hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09385.1
Complex Portal: CPX-16936
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ILK | Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK) | 5 | UniProt NCBI |
| LIMS2 | LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) | 5 | UniProt NCBI |
| PARVG | Gamma-parvin | 5 | UniProt NCBI |
| PARVA | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | 5 | UniProt NCBI |
| LIMS1 | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | 5 | UniProt NCBI |
| PARVB | Beta-parvin (Affixin) | 5 | UniProt NCBI |
| RSU1 | Ras suppressor protein 1 (RSP-1) (Rsu-1) | 4 | UniProt NCBI |
| PXN | Paxillin | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446353 | 1.91833111182e-18 | 0.875 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB | Cell-extracellular matrix interactions |
| REAC:R-HSA-446728 | 8.85107357602e-14 | 0.875 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB | Cell junction organization |
| REAC:R-HSA-446388 | 1.20099045548e-13 | 0.625 | PARVA PXN LIMS1 RSU1 PARVB | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
| REAC:R-HSA-1500931 | 1.18826079278e-12 | 0.875 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB | Cell-Cell communication |
| GO:0034446 | 3.72896859502e-11 | 0.875 | ILK LIMS1 PXN LIMS2 PARVA PARVB PARVG | substrate adhesion-dependent cell spreading |
| GO:0031589 | 1.72618208843e-10 | 1.0 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB PARVG | cell-substrate adhesion |
| GO:0005925 | 5.48076984756e-09 | 1.0 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB PARVG | focal adhesion |
| GO:0030055 | 6.42020114751e-09 | 1.0 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB PARVG | cell-substrate junction |
| CORUM:6920 | 9.82248594942e-09 | 0.375 | ILK LIMS2 PARVA | ILK-LIMS2-PARVA complex |
| CORUM:6919 | 9.82248594942e-09 | 0.375 | ILK LIMS1 PARVA | ILK-LIMS1-PARVA complex |
| REAC:R-HSA-446343 | 9.15972916962e-08 | 0.375 | ILK PXN PARVA | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| GO:0070161 | 4.64378927182e-07 | 1.0 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB PARVG | anchoring junction |
| KEGG:04510 | 5.9088603675e-07 | 0.625 | ILK PARVB PXN PARVG PARVA | Focal adhesion |
| WP:WP306 | 1.08904178306e-06 | 0.625 | ILK PARVB PXN PARVG PARVA | Focal adhesion |
| GO:0007155 | 1.16699531393e-05 | 1.0 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB PARVG | cell adhesion |
| CORUM:5498 | 7.17483486175e-05 | 0.25 | ILK PARVB | ILK-PARVB-ARHGEF6 complex |
| GO:0030054 | 7.49086954877e-05 | 1.0 | RSU1 ILK LIMS1 PXN LIMS2 PARVA PARVB PARVG | cell junction |
| WP:WP2572 | 0.000365897105987 | 0.375 | ILK LIMS1 PARVA | Primary focal segmental glomerulosclerosis FSGS |
| GO:0010811 | 0.00166453822603 | 0.5 | ILK LIMS2 RSU1 LIMS1 | positive regulation of cell-substrate adhesion |
| GO:0010810 | 0.0258663823582 | 0.5 | ILK LIMS2 RSU1 LIMS1 | regulation of cell-substrate adhesion |
| GO:0015629 | 0.0288371790293 | 0.625 | ILK PARVB PXN PARVG PARVA | actin cytoskeleton |
| GO:1900026 | 0.0319547930493 | 0.375 | ILK LIMS2 LIMS1 | positive regulation of substrate adhesion-dependent cell spreading |
| KEGG:05100 | 0.0362501572582 | 0.25 | ILK PXN | Bacterial invasion of epithelial cells |
| CORUM:4025 | 0.0499436884912 | 0.125 | PARVB | ACTN1-PARVB complex |
| CORUM:6510 | 0.0499436884912 | 0.125 | ILK | ILK-SERCA2A-PLN complex |
| CORUM:6927 | 0.0499436884912 | 0.125 | PXN | Robo4-paxillin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ILK | PARVB | 1.0 | 0.092 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction | |
| RSU1 | PARVA | 1.0 | 0.562 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction |
| ILK | PARVA | 1.0 | 0.732 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () Malo bioplex3_HCT116 fraction treiber_WMM |
| ILK | RSU1 | 1.0 | 0.864 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction | |
| ILK | LIMS1 | 1.0 | 0.166 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction | |
| LIMS1 | PARVA | 1.0 | 0.1 |
mutually_exclusive (Q15404)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PARVB | RSU1 | 1.0 | 0.062 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction | |
| LIMS1 | RSU1 | 1.0 | 0.138 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PARVG | LIMS1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LIMS1 | PARVB | 0.999 | 0.108 |
mutually_exclusive (Q9NVD7)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PARVG | RSU1 | 0.999 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PARVB | PARVA | 0.998 | 0.148 |
mutually_exclusive (P48059)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ILK | PARVG | 0.998 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LIMS2 | RSU1 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RSU1 | PXN | 0.985 | 0.082 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PXN | PARVA | 0.982 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PARVB | PXN | 0.981 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ILK | PXN | 0.978 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| LIMS2 | PARVA | 0.978 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LIMS1 | PXN | 0.908 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ILK | LIMS2 | 0.633 | bioplex3_WMM WMM_only | ||
| LIMS2 | LIMS1 | 0.616 | bioplex3_WMM WMM_only | ||
| LIMS2 | PARVB | 0.329 | bioplex3_WMM WMM_only |
Related Complexes