hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09358.1
Complex Portal: CPX-22275
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) | 5 | UniProt NCBI |
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | 5 | UniProt NCBI |
| IRS2 | Insulin receptor substrate 2 (IRS-2) | 5 | UniProt NCBI |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | 5 | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | 5 | UniProt NCBI |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | 5 | UniProt NCBI |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8853659 | 1.39813249167e-17 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | RET signaling |
| KEGG:04930 | 4.1581600334e-17 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Type II diabetes mellitus |
| WP:WP4582 | 4.33145088205e-17 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Cancer immunotherapy by CTLA4 blockade |
| KEGG:04923 | 5.96002938121e-17 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Regulation of lipolysis in adipocytes |
| GO:0097651 | 1.81186556753e-16 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phosphatidylinositol 3-kinase complex, class I |
| GO:0005943 | 1.81186556753e-16 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phosphatidylinositol 3-kinase complex, class IA |
| KEGG:04213 | 3.27557350693e-16 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-2219530 | 6.85979099376e-16 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP3879 | 2.54239927548e-15 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-912631 | 2.72009540098e-15 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Regulation of signaling by CBL |
| REAC:R-HSA-912526 | 5.43955193824e-15 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Interleukin receptor SHC signaling |
| KEGG:04211 | 6.43130579194e-15 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Longevity regulating pathway |
| REAC:R-HSA-6811558 | 1.23590232867e-14 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 1.50141587243e-14 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-198203 | 1.53877147893e-14 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | PI3K/AKT activation |
| KEGG:04960 | 1.60213031118e-14 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Aldosterone-regulated sodium reabsorption |
| REAC:R-HSA-199418 | 2.38805850724e-14 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Negative regulation of the PI3K/AKT network |
| KEGG:04931 | 2.55875177383e-14 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Insulin resistance |
| KEGG:04935 | 2.96068753634e-14 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Growth hormone synthesis, secretion and action |
| REAC:R-HSA-9027276 | 4.10292245564e-14 | 0.714285714286 | IRS2 PIK3CD PIK3R1 PIK3CB PIK3CA | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| KEGG:04973 | 4.3783417459e-14 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Carbohydrate digestion and absorption |
| WP:WP3937 | 6.29638920224e-14 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Microglia pathogen phagocytosis pathway |
| KEGG:04068 | 7.14303931e-14 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | FoxO signaling pathway |
| KEGG:04152 | 7.14303931e-14 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | AMPK signaling pathway |
| REAC:R-HSA-451927 | 1.10947002636e-13 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Interleukin-2 family signaling |
| WP:WP3915 | 1.32078018611e-13 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Angiopoietin like protein 8 regulatory pathway |
| KEGG:04910 | 1.56160316567e-13 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Insulin signaling pathway |
| KEGG:04929 | 2.19577225575e-13 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | GnRH secretion |
| KEGG:04932 | 3.15558911241e-13 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Non-alcoholic fatty liver disease |
| REAC:R-HSA-512988 | 3.26707355154e-13 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| WP:WP4539 | 3.30286905951e-13 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04370 | 4.85333682413e-13 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | VEGF signaling pathway |
| WP:WP4396 | 4.93694422163e-13 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Nonalcoholic fatty liver disease |
| KEGG:05206 | 4.94223806221e-13 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | MicroRNAs in cancer |
| KEGG:05213 | 5.48605800728e-13 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Endometrial cancer |
| KEGG:04664 | 6.18604188538e-13 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Fc epsilon RI signaling pathway |
| WP:WP481 | 6.70886873033e-13 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Insulin signaling |
| KEGG:04140 | 7.19808749655e-13 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Autophagy - animal |
| REAC:R-HSA-1660499 | 1.07471635021e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Synthesis of PIPs at the plasma membrane |
| KEGG:05221 | 1.21367427392e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Acute myeloid leukemia |
| KEGG:05218 | 1.65559366756e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Melanoma |
| KEGG:04917 | 1.65559366756e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Prolactin signaling pathway |
| WP:WP4205 | 1.69659781663e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | MET in type 1 papillary renal cell carcinoma |
| WP:WP4155 | 1.69659781663e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Endometrial cancer |
| WP:WP5293 | 2.10634049714e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Acute myeloid leukemia |
| KEGG:05211 | 2.224109033e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Renal cell carcinoma |
| WP:WP4685 | 2.34024058657e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Melanoma |
| WP:WP1403 | 2.59538678949e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | AMP activated protein kinase signaling |
| KEGG:05230 | 2.68684482259e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Central carbon metabolism in cancer |
| KEGG:05223 | 2.94668854344e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Non-small cell lung cancer |
| KEGG:05214 | 2.94668854344e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Glioma |
| KEGG:04662 | 2.94668854344e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | B cell receptor signaling pathway |
| KEGG:04750 | 3.22713550181e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Inflammatory mediator regulation of TRP channels |
| KEGG:01524 | 3.52947159255e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Platinum drug resistance |
| KEGG:05212 | 4.20525258609e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Pancreatic cancer |
| GO:0005942 | 4.57917841634e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phosphatidylinositol 3-kinase complex |
| WP:WP4255 | 4.6630386595e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Non small cell lung cancer |
| KEGG:01521 | 4.98553521049e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 4.98553521049e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Chronic myeloid leukemia |
| WP:WP1544 | 5.60071704843e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04012 | 5.88285770168e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | ErbB signaling pathway |
| KEGG:05100 | 5.88285770168e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Bacterial invasion of epithelial cells |
| KEGG:05210 | 6.91085293236e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Colorectal cancer |
| KEGG:05235 | 8.08431017814e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| REAC:R-HSA-9006335 | 8.50873618689e-12 | 0.714285714286 | IRS2 PIK3CD PIK3R1 PIK3CB PIK3CA | Signaling by Erythropoietin |
| KEGG:04914 | 9.4192385611e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Progesterone-mediated oocyte maturation |
| KEGG:01522 | 9.4192385611e-12 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Endocrine resistance |
| KEGG:05231 | 1.01526068226e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Choline metabolism in cancer |
| KEGG:04070 | 1.17625880969e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Phosphatidylinositol signaling system |
| KEGG:04625 | 1.17625880969e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | C-type lectin receptor signaling pathway |
| KEGG:05222 | 1.26440368516e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Small cell lung cancer |
| KEGG:04670 | 1.26440368516e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Leukocyte transendothelial migration |
| KEGG:05146 | 1.26440368516e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Amoebiasis |
| WP:WP4806 | 1.29788652537e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04620 | 1.357983161e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Toll-like receptor signaling pathway |
| KEGG:04933 | 1.357983161e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05142 | 1.45726186837e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Chagas disease |
| WP:WP673 | 1.51519162816e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | ErbB signaling pathway |
| WP:WP4263 | 1.51519162816e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-1483255 | 1.56148526259e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | PI Metabolism |
| KEGG:04725 | 1.56251397498e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Cholinergic synapse |
| KEGG:05215 | 1.67402341087e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Prostate cancer |
| KEGG:04666 | 1.67402341087e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Fc gamma R-mediated phagocytosis |
| WP:WP75 | 1.76199227103e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Toll like receptor signaling pathway |
| KEGG:04915 | 1.91700017459e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Estrogen signaling pathway |
| WP:WP2059 | 2.03934296938e-11 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 2.03934296938e-11 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Alzheimer 39 s disease |
| KEGG:04668 | 2.33608042821e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | TNF signaling pathway |
| WP:WP4658 | 2.71175432615e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Small cell lung cancer |
| KEGG:04611 | 2.82883914857e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Platelet activation |
| KEGG:04066 | 3.01116725884e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | HIF-1 signaling pathway |
| KEGG:04722 | 3.20318044424e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Neurotrophin signaling pathway |
| KEGG:04660 | 3.84146365171e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | T cell receptor signaling pathway |
| KEGG:04071 | 3.84146365171e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Sphingolipid signaling pathway |
| WP:WP4829 | 4.05692146329e-11 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | mBDNF and proBDNF regulation of GABA neurotransmission |
| REAC:R-HSA-1257604 | 4.23102586458e-11 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | PIP3 activates AKT signaling |
| KEGG:04919 | 4.32321505287e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Thyroid hormone signaling pathway |
| WP:WP3844 | 4.86774965419e-11 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| KEGG:04926 | 5.13951095219e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Relaxin signaling pathway |
| KEGG:04650 | 5.43857890596e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Natural killer cell mediated cytotoxicity |
| REAC:R-HSA-109704 | 5.90198683103e-11 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | PI3K Cascade |
| REAC:R-HSA-114604 | 5.90198683103e-11 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | GPVI-mediated activation cascade |
| WP:WP710 | 5.90989794225e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | DNA damage response only ATM dependent |
| WP:WP4787 | 6.27889607993e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Osteoblast differentiation and related diseases |
| KEGG:04380 | 7.55411997357e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Osteoclast differentiation |
| KEGG:05135 | 7.55411997357e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Yersinia infection |
| KEGG:04072 | 7.9656924802e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Phospholipase D signaling pathway |
| KEGG:05418 | 8.395774624e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Fluid shear stress and atherosclerosis |
| KEGG:04550 | 9.80376106324e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04210 | 9.80376106324e-11 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Apoptosis |
| REAC:R-HSA-112399 | 1.04147201904e-10 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | IRS-mediated signalling |
| REAC:R-HSA-9006925 | 1.15452446976e-10 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Intracellular signaling by second messengers |
| KEGG:05162 | 1.19822504948e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Measles |
| KEGG:05017 | 1.2585653958e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Spinocerebellar ataxia |
| WP:WP4217 | 1.38245170218e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Ebola virus infection in host |
| KEGG:05224 | 1.3868583733e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Breast cancer |
| KEGG:05160 | 1.67628220838e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Hepatitis C |
| KEGG:05226 | 1.67628220838e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Gastric cancer |
| KEGG:04630 | 1.67628220838e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | JAK-STAT signaling pathway |
| REAC:R-HSA-2428924 | 1.73392066592e-10 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | IGF1R signaling cascade |
| REAC:R-HSA-2404192 | 1.73392066592e-10 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-2428928 | 1.73392066592e-10 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | IRS-related events triggered by IGF1R |
| WP:WP3929 | 1.79011538895e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Chemokine signaling pathway |
| KEGG:05010 | 1.81130942353e-10 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Alzheimer disease |
| WP:WP4630 | 1.97902283749e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Measles virus infection |
| KEGG:04062 | 2.4073823255e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Chemokine signaling pathway |
| KEGG:04218 | 2.51502683233e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Cellular senescence |
| WP:WP51 | 2.52512580033e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Regulation of actin cytoskeleton |
| WP:WP4566 | 2.55659362725e-10 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-74751 | 2.75327037387e-10 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | Insulin receptor signalling cascade |
| GO:0046854 | 2.77276818354e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phosphatidylinositol phosphate biosynthetic process |
| KEGG:05164 | 2.98657575397e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Influenza A |
| WP:WP4239 | 3.04755311062e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04150 | 3.52955847977e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | mTOR signaling pathway |
| KEGG:05161 | 3.52955847977e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Hepatitis B |
| KEGG:04613 | 3.67743425363e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Neutrophil extracellular trap formation |
| WP:WP4666 | 3.8243228151e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Hepatitis B infection |
| KEGG:04360 | 4.49653481698e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Axon guidance |
| WP:WP395 | 5.22949016902e-10 | 0.714285714286 | PIK3CD PIK3R1 PIK3R2 PIK3CA IRS2 | IL 4 signaling pathway |
| KEGG:04024 | 5.25642055118e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | cAMP signaling pathway |
| KEGG:05225 | 5.46223130608e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Hepatocellular carcinoma |
| WP:WP4223 | 5.87758795214e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Ras signaling |
| KEGG:05207 | 6.35388039335e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Chemical carcinogenesis - receptor activation |
| KEGG:04015 | 7.09943130145e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Rap1 signaling pathway |
| REAC:R-HSA-2730905 | 7.48865454753e-10 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Role of LAT2/NTAL/LAB on calcium mobilization |
| REAC:R-HSA-9673767 | 7.48865454753e-10 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants |
| REAC:R-HSA-9673770 | 7.48865454753e-10 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by PDGFRA extracellular domain mutants |
| KEGG:05167 | 7.63584273563e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04510 | 9.12629828154e-10 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Focal adhesion |
| KEGG:05417 | 1.16136422177e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Lipid and atherosclerosis |
| KEGG:05169 | 1.16136422177e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Epstein-Barr virus infection |
| KEGG:05205 | 1.24198456375e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Proteoglycans in cancer |
| KEGG:05415 | 1.24198456375e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Diabetic cardiomyopathy |
| REAC:R-HSA-5663202 | 1.24529577514e-09 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Diseases of signal transduction by growth factor receptors and second messengers |
| KEGG:04014 | 1.32721213953e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Ras signaling pathway |
| KEGG:05203 | 1.41725493834e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Viral carcinogenesis |
| WP:WP306 | 1.58387568002e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Focal adhesion |
| KEGG:05163 | 1.71845966119e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Human cytomegalovirus infection |
| KEGG:05170 | 1.77349219523e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Human immunodeficiency virus 1 infection |
| KEGG:04810 | 1.88796717397e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Regulation of actin cytoskeleton |
| REAC:R-HSA-449147 | 1.97283683132e-09 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Signaling by Interleukins |
| KEGG:05166 | 2.07117322276e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Human T-cell leukemia virus 1 infection |
| KEGG:05208 | 2.33826700981e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Chemical carcinogenesis - reactive oxygen species |
| KEGG:05171 | 2.33826700981e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Coronavirus disease - COVID-19 |
| WP:WP2037 | 3.28495088282e-09 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | Prolactin signaling pathway |
| REAC:R-HSA-1483257 | 3.76199585611e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Phospholipid metabolism |
| REAC:R-HSA-74752 | 4.71190966523e-09 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by Insulin receptor |
| KEGG:05131 | 4.7414365363e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Shigellosis |
| REAC:R-HSA-210993 | 4.86362738832e-09 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Tie2 Signaling |
| GO:0052742 | 6.34970501079e-09 | 0.714285714286 | PIK3R3 PIK3CD PIK3R1 PIK3CB PIK3CA | phosphatidylinositol kinase activity |
| WP:WP2261 | 6.71272926168e-09 | 0.714285714286 | PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | Glioblastoma signaling pathways |
| KEGG:05020 | 7.52364288884e-09 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Prion disease |
| REAC:R-HSA-422475 | 7.8832404951e-09 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Axon guidance |
| REAC:R-HSA-9671555 | 8.47738354883e-09 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by PDGFR in disease |
| REAC:R-HSA-9669938 | 8.47738354883e-09 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Signaling by KIT in disease |
| REAC:R-HSA-9670439 | 8.47738354883e-09 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
| REAC:R-HSA-9675108 | 1.02059347607e-08 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Nervous system development |
| WP:WP3932 | 1.40545569152e-08 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD IRS2 PIK3CB | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-389357 | 1.72490220596e-08 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | CD28 dependent PI3K/Akt signaling |
| WP:WP5420 | 1.91399805659e-08 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | ADHD and autism ASD linked metabolic pathways and SNP |
| KEGG:04151 | 1.91616348863e-08 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | PI3K-Akt signaling pathway |
| REAC:R-HSA-373753 | 2.13041126881e-08 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Nephrin family interactions |
| REAC:R-HSA-2029485 | 2.13041126881e-08 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Role of phospholipids in phagocytosis |
| KEGG:05165 | 2.26329306696e-08 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Human papillomavirus infection |
| WP:WP4172 | 2.40209040189e-08 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | PI3K Akt signaling pathway |
| REAC:R-HSA-201556 | 2.60340792443e-08 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by ALK |
| REAC:R-HSA-2424491 | 2.60340792443e-08 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | DAP12 signaling |
| REAC:R-HSA-1280215 | 4.0895403223e-08 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Cytokine Signaling in Immune system |
| GO:0006661 | 4.65038977351e-08 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phosphatidylinositol biosynthetic process |
| REAC:R-HSA-187037 | 4.67390956289e-08 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-186763 | 5.31720535121e-08 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Downstream signal transduction |
| GO:0016303 | 6.44235965654e-08 | 0.571428571429 | PIK3R3 PIK3CD PIK3CB PIK3CA | 1-phosphatidylinositol-3-kinase activity |
| WP:WP524 | 6.79451505868e-08 | 0.571428571429 | PIK3CD PIK3R2 PIK3CB PIK3CA | G13 signaling pathway |
| GO:0001727 | 7.1034375646e-08 | 0.714285714286 | PIK3R3 PIK3CD PIK3R1 PIK3CB PIK3CA | lipid kinase activity |
| WP:WP4564 | 7.69918368201e-08 | 0.571428571429 | PIK3R3 PIK3CD PIK3CB PIK3CA | Neural crest cell migration during development |
| REAC:R-HSA-389356 | 8.44325418323e-08 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | CD28 co-stimulation |
| REAC:R-HSA-2172127 | 8.44325418323e-08 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | DAP12 interactions |
| KEGG:05168 | 8.61419172836e-08 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Herpes simplex virus 1 infection |
| WP:WP4565 | 9.77598775957e-08 | 0.571428571429 | PIK3R3 PIK3CD PIK3CB PIK3CA | Neural crest cell migration in cancer |
| REAC:R-HSA-166520 | 1.06260765192e-07 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by NTRKs |
| WP:WP4262 | 1.0849730477e-07 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA PIK3CD | Breast cancer pathway |
| GO:0046488 | 1.20570564917e-07 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phosphatidylinositol metabolic process |
| REAC:R-HSA-1266695 | 1.277713074e-07 | 0.571428571429 | PIK3R3 PIK3R1 IRS2 PIK3R2 | Interleukin-7 signaling |
| REAC:R-HSA-1433557 | 2.09160668344e-07 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Signaling by SCF-KIT |
| GO:0019898 | 2.5163311414e-07 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | extrinsic component of membrane |
| KEGG:05200 | 2.78188337783e-07 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Pathways in cancer |
| WP:WP585 | 4.13716175819e-07 | 0.571428571429 | PIK3R1 PIK3R2 IRS2 PIK3CD | Interferon type I signaling pathways |
| REAC:R-HSA-1266738 | 4.40434374571e-07 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Developmental Biology |
| WP:WP5191 | 5.11313310849e-07 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution |
| REAC:R-HSA-186797 | 6.89554075554e-07 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by PDGF |
| GO:0046474 | 7.05430027436e-07 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | glycerophospholipid biosynthetic process |
| GO:0007169 | 7.45253048015e-07 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | transmembrane receptor protein tyrosine kinase signaling pathway |
| REAC:R-HSA-9006934 | 8.52838387165e-07 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3R3 IRS2 PIK3CB | Signaling by Receptor Tyrosine Kinases |
| GO:0043491 | 1.31401039577e-06 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| REAC:R-HSA-388841 | 1.39776635892e-06 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Costimulation by the CD28 family |
| WP:WP4674 | 1.51320063051e-06 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Head and neck squamous cell carcinoma |
| GO:0008654 | 1.54492161377e-06 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phospholipid biosynthetic process |
| GO:0045017 | 1.92417133606e-06 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | glycerolipid biosynthetic process |
| REAC:R-HSA-9009391 | 1.97234251471e-06 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-5673001 | 2.4938543872e-06 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | RAF/MAP kinase cascade |
| REAC:R-HSA-76002 | 2.73811952949e-06 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Platelet activation, signaling and aggregation |
| REAC:R-HSA-5684996 | 2.73811952949e-06 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | MAPK1/MAPK3 signaling |
| GO:0008286 | 4.50697143692e-06 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | insulin receptor signaling pathway |
| REAC:R-HSA-2029480 | 5.03005208045e-06 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-5683057 | 5.45947084881e-06 | 0.714285714286 | IRS2 PIK3R1 PIK3R2 PIK3CB PIK3CA | MAPK family signaling cascades |
| GO:0006650 | 5.60162003734e-06 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | glycerophospholipid metabolic process |
| REAC:R-HSA-9013404 | 6.47472263115e-06 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | RAC2 GTPase cycle |
| REAC:R-HSA-556833 | 6.88986219418e-06 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Metabolism of lipids |
| WP:WP4483 | 6.92358935837e-06 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Relationship between inflammation COX 2 and EGFR |
| REAC:R-HSA-4420097 | 7.83760919267e-06 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | VEGFA-VEGFR2 Pathway |
| WP:WP4659 | 7.84365090311e-06 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Gastrin signaling pathway |
| REAC:R-HSA-202424 | 8.59438461413e-06 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Downstream TCR signaling |
| REAC:R-HSA-194138 | 1.11948091005e-05 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by VEGF |
| REAC:R-HSA-1280218 | 1.12246516662e-05 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Adaptive Immune System |
| GO:0001775 | 1.3847485372e-05 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | cell activation |
| GO:0007167 | 1.47974597074e-05 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | enzyme-linked receptor protein signaling pathway |
| GO:0061695 | 1.48074113953e-05 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-202733 | 1.49262059801e-05 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Cell surface interactions at the vascular wall |
| REAC:R-HSA-1500931 | 1.55267215714e-05 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Cell-Cell communication |
| REAC:R-HSA-202403 | 1.7436993887e-05 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | TCR signaling |
| WP:WP2533 | 1.77389368121e-05 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Glycerophospholipid biosynthetic pathway |
| GO:0006644 | 1.87476889423e-05 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | phospholipid metabolic process |
| WP:WP4481 | 1.98635261751e-05 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Resistin as a regulator of inflammation |
| GO:0046486 | 2.03810553115e-05 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | glycerolipid metabolic process |
| CORUM:3133 | 2.05265451394e-05 | 0.285714285714 | PIK3CA PIK3R1 | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| REAC:R-HSA-2454202 | 2.10045421187e-05 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CB PIK3CA | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-1643685 | 2.13952487064e-05 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Disease |
| WP:WP4871 | 3.00494857537e-05 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP244 | 3.00494857537e-05 | 0.428571428571 | PIK3R1 IRS2 PIK3R2 | Alpha 6 beta 4 signaling pathway |
| GO:0044255 | 3.26099662802e-05 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | cellular lipid metabolic process |
| GO:0035005 | 3.362820138e-05 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| REAC:R-HSA-416476 | 4.09568344531e-05 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | G alpha (q) signalling events |
| REAC:R-HSA-9680350 | 4.24987071653e-05 | 0.428571428571 | PIK3R1 PIK3CB PIK3CA | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-168256 | 5.23329417645e-05 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Immune System |
| GO:0032869 | 5.76456118541e-05 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | cellular response to insulin stimulus |
| WP:WP4971 | 6.94071614722e-05 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Phosphoinositides metabolism |
| WP:WP286 | 6.94071614722e-05 | 0.428571428571 | PIK3R1 PIK3CD PIK3R2 | IL 3 signaling pathway |
| WP:WP5411 | 6.94071614722e-05 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Phosphatidyl inositol phosphate pathway |
| GO:0032868 | 8.34081096788e-05 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | response to insulin |
| GO:0042113 | 8.64202075381e-05 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 IRS2 PIK3CD | B cell activation |
| REAC:R-HSA-9013149 | 8.69731520059e-05 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | RAC1 GTPase cycle |
| GO:0071495 | 0.00011177579938 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | cellular response to endogenous stimulus |
| KEGG:00562 | 0.000151447938236 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Inositol phosphate metabolism |
| GO:0006629 | 0.000151865805802 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | lipid metabolic process |
| WP:WP2032 | 0.000158191102083 | 0.428571428571 | PIK3R1 PIK3CA PIK3R2 | Thyroid stimulating hormone TSH signaling pathway |
| REAC:R-HSA-8939211 | 0.000163659671708 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | ESR-mediated signaling |
| HP:0030381 | 0.000166647713928 | 0.285714285714 | PIK3CD PIK3R1 | Increased proportion of transitional B cells |
| HP:0030379 | 0.000166647713928 | 0.285714285714 | PIK3CD PIK3R1 | Abnormal proportion of transitional B cells |
| REAC:R-HSA-162582 | 0.000187648625697 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | Signal Transduction |
| GO:0009719 | 0.000203698303088 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | response to endogenous stimulus |
| GO:0090407 | 0.000216989356502 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | organophosphate biosynthetic process |
| REAC:R-HSA-109582 | 0.000225025549393 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Hemostasis |
| GO:0046649 | 0.000252464442077 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD IRS2 PIK3R3 | lymphocyte activation |
| GO:0071375 | 0.000253541587871 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | cellular response to peptide hormone stimulus |
| REAC:R-HSA-8851907 | 0.000380832872101 | 0.285714285714 | PIK3CA PIK3R1 | MET activates PI3K/AKT signaling |
| REAC:R-HSA-9028335 | 0.000380832872101 | 0.285714285714 | PIK3CA PIK3R1 | Activated NTRK2 signals through PI3K |
| GO:0036092 | 0.00040312426486 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | phosphatidylinositol-3-phosphate biosynthetic process |
| HP:0011956 | 0.000499829101057 | 0.285714285714 | PIK3CD PIK3R1 | Intestinal lymphoid nodular hyperplasia |
| REAC:R-HSA-9006931 | 0.000518975612289 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Signaling by Nuclear Receptors |
| GO:0043434 | 0.000571035096759 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | response to peptide hormone |
| REAC:R-HSA-9603381 | 0.000571118993049 | 0.285714285714 | PIK3CA PIK3R1 | Activated NTRK3 signals through PI3K |
| GO:0008610 | 0.000596054941006 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | lipid biosynthetic process |
| GO:1901653 | 0.000613633770441 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | cellular response to peptide |
| REAC:R-HSA-1250342 | 0.000799384186586 | 0.285714285714 | PIK3CA PIK3R1 | PI3K events in ERBB4 signaling |
| GO:0045321 | 0.000839757682363 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD IRS2 PIK3R3 | leukocyte activation |
| REAC:R-HSA-5655291 | 0.00106560242715 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR4 in disease |
| GO:0046935 | 0.00122180600483 | 0.428571428571 | PIK3R1 PIK3R2 PIK3R3 | 1-phosphatidylinositol-3-kinase regulator activity |
| GO:1901652 | 0.00152564787471 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | response to peptide |
| GO:0030183 | 0.00159023569175 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CD PIK3R2 | B cell differentiation |
| WP:WP22 | 0.00161645869838 | 0.285714285714 | PIK3R2 PIK3R1 | IL 9 signaling pathway |
| REAC:R-HSA-1963642 | 0.00171179400053 | 0.285714285714 | PIK3CA PIK3R1 | PI3K events in ERBB2 signaling |
| REAC:R-HSA-5654710 | 0.00171179400053 | 0.285714285714 | PIK3CA PIK3R1 | PI-3K cascade:FGFR3 |
| WP:WP2380 | 0.00179934668905 | 0.428571428571 | PIK3R1 IRS2 PIK3R2 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-5654689 | 0.00209171533568 | 0.285714285714 | PIK3CA PIK3R1 | PI-3K cascade:FGFR1 |
| WP:WP3935 | 0.00213062125732 | 0.285714285714 | IRS2 PIK3R3 | Leptin insulin signaling overlap |
| WP:WP205 | 0.00241415310408 | 0.285714285714 | PIK3R2 PIK3R1 | IL 7 signaling pathway |
| HP:0031693 | 0.00249743559672 | 0.285714285714 | PIK3CD PIK3R1 | Severe Epstein Barr virus infection |
| REAC:R-HSA-388396 | 0.0024992370404 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | GPCR downstream signalling |
| REAC:R-HSA-5637810 | 0.00250948572249 | 0.285714285714 | PIK3CA PIK3R1 | Constitutive Signaling by EGFRvIII |
| REAC:R-HSA-5637812 | 0.00250948572249 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by EGFRvIII in Cancer |
| REAC:R-HSA-5654695 | 0.00250948572249 | 0.285714285714 | PIK3CA PIK3R1 | PI-3K cascade:FGFR2 |
| REAC:R-HSA-5654720 | 0.00250948572249 | 0.285714285714 | PIK3CA PIK3R1 | PI-3K cascade:FGFR4 |
| REAC:R-HSA-9034015 | 0.00296507918884 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by NTRK3 (TRKC) |
| REAC:R-HSA-9665348 | 0.00296507918884 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by ERBB2 ECD mutants |
| REAC:R-HSA-9703648 | 0.00296507918884 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FLT3 ITD and TKD mutants |
| REAC:R-HSA-9012999 | 0.00330867736449 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | RHO GTPase cycle |
| REAC:R-HSA-5655332 | 0.00345846977329 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR3 in disease |
| REAC:R-HSA-5654708 | 0.00345846977329 | 0.285714285714 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR3 |
| REAC:R-HSA-180292 | 0.00345846977329 | 0.285714285714 | PIK3CA PIK3R1 | GAB1 signalosome |
| WP:WP5181 | 0.00372433499977 | 0.285714285714 | IRS2 PIK3R1 | Roles of ceramides in development of insulin resistance |
| REAC:R-HSA-1430728 | 0.00383440417299 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | Metabolism |
| REAC:R-HSA-372790 | 0.00417839245303 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Signaling by GPCR |
| GO:0042110 | 0.00442466612135 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA PIK3CD | T cell activation |
| REAC:R-HSA-1236382 | 0.00455853850403 | 0.285714285714 | PIK3CA PIK3R1 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| REAC:R-HSA-5654687 | 0.00455853850403 | 0.285714285714 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR1 |
| REAC:R-HSA-5654716 | 0.00455853850403 | 0.285714285714 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR4 |
| REAC:R-HSA-9703465 | 0.00455853850403 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FLT3 fusion proteins |
| REAC:R-HSA-5637815 | 0.00455853850403 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| REAC:R-HSA-1839117 | 0.00455853850403 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by cytosolic FGFR1 fusion mutants |
| REAC:R-HSA-5654696 | 0.00455853850403 | 0.285714285714 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR2 |
| GO:0019637 | 0.00544685045135 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | organophosphate metabolic process |
| WP:WP3972 | 0.00575727775656 | 0.285714285714 | PIK3CA PIK3R1 | PDGFR beta pathway |
| REAC:R-HSA-9664565 | 0.00580948443663 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by ERBB2 KD Mutants |
| REAC:R-HSA-9006115 | 0.00580948443663 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by NTRK2 (TRKB) |
| GO:0071417 | 0.00611945313393 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | cellular response to organonitrogen compound |
| KEGG:05132 | 0.00620117831779 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Salmonella infection |
| GO:0002376 | 0.00623460731967 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | immune system process |
| REAC:R-HSA-1227990 | 0.0064914715634 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by ERBB2 in Cancer |
| GO:1990234 | 0.0074086488747 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | transferase complex |
| HP:0025352 | 0.00748547207011 | 0.285714285714 | PIK3CA PIK3R2 | Typically de novo |
| HP:0011110 | 0.00748547207011 | 0.285714285714 | PIK3CD PIK3R1 | Recurrent tonsillitis |
| HP:0031692 | 0.00748547207011 | 0.285714285714 | PIK3CD PIK3R1 | Severe cytomegalovirus infection |
| HP:0200117 | 0.00748547207011 | 0.285714285714 | PIK3CD PIK3R1 | Recurrent upper and lower respiratory tract infections |
| GO:0032870 | 0.00772880583459 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | cellular response to hormone stimulus |
| REAC:R-HSA-1643713 | 0.00796834465067 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by EGFR in Cancer |
| WP:WP127 | 0.00822793960978 | 0.285714285714 | PIK3R2 PIK3R1 | IL 5 signaling pathway |
| REAC:R-HSA-983695 | 0.0087631788483 | 0.285714285714 | PIK3CD PIK3R1 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| HP:0002007 | 0.00979738131748 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CA PIK3CD | Frontal bossing |
| HP:0011218 | 0.0101272255372 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CA PIK3CD | Abnormal shape of the frontal region |
| HP:0430000 | 0.0102389831821 | 0.571428571429 | PIK3R1 PIK3R2 PIK3CA PIK3CD | Abnormal frontal bone morphology |
| REAC:R-HSA-1839124 | 0.0104655132242 | 0.285714285714 | PIK3CA PIK3R1 | FGFR1 mutant receptor activation |
| REAC:R-HSA-9682385 | 0.0104655132242 | 0.285714285714 | PIK3CA PIK3R1 | FLT3 signaling in disease |
| WP:WP4558 | 0.010518614161 | 0.285714285714 | PIK3CA PIK3R1 | Overview of interferons mediated signaling pathway |
| WP:WP2828 | 0.010518614161 | 0.285714285714 | PIK3R2 PIK3R1 | Bladder cancer |
| GO:1901699 | 0.0114936933491 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | cellular response to nitrogen compound |
| WP:WP2332 | 0.0124193659106 | 0.285714285714 | PIK3R2 PIK3R1 | Interleukin 11 signaling pathway |
| HP:0032170 | 0.0129659395038 | 0.285714285714 | PIK3CD PIK3R1 | Severe varicella zoster infection |
| WP:WP364 | 0.0130876944592 | 0.285714285714 | PIK3R2 PIK3R1 | IL6 signaling pathway |
| REAC:R-HSA-5654741 | 0.0143201223364 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR3 |
| GO:0042981 | 0.0147464161941 | 0.857142857143 | PIK3R1 PIK3R3 PIK3CA PIK3CD IRS2 PIK3CB | regulation of apoptotic process |
| GO:0007166 | 0.0151539774256 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | cell surface receptor signaling pathway |
| REAC:R-HSA-5655302 | 0.0153773615715 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR1 in disease |
| REAC:R-HSA-5654743 | 0.0153773615715 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR4 |
| GO:0001784 | 0.016587316136 | 0.428571428571 | PIK3R1 PIK3R2 PIK3R3 | phosphotyrosine residue binding |
| WP:WP61 | 0.0166893818359 | 0.285714285714 | PIK3R2 PIK3R1 | Notch signaling pathway |
| GO:0006796 | 0.0172514559342 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | phosphate-containing compound metabolic process |
| REAC:R-HSA-5655253 | 0.0176039638163 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR2 in disease |
| WP:WP2018 | 0.0182511871587 | 0.285714285714 | PIK3R2 PIK3R1 | RANKL RANK signaling pathway |
| GO:0009725 | 0.0182760903465 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | response to hormone |
| GO:0043067 | 0.0184020328836 | 0.857142857143 | PIK3R1 PIK3R3 PIK3CA PIK3CD IRS2 PIK3CB | regulation of programmed cell death |
| GO:0006793 | 0.0184635802849 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | phosphorus metabolic process |
| REAC:R-HSA-9607240 | 0.0187732752758 | 0.285714285714 | PIK3CA PIK3R1 | FLT3 Signaling |
| REAC:R-HSA-5654736 | 0.0187732752758 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR1 |
| WP:WP195 | 0.0198820661203 | 0.285714285714 | PIK3R2 PIK3R1 | IL 1 signaling pathway |
| GO:0098796 | 0.0206938362537 | 0.857142857143 | PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3CB | membrane protein complex |
| REAC:R-HSA-194315 | 0.0209047694901 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Signaling by Rho GTPases |
| GO:0043542 | 0.0224390732175 | 0.571428571429 | PIK3R3 PIK3CD PIK3CB PIK3CA | endothelial cell migration |
| WP:WP304 | 0.0224576883083 | 0.285714285714 | PIK3R2 PIK3R1 | Kit receptor signaling pathway |
| REAC:R-HSA-9716542 | 0.0227764210725 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CA PIK3R2 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0038084 | 0.0238580811979 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | vascular endothelial growth factor signaling pathway |
| WP:WP5072 | 0.0242608328425 | 0.285714285714 | PIK3R2 PIK3R1 | Modulators of TCR signaling and T cell activation |
| GO:0030217 | 0.0248063154794 | 0.571428571429 | PIK3R3 PIK3R1 PIK3CD PIK3R2 | T cell differentiation |
| REAC:R-HSA-9013420 | 0.0251789059 | 0.285714285714 | PIK3R2 PIK3R1 | RHOU GTPase cycle |
| REAC:R-HSA-9696273 | 0.0251789059 | 0.285714285714 | PIK3R2 PIK3R1 | RND1 GTPase cycle |
| REAC:R-HSA-9696270 | 0.028001578843 | 0.285714285714 | PIK3R2 PIK3R1 | RND2 GTPase cycle |
| REAC:R-HSA-9696264 | 0.0294686169459 | 0.285714285714 | PIK3R2 PIK3R1 | RND3 GTPase cycle |
| GO:0010243 | 0.0298045233267 | 0.714285714286 | PIK3R3 PIK3R1 PIK3R2 PIK3CA IRS2 | response to organonitrogen compound |
| HP:0040218 | 0.0315332858987 | 0.285714285714 | PIK3CD PIK3R1 | Reduced natural killer cell count |
| WP:WP69 | 0.0321598473831 | 0.285714285714 | PIK3R2 PIK3R1 | T cell receptor signaling pathway |
| REAC:R-HSA-9035034 | 0.0325139680435 | 0.285714285714 | PIK3R2 PIK3R1 | RHOF GTPase cycle |
| REAC:R-HSA-1227986 | 0.0340922297215 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by ERBB2 |
| REAC:R-HSA-1236394 | 0.0340922297215 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by ERBB4 |
| WP:WP3303 | 0.0343057335824 | 0.285714285714 | PIK3CA PIK3R1 | RAC1 PAK1 p38 MMP2 pathway |
| HP:0025539 | 0.0348446257606 | 0.285714285714 | PIK3CD PIK3R1 | Abnormal B cell subset distribution |
| REAC:R-HSA-177929 | 0.0357075146256 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by EGFR |
| WP:WP5094 | 0.0388021990103 | 0.285714285714 | PIK3R2 PIK3R1 | Orexin receptor pathway |
| WP:WP2034 | 0.039968890476 | 0.285714285714 | PIK3R2 PIK3R1 | Leptin signaling pathway |
| GO:0045309 | 0.0411777400956 | 0.428571428571 | PIK3R1 PIK3R2 PIK3R3 | protein phosphorylated amino acid binding |
| GO:0042221 | 0.0437548495009 | 1.0 | PIK3R2 PIK3CB PIK3R3 PIK3CA PIK3CD IRS2 PIK3R1 | response to chemical |
| REAC:R-HSA-9725370 | 0.0461752771557 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by ALK fusions and activated point mutants |
| REAC:R-HSA-9700206 | 0.0461752771557 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by ALK in cancer |
| REAC:R-HSA-1226099 | 0.0461752771557 | 0.285714285714 | PIK3CA PIK3R1 | Signaling by FGFR in disease |
| WP:WP5098 | 0.0473257570206 | 0.285714285714 | PIK3CD PIK3R1 | T cell activation SARS CoV 2 |
| REAC:R-HSA-9013405 | 0.0480490075434 | 0.285714285714 | PIK3R2 PIK3R1 | RHOD GTPase cycle |
| WP:WP5087 | 0.0480568023702 | 0.428571428571 | PIK3CD PIK3CB PIK3CA | Pleural mesothelioma |
| HP:0040089 | 0.0497326121949 | 0.285714285714 | PIK3CD PIK3R1 | Abnormal natural killer cell count |
| WP:WP23 | 0.0499136541057 | 0.285714285714 | PIK3R2 PIK3R1 | B cell receptor signaling pathway |
| CORUM:2574 | 0.0499958217778 | 0.142857142857 | PIK3R1 | CD19-VAV1-PIK3R1 complex |
| CORUM:7361 | 0.0499958217778 | 0.142857142857 | PIK3R1 | ARAF-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIK3CA | PIK3R3 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| PIK3CB | PIK3R1 | 0.999 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () fraction | |
| PIK3CB | PIK3R3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PIK3CA | PIK3R1 | 0.998 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CA | PIK3R2 | 0.998 | 0.295459408904 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CD | PIK3R3 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3CD | PIK3R1 | 0.997 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PIK3CB | PIK3CA | 0.996 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3R2 | PIK3R1 | 0.995 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| PIK3R2 | PIK3R3 | 0.994 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| IRS2 | PIK3R1 | 0.993 | 0.202 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| PIK3CB | PIK3R2 | 0.992 | 0.350883495146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRS2 | PIK3CD | 0.979 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3R3 | PIK3R1 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| IRS2 | PIK3CB | 0.954 | 0.238 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3CA | PIK3CD | 0.869 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| IRS2 | PIK3R3 | 0.868 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IRS2 | PIK3CA | 0.842 | 0.212 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3CB | PIK3CD | 0.838 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3CD | PIK3R2 | 0.141 | 0.13 |
mutually_exclusive (Q92569)
|
bioplex_WMM bioplex3_WMM WMM_only |
| IRS2 | PIK3R2 | 0.041 | 0.342519858782 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes