List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_09309.1

Confidence: Moderate High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
ACTR3B	Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)	4	UniProt   NCBI
ARPC1B	Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)	5	UniProt   NCBI
ARPC2	Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)	5	UniProt   NCBI
ACTR2	Actin-related protein 2 (Actin-like protein 2)	5	UniProt   NCBI
CHURC1	Protein Churchill	4	UniProt   NCBI
ARPC1A	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)	4	UniProt   NCBI
ARPC5	Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)	5	UniProt   NCBI
ARPC5L	Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)	4	UniProt   NCBI
ACTR3	Actin-related protein 3 (Actin-like protein 3)	5	UniProt   NCBI
ARPC4	Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)	5	UniProt   NCBI
ARPC3	Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005885	3.28833701378e-26	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Arp2/3 protein complex
CORUM:27	7.76518645207e-22	0.636363636364	ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC1B ARPC2	Arp2/3 protein complex
KEGG:05100	4.36321155927e-21	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Bacterial invasion of epithelial cells
KEGG:04666	2.61266078016e-20	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Fc gamma R-mediated phagocytosis
KEGG:05135	3.39899044923e-19	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Yersinia infection
KEGG:04530	2.42534670365e-18	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Tight junction
GO:0034314	8.95727296551e-18	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Arp2/3 complex-mediated actin nucleation
KEGG:05130	1.41868930066e-17	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Pathogenic Escherichia coli infection
REAC:R-HSA-5663213	1.49906583654e-17	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	RHO GTPases Activate WASPs and WAVEs
GO:0045010	2.90108904905e-17	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	actin nucleation
REAC:R-HSA-3928662	4.03476120564e-17	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	EPHB-mediated forward signaling
KEGG:04810	7.86084000731e-17	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Regulation of actin cytoskeleton
KEGG:05132	3.23737092753e-16	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Salmonella infection
KEGG:05131	3.70744853438e-16	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Shigellosis
KEGG:04144	4.42955489239e-16	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	Endocytosis
REAC:R-HSA-9664422	7.29252352972e-16	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	FCGR3A-mediated phagocytosis
REAC:R-HSA-9664417	7.29252352972e-16	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Leishmania phagocytosis
REAC:R-HSA-9664407	7.29252352972e-16	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Parasite infection
REAC:R-HSA-2029482	1.16811838715e-15	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Regulation of actin dynamics for phagocytic cup formation
GO:0051015	1.77987370151e-14	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	actin filament binding
REAC:R-HSA-2029480	1.92035716207e-14	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Fcgamma receptor (FCGR) dependent phagocytosis
REAC:R-HSA-2682334	2.91698377298e-14	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	EPH-Ephrin signaling
WP:WP2272	1.03808168291e-13	0.636363636364	ARPC5L ARPC1A ARPC4 ARPC3 ARPC5 ARPC1B ARPC2	Pathogenic Escherichia coli infection
REAC:R-HSA-9824443	1.90703124732e-12	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Parasitic Infection Pathways
REAC:R-HSA-9658195	1.90703124732e-12	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Leishmania infection
GO:0003779	2.65409439248e-12	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	actin binding
REAC:R-HSA-8856828	3.85690970948e-10	0.636363636364	ARPC1A ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC2	Clathrin-mediated endocytosis
REAC:R-HSA-195258	1.04521536739e-09	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	RHO GTPase Effectors
GO:0035861	1.25730329339e-09	0.636363636364	ARPC1A ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC2	site of double-strand break
GO:0005200	4.28242331955e-09	0.636363636364	ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC1B ARPC2	structural constituent of cytoskeleton
GO:0007015	4.378853658e-09	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	actin filament organization
GO:0090734	1.05542926856e-08	0.636363636364	ARPC1A ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC2	site of DNA damage
GO:0015629	1.18069996579e-08	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	actin cytoskeleton
GO:0008092	3.62492166295e-08	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	cytoskeletal protein binding
REAC:R-HSA-422475	5.17883585274e-08	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Axon guidance
REAC:R-HSA-9675108	6.93528278935e-08	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Nervous system development
GO:0030036	2.66114556618e-07	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	actin cytoskeleton organization
REAC:R-HSA-194315	4.34943461634e-07	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Signaling by Rho GTPases
REAC:R-HSA-9716542	5.17684587533e-07	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
GO:0030029	7.07619082612e-07	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	actin filament-based process
GO:0097435	8.60109457613e-07	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	supramolecular fiber organization
GO:0044877	4.76363801952e-06	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	protein-containing complex binding
REAC:R-HSA-1266738	4.80729188049e-06	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Developmental Biology
REAC:R-HSA-5663205	5.2683939111e-06	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Infectious disease
REAC:R-HSA-168249	6.53504346773e-06	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Innate Immune System
REAC:R-HSA-199991	1.02374892594e-05	0.636363636364	ARPC1A ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC2	Membrane Trafficking
REAC:R-HSA-5653656	1.48868457168e-05	0.636363636364	ARPC1A ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC2	Vesicle-mediated transport
GO:0005925	7.00075091678e-05	0.636363636364	ARPC5L ACTR3 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	focal adhesion
GO:0030055	8.02480736122e-05	0.636363636364	ARPC5L ACTR3 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	cell-substrate junction
GO:0007010	0.000182844865374	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	cytoskeleton organization
GO:0070358	0.000316805542726	0.272727272727	ARPC2 ACTR3 ARPC3	actin polymerization-dependent cell motility
REAC:R-HSA-1643685	0.000360075861783	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Disease
GO:0070062	0.000454628173938	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	extracellular exosome
GO:1903561	0.000498164164505	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	extracellular vesicle
GO:0043230	0.000500837846091	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	extracellular organelle
GO:0065010	0.000500837846091	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	extracellular membrane-bounded organelle
GO:0005198	0.000872055876843	0.636363636364	ACTR3 ARPC4 ARPC3 ACTR2 ARPC5 ARPC1B ARPC2	structural molecule activity
REAC:R-HSA-168256	0.000961215599937	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Immune System
GO:0070161	0.00318056066277	0.636363636364	ARPC5L ACTR3 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	anchoring junction
GO:0005856	0.00324513477631	0.818181818182	ARPC5L ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	cytoskeleton
REAC:R-HSA-162582	0.00386179598205	0.727272727273	ARPC1A ACTR3 ARPC4 ARPC5 ARPC3 ACTR2 ARPC2 ARPC1B	Signal Transduction
TF:M11434_1	0.0081811457128	0.909090909091	ARPC1A ACTR3 ARPC5L ARPC4 ARPC5 CHURC1 ARPC3 ACTR2 ARPC2 ARPC1B	Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1
GO:0005615	0.0117489175163	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	extracellular space
GO:0010592	0.0278578876014	0.272727272727	ARPC2 ACTR2 ACTR3	positive regulation of lamellipodium assembly
GO:0005576	0.0305194206532	0.909090909091	ACTR3B ACTR3 ARPC1A ARPC4 ARPC5 ARPC3 ARPC5L ACTR2 ARPC1B ARPC2	extracellular region
HPA:0310433	0.0339626283727	0.454545454545	ARPC1B ARPC3 ACTR2 ACTR3 ARPC2	lymph node; germinal center cells[High]
HPA:0301171	0.0453815949404	0.727272727273	ARPC5L ACTR3 ARPC1A ARPC5 CHURC1 ARPC3 ACTR2 ARPC2	lung; alveolar cells[>=Low]



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
ACTR3	ARPC4	1.0	0.962
ACTR2	ACTR3	1.0	0.938
ARPC1B	ACTR3	1.0	0.924
ACTR2	ARPC1B	1.0	0.874
ARPC1A	ARPC3	1.0	0.324
ACTR2	ARPC5	1.0	0.866
ACTR3	ARPC3	1.0	0.956
ACTR2	ARPC4	1.0	0.932
ACTR2	ARPC1A	1.0	0.524
ARPC1A	ARPC4	1.0	0.346
ARPC1B	ARPC4	1.0	0.854
ARPC1A	ARPC5	1.0	0.184
ACTR3	ARPC5L	1.0	0.356
ARPC1A	ARPC5L	1.0	0.176
ARPC5	ACTR3	1.0	0.894
ACTR2	ARPC3	1.0	0.942
ACTR3B	ARPC4	1.0	0.902
ARPC3	ARPC5L	1.0	0.282
ACTR2	ARPC2	1.0	0.99
ARPC2	ARPC4	1.0	0.978
ARPC2	ACTR3	1.0	0.966
ACTR3B	ARPC3	1.0	0.81
ARPC1A	ACTR3	1.0	0.476
ARPC2	ARPC5	1.0	0.934
ACTR3B	ARPC5L	0.999	0.190714893617
ARPC1B	ARPC2	0.999	0.936
ARPC2	ARPC3	0.999	0.982
ARPC1B	ARPC3	0.999	0.846
ACTR3B	ARPC1A	0.999	0.184714893617
ARPC5	ARPC4	0.999	0.786
ARPC4	ARPC5L	0.999	0.276
ACTR3B	ARPC1B	0.999	0.522
ARPC1A	ARPC2	0.999	0.456
ARPC5	ARPC3	0.999	0.936
ACTR3B	ARPC5	0.999	0.458
ARPC4	ARPC3	0.999	0.946
ACTR3B	ACTR2	0.999	0.884
CHURC1	ARPC3	0.999	0.092
ACTR3B	ARPC2	0.999	0.866
ARPC1B	ARPC5	0.999	0.806
ARPC2	ARPC5L	0.999	0.33
ACTR2	ARPC5L	0.998	0.35
ACTR3B	CHURC1	0.998	0.158
ARPC1B	ARPC5L	0.998	0.08
ARPC5	ARPC5L	0.998	0.168
CHURC1	ACTR2	0.997	0.114
CHURC1	ACTR3	0.993	0.094
ACTR3B	ACTR3	0.992	0.826
ARPC1A	ARPC1B	0.987	0.212
CHURC1	ARPC4	0.968	0.064
CHURC1	ARPC2	0.962	0.08
CHURC1	ARPC5	0.85	0.074
CHURC1	ARPC1A	0.772	0.082
CHURC1	ARPC5L	0.705	0.114
CHURC1	ARPC1B	0.42	0.068





Related Complexes

Genename	Complexes
ACTR3B	huMAP3_04529.1 huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC1B	huMAP3_04814.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC2	huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ACTR2	huMAP3_04529.1 huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
CHURC1	huMAP3_04529.1 huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC1A	huMAP3_04529.1 huMAP3_04814.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1 huMAP3_14663.1
ARPC5	huMAP3_04814.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC5L	huMAP3_07760.1 huMAP3_09309.1 huMAP3_14624.1
ACTR3	huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC4	huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC3	huMAP3_04814.1 huMAP3_05473.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1