hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09328.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNF | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] | 5 | UniProt NCBI |
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | 5 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| FNTB | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6710 | 1.36501667663e-05 | 0.4 | CAPN1 CAPNS1 | Calpain 1 |
| GO:0004198 | 0.000158467845213 | 0.6 | CAPN1 CAPN8 CAPNS1 | calcium-dependent cysteine-type endopeptidase activity |
| REAC:R-HSA-1474228 | 0.000578912790256 | 0.6 | CAPN1 CAPN8 CAPNS1 | Degradation of the extracellular matrix |
| KEGG:05131 | 0.00175429069912 | 0.6 | CAPN1 TNF CAPNS1 | Shigellosis |
| REAC:R-HSA-8862803 | 0.00318398402781 | 0.4 | CAPN1 CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00318398402781 | 0.4 | CAPN1 CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 0.00418294558639 | 0.4 | CAPN1 CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-1474244 | 0.00594422623006 | 0.6 | CAPN1 CAPN8 CAPNS1 | Extracellular matrix organization |
| WP:WP185 | 0.020275205407 | 0.4 | CAPN1 CAPNS1 | Integrin mediated cell adhesion |
| GO:0110158 | 0.0280843539964 | 0.4 | CAPN1 CAPNS1 | calpain complex |
| KEGG:04210 | 0.0319348346673 | 0.4 | CAPN1 TNF | Apoptosis |
| REAC:R-HSA-6809371 | 0.0333121022189 | 0.4 | CAPN1 CAPNS1 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.035336387757 | 0.4 | CAPN1 CAPNS1 | Keratinization |
| KEGG:04217 | 0.0415700968186 | 0.4 | CAPN1 TNF | Necroptosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAPN1 | CAPNS1 | 1.0 | 0.604 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CAPN8 | CAPN1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPNS1 | 0.987 | 0.336 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN8 | CAPNS1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TNF | CAPNS1 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CAPN2 | CAPN1 | 0.963 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| FNTB | CAPN1 | 0.958 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FNTB | CAPNS1 | 0.952 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FNTB | CAPN8 | 0.678 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FNTB | CAPN2 | 0.614 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CAPN8 | CAPN2 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes