hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09377.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | 5 | UniProt NCBI |
| CREB3 | Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] | 5 | UniProt NCBI |
| CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4] | 5 | UniProt NCBI |
| CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8874211 | 3.36110250117e-12 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | CREB3 factors activate genes |
| WP:WP5272 | 9.27161434468e-11 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | LDL influence on CD14 and TLR4 |
| WP:WP4756 | 1.10934052335e-09 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Renin angiotensin aldosterone system RAAS |
| KEGG:04962 | 2.14706370351e-09 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 2.18610122539e-09 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Vasopressin regulated water reabsorption |
| KEGG:05030 | 2.37917869848e-09 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Cocaine addiction |
| KEGG:04927 | 2.62961856148e-09 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Cortisol synthesis and secretion |
| KEGG:05031 | 9.28013604904e-09 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Amphetamine addiction |
| KEGG:04918 | 1.14562141269e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Thyroid hormone synthesis |
| KEGG:04911 | 1.5905985445e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Insulin secretion |
| KEGG:04925 | 2.70321405067e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Aldosterone synthesis and secretion |
| KEGG:04211 | 3.90869434957e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Longevity regulating pathway |
| KEGG:04928 | 4.31719794599e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04916 | 4.31719794599e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Melanogenesis |
| KEGG:04725 | 5.73621464289e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Cholinergic synapse |
| KEGG:05215 | 6.00301532395e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Prostate cancer |
| WP:WP4321 | 6.39317995629e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Thermogenesis |
| KEGG:04915 | 6.56442584798e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Estrogen signaling pathway |
| KEGG:04922 | 6.56442584798e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Glucagon signaling pathway |
| KEGG:04668 | 7.47923615054e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | TNF signaling pathway |
| KEGG:04931 | 8.48648131623e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Insulin resistance |
| KEGG:04935 | 9.21229879722e-08 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Growth hormone synthesis, secretion and action |
| KEGG:04926 | 1.2590347257e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Relaxin signaling pathway |
| KEGG:04728 | 1.30699795334e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Dopaminergic synapse |
| KEGG:04152 | 1.51268026593e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | AMPK signaling pathway |
| REAC:R-HSA-381119 | 1.85292875346e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Unfolded Protein Response (UPR) |
| KEGG:04261 | 1.86555402677e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Adrenergic signaling in cardiomyocytes |
| KEGG:04022 | 2.27683548524e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | cGMP-PKG signaling pathway |
| KEGG:04934 | 2.27683548524e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Cushing syndrome |
| WP:WP4666 | 3.35937426591e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Hepatitis B infection |
| KEGG:05161 | 4.50852953757e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Hepatitis B |
| KEGG:05034 | 4.63290276619e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Alcoholism |
| KEGG:04024 | 5.87148623437e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | cAMP signaling pathway |
| KEGG:05207 | 6.6586086216e-07 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Chemical carcinogenesis - receptor activation |
| KEGG:05203 | 1.13419726708e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Viral carcinogenesis |
| KEGG:05163 | 1.28909526208e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Human cytomegalovirus infection |
| KEGG:05166 | 1.45934209606e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Human T-cell leukemia virus 1 infection |
| KEGG:04714 | 1.67867432092e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Thermogenesis |
| KEGG:05020 | 3.44122097545e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Prion disease |
| WP:WP3932 | 3.67968103286e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:05016 | 5.16363029565e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Huntington disease |
| WP:WP4172 | 5.25751448284e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | PI3K Akt signaling pathway |
| KEGG:04151 | 6.41284406676e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | PI3K-Akt signaling pathway |
| KEGG:05165 | 7.16515850814e-06 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Human papillomavirus infection |
| WP:WP45 | 1.4517114839e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | G1 to S cell cycle control |
| REAC:R-HSA-2262752 | 0.00108429068544 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.00112698633356 | 1.0 | CREB3L4 CREB3L3 CREB3L2 CREB3 | Cellular responses to stimuli |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CREB3L3 | CREB3L2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3 | CREB3L2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CREB3L3 | CREB3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L3 | CREB3L4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3 | CREB3L4 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L4 | CREB3L2 | 0.578 | bioplex3_WMM WMM_only |
Related Complexes