hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09319.1

Complex Portal: CPX-11851

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
CDK3	Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)	5	UniProt NCBI
CKS2	Cyclin-dependent kinases regulatory subunit 2 (CKS-2)	4	UniProt NCBI
CDK2	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)	5	UniProt NCBI
MIDEAS	Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)	4	UniProt NCBI
SKP2	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)	5	UniProt NCBI
E2F5	Transcription factor E2F5 (E2F-5)	5	UniProt NCBI
CCNO	Cyclin-O	5	UniProt NCBI
CCNB1	G2/mitotic-specific cyclin-B1	5	UniProt NCBI
GMNN	Geminin	5	UniProt NCBI
E2F4	Transcription factor E2F4 (E2F-4)	5	UniProt NCBI
CDKN1C	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)	5	UniProt NCBI
CCNE2	G1/S-specific cyclin-E2	5	UniProt NCBI
CDKN1B	Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)	5	UniProt NCBI
CDK1	Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)	5	UniProt NCBI
CCNE1	G1/S-specific cyclin-E1	5	UniProt NCBI
CDK5R1	Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-453279	1.12412741051e-11	0.666666666667	CDKN1B E2F4 GMNN E2F5 CDK1 SKP2 CCNE2 CDKN1C	Mitotic G1 phase and G1/S transition
WP:WP179	1.47956457322e-10	0.583333333333	CDKN1B E2F4 CDKN1C E2F5 CDK1 SKP2 CCNE2	Cell cycle
REAC:R-HSA-69231	1.71505814637e-10	0.5	CDKN1B E2F4 CDKN1C E2F5 SKP2 CCNE2	Cyclin D associated events in G1
REAC:R-HSA-69236	1.71505814637e-10	0.5	CDKN1B E2F4 CDKN1C E2F5 SKP2 CCNE2	G1 Phase
KEGG:04110	4.3082284691e-10	0.583333333333	CDKN1B E2F4 CDKN1C E2F5 CDK1 SKP2 CCNE2	Cell cycle
REAC:R-HSA-69206	7.7643115826e-10	0.583333333333	CDKN1B E2F4 GMNN E2F5 CDK1 SKP2 CCNE2	G1/S Transition
REAC:R-HSA-69278	3.16405557461e-07	0.666666666667	CDKN1B E2F4 GMNN E2F5 CDK1 SKP2 CCNE2 CDKN1C	Cell Cycle, Mitotic
REAC:R-HSA-69242	3.58854444493e-07	0.5	CDKN1B E2F4 GMNN E2F5 SKP2 CCNE2	S Phase
REAC:R-HSA-69202	1.02544521764e-06	0.416666666667	SKP2 CCNE2 CDKN1B E2F4 E2F5	Cyclin E associated events during G1/S transition
REAC:R-HSA-1538133	1.04810576875e-06	0.333333333333	E2F5 CDK1 E2F4 CCNE2	G0 and Early G1
REAC:R-HSA-69656	1.15931112782e-06	0.416666666667	SKP2 CCNE2 CDKN1B E2F4 E2F5	Cyclin A:Cdk2-associated events at S phase entry
REAC:R-HSA-1640170	1.62447510678e-06	0.666666666667	CDKN1B E2F4 GMNN E2F5 CDK1 SKP2 CCNE2 CDKN1C	Cell Cycle
REAC:R-HSA-9687139	3.65636349185e-06	0.333333333333	SKP2 CDKN1B CDKN1C CCNE2	Aberrant regulation of mitotic cell cycle due to RB1 defects
REAC:R-HSA-9675126	4.60795954643e-06	0.333333333333	SKP2 CDKN1B CDKN1C CCNE2	Diseases of mitotic cell cycle
WP:WP5180	9.41531542993e-06	0.333333333333	E2F5 CDKN1B GMNN E2F4	DYRK1A involvement regarding cell proliferation in brain development
REAC:R-HSA-6791312	1.03589577395e-05	0.333333333333	CDKN1B CDK1 E2F4 CCNE2	TP53 Regulates Transcription of Cell Cycle Genes
WP:WP45	1.88333254966e-05	0.333333333333	CDKN1B CDK1 CDKN1C CCNE2	G1 to S cell cycle control
GO:0000307	2.43176887518e-05	0.416666666667	CDK1 CCNE2 CDK5R1 CDK3 CCNO	cyclin-dependent protein kinase holoenzyme complex
REAC:R-HSA-1362300	5.20022177987e-05	0.25	E2F5 E2F4 CDK1	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
WP:WP2446	6.23393472841e-05	0.333333333333	SKP2 CDK1 CCNE2 CDKN1B	Retinoblastoma gene in cancer
REAC:R-HSA-9661069	7.7645792219e-05	0.25	CDKN1B CDKN1C CCNE2	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
REAC:R-HSA-9659787	7.7645792219e-05	0.25	CDKN1B CDKN1C CCNE2	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
KEGG:04218	0.000195515267753	0.333333333333	E2F5 CDK1 E2F4 CCNE2	Cellular senescence
REAC:R-HSA-69205	0.000332450747125	0.25	E2F5 E2F4 CDK1	G1/S-Specific Transcription
CORUM:5117	0.000375413311943	0.166666666667	E2F5 E2F4	RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2)
CORUM:2975	0.000375413311943	0.166666666667	E2F5 E2F4	SMAD3-E2F4/5-p107-DP1 complex
CORUM:5118	0.000562863068691	0.166666666667	E2F5 E2F4	RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2)
CORUM:1474	0.000562863068691	0.166666666667	E2F5 E2F4	SMAD3/4-E2F4/5-p107-DP1 complex
CORUM:3015	0.000562863068691	0.166666666667	SKP2 CDKN1B	p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex
KEGG:05203	0.000603372367254	0.333333333333	SKP2 CDK1 CCNE2 CDKN1B	Viral carcinogenesis
GO:0000278	0.000716188242473	0.666666666667	CDKN1B CDKN1C GMNN CDK3 CDK1 SKP2 CCNE2 CCNO	mitotic cell cycle
REAC:R-HSA-3700989	0.00120961672795	0.416666666667	CDKN1B CDK5R1 CDK1 E2F4 CCNE2	Transcriptional Regulation by TP53
REAC:R-HSA-212436	0.00128741520018	0.583333333333	CDK5R1 CDKN1B E2F4 E2F5 CDK1 SKP2 CCNE2	Generic Transcription Pathway
GO:0016538	0.00143377293746	0.333333333333	CDKN1B CDK5R1 CCNO CCNE2	cyclin-dependent protein serine/threonine kinase regulator activity
GO:1902554	0.00165928176801	0.416666666667	CDK1 CCNE2 CDK5R1 CDK3 CCNO	serine/threonine protein kinase complex
GO:0051726	0.00188538998373	0.666666666667	CDK5R1 CDKN1B CDKN1C GMNN CDK3 CDK1 SKP2 CCNE2	regulation of cell cycle
WP:WP1530	0.00209712835347	0.25	CDKN1B CCNE2 CDK1	miRNA regulation of DNA damage response
WP:WP707	0.00209712835347	0.25	CDKN1B CCNE2 CDK1	DNA damage response
GO:0007049	0.00215586789473	0.75	CDK5R1 CDKN1B CDKN1C GMNN CDK3 CDK1 SKP2 CCNE2 CCNO	cell cycle
KEGG:05222	0.00216488710278	0.25	SKP2 CCNE2 CDKN1B	Small cell lung cancer
REAC:R-HSA-73857	0.00267974630382	0.583333333333	CDK5R1 CDKN1B E2F4 E2F5 CDK1 SKP2 CCNE2	RNA Polymerase II Transcription
GO:1902911	0.00313308982074	0.416666666667	CDK1 CCNE2 CDK5R1 CDK3 CCNO	protein kinase complex
REAC:R-HSA-187577	0.00383047897444	0.25	SKP2 CCNE2 CDKN1B	SCF(Skp2)-mediated degradation of p27/p21
WP:WP4658	0.00539210847555	0.25	CDKN1B CDKN1C CCNE2	Small cell lung cancer
WP:WP2431	0.00557546122595	0.25	E2F5 CDK1 CDKN1B	Spinal cord injury
GO:0044772	0.00601455162263	0.5	CDKN1B CCNO CDK3 CDK1 SKP2 CCNE2	mitotic cell cycle phase transition
REAC:R-HSA-74160	0.00615586937905	0.583333333333	CDK5R1 CDKN1B E2F4 E2F5 CDK1 SKP2 CCNE2	Gene expression (Transcription)
GO:1904029	0.00662921233348	0.333333333333	CDKN1B CDK5R1 CDKN1C CCNE2	regulation of cyclin-dependent protein kinase activity
GO:0000082	0.0068098021003	0.416666666667	SKP2 CDKN1B CDK1 CDK3 CCNE2	G1/S transition of mitotic cell cycle
WP:WP4970	0.00753607712322	0.166666666667	CDKN1B CDKN1C	Galanin receptor pathway
GO:0019887	0.00835872057838	0.416666666667	CDKN1B CCNE2 CDK5R1 CCNO CDKN1C	protein kinase regulator activity
WP:WP3640	0.0109661197546	0.166666666667	SKP2 CDKN1B	Imatinib and chronic myeloid leukemia
GO:0044843	0.0126209961859	0.416666666667	SKP2 CDKN1B CDK1 CDK3 CCNE2	cell cycle G1/S phase transition
WP:WP366	0.0128217455012	0.25	E2F5 E2F4 CDK1	TGF beta signaling pathway
REAC:R-HSA-69052	0.0129690076343	0.25	SKP2 GMNN CCNE2	Switching of origins to a post-replicative state
REAC:R-HSA-6804116	0.0130338557741	0.166666666667	CDKN1B CCNE2	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
GO:0019207	0.018006287065	0.416666666667	CDKN1B CCNE2 CDK5R1 CCNO CDKN1C	kinase regulator activity
KEGG:05169	0.0193581446291	0.25	SKP2 CCNE2 CDKN1B	Epstein-Barr virus infection
GO:0044770	0.0219931947795	0.5	CDKN1B CCNO CDK3 CDK1 SKP2 CCNE2	cell cycle phase transition
REAC:R-HSA-6804114	0.0226842574326	0.166666666667	CDK1 E2F4	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
REAC:R-HSA-1362277	0.0255081481249	0.166666666667	E2F5 E2F4	Transcription of E2F targets under negative control by DREAM complex
REAC:R-HSA-69239	0.0298244949702	0.25	SKP2 GMNN CCNE2	Synthesis of DNA
GO:1990234	0.0366031267585	0.583333333333	CDK5R1 CDKN1B CCNO CDK3 CDK1 SKP2 CCNE2	transferase complex
WP:WP3941	0.0447852947857	0.166666666667	CDKN1B CDKN1C	Oxidative damage response
CORUM:5320	0.0499436884912	0.0833333333333	SKP2	CDH1-SKP2 complex
CORUM:2628	0.0499436884912	0.0833333333333	CDK3	CCNC-CDK3 complex
CORUM:1656	0.0499436884912	0.0833333333333	CDKN1B	p27-cyclinE-CDK2 complex
CORUM:5543	0.0499436884912	0.0833333333333	CDK1	CCNB1-CDC2 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CCNB1	CDKN1B	1.0	0.26236
CCNB1	CKS2	1.0	0.152
CDKN1B	CCNE1	1.0	0.102
CDKN1B	CKS2	1.0	0.036
CDK1	CKS2	1.0	0.23	structurally_consistent (dimer)
CDKN1B	CDK1	1.0	0.158	structurally_consistent (P20248)
CCNB1	CDK2	0.999	0.161	structurally_consistent (dimer)
CDK2	CCNE2	0.999		structurally_consistent (dimer)
SKP2	CDK2	0.999	0.278
CDKN1B	CDK2	0.999	0.1424	structurally_consistent (P20248) structurally_consistent (dimer)
CDKN1B	CDKN1C	0.999	0.158	mutually_exclusive (P30281)
CKS2	CDK2	0.999	0.062	structurally_consistent (dimer)
CCNE1	CCNE2	0.999
CCNB1	CDK1	0.999	0.3
CCNB1	CCNE1	0.998	0.102
SKP2	CDKN1C	0.998	0.086
CDKN1B	SKP2	0.998	0.174	mutually_exclusive (P11802)
CDK2	CDKN1C	0.998	0.172	structurally_consistent (dimer)
CKS2	SKP2	0.998	0.098
CDK2	CCNE1	0.998	0.15	structurally_consistent (dimer)
CDK1	CDK2	0.998	0.288	mutually_exclusive (P20248)
CDKN1B	CCNE2	0.997
CKS2	CDKN1C	0.997	0.026
CDK3	CDK2	0.997		structurally_consistent (dimer)
SKP2	GMNN	0.997	0.27
SKP2	CDK3	0.996
CDK1	CDKN1C	0.996	0.298
GMNN	CDK2	0.996	0.193555555556
CDK1	SKP2	0.996	0.372
CKS2	CDK3	0.995		structurally_consistent (dimer)
CCNB1	SKP2	0.994	0.354	mutually_exclusive (P20248)
CCNB1	CCNE2	0.992
CKS2	CCNE2	0.992
CKS2	CCNE1	0.992	0.126
CDKN1B	GMNN	0.992	0.148
CDK3	CCNE2	0.991		structurally_consistent (dimer)
CDKN1B	CDK3	0.99		structurally_consistent (dimer)
MIDEAS	CDKN1C	0.987	0.06
CCNB1	CDK3	0.984
CDK2	CDK5R1	0.984		structurally_consistent (dimer)
CDKN1B	MIDEAS	0.983	0.094
CDK3	CDKN1C	0.982		structurally_consistent (dimer)
CDK3	CCNE1	0.982
SKP2	CCNE2	0.98
SKP2	CCNE1	0.977	0.158
CDK1	GMNN	0.976	0.142
E2F4	GMNN	0.974	0.072
E2F4	E2F5	0.974
CKS2	GMNN	0.974	0.084
CCNB1	CDKN1C	0.973	0.12	structurally_consistent (dimer)
GMNN	CDK3	0.967
MIDEAS	CDK2	0.966	0.038
E2F5	CDK2	0.965
CCNO	CDK3	0.963
E2F4	CDK2	0.962	0.284
GMNN	E2F5	0.961
CCNO	CDK2	0.96
CDK1	CCNE1	0.955	0.254946428571
MIDEAS	SKP2	0.937	0.056
CKS2	CCNO	0.937
CDK1	CCNE2	0.936
GMNN	CDKN1C	0.92	0.126
CCNE2	CDKN1C	0.92
CDK1	CCNO	0.914
CCNO	E2F5	0.892
CDKN1B	CCNO	0.887
SKP2	CCNO	0.882
GMNN	CCNE1	0.855	0.099
MIDEAS	GMNN	0.77	0.024
CCNO	CCNE2	0.768
E2F4	CDK1	0.752	0.286385542169
CKS2	MIDEAS	0.749	0.012
CKS2	E2F5	0.746
E2F4	SKP2	0.702	0.302
E2F4	CKS2	0.681	0.102
CDK3	E2F5	0.675
CCNB1	E2F5	0.634
E2F4	CDKN1C	0.634	0.074
E2F4	CDKN1B	0.587	0.178
CDK1	MIDEAS	0.466	0.0484553571429
E2F5	CCNE1	0.455
CCNO	CCNE1	0.455
E2F4	CCNB1	0.416	0.164
CCNE1	CDKN1C	0.413	0.056
E2F4	CCNO	0.405
CCNB1	CCNO	0.388
E2F5	CCNE2	0.384
E2F4	CCNE2	0.384
GMNN	CCNE2	0.367
E2F4	CCNE1	0.362	0.124
CCNB1	GMNN	0.358	0.246
E2F4	CDK3	0.325
CDK1	CDK3	0.32		structurally_consistent (dimer)
SKP2	E2F5	0.251
MIDEAS	CCNE1	0.232	0.152
E2F5	CDKN1C	0.188
CDKN1B	E2F5	0.188
CDK1	E2F5	0.118
MIDEAS	CCNE2	0.063
MIDEAS	CDK3	0.06
CDK3	CDK5R1	0.055
CDKN1B	CDK5R1	0.043		mutually_exclusive (P24941)
CCNB1	CDK5R1	0.043
E2F4	MIDEAS	0.042	0.088
CCNB1	MIDEAS	0.028	0.06
CDK1	CDK5R1	0.016

Related Complexes

Genename	Complexes
CDK3	huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CKS2	huMAP3_01026.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CDK2	huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
MIDEAS	huMAP3_01026.1 huMAP3_01287.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_06587.1 huMAP3_07709.1 huMAP3_08377.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09319.1 huMAP3_09513.1 huMAP3_10311.1 huMAP3_10449.1 huMAP3_14722.1
SKP2	huMAP3_01026.1 huMAP3_04611.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14632.1 huMAP3_14722.1
E2F5	huMAP3_03477.1 huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_13863.1 huMAP3_14722.1
CCNO	huMAP3_02428.1 huMAP3_04688.1 huMAP3_05982.1 huMAP3_06121.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_13863.1 huMAP3_14722.1
CCNB1	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
GMNN	huMAP3_02716.1 huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
E2F4	huMAP3_00125.1 huMAP3_03477.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1
CDKN1C	huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNE2	huMAP3_04688.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CDKN1B	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CDK1	huMAP3_00736.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CCNE1	huMAP3_04688.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_14722.1
CDK5R1	huMAP3_04028.1 huMAP3_04468.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_09793.1 huMAP3_10253.1 huMAP3_10449.1 huMAP3_15344.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09319.1

Complex Portal: CPX-11851