hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09315.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SARS2 | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | 5 | UniProt NCBI |
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | 5 | UniProt NCBI |
| ORC5 | Origin recognition complex subunit 5 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000808 | 2.15253635486e-05 | 0.75 | ORC5 ORC2 LRWD1 | origin recognition complex |
| GO:0005664 | 2.15253635486e-05 | 0.75 | ORC5 ORC2 LRWD1 | nuclear origin of replication recognition complex |
| CORUM:1034 | 3.07520988333e-05 | 0.5 | ORC2 ORC5 | ORC 2-5 complex (origin recognition 2-5 complex) |
| CORUM:1038 | 5.12488211613e-05 | 0.5 | ORC2 ORC5 | ORC 1-5 complex (origin recognition 1-5 complex) |
| CORUM:1033 | 7.68662167609e-05 | 0.5 | ORC2 ORC5 | ORC complex (origin recognition complex) |
| CORUM:1031 | 7.68662167609e-05 | 0.5 | ORC2 ORC5 | ORC complex (origin recognition complex) |
| CORUM:389 | 7.68662167609e-05 | 0.5 | ORC2 ORC5 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68689 | 0.000286914834749 | 0.5 | ORC2 ORC5 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113507 | 0.000368856835097 | 0.5 | ORC2 ORC5 | E2F-enabled inhibition of pre-replication complex formation |
| GO:0006270 | 0.00190418300832 | 0.75 | ORC5 ORC2 LRWD1 | DNA replication initiation |
| WP:WP466 | 0.002190823719 | 0.5 | ORC2 ORC5 | DNA replication |
| REAC:R-HSA-113510 | 0.00236402400204 | 0.5 | ORC2 ORC5 | E2F mediated regulation of DNA replication |
| WP:WP45 | 0.00511942554749 | 0.5 | ORC2 ORC5 | G1 to S cell cycle control |
| REAC:R-HSA-68962 | 0.00539805716719 | 0.5 | ORC2 ORC5 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.00643909852192 | 0.5 | ORC2 ORC5 | Activation of ATR in response to replication stress |
| REAC:R-HSA-68616 | 0.0162811003561 | 0.5 | ORC2 ORC5 | Assembly of the ORC complex at the origin of replication |
| WP:WP179 | 0.0168573248614 | 0.5 | ORC2 ORC5 | Cell cycle |
| REAC:R-HSA-68949 | 0.0246065982605 | 0.5 | ORC2 ORC5 | Orc1 removal from chromatin |
| KEGG:04110 | 0.0280208578488 | 0.5 | ORC2 ORC5 | Cell cycle |
| REAC:R-HSA-69052 | 0.0407325822829 | 0.5 | ORC2 ORC5 | Switching of origins to a post-replicative state |
| CORUM:2205 | 0.049938562206 | 0.25 | ORC5 | ORC5-ORC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ORC2 | LRWD1 | 1.0 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction |
| ORC2 | ORC5 | 0.994 | 0.456 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| LRWD1 | ORC5 | 0.991 | 0.672 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| LRWD1 | SARS2 | 0.99 | 0.036 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| ORC2 | SARS2 | 0.005 | 0.02 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SARS2 | ORC5 | 0.004 | 0.028 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
Related Complexes