hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09283.1
Complex Portal: CPX-14299
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DCAF8L2 | DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C) | 2 | UniProt NCBI |
| DCAF16 | DDB1- and CUL4-associated factor 16 | 4 | UniProt NCBI |
| DCAF6 | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | 5 | UniProt NCBI |
| RBX1 | E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)] | 5 | UniProt NCBI |
| CRBN | Protein cereblon | 5 | UniProt NCBI |
| CUL4A | Cullin-4A (CUL-4A) | 5 | UniProt NCBI |
| CUL4B | Cullin-4B (CUL-4B) | 5 | UniProt NCBI |
| DDB1 | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | 5 | UniProt NCBI |
| BRWD3 | Bromodomain and WD repeat-containing protein 3 | 5 | UniProt NCBI |
| DDA1 | DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0080008 | 5.61926895674e-19 | 0.9 | CRBN DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 DCAF8L2 | Cul4-RING E3 ubiquitin ligase complex |
| GO:0031461 | 1.47714963752e-12 | 0.9 | CRBN DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 DCAF8L2 | cullin-RING ubiquitin ligase complex |
| CORUM:6875 | 8.06664600281e-12 | 0.4 | DDB1 CUL4A RBX1 CRBN | CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase |
| CORUM:1162 | 4.03199797571e-11 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) |
| GO:0000151 | 1.40985089719e-10 | 0.9 | CRBN DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 DCAF8L2 | ubiquitin ligase complex |
| GO:0031464 | 4.5311021153e-09 | 0.5 | CUL4B CUL4A DDB1 RBX1 CRBN | Cul4A-RING E3 ubiquitin ligase complex |
| REAC:R-HSA-8951664 | 5.20521072069e-09 | 0.7 | DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 | Neddylation |
| CORUM:2722 | 1.68385473419e-08 | 0.3 | DDB1 RBX1 CUL4A | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
| CORUM:391 | 1.68385473419e-08 | 0.3 | DDB1 RBX1 CUL4A | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
| CORUM:2172 | 6.73299894294e-08 | 0.3 | DDB1 RBX1 CUL4A | Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) |
| CORUM:1214 | 1.68264493604e-07 | 0.3 | DDB1 RBX1 CUL4A | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
| CORUM:1211 | 3.36408067008e-07 | 0.3 | CUL4B RBX1 DDB1 | Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) |
| REAC:R-HSA-110314 | 7.25322049724e-07 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Recognition of DNA damage by PCNA-containing replication complex |
| WP:WP4753 | 1.32525793849e-06 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Nucleotide excision repair |
| GO:1990234 | 1.54664239811e-06 | 0.9 | CRBN DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 DCAF8L2 | transferase complex |
| REAC:R-HSA-5696394 | 1.94851007479e-06 | 0.4 | CUL4B DDB1 RBX1 CUL4A | DNA Damage Recognition in GG-NER |
| KEGG:03420 | 2.31932768775e-06 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Nucleotide excision repair |
| GO:0140535 | 2.59440577325e-06 | 0.9 | CRBN DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 DCAF8L2 | intracellular protein-containing complex |
| REAC:R-HSA-5696400 | 2.67060771041e-06 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 2.95075305606e-06 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Formation of Incision Complex in GG-NER |
| CORUM:728 | 3.69251717673e-06 | 0.3 | DDB1 RBX1 CUL4A | CSA-POLIIa complex |
| CORUM:727 | 3.69251717673e-06 | 0.3 | DDB1 RBX1 CUL4A | CSA complex |
| CORUM:726 | 3.69251717673e-06 | 0.3 | DDB1 RBX1 CUL4A | DDB2 complex |
| REAC:R-HSA-73893 | 4.69441276875e-06 | 0.4 | CUL4B DDB1 RBX1 CUL4A | DNA Damage Bypass |
| REAC:R-HSA-6781823 | 7.11352916135e-06 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Formation of TC-NER Pre-Incision Complex |
| WP:WP5114 | 1.15733662318e-05 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-6782210 | 1.55950062043e-05 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.66291944782e-05 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 3.52668021108e-05 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 4.77943696984e-05 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Global Genome Nucleotide Excision Repair (GG-NER) |
| WP:WP4946 | 6.75663156792e-05 | 0.4 | CUL4B DDB1 RBX1 CUL4A | DNA repair pathways full network |
| KEGG:04120 | 7.05246698215e-05 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Ubiquitin mediated proteolysis |
| CORUM:6486 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4A-DDB1-DTL complex |
| CORUM:223 | 9.22394575203e-05 | 0.2 | RBX1 CUL4A | CAND1-CUL4A-RBX1 complex |
| CORUM:224 | 9.22394575203e-05 | 0.2 | CUL4B RBX1 | CAND1-CUL4B-RBX1 complex |
| CORUM:6553 | 9.22394575203e-05 | 0.2 | CUL4B DDB1 | CUL4B-DDB1-TLE3 complex |
| CORUM:6550 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4B-DDB1-TLE1 complex |
| CORUM:6495 | 9.22394575203e-05 | 0.2 | CUL4B DDB1 | CUL4B-DDB1-GRWD1 complex |
| CORUM:6494 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4A-DDB1-WDR61 complex |
| CORUM:6493 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4A-DDB1-WDR57 complex |
| CORUM:6492 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4A-DDB1-WDR5B complex |
| CORUM:6491 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4A-DDB1-RBBP5 complex |
| CORUM:6490 | 9.22394575203e-05 | 0.2 | CUL4B DDB1 | CUL4B-DDB1-WDR26 complex |
| CORUM:6489 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4A-DDB1-WDR5 complex |
| CORUM:6488 | 9.22394575203e-05 | 0.2 | DDB1 CUL4A | CUL4A-DDB1-EED complex |
| CORUM:6487 | 9.22394575203e-05 | 0.2 | CUL4B DDB1 | CUL4B-DDB1-TLE2 complex |
| GO:0031465 | 0.000115261178119 | 0.3 | CUL4B RBX1 DDB1 | Cul4B-RING E3 ubiquitin ligase complex |
| REAC:R-HSA-5696398 | 0.000138239115309 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Nucleotide Excision Repair |
| CORUM:6291 | 0.000184411585051 | 0.2 | DDB1 CUL4A | Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A) |
| KEGG:05170 | 0.000292946666588 | 0.4 | CUL4B DDB1 RBX1 CUL4A | Human immunodeficiency virus 1 infection |
| CORUM:6482 | 0.000307240465423 | 0.2 | CUL4B DDB1 | CUL4B-DDB1-DTL-CSN complex |
| GO:1902494 | 0.000662262703055 | 0.9 | CRBN DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 DCAF8L2 | catalytic complex |
| REAC:R-HSA-597592 | 0.000686921776836 | 0.7 | DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 | Post-translational protein modification |
| WP:WP4541 | 0.00313738741595 | 0.3 | DDB1 RBX1 CUL4A | Hippo Merlin signaling dysregulation |
| GO:0010498 | 0.00540027779009 | 0.6 | CRBN CUL4A DDA1 CUL4B RBX1 DDB1 | proteasomal protein catabolic process |
| REAC:R-HSA-392499 | 0.00618775137334 | 0.7 | DCAF16 CUL4A DDA1 CUL4B RBX1 DDB1 DCAF6 | Metabolism of proteins |
| GO:0034644 | 0.0065610560312 | 0.4 | CUL4B DDB1 RBX1 CUL4A | cellular response to UV |
| REAC:R-HSA-73894 | 0.00865291682553 | 0.4 | CUL4B DDB1 RBX1 CUL4A | DNA Repair |
| GO:0071482 | 0.0137249930817 | 0.4 | CUL4B DDB1 RBX1 CUL4A | cellular response to light stimulus |
| CORUM:929 | 0.0170546710554 | 0.2 | DDB1 CUL4A | CEN complex |
| GO:0016567 | 0.0177136229011 | 0.6 | CRBN CUL4A DDA1 CUL4B RBX1 DDB1 | protein ubiquitination |
| GO:0032446 | 0.0378180251524 | 0.6 | CRBN CUL4A DDA1 CUL4B RBX1 DDB1 | protein modification by small protein conjugation |
| GO:0009411 | 0.0422468474482 | 0.4 | CUL4B DDB1 RBX1 CUL4A | response to UV |
| GO:0051603 | 0.0442859893992 | 0.6 | CRBN CUL4A DDA1 CUL4B RBX1 DDB1 | proteolysis involved in protein catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CUL4A | CUL4B | 0.999 | 0.374 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| DDB1 | DDA1 | 0.999 | 0.2 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt hein () fraction boldt_WMM |
| CUL4A | DDA1 | 0.999 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CUL4A | RBX1 | 0.998 | 0.878 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () | |
| CUL4B | DDB1 | 0.998 | 0.272 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| CRBN | CUL4B | 0.997 | 0.136 |
structurally_consistent (Q16531)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CUL4B | DCAF16 | 0.997 | 0.128 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CUL4A | BRWD3 | 0.996 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| CUL4B | RBX1 | 0.996 | 0.138 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () | |
| CUL4A | DDB1 | 0.995 | 0.628 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM |
| CUL4B | DDA1 | 0.994 | 0.092 |
structurally_consistent (Q16531)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| DDB1 | BRWD3 | 0.991 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| BRWD3 | DDA1 | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| CRBN | CUL4A | 0.985 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CRBN | DDB1 | 0.983 | 0.307 |
mixed_interface
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DCAF16 | DCAF6 | 0.98 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CUL4B | DCAF6 | 0.972 | 0.096 |
structurally_consistent (Q16531)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| DDB1 | RBX1 | 0.969 | 0.638 | hein_WMM bioplex3_HEK293 bioplex3_WMM boldt hein () boldt_WMM | |
| CUL4A | DCAF6 | 0.964 | 0.154 |
structurally_consistent (Q16531)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| DDB1 | DCAF16 | 0.962 | 0.260682464455 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| DDA1 | DCAF6 | 0.956 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CUL4B | BRWD3 | 0.955 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| BRWD3 | RBX1 | 0.941 | hein_WMM hein () | ||
| CUL4A | DCAF16 | 0.927 | 0.198 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| DCAF16 | DDA1 | 0.849 | 0.122 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| DDB1 | DCAF6 | 0.829 | 0.256 |
mutually_exclusive (Q8TEB1)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| RBX1 | DDA1 | 0.785 | 0.306 | hein_WMM WMM_only | |
| CRBN | RBX1 | 0.75 | 0.3 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CRBN | DCAF6 | 0.688 | 0.072 |
mutually_exclusive (Q16531)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CRBN | DCAF16 | 0.545 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| RBX1 | DCAF16 | 0.461 | 0.274 | hein_WMM bioplex3_WMM WMM_only | |
| RBX1 | DCAF6 | 0.346 | 0.308579710145 | hein_WMM bioplex3_WMM WMM_only | |
| CRBN | DDA1 | 0.058 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes