hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09338.1

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
EIF2B2	Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)	5	UniProt NCBI
EIF2B1	Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha)	5	UniProt NCBI
EIF2B4	Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)	5	UniProt NCBI
GMPPA	Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha)	5	UniProt NCBI
EXOG	Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)	5	UniProt NCBI
PTAFR	Platelet-activating factor receptor (PAF-R) (PAFr)	5	UniProt NCBI
SPN	Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]	5	UniProt NCBI
EIF2B5	Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7292	4.80104919782e-12	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
REAC:R-HSA-72731	1.01530006227e-10	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	Recycling of eIF2:GDP
GO:0005851	1.97323122031e-09	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	eukaryotic translation initiation factor 2B complex
CORUM:7291	1.87066161015e-08	0.5	EIF2B5 EIF2B2 EIF2B4	EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
WP:WP107	1.19388313242e-07	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	Translation factors
GO:0014003	9.38024124582e-07	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	oligodendrocyte development
REAC:R-HSA-72613	1.09966659651e-05	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	Eukaryotic Translation Initiation
REAC:R-HSA-72737	1.09966659651e-05	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	Cap-dependent Translation Initiation
GO:0048709	2.05958456954e-05	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	oligodendrocyte differentiation
GO:0003743	5.33450584461e-05	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	translation initiation factor activity
GO:0021782	9.04396960067e-05	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	glial cell development
GO:0009408	0.000191285986513	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	response to heat
KEGG:05168	0.000291862334988	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	Herpes simplex virus 1 infection
GO:0008135	0.000359278119226	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	translation factor activity, RNA binding
REAC:R-HSA-72766	0.000394777308295	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	Translation
GO:0009749	0.000426352174493	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	response to glucose
GO:0009746	0.000476002909429	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	response to hexose
GO:0034284	0.000476002909429	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	response to monosaccharide
GO:0009266	0.000619048899658	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	response to temperature stimulus
GO:0009743	0.000684451996602	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	response to carbohydrate
GO:0090079	0.000792088897246	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	translation regulator activity, nucleic acid binding
HP:0000869	0.000813158327929	0.5	EIF2B4 EIF2B2 EIF2B1	Secondary amenorrhea
WP:WP5316	0.000945394450017	0.5	EIF2B5 EIF2B2 EIF2B4	Primary ovarian insufficiency
GO:0010001	0.00104484947805	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	glial cell differentiation
GO:0050852	0.00114118555867	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	T cell receptor signaling pathway
GO:0001541	0.00185822071527	0.5	EIF2B5 EIF2B2 EIF2B4	ovarian follicle development
GO:0006413	0.00186589865871	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	translational initiation
GO:0045182	0.00225224503687	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	translation regulator activity
GO:0050851	0.0029910931425	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	antigen receptor-mediated signaling pathway
GO:0042063	0.00331023080209	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	gliogenesis
GO:0008585	0.00560226816097	0.5	EIF2B5 EIF2B2 EIF2B4	female gonad development
GO:0046545	0.00627357313526	0.5	EIF2B5 EIF2B2 EIF2B4	development of primary female sexual characteristics
GO:0046660	0.0104402436969	0.5	EIF2B5 EIF2B2 EIF2B4	female sex differentiation
GO:0005085	0.0115447654956	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	guanyl-nucleotide exchange factor activity
HP:0000141	0.0153102613551	0.5	EIF2B4 EIF2B2 EIF2B1	Amenorrhea
HP:0000648	0.0175320772209	0.666666666667	EIF2B4 GMPPA EIF2B2 EIF2B1	Optic atrophy
HP:0002317	0.0208218734023	0.5	EIF2B4 EIF2B2 EIF2B1	Unsteady gait
REAC:R-HSA-392499	0.0215959266916	0.833333333333	EIF2B5 EIF2B4 GMPPA EIF2B2 EIF2B1	Metabolism of proteins
GO:0002429	0.0254900482337	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	immune response-activating cell surface receptor signaling pathway
GO:0043434	0.0292377969225	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	response to peptide hormone
GO:0002768	0.0359397466361	0.666666666667	EIF2B5 EIF2B4 EIF2B2 EIF2B1	immune response-regulating cell surface receptor signaling pathway
HP:0012795	0.0416401881978	0.666666666667	EIF2B4 GMPPA EIF2B2 EIF2B1	Abnormal optic disc morphology
HP:0002352	0.0442030419385	0.5	EIF2B4 EIF2B2 EIF2B1	Leukoencephalopathy

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
EIF2B2	EIF2B5	1.0	0.882	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B4	EIF2B2	1.0	0.38	bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B2	EIF2B1	1.0	0.538	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B5	EIF2B1	1.0	0.57	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B4	EIF2B5	1.0	0.472	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EIF2B4	EIF2B1	0.998	0.094	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
EXOG	EIF2B2	0.998	0.028	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GMPPA	EIF2B5	0.981	0.078	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
EIF2B2	PTAFR	0.977		bioplex3_WMM bioplex3_HCT116 WMM_only
EXOG	EIF2B1	0.97	0.048	bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
SPN	EIF2B1	0.969	0.054	bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 bioplex_WMM
EXOG	EIF2B5	0.969	0.044	bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
EIF2B4	PTAFR	0.968		bioplex3_WMM bioplex3_HCT116 WMM_only
EIF2B2	SPN	0.962	0.042	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PTAFR	EIF2B5	0.959		bioplex3_WMM bioplex3_HCT116 WMM_only
EIF2B4	SPN	0.949	0.074	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SPN	EIF2B5	0.94	0.052	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EIF2B4	EXOG	0.461	0.044	bioplex_WMM bioplex3_WMM WMM_only
GMPPA	EIF2B2	0.238	0.076	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
GMPPA	EXOG	0.164	0.02	bioplex_WMM bioplex3_WMM WMM_only
EIF2B4	GMPPA	0.068	0.026	bioplex_WMM bioplex3_WMM WMM_only
GMPPA	EIF2B1	0.044	0.062	bioplex_WMM bioplex3_WMM fraction
PTAFR	EIF2B1	0.021		bioplex3_WMM bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
EIF2B2	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08680.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EIF2B1	huMAP3_08485.1 huMAP3_08680.1 huMAP3_08968.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1
EIF2B4	huMAP3_00951.1 huMAP3_03018.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
GMPPA	huMAP3_01176.1 huMAP3_01694.1 huMAP3_04428.1 huMAP3_05572.1 huMAP3_07434.1 huMAP3_08136.1 huMAP3_08680.1 huMAP3_09338.1 huMAP3_09461.1 huMAP3_09879.1 huMAP3_12121.1 huMAP3_12737.1 huMAP3_14794.1
EXOG	huMAP3_02090.1 huMAP3_02469.1 huMAP3_02659.1 huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09053.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11700.1
PTAFR	huMAP3_02469.1 huMAP3_02659.1 huMAP3_07141.1 huMAP3_08184.1 huMAP3_08680.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_10287.1 huMAP3_10530.1
SPN	huMAP3_02351.1 huMAP3_02659.1 huMAP3_03078.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08370.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
EIF2B5	huMAP3_08184.1 huMAP3_08570.1 huMAP3_08680.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09399.1 huMAP3_09406.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_11977.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09338.1