hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09400.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | 5 | UniProt NCBI |
| USP14 | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | 5 | UniProt NCBI |
| PGD | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | 5 | UniProt NCBI |
| ARHGDIA | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00480 | 0.0030591266514 | 0.5 | PGD IDH1 | Glutathione metabolism |
| KEGG:01200 | 0.0133093129958 | 0.5 | PGD IDH1 | Carbon metabolism |
| CORUM:404 | 0.0249718442456 | 0.25 | IDH1 | Isocitrate dehydrogenase [NADP], cytoplasmic |
| REAC:R-HSA-9759194 | 0.0305753786405 | 0.5 | PGD IDH1 | Nuclear events mediated by NFE2L2 |
| REAC:R-HSA-2978092 | 0.0499436884912 | 0.25 | IDH1 | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate |
| REAC:R-HSA-389542 | 0.0499436884912 | 0.25 | IDH1 | NADPH regeneration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IDH1 | PGD | 0.991 | 0.386 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| IDH1 | ARHGDIA | 0.959 | 0.22 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| IDH1 | USP14 | 0.955 | 0.252 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| ARHGDIA | PGD | 0.759 | 0.198 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| PGD | USP14 | 0.648 | 0.296 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| ARHGDIA | USP14 | 0.078 | 0.444 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM fraction |
Related Complexes