hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09324.1
Complex Portal: CPX-24303
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AQP5 | Aquaporin-5 (AQP-5) | 5 | UniProt NCBI |
| ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | 5 | UniProt NCBI |
| SERINC2 | Serine incorporator 2 (Tumor differentially expressed protein 2-like) | 3 | UniProt NCBI |
| ATP6V0E1 | V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1) | 5 | UniProt NCBI |
| TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 1.64931336911e-06 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Collecting duct acid secretion |
| REAC:R-HSA-77387 | 1.01974564564e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Insulin receptor recycling |
| REAC:R-HSA-917977 | 1.01974564564e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Transferrin endocytosis and recycling |
| KEGG:05110 | 1.31851389117e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Vibrio cholerae infection |
| REAC:R-HSA-1222556 | 1.39876172793e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | ROS and RNS production in phagocytes |
| KEGG:04721 | 3.17476783734e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Synaptic vesicle cycle |
| KEGG:05120 | 3.68305888879e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:05323 | 4.64569454207e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Rheumatoid arthritis |
| REAC:R-HSA-917937 | 6.86227830674e-05 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Iron uptake and transport |
| REAC:R-HSA-74752 | 0.000117314199984 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Signaling by Insulin receptor |
| KEGG:00190 | 0.000272164365812 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Oxidative phosphorylation |
| KEGG:04145 | 0.000345020494504 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Phagosome |
| REAC:R-HSA-983712 | 0.000955846750913 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Ion channel transport |
| REAC:R-HSA-382551 | 0.00137916640811 | 0.8 | AQP5 TCIRG1 ATP6V0A2 ATP6V0E1 | Transport of small molecules |
| GO:0007035 | 0.00314081658857 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | vacuolar acidification |
| KEGG:05165 | 0.00379627929445 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Human papillomavirus infection |
| GO:0051452 | 0.0102064666638 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | intracellular pH reduction |
| GO:0030670 | 0.0109904490822 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | phagocytic vesicle membrane |
| REAC:R-HSA-9639288 | 0.0208015819243 | 0.4 | ATP6V0E1 TCIRG1 | Amino acids regulate mTORC1 |
| GO:1902600 | 0.0250826699056 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | proton transmembrane transport |
| GO:0051453 | 0.0327001087246 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | regulation of intracellular pH |
| KEGG:04142 | 0.0335445792486 | 0.4 | ATP6V0A2 TCIRG1 | Lysosome |
| GO:0030641 | 0.036132773595 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | regulation of cellular pH |
| REAC:R-HSA-9006934 | 0.0398305153279 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | Signaling by Receptor Tyrosine Kinases |
| GO:0006885 | 0.0417184596383 | 0.6 | ATP6V0E1 ATP6V0A2 TCIRG1 | regulation of pH |
| KEGG:05152 | 0.0471742362289 | 0.4 | ATP6V0A2 TCIRG1 | Tuberculosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TCIRG1 | ATP6V0A2 | 0.992 | 0.062 |
mutually_exclusive (P27449)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TCIRG1 | SERINC2 | 0.971 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ATP6V0E1 | ATP6V0A2 | 0.966 | bioplex3_HEK293 bioplex () | ||
| ATP6V0A2 | AQP5 | 0.954 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SERINC2 | ATP6V0A2 | 0.951 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
Related Complexes