hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09375.1
Complex Portal: CPX-21186
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RMDN2 | Regulator of microtubule dynamics protein 2 (RMD-2) (hRMD-2) (Protein FAM82A1) | 5 | UniProt NCBI |
| VAPB | Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) | 5 | UniProt NCBI |
| SGPP1 | Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) | 5 | UniProt NCBI |
| PITPNM2 | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | 5 | UniProt NCBI |
| ACBD5 | Acyl-CoA-binding domain-containing protein 5 | 5 | UniProt NCBI |
| SLC39A8 | Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-556833 | 0.00784925061173 | 0.666666666667 | VAPB PITPNM2 ACBD5 SGPP1 | Metabolism of lipids |
| REAC:R-HSA-1660661 | 0.0144005758041 | 0.333333333333 | VAPB SGPP1 | Sphingolipid de novo biosynthesis |
| HPA:0360052 | 0.0400703067036 | 1.0 | SLC39A8 ACBD5 RMDN2 SGPP1 VAPB PITPNM2 | parathyroid gland; glandular cells[>=Medium] |
| HPA:0090181 | 0.044692740938 | 1.0 | SLC39A8 ACBD5 RMDN2 SGPP1 VAPB PITPNM2 | cerebellum; cells in granular layer[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VAPB | ACBD5 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | ||
| PITPNM2 | VAPB | 0.999 | 0.099 |
mutually_exclusive (Q9P0L0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VAPB | RMDN2 | 0.996 | 0.158 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLC39A8 | RMDN2 | 0.984 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLC39A8 | VAPB | 0.97 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLC39A8 | SGPP1 | 0.968 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PITPNM2 | ACBD5 | 0.797 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PITPNM2 | RMDN2 | 0.782 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| VAPB | SGPP1 | 0.497 | 0.1 |
mutually_exclusive (Q9Y3E0)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ACBD5 | RMDN2 | 0.276 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| SGPP1 | RMDN2 | 0.133 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| SGPP1 | ACBD5 | 0.048 | hein_WMM WMM_only |
Related Complexes