hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09299.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C16orf96 | Uncharacterized protein C16orf96 | 2 | UniProt NCBI |
| SOS2 | Son of sevenless homolog 2 (SOS-2) | 5 | UniProt NCBI |
| ARHGEF35 | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | 2 | UniProt NCBI |
| ARHGEF5 | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | 5 | UniProt NCBI |
| GLS2 | Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase) | 5 | UniProt NCBI |
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 5 | UniProt NCBI |
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | 3 | UniProt NCBI |
| SHC1 | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-193648 | 0.000159603643781 | 0.428571428571 | SOS2 ARHGEF35 ARHGEF5 | NRAGE signals death through JNK |
| REAC:R-HSA-204998 | 0.000377325314633 | 0.428571428571 | SOS2 ARHGEF35 ARHGEF5 | Cell death signalling via NRAGE, NRIF and NADE |
| REAC:R-HSA-416482 | 0.000487210059522 | 0.428571428571 | SOS2 ARHGEF35 ARHGEF5 | G alpha (12/13) signalling events |
| REAC:R-HSA-193704 | 0.000833024196193 | 0.428571428571 | SOS2 ARHGEF35 ARHGEF5 | p75 NTR receptor-mediated signalling |
| WP:WP4928 | 0.00161645869838 | 0.285714285714 | SOS2 GAREM2 | MAPK pathway in congenital thyroid cancer |
| KEGG:05206 | 0.00180438218152 | 0.428571428571 | SOS2 GRB2 GLS2 | MicroRNAs in cancer |
| REAC:R-HSA-8983432 | 0.00296507918884 | 0.285714285714 | SOS2 GRB2 | Interleukin-15 signaling |
| REAC:R-HSA-73887 | 0.00423749994086 | 0.428571428571 | SOS2 ARHGEF35 ARHGEF5 | Death Receptor Signaling |
| WP:WP422 | 0.00621644086214 | 0.285714285714 | SOS2 GRB2 | MAPK cascade |
| WP:WP4535 | 0.0124193659106 | 0.285714285714 | SOS2 GRB2 | Envelope proteins and their potential roles in EDMD physiopathology |
| KEGG:05213 | 0.0134546613266 | 0.285714285714 | SOS2 GRB2 | Endometrial cancer |
| KEGG:04664 | 0.0139791020136 | 0.285714285714 | SOS2 GRB2 | Fc epsilon RI signaling pathway |
| KEGG:05221 | 0.0173334447573 | 0.285714285714 | SOS2 GRB2 | Acute myeloid leukemia |
| KEGG:04917 | 0.0191438277044 | 0.285714285714 | SOS2 GRB2 | Prolactin signaling pathway |
| REAC:R-HSA-451927 | 0.0199798926111 | 0.285714285714 | SOS2 GRB2 | Interleukin-2 family signaling |
| KEGG:05211 | 0.0210427715268 | 0.285714285714 | SOS2 GRB2 | Renal cell carcinoma |
| KEGG:05214 | 0.0230300913808 | 0.285714285714 | SOS2 GRB2 | Glioma |
| KEGG:04912 | 0.0230300913808 | 0.285714285714 | SOS2 GRB2 | GnRH signaling pathway |
| KEGG:04662 | 0.0230300913808 | 0.285714285714 | SOS2 GRB2 | B cell receptor signaling pathway |
| KEGG:05223 | 0.0230300913808 | 0.285714285714 | SOS2 GRB2 | Non-small cell lung cancer |
| KEGG:04540 | 0.0251056026519 | 0.285714285714 | SOS2 GRB2 | Gap junction |
| KEGG:01521 | 0.0272691209555 | 0.285714285714 | SOS2 GRB2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 0.0272691209555 | 0.285714285714 | SOS2 GRB2 | Chronic myeloid leukemia |
| WP:WP4205 | 0.028073243565 | 0.285714285714 | SOS2 GRB2 | MET in type 1 papillary renal cell carcinoma |
| WP:WP4155 | 0.028073243565 | 0.285714285714 | SOS2 GRB2 | Endometrial cancer |
| KEGG:04012 | 0.0287602683365 | 0.285714285714 | SOS2 GRB2 | ErbB signaling pathway |
| WP:WP5293 | 0.0300823189809 | 0.285714285714 | SOS2 GRB2 | Acute myeloid leukemia |
| KEGG:05210 | 0.0302903935943 | 0.285714285714 | SOS2 GRB2 | Colorectal cancer |
| WP:WP4685 | 0.0311125325099 | 0.285714285714 | SOS2 GRB2 | Melanoma |
| KEGG:01522 | 0.0334673599343 | 0.285714285714 | SOS2 GRB2 | Endocrine resistance |
| KEGG:05231 | 0.0342858776489 | 0.285714285714 | SOS2 GRB2 | Choline metabolism in cancer |
| WP:WP4255 | 0.0388021990103 | 0.285714285714 | SOS2 GRB2 | Non small cell lung cancer |
| KEGG:05215 | 0.040286633797 | 0.285714285714 | SOS2 GRB2 | Prostate cancer |
| KEGG:04915 | 0.0420880817615 | 0.285714285714 | SOS2 GRB2 | Estrogen signaling pathway |
| KEGG:04722 | 0.0496787672026 | 0.285714285714 | SOS2 GRB2 | Neurotrophin signaling pathway |
| KEGG:04935 | 0.0496787672026 | 0.285714285714 | SOS2 GRB2 | Growth hormone synthesis, secretion and action |
| CORUM:2540 | 0.0499958217778 | 0.142857142857 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| CORUM:2892 | 0.0499958217778 | 0.142857142857 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:3096 | 0.0499958217778 | 0.142857142857 | GRB2 | ITGA6-ITGB4-SHC1-GRB2 complex |
| CORUM:2895 | 0.0499958217778 | 0.142857142857 | GRB2 | SHC-GRB2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SOS2 | GRB2 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ARHGEF35 | ARHGEF5 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| GRB2 | GAREM2 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SHC1 | GRB2 | 0.976 | bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| GLS2 | GRB2 | 0.974 | 0.2 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| C16orf96 | GRB2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARHGEF35 | GRB2 | 0.965 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ARHGEF5 | GRB2 | 0.954 | 0.134 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| SOS2 | ARHGEF35 | 0.904 | bioplex3_WMM WMM_only | |
| SOS2 | ARHGEF5 | 0.869 | 0.092 | bioplex3_WMM WMM_only |
| SHC1 | GAREM2 | 0.796 | bioplex3_WMM WMM_only | |
| SHC1 | ARHGEF35 | 0.715 | bioplex3_WMM WMM_only | |
| SHC1 | SOS2 | 0.675 | bioplex3_WMM WMM_only | |
| C16orf96 | GAREM2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| C16orf96 | SOS2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| SOS2 | GAREM2 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHC1 | ARHGEF5 | 0.331 | bioplex3_WMM youn_WMM WMM_only | |
| ARHGEF5 | GAREM2 | 0.214 | bioplex3_WMM WMM_only | |
| C16orf96 | ARHGEF35 | 0.214 | bioplex3_WMM WMM_only | |
| ARHGEF35 | GAREM2 | 0.214 | bioplex3_WMM WMM_only | |
| C16orf96 | ARHGEF5 | 0.214 | bioplex3_WMM WMM_only | |
| SHC1 | C16orf96 | 0.131 | bioplex3_WMM WMM_only | |
| C16orf96 | GLS2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| GLS2 | GAREM2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| SOS2 | GLS2 | 0.11 | 0.154 | bioplex_WMM bioplex3_WMM WMM_only |
| ARHGEF35 | GLS2 | 0.015 | bioplex3_WMM WMM_only | |
| ARHGEF5 | GLS2 | 0.015 | 0.104 | bioplex3_WMM WMM_only |
| SHC1 | GLS2 | 0.013 | bioplex3_WMM WMM_only |
Related Complexes