagine N-linked glycosylation |
| GO:0030658 | 8.23973088303e-06 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | transport vesicle membrane |
| REAC:R-HSA-9705671 | 8.90603806515e-06 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| GO:0006888 | 9.39170949702e-06 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-2132295 | 1.06250680796e-05 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | MHC class II antigen presentation |
| REAC:R-HSA-8957322 | 1.25811210353e-05 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Metabolism of steroids |
| GO:0030662 | 2.86173348886e-05 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | coated vesicle membrane |
| REAC:R-HSA-9705683 | 7.16747314362e-05 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | SARS-CoV-2-host interactions |
| REAC:R-HSA-199991 | 9.7213397673e-05 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000127442072623 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | Vesicle-mediated transport |
| CORUM:7141 | 0.000170782642132 | 0.333333333333 | SEC23A SEC23IP | Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP) |
| TF:M11235_1 | 0.000316805542726 | 0.5 | SEC23A SEC24D SEC24A | Factor: OASIS; motif: YGCCACGTCANC; match class: 1 |
| REAC:R-HSA-9694516 | 0.000318900644564 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | SARS-CoV-2 Infection |
| GO:0030133 | 0.000433438579299 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | transport vesicle |
| GO:0048193 | 0.00061299016503 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | Golgi vesicle transport |
| GO:0016050 | 0.000749076431754 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | vesicle organization |
| REAC:R-HSA-983169 | 0.000819993078611 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-9679506 | 0.00114132145279 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | SARS-CoV Infections |
| KEGG:05130 | 0.00142678193098 | 0.5 | SEC24A SEC24C SEC24D | Pathogenic Escherichia coli infection |
| HP:0002868 | 0.00388470114881 | 0.333333333333 | SEC23A SEC24D | Narrow iliac wing |
| REAC:R-HSA-597592 | 0.00433380037126 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | Post-translational protein modification |
| REAC:R-HSA-556833 | 0.00784925061173 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Metabolism of lipids |
| GO:0046907 | 0.008082403103 | 1.0 | SEC24C SEC23B SEC23A SEC23IP SEC24A SEC24D | intracellular transport |
| REAC:R-HSA-1280218 | 0.0108211006853 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Adaptive Immune System |
| REAC:R-HSA-9824446 | 0.013543022596 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Viral Infection Pathways |
| REAC:R-HSA-392499 | 0.0215959266916 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23IP | Metabolism of proteins |
| GO:0061024 | 0.0246525034371 | 0.833333333333 | SEC24A SEC23A SEC24D SEC24C SEC23B | membrane organization |
| REAC:R-HSA-5663205 | 0.0303849890339 | 0.666666666667 | SEC23A SEC24D SEC24C SEC24A | Infectious disease |
| GO:0051649 | 0.0361725108126 | 1.0 | SEC24C SEC23B SEC23A SEC23IP SEC24A SEC24D | establishment of localization in cell |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SEC23B | SEC24A | 1.0 | 0.25 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23B | SEC24C | 1.0 | 0.268 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24C | 1.0 | 0.53 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction treiber_WMM |
| SEC23B | SEC23A | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24A | 1.0 | 0.308 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| SEC23A | SEC23IP | 0.995 | 0.254 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| SEC23B | SEC24D | 0.993 | 0.208 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SEC24C | SEC24A | 0.991 | 0.386 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| SEC23B | SEC23IP | 0.99 | 0.092 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SEC23A | SEC24D | 0.981 | 0.302631578947 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24A | 0.963 | 0.266 | bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24C | 0.602 | 0.136 | bioplex_WMM bioplex3_WMM Malo fraction |
| SEC23IP | SEC24A | 0.124 | 0.216 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SEC24D | SEC23IP | 0.106 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| SEC23IP | SEC24C | 0.07 | 0.516 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM treiber_WMM |
Related Complexes