hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09367.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRRG1 | Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1) | 4 | UniProt NCBI |
| TMEM252 | Transmembrane protein 252 | 2 | UniProt NCBI |
| PRRG4 | Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4) | 5 | UniProt NCBI |
| ARRDC1 | Arrestin domain-containing protein 1 (Alpha-arrestin 1) | 5 | UniProt NCBI |
| HECW1 | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | 5 | UniProt NCBI |
| WWOX | WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1) | 5 | UniProt NCBI |
| HECW2 | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | 5 | UniProt NCBI |
| STXBP4 | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | 5 | UniProt NCBI |
| CUEDC1 | CUE domain-containing protein 1 | 3 | UniProt NCBI |
| NDFIP2 | NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413) | 5 | UniProt NCBI |
| TMEM171 | Transmembrane protein 171 | 3 | UniProt NCBI |
| ILDR1 | Immunoglobulin-like domain-containing receptor 1 (Angulin-2) | 5 | UniProt NCBI |
| WBP1 | WW domain-binding protein 1 (WBP-1) | 3 | UniProt NCBI |
| NEDD4L | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | 5 | UniProt NCBI |
| FAIM2 | Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2) | 5 | UniProt NCBI |
| NEDD4 | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | 5 | UniProt NCBI |
| ITCH | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0048814 | 0.00220749165733 | 0.235294117647 | HECW1 NEDD4 NEDD4L HECW2 | regulation of dendrite morphogenesis |
| REAC:R-HSA-1236394 | 0.00505652633168 | 0.176470588235 | ITCH WWOX NEDD4 | Signaling by ERBB4 |
| REAC:R-HSA-1253288 | 0.0114554901828 | 0.117647058824 | NEDD4 ITCH | Downregulation of ERBB4 signaling |
| GO:0050773 | 0.0118093229617 | 0.235294117647 | HECW1 NEDD4 NEDD4L HECW2 | regulation of dendrite development |
| GO:0016567 | 0.0475481045526 | 0.411764705882 | ITCH HECW2 NEDD4 ARRDC1 HECW1 NEDD4L NDFIP2 | protein ubiquitination |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| NEDD4 | ILDR1 | 0.998 | |
| NEDD4L | ILDR1 | 0.997 | |
| NEDD4 | TMEM171 | 0.996 | |
| HECW1 | TMEM171 | 0.996 | |
| ILDR1 | HECW2 | 0.995 | |
| HECW1 | ILDR1 | 0.995 | |
| NEDD4L | TMEM171 | 0.994 | |
| CUEDC1 | ITCH | 0.993 | 0.086 |
| HECW2 | TMEM171 | 0.993 | |
| CUEDC1 | STXBP4 | 0.992 | 0.118 |
| NEDD4 | PRRG1 | 0.992 | |
| NDFIP2 | ITCH | 0.991 | 0.064 |
| HECW1 | PRRG1 | 0.99 | |
| NEDD4 | NEDD4L | 0.99 | |
| STXBP4 | TMEM171 | 0.99 | |
| PRRG1 | HECW2 | 0.99 | |
| NEDD4 | NDFIP2 | 0.989 | |
| ARRDC1 | ITCH | 0.989 | 0.094 |
| CUEDC1 | HECW2 | 0.988 | 0.118 |
| TMEM252 | STXBP4 | 0.988 | |
| TMEM171 | ITCH | 0.988 | |
| NEDD4L | PRRG1 | 0.987 | |
| NEDD4 | HECW2 | 0.985 | |
| CUEDC1 | TMEM171 | 0.984 | |
| NEDD4L | STXBP4 | 0.983 | 0.09 |
| NEDD4 | ARRDC1 | 0.98 | |
| NEDD4 | FAIM2 | 0.98 | |
| PRRG4 | NEDD4 | 0.977 | |
| PRRG4 | NEDD4L | 0.97 | |
| NEDD4L | TMEM252 | 0.969 | |
| NEDD4L | WWOX | 0.969 | 0.226 |
| NEDD4 | WBP1 | 0.967 | |
| ARRDC1 | NEDD4L | 0.967 | 0.116 |
| NEDD4L | WBP1 | 0.966 | |
| NEDD4L | HECW2 | 0.966 | 0.192 |
| HECW1 | HECW2 | 0.964 | 0.202 |
| PRRG4 | STXBP4 | 0.958 | |
| WWOX | TMEM171 | 0.957 | |
| WBP1 | ITCH | 0.957 | |
| NEDD4 | STXBP4 | 0.957 | |
| HECW1 | NEDD4L | 0.956 | 0.094 |
| NEDD4L | NDFIP2 | 0.955 | 0.058 |
| WWOX | WBP1 | 0.955 | |
| NEDD4 | HECW1 | 0.953 | |
| NEDD4 | ITCH | 0.952 | |
| ILDR1 | ITCH | 0.95 | |
| HECW2 | WBP1 | 0.949 | |
| HECW2 | ITCH | 0.941 | 0.19 |
| CUEDC1 | NEDD4 | 0.922 | |
| NEDD4 | TMEM252 | 0.918 | |
| HECW1 | ITCH | 0.913 | 0.066 |
| NEDD4L | ITCH | 0.908 | 0.08 |
| CUEDC1 | NEDD4L | 0.863 | 0.106 |
| PRRG1 | STXBP4 | 0.8 | |
| HECW2 | WWOX | 0.789 | 0.11 |
| HECW2 | STXBP4 | 0.706 | 0.196 |
| CUEDC1 | ARRDC1 | 0.678 | 0.088 |
| NEDD4 | WWOX | 0.667 | |
| STXBP4 | ITCH | 0.608 | 0.14 |
| WWOX | ITCH | 0.473 | 0.172958333333 |
| HECW1 | STXBP4 | 0.454 | 0.076 |
| HECW1 | WWOX | 0.329 | |
| CUEDC1 | WWOX | 0.325 | 0.134 |
| CUEDC1 | HECW1 | 0.313 | 0.066 |
| ARRDC1 | HECW2 | 0.291 | 0.13 |
| NDFIP2 | WBP1 | 0.278 | |
| PRRG4 | ITCH | 0.197 | |
| PRRG1 | ITCH | 0.131 | |
| NDFIP2 | WWOX | 0.112 | 0.108 |
| ARRDC1 | PRRG1 | 0.11 | |
| HECW2 | NDFIP2 | 0.106 | 0.066 |
| NDFIP2 | STXBP4 | 0.08 | 0.096 |
| ARRDC1 | NDFIP2 | 0.079 | 0.13 |
| TMEM252 | ITCH | 0.071 | |
| PRRG1 | NDFIP2 | 0.067 | |
| CUEDC1 | NDFIP2 | 0.067 | 0.086 |
| WWOX | STXBP4 | 0.052 | 0.174 |
| FAIM2 | NEDD4L | 0.022 | |
| ARRDC1 | STXBP4 | 0.022 | 0.132 |
| FAIM2 | ITCH | 0.012 |
Related Complexes