hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09333.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AMACR | Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) | 5 | UniProt NCBI |
| COQ6 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6) | 5 | UniProt NCBI |
| CPT2 | Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II) | 5 | UniProt NCBI |
| QRSL1 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) | 5 | UniProt NCBI |
| GUF1 | Translation factor GUF1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1) (Ribosomal back-translocase) | 4 | UniProt NCBI |
| GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2) | 5 | UniProt NCBI |
| GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6959 | 7.02338504734e-09 | 0.428571428571 | GATC QRSL1 GATB | GATB-GATC-QRSL1 complex |
| GO:0050567 | 3.36420143768e-06 | 0.428571428571 | GATC QRSL1 GATB | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| GO:0030956 | 3.36420143768e-06 | 0.428571428571 | GATC QRSL1 GATB | glutamyl-tRNA(Gln) amidotransferase complex |
| GO:0070681 | 3.36420143768e-06 | 0.428571428571 | GATC QRSL1 GATB | glutaminyl-tRNAGln biosynthesis via transamidation |
| HP:0003236 | 2.90803372465e-05 | 0.714285714286 | GATC QRSL1 GATB AMACR CPT2 | Elevated circulating creatine kinase concentration |
| HP:0040081 | 3.78512118805e-05 | 0.714285714286 | GATC QRSL1 GATB AMACR CPT2 | Abnormal circulating creatine kinase concentration |
| HP:0011021 | 3.99793663825e-05 | 0.714285714286 | GATC QRSL1 GATB AMACR CPT2 | Abnormality of circulating enzyme level |
| KEGG:00970 | 4.29830272396e-05 | 0.428571428571 | GATC QRSL1 GATB | Aminoacyl-tRNA biosynthesis |
| HP:0008163 | 0.000147554136555 | 0.428571428571 | GATC QRSL1 GATB | Decreased circulating cortisol level |
| GO:0016884 | 0.000282244947588 | 0.428571428571 | GATC QRSL1 GATB | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
| HP:0001410 | 0.000641321903356 | 0.571428571429 | GATC QRSL1 AMACR CPT2 | Decreased liver function |
| HP:0025155 | 0.000715664327131 | 0.571428571429 | GATC QRSL1 AMACR CPT2 | Abnormality of hepatobiliary system physiology |
| HP:0008207 | 0.000857953877823 | 0.428571428571 | GATC QRSL1 GATB | Primary adrenal insufficiency |
| HP:0011731 | 0.00104065814502 | 0.428571428571 | GATC QRSL1 GATB | Abnormality of circulating cortisol level |
| HP:0012111 | 0.00110685540724 | 0.428571428571 | GATC QRSL1 GATB | Abnormality of circulating glucocorticoid level |
| HP:0010876 | 0.00115237208853 | 0.714285714286 | GATC QRSL1 GATB AMACR CPT2 | Abnormal circulating protein concentration |
| HP:0001943 | 0.00148300663271 | 0.571428571429 | GATC GATB CPT2 QRSL1 | Hypoglycemia |
| HP:0011014 | 0.00162563884525 | 0.714285714286 | GATC QRSL1 GATB AMACR CPT2 | Abnormal glucose homeostasis |
| HP:0001790 | 0.00183245862427 | 0.428571428571 | GATC QRSL1 GATB | Nonimmune hydrops fetalis |
| GO:0005739 | 0.00195755801633 | 1.0 | CPT2 GATC QRSL1 COQ6 AMACR GUF1 GATB | mitochondrion |
| HP:0000007 | 0.00298121475416 | 1.0 | CPT2 GATC QRSL1 COQ6 AMACR GUF1 GATB | Autosomal recessive inheritance |
| HP:0011015 | 0.00333099705828 | 0.571428571429 | GATC GATB CPT2 QRSL1 | Abnormal blood glucose concentration |
| HP:0000846 | 0.00394880725781 | 0.428571428571 | GATC QRSL1 GATB | Adrenal insufficiency |
| KEGG:01100 | 0.00514114776296 | 0.714285714286 | GATC QRSL1 GATB AMACR COQ6 | Metabolic pathways |
| HP:0001941 | 0.00979738131748 | 0.571428571429 | GATC GATB CPT2 QRSL1 | Acidosis |
| HP:0011733 | 0.00987874787138 | 0.428571428571 | GATC QRSL1 GATB | Abnormality of adrenal physiology |
| HP:0001789 | 0.0117122371727 | 0.428571428571 | GATC QRSL1 GATB | Hydrops fetalis |
| HP:0004360 | 0.0124114275939 | 0.571428571429 | GATC GATB CPT2 QRSL1 | Abnormality of acid-base homeostasis |
| HP:0010964 | 0.0199339480346 | 0.285714285714 | AMACR CPT2 | Abnormal circulating long-chain fatty-acid concentration |
| HP:0001622 | 0.0264363867202 | 0.428571428571 | GATC QRSL1 GATB | Premature birth |
| GO:0016879 | 0.0329865610647 | 0.428571428571 | GATC QRSL1 GATB | ligase activity, forming carbon-nitrogen bonds |
| GO:0043038 | 0.0355834449793 | 0.428571428571 | GATC QRSL1 GATB | amino acid activation |
| GO:0043039 | 0.0355834449793 | 0.428571428571 | GATC QRSL1 GATB | tRNA aminoacylation |
| HP:0032180 | 0.0412670430832 | 0.714285714286 | GATC QRSL1 GATB AMACR CPT2 | Abnormal circulating metabolite concentration |
| HP:0000834 | 0.0443180476273 | 0.428571428571 | GATC QRSL1 GATB | Abnormality of the adrenal glands |
| HP:0000818 | 0.0473243155486 | 0.714285714286 | GATC QRSL1 GATB AMACR COQ6 | Abnormality of the endocrine system |
| HP:0001511 | 0.0478764522021 | 0.571428571429 | GUF1 GATB QRSL1 GATC | Intrauterine growth retardation |
| HP:0003287 | 0.04831924436 | 0.428571428571 | GATC CPT2 QRSL1 | Abnormality of mitochondrial metabolism |
| HP:0003128 | 0.0499840105553 | 0.428571428571 | GATC QRSL1 GATB | Lactic acidosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GATC | QRSL1 | 1.0 | 0.68 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GATC | GATB | 0.999 | 0.764 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| QRSL1 | GATB | 0.999 | 0.296 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| QRSL1 | COQ6 | 0.99 | 0.014 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| GUF1 | AMACR | 0.99 | 0.124 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| COQ6 | AMACR | 0.979 | 0.07 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| AMACR | GATB | 0.978 | 0.038 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| AMACR | CPT2 | 0.97 | 0.206 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| QRSL1 | CPT2 | 0.969 | 0.036 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GATB | CPT2 | 0.785 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
| GUF1 | COQ6 | 0.76 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only |
| GUF1 | GATB | 0.682 | 0.416 | bioplex3_WMM youn_WMM WMM_only |
| COQ6 | CPT2 | 0.655 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| COQ6 | GATB | 0.613 | 0.028 | bioplex3_WMM WMM_only |
| GATC | CPT2 | 0.548 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GUF1 | CPT2 | 0.513 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| GATC | COQ6 | 0.22 | 0.044 | bioplex3_WMM WMM_only |
| GUF1 | QRSL1 | 0.02 | 0.124 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes