hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09384.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CREB3 | Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] | 5 | UniProt NCBI |
| CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | 5 | UniProt NCBI |
| CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | 5 | UniProt NCBI |
| CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4] | 5 | UniProt NCBI |
| CREB3L1 | Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8874211 | 6.13935741343e-16 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | CREB3 factors activate genes |
| WP:WP5272 | 1.31536503859e-13 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | LDL influence on CD14 and TLR4 |
| WP:WP4756 | 3.14764546076e-12 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Renin angiotensin aldosterone system RAAS |
| KEGG:04962 | 5.75238954328e-12 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Vasopressin-regulated water reabsorption |
| KEGG:05030 | 6.5513325354e-12 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Cocaine addiction |
| KEGG:04927 | 7.43664774289e-12 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Cortisol synthesis and secretion |
| WP:WP5085 | 7.44341863012e-12 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Vasopressin regulated water reabsorption |
| KEGG:05031 | 3.66042126707e-11 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Amphetamine addiction |
| KEGG:04918 | 4.77452318502e-11 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Thyroid hormone synthesis |
| KEGG:04911 | 7.22089904072e-11 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Insulin secretion |
| KEGG:04925 | 1.40824861687e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Aldosterone synthesis and secretion |
| KEGG:04211 | 2.23987247742e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Longevity regulating pathway |
| KEGG:04928 | 2.53822378977e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04916 | 2.53822378977e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Melanogenesis |
| KEGG:04725 | 3.62865080374e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Cholinergic synapse |
| KEGG:05215 | 3.84210085102e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Prostate cancer |
| KEGG:04922 | 4.2991270148e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Glucagon signaling pathway |
| KEGG:04915 | 4.2991270148e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Estrogen signaling pathway |
| KEGG:04668 | 5.06523379089e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | TNF signaling pathway |
| WP:WP4321 | 5.26060699963e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Thermogenesis |
| KEGG:04931 | 5.93685401923e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Insulin resistance |
| KEGG:04935 | 6.58173065962e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Growth hormone synthesis, secretion and action |
| REAC:R-HSA-381119 | 9.02544477605e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Unfolded Protein Response (UPR) |
| KEGG:04926 | 9.74477699998e-10 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Relaxin signaling pathway |
| KEGG:04728 | 1.02132758942e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Dopaminergic synapse |
| KEGG:04152 | 1.22708457363e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | AMPK signaling pathway |
| KEGG:04261 | 1.59663824668e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Adrenergic signaling in cardiomyocytes |
| KEGG:04934 | 2.05030220587e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Cushing syndrome |
| KEGG:04022 | 2.05030220587e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | cGMP-PKG signaling pathway |
| WP:WP4666 | 4.22580749122e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Hepatitis B infection |
| KEGG:05161 | 4.83168116998e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Hepatitis B |
| KEGG:05034 | 4.99944787727e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Alcoholism |
| KEGG:04024 | 6.7292958936e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | cAMP signaling pathway |
| KEGG:05207 | 7.87918813219e-09 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Chemical carcinogenesis - receptor activation |
| KEGG:05203 | 1.53624627091e-08 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Viral carcinogenesis |
| KEGG:05163 | 1.80361450234e-08 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Human cytomegalovirus infection |
| KEGG:05166 | 2.10697652741e-08 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Human T-cell leukemia virus 1 infection |
| KEGG:04714 | 2.51109626226e-08 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Thermogenesis |
| KEGG:05020 | 6.17206457492e-08 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Prion disease |
| WP:WP3932 | 8.49179843868e-08 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:05016 | 1.02604700914e-07 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Huntington disease |
| WP:WP45 | 1.04670169416e-07 | 0.8 | CREB3 CREB3L3 CREB3L1 CREB3L4 | G1 to S cell cycle control |
| WP:WP4172 | 1.32767389374e-07 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | PI3K Akt signaling pathway |
| KEGG:04151 | 1.34586235403e-07 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | PI3K-Akt signaling pathway |
| KEGG:05165 | 1.54641002851e-07 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Human papillomavirus infection |
| REAC:R-HSA-2262752 | 4.74672993161e-05 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 4.98167253052e-05 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | Cellular responses to stimuli |
| HPA:0480892 | 0.00625267658924 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | small intestine; goblet cells[>=Medium] |
| HPA:0150891 | 0.0102818072433 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | duodenum; goblet cells[>=Low] |
| HPA:0480891 | 0.0106478450711 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | small intestine; goblet cells[>=Low] |
| HPA:0151302 | 0.0130253489728 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | duodenum; enterocytes[>=Medium] |
| HPA:0481302 | 0.0133449870931 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | small intestine; enterocytes[>=Medium] |
| HPA:0131291 | 0.0138891082735 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | colon; endocrine cells[>=Low] |
| HPA:0151292 | 0.0149049151547 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | duodenum; endocrine cells[>=Medium] |
| HPA:0481292 | 0.0150207060255 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | small intestine; endocrine cells[>=Medium] |
| HPA:0481291 | 0.0179798920126 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | small intestine; endocrine cells[>=Low] |
| HPA:0151291 | 0.0187750565941 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | duodenum; endocrine cells[>=Low] |
| GO:0000978 | 0.0192772113985 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000987 | 0.0213878677719 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | cis-regulatory region sequence-specific DNA binding |
| HPA:0151301 | 0.0240343220231 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | duodenum; enterocytes[>=Low] |
| HPA:0481301 | 0.0268210610628 | 0.6 | CREB3L1 CREB3L3 CREB3L4 | small intestine; enterocytes[>=Low] |
| GO:0000981 | 0.0378314216665 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 0.0435745197674 | 1.0 | CREB3 CREB3L4 CREB3L3 CREB3L1 CREB3L2 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CREB3L3 | CREB3L2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3 | CREB3L2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CREB3L3 | CREB3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L3 | CREB3L4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L1 | CREB3L2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CREB3 | CREB3L4 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L4 | CREB3L2 | 0.578 | bioplex3_WMM WMM_only |
Related Complexes