hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09352.1
Complex Portal: CPX-18802
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMDT1 | Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial) | 5 | UniProt NCBI |
| MCUB | Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B) | 5 | UniProt NCBI |
| IL2RA | Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6473 | 3.41705576683e-05 | 0.666666666667 | SMDT1 MCUB | mitochondrial calcium uniporter complex |
| REAC:R-HSA-8949664 | 0.000817692256233 | 0.666666666667 | SMDT1 MCUB | Processing of SMDT1 |
| REAC:R-HSA-8949215 | 0.00157362645287 | 0.666666666667 | SMDT1 MCUB | Mitochondrial calcium ion transport |
| GO:1990246 | 0.0210651876021 | 0.666666666667 | SMDT1 MCUB | uniplex complex |
| CORUM:1707 | 0.0499402709677 | 0.333333333333 | IL2RA | IL2-IL2RA-IL2RB complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SMDT1 | MCUB | 0.986 | 0.15 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| MCUB | IL2RA | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SMDT1 | IL2RA | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SMDT1 | huMAP3_01161.1 huMAP3_05571.1 huMAP3_09197.1 huMAP3_09352.1 |
| MCUB | huMAP3_01161.1 huMAP3_08275.1 huMAP3_09197.1 huMAP3_09352.1 |
| IL2RA | huMAP3_08275.1 huMAP3_08478.1 huMAP3_09197.1 huMAP3_09352.1 huMAP3_11943.1 huMAP3_12565.1 |