hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09295.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FAM219A | Protein FAM219A | 3 | UniProt NCBI |
| RAD50 | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | 5 | UniProt NCBI |
| FBXO10 | F-box only protein 10 | 5 | UniProt NCBI |
| NBN | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:972 | 1.53774525569e-05 | 0.5 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:71 | 1.53774525569e-05 | 0.5 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:331 | 1.53774525569e-05 | 0.5 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:618 | 1.53774525569e-05 | 0.5 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:73 | 1.53774525569e-05 | 0.5 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:1081 | 1.53774525569e-05 | 0.5 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:173 | 1.53774525569e-05 | 0.5 | NBN RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:2767 | 1.53774525569e-05 | 0.5 | NBN RAD50 | RAD50-MRE11-NBN-p200-p350 complex |
| CORUM:619 | 3.07520988333e-05 | 0.5 | NBN RAD50 | MRE11A-RAD50-NBN-TRF2 complex |
| CORUM:2218 | 3.07520988333e-05 | 0.5 | NBN RAD50 | MDC1-MRE11-RAD50-NBS1 complex |
| CORUM:202 | 3.07520988333e-05 | 0.5 | NBN RAD50 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:627 | 3.07520988333e-05 | 0.5 | NBN RAD50 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) |
| CORUM:964 | 3.07520988333e-05 | 0.5 | NBN RAD50 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:1189 | 5.12488211613e-05 | 0.5 | NBN RAD50 | DNA double-strand break end-joining complex |
| WP:WP2942 | 5.36057998926e-05 | 0.5 | NBN RAD50 | DDX1 as a regulatory component of the Drosha microprocessor |
| CORUM:5197 | 7.68662167609e-05 | 0.5 | NBN RAD50 | PTIP-DNA damage response complex |
| CORUM:2217 | 7.68662167609e-05 | 0.5 | NBN RAD50 | MDC1-MRN-ATM-FANCD2 complex |
| WP:WP5118 | 0.000140344895657 | 0.5 | NBN RAD50 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome |
| CORUM:2815 | 0.000143457417375 | 0.5 | NBN RAD50 | BRCA1-BARD1-BACH1-DNA damage complex II |
| REAC:R-HSA-5693548 | 0.000153732433522 | 0.5 | NBN RAD50 | Sensing of DNA Double Strand Breaks |
| WP:WP186 | 0.000168398502686 | 0.5 | NBN RAD50 | Homologous recombination |
| CORUM:433 | 0.000338026191524 | 0.5 | NBN RAD50 | BASC complex (BRCA1-associated genome surveillance complex) |
| REAC:R-HSA-5685939 | 0.000563428413222 | 0.5 | NBN RAD50 | HDR through MMEJ (alt-NHEJ) |
| WP:WP2516 | 0.00178944501344 | 0.5 | NBN RAD50 | ATM signaling pathway |
| KEGG:03440 | 0.00194963326435 | 0.5 | NBN RAD50 | Homologous recombination |
| WP:WP3878 | 0.0020866894725 | 0.5 | NBN RAD50 | ATM signaling in development and disease |
| REAC:R-HSA-9709603 | 0.00282403231951 | 0.5 | NBN RAD50 | Impaired BRCA2 binding to PALB2 |
| HP:0030406 | 0.00303997345979 | 0.5 | NBN RAD50 | Primary peritoneal carcinoma |
| REAC:R-HSA-9704331 | 0.00306932002175 | 0.5 | NBN RAD50 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9701193 | 0.00306932002175 | 0.5 | NBN RAD50 | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-9701192 | 0.00306932002175 | 0.5 | NBN RAD50 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9704646 | 0.00306932002175 | 0.5 | NBN RAD50 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| WP:WP3959 | 0.00337093843289 | 0.5 | NBN RAD50 | DNA IR double strand breaks and cellular response via ATM |
| REAC:R-HSA-5693554 | 0.00359044851421 | 0.5 | NBN RAD50 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| WP:WP1530 | 0.00528146385782 | 0.5 | NBN RAD50 | miRNA regulation of DNA damage response |
| WP:WP707 | 0.00528146385782 | 0.5 | NBN RAD50 | DNA damage response |
| REAC:R-HSA-5693568 | 0.00539805716719 | 0.5 | NBN RAD50 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 0.00573491177379 | 0.5 | NBN RAD50 | Resolution of D-Loop Structures |
| REAC:R-HSA-9709570 | 0.00573491177379 | 0.5 | NBN RAD50 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 0.006081926491 | 0.5 | NBN RAD50 | HDR through Single Strand Annealing (SSA) |
| WP:WP4016 | 0.00742144474402 | 0.5 | NBN RAD50 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-5693616 | 0.007571530532 | 0.5 | NBN RAD50 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 0.0079693038543 | 0.5 | NBN RAD50 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 0.0079693038543 | 0.5 | NBN RAD50 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 0.008795277704 | 0.5 | NBN RAD50 | Homologous DNA Pairing and Strand Exchange |
| HP:0011027 | 0.0108451581837 | 0.5 | NBN RAD50 | Abnormal fallopian tube morphology |
| REAC:R-HSA-9675135 | 0.0120053783973 | 0.5 | NBN RAD50 | Diseases of DNA repair |
| WP:WP4946 | 0.0159973744593 | 0.5 | NBN RAD50 | DNA repair pathways full network |
| GO:0031860 | 0.0168521501606 | 0.5 | NBN RAD50 | telomeric 3' overhang formation |
| HP:0100787 | 0.0176079483787 | 0.5 | NBN RAD50 | Prostate neoplasm |
| HP:0012125 | 0.0176079483787 | 0.5 | NBN RAD50 | Prostate cancer |
| REAC:R-HSA-5693571 | 0.0186613511621 | 0.5 | NBN RAD50 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5685942 | 0.0218635493976 | 0.5 | NBN RAD50 | HDR through Homologous Recombination (HRR) |
| WP:WP4262 | 0.0221503925292 | 0.5 | NBN RAD50 | Breast cancer pathway |
| REAC:R-HSA-2559586 | 0.022534212454 | 0.5 | NBN RAD50 | DNA Damage/Telomere Stress Induced Senescence |
| KEGG:04218 | 0.0240987471983 | 0.5 | NBN RAD50 | Cellular senescence |
| HP:0008775 | 0.0246976114972 | 0.5 | NBN RAD50 | Abnormal prostate morphology |
| REAC:R-HSA-5693565 | 0.0253175164514 | 0.5 | NBN RAD50 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0260384914588 | 0.5 | NBN RAD50 | DNA Double Strand Break Response |
| REAC:R-HSA-912446 | 0.0260384914588 | 0.5 | NBN RAD50 | Meiotic recombination |
| GO:0030870 | 0.0280843539964 | 0.5 | NBN RAD50 | Mre11 complex |
| HP:0033019 | 0.0375654511359 | 0.5 | NBN RAD50 | Male reproductive system neoplasm |
| REAC:R-HSA-69473 | 0.0380580405855 | 0.5 | NBN RAD50 | G2/M DNA damage checkpoint |
| REAC:R-HSA-6804756 | 0.0398310607487 | 0.5 | NBN RAD50 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.0407325822829 | 0.5 | NBN RAD50 | Processing of DNA double-strand break ends |
| GO:0070533 | 0.042122686785 | 0.5 | NBN RAD50 | BRCA1-C complex |
| HP:0003220 | 0.0441432413831 | 0.5 | NBN RAD50 | Abnormality of chromosome stability |
| REAC:R-HSA-1500620 | 0.0492961191682 | 0.5 | NBN RAD50 | Meiosis |
| CORUM:7104 | 0.049938562206 | 0.25 | NBN | NBS1-RNF8-VRK1 complex |
| CORUM:7103 | 0.049938562206 | 0.25 | NBN | NBS1-VRK1 complex |
| CORUM:2776 | 0.049938562206 | 0.25 | RAD50 | RAD50-BRCA1 complex |
| CORUM:2723 | 0.049938562206 | 0.25 | NBN | ATM-NBN complex |
| CORUM:264 | 0.049938562206 | 0.25 | RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:72 | 0.049938562206 | 0.25 | RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:263 | 0.049938562206 | 0.25 | RAD50 | R/M complex (RAD50-MRE11 complex) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD50 | FAM219A | 0.997 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FAM219A | NBN | 0.974 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FBXO10 | FAM219A | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAD50 | NBN | 0.951 | 0.522 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| FBXO10 | NBN | 0.186 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only |
| FBXO10 | RAD50 | 0.099 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes