hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09309.1

Complex Portal: CPX-11663

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
ACTR3B	Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)	4	UniProt NCBI
ARPC1B	Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)	5	UniProt NCBI
ARPC2	Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)	5	UniProt NCBI
ACTR2	Actin-related protein 2 (Actin-like protein 2)	5	UniProt NCBI
CHURC1	Protein Churchill	4	UniProt NCBI
ARPC1A	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)	4	UniProt NCBI
ARPC5	Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)	5	UniProt NCBI
ARPC5L	Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)	4	UniProt NCBI
ACTR3	Actin-related protein 3 (Actin-like protein 3)	5	UniProt NCBI
ARPC4	Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)	5	UniProt NCBI
ARPC3	Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005885	3.28833701378e-26	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	Arp2/3 protein complex
CORUM:27	7.76518645207e-22	0.636363636364	ARPC5 ARPC2 ARPC1B ACTR3 ACTR2 ARPC4 ARPC3	Arp2/3 protein complex
KEGG:05100	4.36321155927e-21	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Bacterial invasion of epithelial cells
KEGG:04666	2.61266078016e-20	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Fc gamma R-mediated phagocytosis
KEGG:05135	3.39899044923e-19	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Yersinia infection
KEGG:04530	2.42534670365e-18	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Tight junction
GO:0034314	8.95727296551e-18	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	Arp2/3 complex-mediated actin nucleation
KEGG:05130	1.41868930066e-17	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Pathogenic Escherichia coli infection
REAC:R-HSA-5663213	1.49906583654e-17	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	RHO GTPases Activate WASPs and WAVEs
GO:0045010	2.90108904905e-17	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	actin nucleation
REAC:R-HSA-3928662	4.03476120564e-17	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	EPHB-mediated forward signaling
KEGG:04810	7.86084000731e-17	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Regulation of actin cytoskeleton
KEGG:05132	3.23737092753e-16	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Salmonella infection
KEGG:05131	3.70744853438e-16	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Shigellosis
KEGG:04144	4.42955489239e-16	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	Endocytosis
REAC:R-HSA-9664422	7.29252352972e-16	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	FCGR3A-mediated phagocytosis
REAC:R-HSA-9664417	7.29252352972e-16	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Leishmania phagocytosis
REAC:R-HSA-9664407	7.29252352972e-16	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Parasite infection
REAC:R-HSA-2029482	1.16811838715e-15	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Regulation of actin dynamics for phagocytic cup formation
GO:0051015	1.77987370151e-14	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	actin filament binding
REAC:R-HSA-2029480	1.92035716207e-14	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Fcgamma receptor (FCGR) dependent phagocytosis
REAC:R-HSA-2682334	2.91698377298e-14	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	EPH-Ephrin signaling
WP:WP2272	1.03808168291e-13	0.636363636364	ARPC1B ARPC5L ARPC1A ARPC2 ARPC5 ARPC4 ARPC3	Pathogenic Escherichia coli infection
REAC:R-HSA-9824443	1.90703124732e-12	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Parasitic Infection Pathways
REAC:R-HSA-9658195	1.90703124732e-12	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Leishmania infection
GO:0003779	2.65409439248e-12	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	actin binding
REAC:R-HSA-8856828	3.85690970948e-10	0.636363636364	ACTR3 ARPC5 ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	Clathrin-mediated endocytosis
REAC:R-HSA-195258	1.04521536739e-09	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	RHO GTPase Effectors
GO:0035861	1.25730329339e-09	0.636363636364	ACTR3 ARPC5 ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	site of double-strand break
GO:0005200	4.28242331955e-09	0.636363636364	ARPC5 ARPC2 ARPC1B ACTR3 ACTR2 ARPC4 ARPC3	structural constituent of cytoskeleton
GO:0007015	4.378853658e-09	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	actin filament organization
GO:0090734	1.05542926856e-08	0.636363636364	ACTR3 ARPC5 ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	site of DNA damage
GO:0015629	1.18069996579e-08	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	actin cytoskeleton
GO:0008092	3.62492166295e-08	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	cytoskeletal protein binding
REAC:R-HSA-422475	5.17883585274e-08	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Axon guidance
REAC:R-HSA-9675108	6.93528278935e-08	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Nervous system development
GO:0030036	2.66114556618e-07	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	actin cytoskeleton organization
REAC:R-HSA-194315	4.34943461634e-07	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Signaling by Rho GTPases
REAC:R-HSA-9716542	5.17684587533e-07	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
GO:0030029	7.07619082612e-07	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	actin filament-based process
GO:0097435	8.60109457613e-07	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	supramolecular fiber organization
GO:0044877	4.76363801952e-06	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	protein-containing complex binding
REAC:R-HSA-1266738	4.80729188049e-06	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Developmental Biology
REAC:R-HSA-5663205	5.2683939111e-06	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Infectious disease
REAC:R-HSA-168249	6.53504346773e-06	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Innate Immune System
REAC:R-HSA-199991	1.02374892594e-05	0.636363636364	ACTR3 ARPC5 ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	Membrane Trafficking
REAC:R-HSA-5653656	1.48868457168e-05	0.636363636364	ACTR3 ARPC5 ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	Vesicle-mediated transport
GO:0005925	7.00075091678e-05	0.636363636364	ARPC5 ARPC2 ARPC1B ARPC5L ACTR3 ACTR2 ARPC3	focal adhesion
GO:0030055	8.02480736122e-05	0.636363636364	ARPC5 ARPC2 ARPC1B ARPC5L ACTR3 ACTR2 ARPC3	cell-substrate junction
GO:0007010	0.000182844865374	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	cytoskeleton organization
GO:0070358	0.000316805542726	0.272727272727	ARPC2 ARPC3 ACTR3	actin polymerization-dependent cell motility
REAC:R-HSA-1643685	0.000360075861783	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Disease
GO:0070062	0.000454628173938	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	extracellular exosome
GO:1903561	0.000498164164505	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	extracellular vesicle
GO:0043230	0.000500837846091	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	extracellular organelle
GO:0065010	0.000500837846091	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	extracellular membrane-bounded organelle
GO:0005198	0.000872055876843	0.636363636364	ARPC5 ARPC2 ARPC1B ACTR3 ACTR2 ARPC4 ARPC3	structural molecule activity
REAC:R-HSA-168256	0.000961215599937	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Immune System
GO:0070161	0.00318056066277	0.636363636364	ARPC5 ARPC2 ARPC1B ARPC5L ACTR3 ACTR2 ARPC3	anchoring junction
GO:0005856	0.00324513477631	0.818181818182	ARPC5 ACTR3 ARPC1B ARPC5L ARPC1A ARPC2 ACTR2 ARPC4 ARPC3	cytoskeleton
REAC:R-HSA-162582	0.00386179598205	0.727272727273	ARPC5 ARPC2 ARPC1B ARPC1A ACTR3 ACTR2 ARPC4 ARPC3	Signal Transduction
TF:M11434_1	0.0081811457128	0.909090909091	ACTR2 ARPC1B ARPC4 ARPC1A ARPC5L ARPC2 ARPC5 CHURC1 ACTR3 ARPC3	Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1
GO:0005615	0.0117489175163	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	extracellular space
GO:0010592	0.0278578876014	0.272727272727	ARPC2 ACTR3 ACTR2	positive regulation of lamellipodium assembly
GO:0005576	0.0305194206532	0.909090909091	ARPC5 ACTR3 ARPC1B ARPC1A ARPC5L ARPC2 ACTR2 ARPC4 ACTR3B ARPC3	extracellular region
HPA:0310433	0.0339626283727	0.454545454545	ARPC1B ACTR3 ACTR2 ARPC3 ARPC2	lymph node; germinal center cells[High]
HPA:0301171	0.0453815949404	0.727272727273	ACTR3 ARPC5 ARPC5L ARPC1A ARPC2 ACTR2 CHURC1 ARPC3	lung; alveolar cells[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ACTR3	ARPC4	1.0	0.962
ACTR2	ACTR3	1.0	0.938	structurally_consistent (O15144) structurally_consistent (dimer)
ARPC1B	ACTR3	1.0	0.924
ACTR2	ARPC1B	1.0	0.874	structurally_consistent (P59998)
ARPC1A	ARPC3	1.0	0.324
ACTR2	ARPC5	1.0	0.866	structurally_consistent (P61158) structurally_consistent (dimer)
ACTR3	ARPC3	1.0	0.956	structurally_consistent (dimer)
ACTR2	ARPC4	1.0	0.932	structurally_consistent (dimer)
ACTR2	ARPC1A	1.0	0.524	structurally_consistent (Q9BPX5) structurally_consistent (dimer)
ARPC1A	ARPC4	1.0	0.346	structurally_consistent (dimer)
ARPC1B	ARPC4	1.0	0.854	mutually_exclusive (Q92747) structurally_consistent (dimer)
ARPC1A	ARPC5	1.0	0.184	structurally_consistent (dimer)
ACTR3	ARPC5L	1.0	0.356	structurally_consistent (P61160)
ARPC1A	ARPC5L	1.0	0.176	structurally_consistent (dimer)
ARPC5	ACTR3	1.0	0.894	structurally_consistent (P61160) structurally_consistent (dimer)
ACTR2	ARPC3	1.0	0.942	structurally_consistent (P61158) structurally_consistent (dimer)
ACTR3B	ARPC4	1.0	0.902
ARPC3	ARPC5L	1.0	0.282
ACTR2	ARPC2	1.0	0.99	structurally_consistent (dimer)
ARPC2	ARPC4	1.0	0.978	structurally_consistent (dimer)
ARPC2	ACTR3	1.0	0.966	structurally_consistent (dimer)
ACTR3B	ARPC3	1.0	0.81
ARPC1A	ACTR3	1.0	0.476
ARPC2	ARPC5	1.0	0.934	structurally_consistent (P59998)
ACTR3B	ARPC5L	0.999	0.190714893617	structurally_consistent (dimer)
ARPC1B	ARPC2	0.999	0.936
ARPC2	ARPC3	0.999	0.982	structurally_consistent (P61158)
ARPC1B	ARPC3	0.999	0.846
ACTR3B	ARPC1A	0.999	0.184714893617	mutually_exclusive (O15143)
ARPC5	ARPC4	0.999	0.786	structurally_consistent (P61160) structurally_consistent (dimer)
ARPC4	ARPC5L	0.999	0.276	mutually_exclusive (Q92747) structurally_consistent (dimer)
ACTR3B	ARPC1B	0.999	0.522	structurally_consistent (dimer)
ARPC1A	ARPC2	0.999	0.456
ARPC5	ARPC3	0.999	0.936
ACTR3B	ARPC5	0.999	0.458
ARPC4	ARPC3	0.999	0.946
ACTR3B	ACTR2	0.999	0.884
CHURC1	ARPC3	0.999	0.092	structurally_consistent (P61160)
ACTR3B	ARPC2	0.999	0.866
ARPC1B	ARPC5	0.999	0.806	structurally_consistent (dimer)
ARPC2	ARPC5L	0.999	0.33	structurally_consistent (P59998)
ACTR2	ARPC5L	0.998	0.35	structurally_consistent (P59998) structurally_consistent (dimer)
ACTR3B	CHURC1	0.998	0.158
ARPC1B	ARPC5L	0.998	0.08	structurally_consistent (Q9P1U1)
ARPC5	ARPC5L	0.998	0.168	mutually_exclusive (P61160)
CHURC1	ACTR2	0.997	0.114	structurally_consistent (dimer)
CHURC1	ACTR3	0.993	0.094
ACTR3B	ACTR3	0.992	0.826
ARPC1A	ARPC1B	0.987	0.212	mutually_exclusive (O15511) structurally_consistent (dimer)
CHURC1	ARPC4	0.968	0.064	mutually_exclusive (P61160)
CHURC1	ARPC2	0.962	0.08	structurally_consistent (P61160)
CHURC1	ARPC5	0.85	0.074	structurally_consistent (P61160)
CHURC1	ARPC1A	0.772	0.082	structurally_consistent (P61160)
CHURC1	ARPC5L	0.705	0.114	mutually_exclusive (P61160)
CHURC1	ARPC1B	0.42	0.068

Related Complexes

Genename	Complexes
ACTR3B	huMAP3_04529.1 huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC1B	huMAP3_04814.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC2	huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ACTR2	huMAP3_04529.1 huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
CHURC1	huMAP3_04529.1 huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC1A	huMAP3_04529.1 huMAP3_04814.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1 huMAP3_14663.1
ARPC5	huMAP3_04814.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC5L	huMAP3_07760.1 huMAP3_09309.1 huMAP3_14624.1
ACTR3	huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC4	huMAP3_04814.1 huMAP3_08269.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1
ARPC3	huMAP3_04814.1 huMAP3_05473.1 huMAP3_07760.1 huMAP3_09309.1 huMAP3_13904.1 huMAP3_14624.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09309.1

Complex Portal: CPX-11663