hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09401.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RABGGTA | Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) | 5 | UniProt NCBI |
| RAB17 | Ras-related protein Rab-17 | 5 | UniProt NCBI |
| CHM | Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) | 5 | UniProt NCBI |
| RAB7B | Ras-related protein Rab-7b | 5 | UniProt NCBI |
| CHML | Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) | 5 | UniProt NCBI |
| RAB9B | Ras-related protein Rab-9B (Rab-9-like protein) (Rab-9L) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 1.8917997191e-10 | 1.0 | RABGGTA RAB9B RAB7B RAB17 CHM | RAB geranylgeranylation |
| CORUM:6956 | 1.36501667663e-05 | 0.4 | RABGGTA CHM | REP-RGGT-Rab complex |
| REAC:R-HSA-8876198 | 0.000264137476094 | 0.6 | RAB9B CHM RAB7B | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 0.000630278165562 | 0.6 | RAB9B CHM RAB7B | Rab regulation of trafficking |
| REAC:R-HSA-597592 | 0.000685877408784 | 1.0 | RABGGTA RAB9B RAB7B RAB17 CHM | Post-translational protein modification |
| REAC:R-HSA-6803205 | 0.0011839189519 | 0.4 | RABGGTA CHM | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-392499 | 0.00352060064826 | 1.0 | RABGGTA RAB9B RAB7B RAB17 CHM | Metabolism of proteins |
| REAC:R-HSA-5633008 | 0.0106339701454 | 0.4 | RABGGTA CHM | TP53 Regulates Transcription of Cell Death Genes |
| GO:0004663 | 0.0140440992017 | 0.4 | RABGGTA CHM | Rab geranylgeranyltransferase activity |
| GO:0005968 | 0.0280843539964 | 0.4 | RABGGTA CHM | Rab-protein geranylgeranyltransferase complex |
| KEGG:04148 | 0.0340898047114 | 0.4 | RAB17 RAB7B | Efferocytosis |
| GO:0004661 | 0.0468008499735 | 0.4 | RABGGTA CHM | protein geranylgeranyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RABGGTA | RAB7B | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RABGGTA | RAB9B | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RABGGTA | CHML | 0.995 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RABGGTA | CHM | 0.994 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CHM | CHML | 0.991 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| RAB7B | CHML | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAB7B | CHM | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CHM | RAB9B | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAB17 | CHM | 0.955 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RAB17 | CHML | 0.95 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CHML | RAB9B | 0.685 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes