hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09364.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPR50 | Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain] | 5 | UniProt NCBI |
| SDC2 | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) | 5 | UniProt NCBI |
| USF3 | Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3) | 5 | UniProt NCBI |
| SDC4 | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | 5 | UniProt NCBI |
| SDC1 | Syndecan-1 (SYND1) (CD antigen CD138) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656237 | 0.000931962666506 | 0.5 | SDC1 SDC4 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-3656253 | 0.000931962666506 | 0.5 | SDC1 SDC4 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-9694614 | 0.0013924419067 | 0.5 | SDC1 SDC4 | Attachment and Entry |
| REAC:R-HSA-3560783 | 0.00156635412759 | 0.5 | SDC1 SDC4 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-3560801 | 0.00156635412759 | 0.5 | SDC1 SDC4 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-4420332 | 0.00156635412759 | 0.5 | SDC1 SDC4 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3000170 | 0.00236402400204 | 0.5 | SDC1 SDC4 | Syndecan interactions |
| REAC:R-HSA-2024096 | 0.00236402400204 | 0.5 | SDC1 SDC4 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.00282403231951 | 0.5 | SDC1 SDC4 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.00386628370571 | 0.5 | SDC1 SDC4 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 0.00539805716719 | 0.5 | SDC1 SDC4 | Early SARS-CoV-2 Infection Events |
| KEGG:04512 | 0.00551283411821 | 0.5 | SDC1 SDC4 | ECM-receptor interaction |
| REAC:R-HSA-3560782 | 0.00718390333861 | 0.5 | SDC1 SDC4 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.0079693038543 | 0.5 | SDC1 SDC4 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.00922347264132 | 0.5 | SDC1 SDC4 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 0.0105688559686 | 0.5 | SDC1 SDC4 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-3000171 | 0.0115164156767 | 0.5 | SDC1 SDC4 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-1638091 | 0.012504459305 | 0.5 | SDC1 SDC4 | Heparan sulfate/heparin (HS-GAG) metabolism |
| KEGG:04514 | 0.0133093129958 | 0.5 | SDC1 SDC4 | Cell adhesion molecules |
| KEGG:05418 | 0.0168426929383 | 0.5 | SDC1 SDC4 | Fluid shear stress and atherosclerosis |
| GO:1903553 | 0.0168521501606 | 0.5 | SDC1 SDC4 | positive regulation of extracellular exosome assembly |
| REAC:R-HSA-2187338 | 0.0305753786405 | 0.5 | SDC1 SDC4 | Visual phototransduction |
| KEGG:05205 | 0.0406374666322 | 0.5 | SDC1 SDC4 | Proteoglycans in cancer |
| GO:1903551 | 0.042122686785 | 0.5 | SDC1 SDC4 | regulation of extracellular exosome assembly |
| GO:0071971 | 0.042122686785 | 0.5 | SDC1 SDC4 | extracellular exosome assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SDC2 | SDC4 | 0.999 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SDC2 | USF3 | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPR50 | SDC2 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SDC2 | SDC1 | 0.978 | 0.124 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SDC1 | SDC4 | 0.907 | 0.204 | bioplex_WMM bioplex3_WMM WMM_only |
| USF3 | SDC4 | 0.714 | bioplex3_WMM WMM_only | |
| USF3 | SDC1 | 0.688 | bioplex3_WMM WMM_only | |
| GPR50 | SDC4 | 0.093 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPR50 | USF3 | 0.042 | bioplex3_WMM WMM_only | |
| GPR50 | SDC1 | 0.026 | bioplex3_WMM WMM_only |
Related Complexes