hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09403.1
Complex Portal: CPX-14155
Confidence: Moderate High  
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP2M1 | AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) | 5 | UniProt   NCBI |
| RALBP1 | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | 5 | UniProt   NCBI |
| AP2S1 | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | 5 | UniProt   NCBI |
| REPS1 | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | 5 | UniProt   NCBI |
| CLINT1 | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | 5 | UniProt   NCBI |
| AP2A2 | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | 5 | UniProt   NCBI |
| ITSN2 | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | 5 | UniProt   NCBI |
| ARFGAP1 | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | 5 | UniProt   NCBI |
| AAGAB | Alpha- and gamma-adaptin-binding protein p34 | 5 | UniProt   NCBI |
| AAK1 | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | 5 | UniProt   NCBI |
| EPS15L1 | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | 5 | UniProt   NCBI |
| SPAG6 | Sperm-associated antigen 6 (Protein PF16 homolog) (Repro-SA-1) (Sperm flagellar protein) | 5 | UniProt   NCBI |
| EPS15 | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | 5 | UniProt   NCBI |
| AP1S1 | AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) | 5 | UniProt   NCBI |
| AP1B1 | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | 5 | UniProt   NCBI |
| SGIP1 | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | 5 | UniProt   NCBI |
| NECAP1 | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | 4 | UniProt   NCBI |
| AP2B1 | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | 5 | UniProt   NCBI |
| CCDC32 | Coiled-coil domain-containing protein 32 | 5 | UniProt   NCBI |
| NECAP2 | Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) | 4 | UniProt   NCBI |
| FCHO2 | F-BAR domain only protein 2 | 5 | UniProt   NCBI |
| SYNJ1 | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | 5 | UniProt   NCBI |
| ITSN1 | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | 5 | UniProt   NCBI |
| AP2A1 | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | 5 | UniProt   NCBI |
| REPS2 | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | 5 | UniProt   NCBI |
| STON2 | Stonin-2 (Stoned B) | 5 | UniProt   NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
|   GO:0005905 | 8.0021230811e-32 | 0.615384615385 | AP2M1 REPS1 STON2 NECAP2 EPS15 EPS15L1 AP2B1 CCDC32 SYNJ1 FCHO2 AP2S1 AP2A2 AAK1 SGIP1 ITSN1 AP2A1 | clathrin-coated pit |
|   REAC:R-HSA-8856828 | 9.93942984297e-32 | 0.730769230769 | AP2M1 ITSN1 NECAP2 REPS2 ITSN2 REPS1 AP2B1 NECAP1 EPS15 SYNJ1 FCHO2 STON2 ARFGAP1 AAK1 AP2A1 AP2A2 SGIP1 EPS15L1 AP2S1 | Clathrin-mediated endocytosis |
|   REAC:R-HSA-8856825 | 1.11438718278e-29 | 0.653846153846 | AP2M1 STON2 NECAP2 REPS2 ITSN2 REPS1 AP2B1 NECAP1 EPS15 ITSN1 FCHO2 AP2S1 AP2A2 AAK1 SGIP1 EPS15L1 AP2A1 | Cargo recognition for clathrin-mediated endocytosis |
|   GO:0030118 | 4.24211047215e-29 | 0.576923076923 | AP2M1 STON2 AP1B1 EPS15 EPS15L1 AP2B1 NECAP1 NECAP2 SYNJ1 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | clathrin coat |
|   GO:0006897 | 3.0091943641e-25 | 0.846153846154 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 AP2B1 EPS15 REPS1 ARFGAP1 CCDC32 AP1S1 AAK1 ITSN2 STON2 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | endocytosis |
|   REAC:R-HSA-199991 | 3.0829889717e-25 | 0.846153846154 | AP2M1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 EPS15 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 AP1S1 AAK1 ITSN2 STON2 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | Membrane Trafficking |
|   REAC:R-HSA-5653656 | 1.0325166651e-24 | 0.846153846154 | AP2M1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 EPS15 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 AP1S1 AAK1 ITSN2 STON2 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | Vesicle-mediated transport |
|   GO:0048475 | 4.29293598258e-23 | 0.576923076923 | AP2M1 STON2 AP1B1 EPS15 EPS15L1 AP2B1 NECAP1 NECAP2 SYNJ1 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | coated membrane |
|   GO:0030117 | 4.29293598258e-23 | 0.576923076923 | AP2M1 STON2 AP1B1 EPS15 EPS15L1 AP2B1 NECAP1 NECAP2 SYNJ1 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | membrane coat |
|   GO:0098657 | 1.22886538362e-22 | 0.846153846154 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 AP2B1 EPS15 REPS1 ARFGAP1 CCDC32 AP1S1 AAK1 ITSN2 STON2 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | import into cell |
|   GO:0030125 | 1.25069184812e-22 | 0.461538461538 | AP2M1 STON2 AP1B1 NECAP1 AP2B1 NECAP2 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | clathrin vesicle coat |
|   GO:0030132 | 1.43217856191e-22 | 0.384615384615 | AP2M1 AP2A1 EPS15 EPS15L1 AP2B1 SYNJ1 AP2S1 AP2A2 SGIP1 STON2 | clathrin coat of coated pit |
|   GO:0016192 | 1.16074857878e-20 | 0.923076923077 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 EPS15 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 CCDC32 AP1S1 AAK1 ITSN2 STON2 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | vesicle-mediated transport |
|   GO:0030120 | 1.66274809794e-18 | 0.461538461538 | AP2M1 STON2 AP1B1 NECAP1 AP2B1 NECAP2 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | vesicle coat |
|   GO:0072583 | 7.31589521652e-18 | 0.423076923077 | AP2M1 AP2A1 AP2B1 FCHO2 CCDC32 ITSN2 AP2S1 AP2A2 AAK1 ITSN1 STON2 | clathrin-dependent endocytosis |
|   GO:0030136 | 1.85991535084e-17 | 0.538461538462 | AP2M1 STON2 AP1B1 NECAP1 FCHO2 AP2B1 NECAP2 CLINT1 AP2S1 AP2A2 AP2A1 AAK1 SGIP1 AP1S1 | clathrin-coated vesicle |
|   GO:0030131 | 8.99743469611e-17 | 0.346153846154 | AP2M1 STON2 AP1B1 AP2B1 AP2S1 AP2A2 AP2A1 SGIP1 AP1S1 | clathrin adaptor complex |
|   GO:0030665 | 8.26847774596e-16 | 0.461538461538 | AP2M1 STON2 AP1B1 NECAP1 AP2B1 NECAP2 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | clathrin-coated vesicle membrane |
|   GO:0006898 | 1.02290225553e-15 | 0.538461538462 | AP2M1 STON2 AP2A1 EPS15 FCHO2 AP2B1 CCDC32 ITSN2 AP2S1 AP2A2 AAK1 SGIP1 ITSN1 AP1S1 | receptor-mediated endocytosis |
|   GO:0030128 | 9.31369988243e-15 | 0.269230769231 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 SGIP1 STON2 | clathrin coat of endocytic vesicle |
|   GO:0030122 | 9.31369988243e-15 | 0.269230769231 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 SGIP1 STON2 | AP-2 adaptor complex |
|   GO:0030135 | 1.01070828397e-14 | 0.538461538462 | AP2M1 STON2 AP1B1 NECAP1 FCHO2 AP2B1 NECAP2 CLINT1 AP2S1 AP2A2 AP2A1 AAK1 SGIP1 AP1S1 | coated vesicle |
|   GO:0030119 | 1.2835407938e-13 | 0.346153846154 | AP2M1 STON2 AP1B1 AP2B1 AP2S1 AP2A2 AP2A1 SGIP1 AP1S1 | AP-type membrane coat adaptor complex |
|   GO:0030662 | 2.90826141867e-13 | 0.461538461538 | AP2M1 STON2 AP1B1 NECAP1 AP2B1 NECAP2 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | coated vesicle membrane |
|   REAC:R-HSA-164938 | 8.33654948942e-13 | 0.269230769231 | AP2M1 AP1B1 AP2B1 AP2S1 AP2A1 AP2A2 AP1S1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
|   GO:0006810 | 8.45557373989e-13 | 0.961538461538 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 EPS15 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 CCDC32 AP1S1 AAK1 STON2 ITSN2 SPAG6 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | transport |
|   REAC:R-HSA-164952 | 6.32323913322e-12 | 0.269230769231 | AP2M1 AP1B1 AP2B1 AP2S1 AP2A1 AP2A2 AP1S1 | The role of Nef in HIV-1 replication and disease pathogenesis |
|   GO:0051234 | 8.14094176508e-12 | 0.961538461538 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 EPS15 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 CCDC32 AP1S1 AAK1 STON2 ITSN2 SPAG6 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | establishment of localization |
|   GO:0099003 | 7.6342245971e-11 | 0.384615384615 | AP2M1 AP2A1 AP2B1 FCHO2 SYNJ1 ITSN2 AP2S1 AP2A2 ITSN1 STON2 | vesicle-mediated transport in synapse |
|   REAC:R-HSA-182218 | 7.75544066856e-11 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Nef Mediated CD8 Down-regulation |
|   WP:WP437 | 2.25841829592e-10 | 0.346153846154 | AP2M1 RALBP1 AP2B1 EPS15L1 EPS15 SYNJ1 AP2S1 REPS2 AP2A1 | EGF EGFR signaling pathway |
|   GO:0048488 | 3.13774716735e-10 | 0.307692307692 | AP2M1 STON2 AP2B1 FCHO2 SYNJ1 ITSN2 AP2S1 ITSN1 | synaptic vesicle endocytosis |
|   GO:0140238 | 3.13774716735e-10 | 0.307692307692 | AP2M1 STON2 AP2B1 FCHO2 SYNJ1 ITSN2 AP2S1 ITSN1 | presynaptic endocytosis |
|   GO:0051179 | 3.6427541952e-10 | 0.961538461538 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 EPS15 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 CCDC32 AP1S1 AAK1 STON2 ITSN2 SPAG6 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | localization |
|   REAC:R-HSA-167590 | 4.64212294799e-10 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Nef Mediated CD4 Down-regulation |
|   GO:0036465 | 1.49968179871e-09 | 0.307692307692 | AP2M1 STON2 AP2B1 FCHO2 SYNJ1 ITSN2 AP2S1 ITSN1 | synaptic vesicle recycling |
|   GO:0035615 | 2.53275250926e-09 | 0.230769230769 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 STON2 | clathrin adaptor activity |
|   REAC:R-HSA-177504 | 2.90743184486e-09 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Retrograde neurotrophin signalling |
|   GO:0140312 | 4.21629937029e-09 | 0.230769230769 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 STON2 | cargo adaptor activity |
|   REAC:R-HSA-5140745 | 4.718916639e-09 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
|   REAC:R-HSA-5099900 | 1.09844381362e-08 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | WNT5A-dependent internalization of FZD4 |
|   GO:0140239 | 1.24087050697e-08 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | postsynaptic endocytosis |
|   GO:0098884 | 1.24087050697e-08 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | postsynaptic neurotransmitter receptor internalization |
|   REAC:R-HSA-8866427 | 1.59582220608e-08 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | VLDLR internalisation and degradation |
|   REAC:R-HSA-8964038 | 3.12277010272e-08 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | LDL clearance |
|   WP:WP4159 | 6.03150811331e-08 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | GABA receptor signaling |
|   GO:0098796 | 1.81851832196e-07 | 0.576923076923 | AP2M1 STON2 AP1B1 EPS15 EPS15L1 AP2B1 NECAP1 NECAP2 SYNJ1 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | membrane protein complex |
|   KEGG:04144 | 2.76085658905e-07 | 0.307692307692 | AP2M1 AP2A1 EPS15 EPS15L1 AP2B1 ARFGAP1 AP2A2 AP2S1 | Endocytosis |
|   REAC:R-HSA-2132295 | 3.18651607298e-07 | 0.269230769231 | AP2M1 AP1B1 AP2B1 AP2S1 AP2A1 AP2A2 AP1S1 | MHC class II antigen presentation |
|   GO:0099504 | 3.79958586928e-07 | 0.307692307692 | AP2M1 STON2 AP2B1 FCHO2 SYNJ1 ITSN2 AP2S1 ITSN1 | synaptic vesicle cycle |
|   GO:0030669 | 4.23747384547e-07 | 0.269230769231 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 SGIP1 STON2 | clathrin-coated endocytic vesicle membrane |
|   GO:0099590 | 4.65189095178e-07 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | neurotransmitter receptor internalization |
|   REAC:R-HSA-162909 | 5.07673923409e-07 | 0.269230769231 | AP2M1 AP1B1 AP2B1 AP2S1 AP2A1 AP2A2 AP1S1 | Host Interactions of HIV factors |
|   REAC:R-HSA-8964043 | 7.21734752159e-07 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Plasma lipoprotein clearance |
|   KEGG:04961 | 1.13081219866e-06 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Endocrine and other factor-regulated calcium reabsorption |
|   WP:WP2267 | 1.33519467089e-06 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Synaptic vesicle pathway |
|   REAC:R-HSA-2682334 | 1.70396587813e-06 | 0.230769230769 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 ITSN1 | EPH-Ephrin signaling |
|   GO:0045334 | 1.76139092252e-06 | 0.269230769231 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 SGIP1 STON2 | clathrin-coated endocytic vesicle |
|   REAC:R-HSA-3928665 | 3.8366470447e-06 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | EPH-ephrin mediated repulsion of cells |
|   KEGG:04721 | 3.96388247465e-06 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Synaptic vesicle cycle |
|   GO:0097708 | 4.65443944099e-06 | 0.653846153846 | AP2M1 STON2 SPAG6 ITSN2 FCHO2 AP2B1 NECAP1 NECAP2 CLINT1 AP1B1 AP2S1 AP2A2 AP2A1 AAK1 SGIP1 ITSN1 AP1S1 | intracellular vesicle |
|   REAC:R-HSA-437239 | 4.83099205198e-06 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Recycling pathway of L1 |
|   GO:0036020 | 4.99643216435e-06 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | endolysosome membrane |
|   GO:0012506 | 5.35268578465e-06 | 0.5 | AP2M1 STON2 AP1B1 NECAP1 AP2B1 NECAP2 SYNJ1 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | vesicle membrane |
|   REAC:R-HSA-174824 | 1.89275388165e-05 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Plasma lipoprotein assembly, remodeling, and clearance |
|   REAC:R-HSA-162906 | 2.64686315656e-05 | 0.269230769231 | AP2M1 AP1B1 AP2B1 AP2S1 AP2A1 AP2A2 AP1S1 | HIV Infection |
|   GO:0012505 | 3.11035241402e-05 | 0.807692307692 | AP2M1 ITSN1 SPAG6 AP1S1 EPS15 REPS1 AP2B1 NECAP2 CCDC32 SYNJ1 FCHO2 CLINT1 AP1B1 STON2 ARFGAP1 AAK1 AP2A1 AP2A2 SGIP1 EPS15L1 AP2S1 | endomembrane system |
|   GO:0098797 | 4.48162939872e-05 | 0.384615384615 | AP2M1 AP2A1 EPS15 EPS15L1 AP2B1 SYNJ1 AP2S1 AP2A2 SGIP1 STON2 | plasma membrane protein complex |
|   GO:0036019 | 4.65724331912e-05 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | endolysosome |
|   GO:0005829 | 6.74085922212e-05 | 0.884615384615 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 EPS15 AP2A1 FCHO2 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 AAGAB AP1S1 AAK1 ITSN2 STON2 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | cytosol |
|   GO:0030659 | 7.711199658e-05 | 0.461538461538 | AP2M1 STON2 AP1B1 NECAP1 AP2B1 NECAP2 CLINT1 AP2S1 SGIP1 AP2A1 AP2A2 AP1S1 | cytoplasmic vesicle membrane |
|   GO:0099072 | 9.75511128738e-05 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | regulation of postsynaptic membrane neurotransmitter receptor levels |
|   REAC:R-HSA-9679191 | 0.000110316735204 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Potential therapeutics for SARS |
|   CORUM:3231 | 0.000146312725026 | 0.0769230769231 | EPS15 STON2 | Eps15-stonin2 complex |
|   REAC:R-HSA-4086400 | 0.000155279030708 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | PCP/CE pathway |
|   HPA:0100212 | 0.000205248836614 | 0.576923076923 | ITSN2 RALBP1 AAGAB REPS1 AP2B1 EPS15 SYNJ1 CLINT1 ARFGAP1 AAK1 AP2A1 AP2A2 SGIP1 EPS15L1 AP1B1 | cerebral cortex; neuropil[>=Medium] |
|   REAC:R-HSA-187037 | 0.000213641032411 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Signaling by NTRK1 (TRKA) |
|   GO:0030666 | 0.000241105681631 | 0.269230769231 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 SGIP1 STON2 | endocytic vesicle membrane |
|   REAC:R-HSA-373760 | 0.000274461671961 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | L1CAM interactions |
|   REAC:R-HSA-166520 | 0.000476820004078 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Signaling by NTRKs |
|   GO:0031410 | 0.000712539072134 | 0.576923076923 | AP2M1 STON2 SPAG6 NECAP1 FCHO2 AP2B1 NECAP2 CLINT1 AP1B1 AP2S1 AP2A2 AP2A1 AAK1 SGIP1 AP1S1 | cytoplasmic vesicle |
|   GO:0051649 | 0.000728078675148 | 0.538461538462 | AP2M1 AP2A1 REPS2 ITSN2 EPS15L1 AP2B1 EPS15 SYNJ1 FCHO2 AP2S1 REPS1 AP2A2 ITSN1 STON2 | establishment of localization in cell |
|   REAC:R-HSA-432722 | 0.000732049677095 | 0.153846153846 | CLINT1 NECAP1 AP1S1 AP1B1 | Golgi Associated Vesicle Biogenesis |
|   CORUM:7476 | 0.000875955084067 | 0.0769230769231 | AP1S1 AP1B1 | AP1B1-AP1G2-AP1M-1AP1S1 complex |
|   CORUM:247 | 0.000875955084067 | 0.0769230769231 | RALBP1 AP2A1 | RalBP1-CCNB1-AP2A-NUMB-EPN1 complex |
|   GO:0016020 | 0.0010134217401 | 0.923076923077 | AP2M1 RALBP1 SYNJ1 SGIP1 ITSN1 NECAP2 AP2A1 FCHO2 EPS15 AP2B1 AP1B1 NECAP1 REPS1 ARFGAP1 CCDC32 AP1S1 AAK1 ITSN2 STON2 REPS2 CLINT1 EPS15L1 AP2A2 AP2S1 | membrane |
|   REAC:R-HSA-3858494 | 0.00113856232025 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Beta-catenin independent WNT signaling |
|   GO:0051641 | 0.00138097838818 | 0.653846153846 | AP2M1 ITSN1 AP1B1 REPS2 ITSN2 REPS1 AP2B1 EPS15 SYNJ1 FCHO2 STON2 AP2S1 AP2A2 AP2A1 AAK1 EPS15L1 AP1S1 | cellular localization |
|   REAC:R-HSA-199992 | 0.00208185276286 | 0.153846153846 | CLINT1 NECAP1 AP1S1 AP1B1 | trans-Golgi Network Vesicle Budding |
|   WP:WP4829 | 0.00217050929724 | 0.115384615385 | AP2A2 AP2A1 AP2B1 | mBDNF and proBDNF regulation of GABA neurotransmission |
|   REAC:R-HSA-9006934 | 0.00237177121927 | 0.269230769231 | AP2M1 AP2A1 AP2B1 EPS15L1 EPS15 AP2S1 AP2A2 | Signaling by Receptor Tyrosine Kinases |
|   CORUM:36 | 0.00406992199302 | 0.0769230769231 | AP1S1 AP1B1 | AP1 adaptor complex |
|   WP:WP4549 | 0.00489843163271 | 0.153846153846 | AP2A1 AP2M1 AP2S1 AP2B1 | Fragile X syndrome |
|   GO:0031982 | 0.00500976251589 | 0.692307692308 | AP2M1 STON2 SPAG6 ITSN2 FCHO2 AP2B1 NECAP1 NECAP2 SYNJ1 CLINT1 AP1B1 AP2S1 AP2A2 AP2A1 AAK1 SGIP1 ITSN1 AP1S1 | vesicle |
|   CORUM:144 | 0.00522703037325 | 0.0769230769231 | AP1S1 AP1B1 | Gamma-BAR-AP1 complex |
|   KEGG:05016 | 0.00660876577482 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Huntington disease |
|   GO:0030139 | 0.0115359576628 | 0.269230769231 | AP2M1 AP2A1 AP2B1 AP2S1 AP2A2 SGIP1 STON2 | endocytic vesicle |
|   GO:0098588 | 0.0124969405101 | 0.5 | AP2M1 STON2 AP1B1 AP1S1 NECAP1 AP2B1 NECAP2 CLINT1 ARFGAP1 SGIP1 AP2A1 AP2A2 AP2S1 | bounding membrane of organelle |
|   GO:0005886 | 0.0187231384448 | 0.692307692308 | AP2M1 ITSN1 RALBP1 REPS2 ITSN2 REPS1 AP2B1 EPS15 SYNJ1 FCHO2 CLINT1 STON2 AP2S1 AAK1 AP2A2 SGIP1 EPS15L1 AP2A1 | plasma membrane |
|   GO:0031623 | 0.023507769549 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | receptor internalization |
|   HPA:0050011 | 0.0236299349881 | 0.5 | EPS15 STON2 AP1B1 AAGAB EPS15L1 NECAP2 CLINT1 ARFGAP1 SGIP1 AP2A1 AP2A2 ITSN1 AP1S1 | breast; adipocytes[>=Low] |
|   REAC:R-HSA-5663205 | 0.0271178451618 | 0.307692307692 | AP2M1 AP1B1 EPS15 AP2B1 AP2S1 AP2A1 AP2A2 AP1S1 | Infectious disease |
|   HPA:0100211 | 0.0353530794953 | 0.653846153846 | ITSN2 STON2 RALBP1 AAGAB REPS1 AP2B1 EPS15 SYNJ1 CLINT1 AP1B1 ARFGAP1 AAK1 AP2A1 AP2A2 SGIP1 EPS15L1 AP1S1 | cerebral cortex; neuropil[>=Low] |
|   REAC:R-HSA-1280218 | 0.0373215595907 | 0.269230769231 | AP2M1 AP1B1 AP2B1 AP2S1 AP2A1 AP2A2 AP1S1 | Adaptive Immune System |
|   REAC:R-HSA-164940 | 0.0424231490934 | 0.0769230769231 | AP1S1 AP1B1 | Nef mediated downregulation of MHC class I complex cell surface expression |
|   HPA:0100132 | 0.044334103782 | 0.653846153846 | EPS15 STON2 RALBP1 CLINT1 REPS1 AP2B1 NECAP2 SYNJ1 ITSN1 AAGAB AP1S1 AAK1 AP2A1 AP2A2 SGIP1 EPS15L1 AP1B1 | cerebral cortex; neuronal cells[>=Medium] |
|   GO:0030100 | 0.0467212760119 | 0.230769230769 | STON2 CCDC32 AP2S1 SGIP1 AAK1 ARFGAP1 | regulation of endocytosis |
|   REAC:R-HSA-195721 | 0.0485097091851 | 0.192307692308 | AP2A1 AP2M1 AP2B1 AP2S1 AP2A2 | Signaling by WNT |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
|  AP2A2 |  AP2M1 | 1.0 | 0.418           |
mixed_interface        
|
|  RALBP1 |  REPS1 | 1.0 | 0.374           |
structurally_consistent (dimer)        
|
|  AP2S1 |  AP2A1 | 1.0 | 0.71           |
structurally_consistent (dimer)        
|
|  AP2B1 |  AP2A1 | 1.0 | 0.93           |
structurally_consistent (dimer)        
|
|  AP2M1 |  EPS15 | 1.0 | 0.25           |          |
|  AP2A2 |  AP2B1 | 1.0 | 0.336153846154           |          |
|  AP2S1 |  AP2M1 | 1.0 | 0.706           |
mixed_interface        
|
|  AP2S1 |  AAK1 | 1.0 | 0.132           |          |
|  RALBP1 |  REPS2 | 1.0 | 0.28           |
structurally_consistent (dimer)        
|
|  AP2B1 |  AP2S1 | 1.0 | 0.7           |
structurally_consistent (O95782)        
|
|  NECAP2 |  AP2M1 | 1.0 | 0.1           |
structurally_consistent (dimer)        
|
|  AP2A2 |  AP2S1 | 1.0 | 0.282           |
structurally_consistent (dimer)        
|
|  ITSN1 |  AP2M1 | 1.0 |            |          |
|  CCDC32 |  AP2S1 | 1.0 | 0.13           |
structurally_consistent (dimer)        
|
|  AP2M1 |  AAK1 | 1.0 | 0.224           |          |
|  AP2S1 |  EPS15 | 1.0 | 0.104           |
structurally_consistent (dimer)        
|
|  AP2B1 |  EPS15 | 1.0 | 0.186           |          |
|  AP2B1 |  AP2M1 | 1.0 | 0.826           |
structurally_consistent (dimer)        
|
|  AP2B1 |  NECAP2 | 1.0 | 0.09           |
mutually_exclusive (Q96CW1)        
|
|  AP2S1 |  AP1B1 | 1.0 | 0.258           |          |
|  NECAP2 |  AP2A1 | 1.0 | 0.184           |          |
|  EPS15L1 |  AP2M1 | 1.0 | 0.186           |          |
|  AP2M1 |  AP1B1 | 1.0 | 0.384           |
structurally_consistent (dimer)        
|
|  NECAP2 |  AP1B1 | 0.999 | 0.14           |
mutually_exclusive (Q96CW1)        
|
|  EPS15L1 |  EPS15 | 0.999 | 0.182           |
mutually_exclusive (Q59EK9)        
|
|  AP2B1 |  AP1B1 | 0.999 | 0.718           |
mutually_exclusive (Q9Y6Q5)        
|
|  REPS1 |  AAK1 | 0.999 | 0.036           |          |
|  EPS15L1 |  AP2S1 | 0.999 | 0.222           |          |
|  EPS15L1 |  AP2A1 | 0.999 | 0.32           |          |
|  ITSN2 |  SGIP1 | 0.999 |            |          |
|  AP2A2 |  NECAP2 | 0.999 | 0.138416666667           |          |
|  AP1B1 |  AP2A1 | 0.999 | 0.49           |          |
|  ITSN1 |  AP2S1 | 0.999 |            |          |
|  CCDC32 |  AAGAB | 0.999 | 0.11           |
mutually_exclusive (P53680)        
|
|  AP2B1 |  ITSN1 | 0.999 |            |          |
|  NECAP2 |  AP2S1 | 0.999 | 0.076           |
structurally_consistent (dimer)        
|
|  AP2M1 |  AP2A1 | 0.999 | 0.956           |
mutually_exclusive (P53680)        
|
|  AP2A2 |  AAGAB | 0.999 | 0.1305           |          |
|  EPS15L1 |  FCHO2 | 0.999 | 0.138           |          |
|  AP2B1 |  STON2 | 0.999 | 0.134           |          |
|  AP2A2 |  EPS15L1 | 0.999 | 0.313555555556           |          |
|  AP2B1 |  EPS15L1 | 0.999 | 0.446           |          |
|  EPS15 |  AP2A1 | 0.999 | 0.186           |          |
|  AP2S1 |  FCHO2 | 0.999 | 0.074           |
structurally_consistent (dimer)        
|
|  AP2B1 |  FCHO2 | 0.999 | 0.114           |          |
|  AP2S1 |  REPS1 | 0.999 | 0.044           |          |
|  FCHO2 |  EPS15 | 0.998 | 0.142545454545           |          |
|  AAGAB |  AP2S1 | 0.998 | 0.058           |
structurally_consistent (dimer)        
|
|  AP2A2 |  AP1B1 | 0.998 | 0.266           |
mutually_exclusive (O43747)        
|
|  EPS15L1 |  ITSN1 | 0.998 |            |          |
|  REPS1 |  EPS15 | 0.998 | 0.07           |          |
|  AP2A1 |  AAK1 | 0.998 | 0.158           |          |
|  FCHO2 |  AP2A1 | 0.998 | 0.188275862069           |          |
|  ITSN1 |  SGIP1 | 0.998 |            |          |
|  AP2S1 |  STON2 | 0.998 | 0.09           |          |
|  REPS2 |  REPS1 | 0.998 | 0.144           |
mutually_exclusive (Q15311)        
|
|  AP2A2 |  CCDC32 | 0.998 | 0.13           |          |
|  RALBP1 |  AP2A1 | 0.998 | 0.14           |          |
|  AP2B1 |  AAK1 | 0.998 | 0.198           |          |
|  AAGAB |  AP2A1 | 0.998 | 0.1085           |          |
|  REPS1 |  STON2 | 0.998 | 0.092           |          |
|  SGIP1 |  EPS15 | 0.997 |            |          |
|  AP2M1 |  RALBP1 | 0.997 | 0.116           |
structurally_consistent (dimer)        
|
|  AP2B1 |  REPS1 | 0.997 | 0.152           |          |
|  AP2M1 |  REPS1 | 0.997 | 0.13           |          |
|  FCHO2 |  STON2 | 0.997 | 0.066           |          |
|  AP1B1 |  EPS15 | 0.997 | 0.198           |          |
|  AP2A1 |  STON2 | 0.997 | 0.162           |          |
|  ITSN2 |  EPS15L1 | 0.997 | 0.118           |          |
|  AP2S1 |  SGIP1 | 0.997 |            |
structurally_consistent (dimer)        
|
|  EPS15L1 |  AP1B1 | 0.997 | 0.38           |          |
|  EPS15L1 |  SGIP1 | 0.996 |            |          |
|  ITSN1 |  AP1B1 | 0.996 |            |          |
|  EPS15 |  AAK1 | 0.996 | 0.052           |          |
|  SPAG6 |  SGIP1 | 0.996 |            |          |
|  ITSN2 |  AP2M1 | 0.996 | 0.166           |          |
|  REPS1 |  AP2A1 | 0.996 | 0.112           |          |
|  CLINT1 |  AAK1 | 0.996 | 0.11           |          |
|  AP2A2 |  EPS15 | 0.996 | 0.218           |          |
|  NECAP2 |  NECAP1 | 0.996 | 0.076           |          |
|  EPS15 |  STON2 | 0.995 | 0.11           |          |
|  AP2B1 |  CLINT1 | 0.995 | 0.268           |          |
|  RALBP1 |  AAK1 | 0.995 | 0.154           |          |
|  FCHO2 |  AP1B1 | 0.994 | 0.208           |          |
|  AP2A2 |  AP2A1 | 0.994 | 0.3585           |          |
|  CCDC32 |  AP2A1 | 0.994 | 0.132           |          |
|  AP2M1 |  STON2 | 0.994 | 0.138           |          |
|  AP2S1 |  RALBP1 | 0.993 | 0.204           |          |
|  ARFGAP1 |  AP2A1 | 0.993 | 0.186           |          |
|  CLINT1 |  AP2A1 | 0.992 | 0.224           |          |
|  AP2M1 |  SGIP1 | 0.992 |            |
mutually_exclusive (P53680)        
|
|  AP2M1 |  AP1S1 | 0.992 | 0.078           |          |
|  SGIP1 |  AP2A1 | 0.99 |            |          |
|  AP2M1 |  NECAP1 | 0.99 | 0.158           |
structurally_consistent (dimer)        
|
|  REPS1 |  CLINT1 | 0.99 | 0.156           |          |
|  AAGAB |  AP2M1 | 0.99 | 0.086           |
mutually_exclusive (P53680)        
|
|  AP2B1 |  NECAP1 | 0.989 | 0.108           |          |
|  AP2B1 |  AP1S1 | 0.989 | 0.186           |          |
|  CCDC32 |  AP2M1 | 0.989 | 0.104           |
mutually_exclusive (P53680)        
|
|  AP1S1 |  AAK1 | 0.988 | 0.036           |          |
|  NECAP1 |  REPS1 | 0.988 | 0.09           |          |
|  AP2A2 |  SGIP1 | 0.988 |            |          |
|  AP1S1 |  SYNJ1 | 0.987 | 0.072           |          |
|  FCHO2 |  AP2M1 | 0.987 | 0.104           |
structurally_consistent (dimer)        
|
|  RALBP1 |  EPS15 | 0.986 | 0.09           |          |
|  AP1S1 |  AP1B1 | 0.985 | 0.112           |
mutually_exclusive (O43747)        
|
|  FCHO2 |  NECAP1 | 0.985 | 0.102           |          |
|  EPS15L1 |  RALBP1 | 0.985 | 0.126           |          |
|  AP2B1 |  RALBP1 | 0.985 | 0.124           |
mutually_exclusive (Q96CW1)        
|
|  ITSN2 |  ITSN1 | 0.985 |            |          |
|  AP1B1 |  NECAP1 | 0.984 | 0.278           |
structurally_consistent (dimer)        
|
|  AP2B1 |  SGIP1 | 0.984 |            |          |
|  AP1B1 |  RALBP1 | 0.983 | 0.16           |
mutually_exclusive (Q96CW1)        
|
|  ITSN2 |  AP2S1 | 0.982 | 0.084           |          |
|  AP2A2 |  STON2 | 0.982 | 0.166           |          |
|  FCHO2 |  AP1S1 | 0.982 | 0.068           |          |
|  AP2B1 |  AAGAB | 0.981 | 0.13           |          |
|  RALBP1 |  STON2 | 0.98 | 0.138           |          |
|  AP2B1 |  ARFGAP1 | 0.98 | 0.196           |          |
|  FCHO2 |  AAK1 | 0.98 | 0.028           |          |
|  AP1B1 |  SGIP1 | 0.98 |            |          |
|  AP2M1 |  CLINT1 | 0.979 | 0.148           |          |
|  AP2A2 |  ARFGAP1 | 0.979 | 0.244857142857           |          |
|  AP2A2 |  RALBP1 | 0.978 | 0.168           |          |
|  NECAP1 |  CLINT1 | 0.977 | 0.136           |          |
|  AP2A2 |  ITSN1 | 0.976 |            |          |
|  AP2M1 |  SYNJ1 | 0.976 | 0.155166666667           |          |
|  NECAP1 |  AAK1 | 0.976 | 0.09           |          |
|  ITSN2 |  AP2A1 | 0.975 | 0.18           |          |
|  ITSN1 |  RALBP1 | 0.975 |            |          |
|  REPS2 |  AAK1 | 0.975 | 0.0945           |          |
|  AP1B1 |  STON2 | 0.974 | 0.174           |          |
|  AP2B1 |  CCDC32 | 0.974 | 0.06           |          |
|  ITSN2 |  AP1B1 | 0.973 | 0.126           |          |
|  SYNJ1 |  NECAP1 | 0.972 | 0.202           |          |
|  NECAP1 |  STON2 | 0.97 | 0.108           |          |
|  CLINT1 |  EPS15 | 0.97 | 0.252           |          |
|  EPS15L1 |  STON2 | 0.97 | 0.122           |          |
|  AP1S1 |  NECAP1 | 0.968 | 0.048           |
structurally_consistent (Q9Y6Q5)        
|
|  AP2M1 |  ARFGAP1 | 0.968 | 0.118           |          |
|  FCHO2 |  SYNJ1 | 0.966 | 0.138           |          |
|  NECAP1 |  EPS15 | 0.965 | 0.146           |          |
|  AP1B1 |  REPS1 | 0.965 | 0.114           |          |
|  CLINT1 |  STON2 | 0.964 | 0.1           |          |
|  FCHO2 |  REPS1 | 0.964 | 0.04           |          |
|  AP2A2 |  ITSN2 | 0.963 | 0.36           |          |
|  SYNJ1 |  RALBP1 | 0.963 | 0.136           |          |
|  RALBP1 |  CLINT1 | 0.962 | 0.11           |          |
|  AP1B1 |  SYNJ1 | 0.961 | 0.194           |          |
|  AP2A2 |  FCHO2 | 0.959 | 0.146           |          |
|  ITSN1 |  EPS15 | 0.959 |            |          |
|  AP1S1 |  RALBP1 | 0.958 | 0.062           |          |
|  AP1S1 |  REPS1 | 0.958 | 0.052           |          |
|  ITSN1 |  STON2 | 0.957 |            |          |
|  ITSN2 |  AP2B1 | 0.957 | 0.082           |          |
|  ITSN1 |  AP2A1 | 0.955 |            |          |
|  STON2 |  AAK1 | 0.955 | 0.074           |          |
|  AP1B1 |  CLINT1 | 0.954 | 0.276           |          |
|  AP2A2 |  AAK1 | 0.953 | 0.258           |          |
|  EPS15L1 |  AAK1 | 0.953 | 0.122           |          |
|  SYNJ1 |  REPS1 | 0.953 | 0.188           |          |
|  AAGAB |  AP1S1 | 0.948 | 0.038           |
mutually_exclusive (O75843)        
structurally_consistent (dimer)         |
|  FCHO2 |  RALBP1 | 0.947 | 0.078           |          |
|  AP1S1 |  STON2 | 0.945 | 0.074           |          |
|  AP2S1 |  SYNJ1 | 0.942 | 0.086           |          |
|  ITSN2 |  EPS15 | 0.935 | 0.15           |          |
|  ITSN2 |  FCHO2 | 0.932 | 0.052           |          |
|  NECAP2 |  AAK1 | 0.929 | 0.052           |          |
|  AP1S1 |  AP2A1 | 0.929 | 0.204           |
structurally_consistent (dimer)        
|
|  AP2A2 |  AP1S1 | 0.929 | 0.158235294118           |
structurally_consistent (O43747)        
structurally_consistent (dimer)         |
|  AP2A2 |  REPS1 | 0.928 | 0.288079365079           |          |
|  NECAP2 |  EPS15L1 | 0.927 | 0.096           |          |
|  EPS15L1 |  REPS1 | 0.927 | 0.112           |
mutually_exclusive (Q59EK9)        
|
|  AP2B1 |  SYNJ1 | 0.924 | 0.198           |          |
|  NECAP1 |  RALBP1 | 0.924 | 0.142           |
mutually_exclusive (Q96CW1)        
|
|  AP2S1 |  CLINT1 | 0.923 | 0.282           |          |
|  ITSN1 |  REPS1 | 0.922 |            |          |
|  SYNJ1 |  AAK1 | 0.922 | 0.14           |          |
|  AP1B1 |  ARFGAP1 | 0.913 | 0.088           |          |
|  NECAP2 |  ITSN1 | 0.913 |            |          |
|  AAGAB |  AP1B1 | 0.907 | 0.066           |          |
|  ITSN1 |  AAK1 | 0.905 |            |          |
|  NECAP1 |  AP2A1 | 0.898 | 0.168           |
mutually_exclusive (P53680)        
|
|  AP1S1 |  CLINT1 | 0.896 | 0.23           |          |
|  AP1B1 |  AAK1 | 0.89 | 0.176           |          |
|  AP2S1 |  AP1S1 | 0.876 | 0.1           |          |
|  NECAP2 |  REPS1 | 0.847 | 0.04           |          |
|  NECAP2 |  RALBP1 | 0.846 | 0.138           |
mutually_exclusive (Q96CW1)        
|
|  CCDC32 |  AP1B1 | 0.845 | 0.092           |          |
|  SYNJ1 |  STON2 | 0.836 | 0.16           |          |
|  ITSN1 |  FCHO2 | 0.831 |            |          |
|  AP2S1 |  REPS2 | 0.824 | 0.12           |
structurally_consistent (dimer)        
|
|  SYNJ1 |  AP2A1 | 0.823 | 0.264           |          |
|  AP2A2 |  CLINT1 | 0.817 | 0.106           |          |
|  NECAP2 |  EPS15 | 0.81 | 0.17           |          |
|  AP2S1 |  ARFGAP1 | 0.784 | 0.036           |          |
|  AP2A2 |  SYNJ1 | 0.778 | 0.118           |          |
|  NECAP2 |  FCHO2 | 0.761 | 0.042           |
structurally_consistent (Q96CW1)        
|
|  ITSN2 |  SPAG6 | 0.754 |            |          |
|  AP2M1 |  REPS2 | 0.747 | 0.138           |          |
|  ITSN1 |  AP1S1 | 0.732 |            |          |
|  ITSN1 |  SPAG6 | 0.715 |            |          |
|  AAGAB |  FCHO2 | 0.702 | 0.04           |          |
|  AAGAB |  ITSN1 | 0.656 |            |          |
|  SYNJ1 |  EPS15 | 0.638 | 0.07           |          |
|  CCDC32 |  ITSN1 | 0.617 |            |          |
|  CCDC32 |  AAK1 | 0.617 | 0.072           |          |
|  AP2S1 |  NECAP1 | 0.615 | 0.082           |
structurally_consistent (dimer)        
|
|  ITSN2 |  STON2 | 0.595 | 0.1           |          |
|  CCDC32 |  FCHO2 | 0.572 | 0.052           |          |
|  AP1S1 |  EPS15 | 0.569 | 0.096           |          |
|  CCDC32 |  EPS15 | 0.563 | 0.026           |          |
|  AAGAB |  AAK1 | 0.517 | 0.066           |          |
|  NECAP2 |  STON2 | 0.487 | 0.064           |          |
|  CCDC32 |  EPS15L1 | 0.475 | 0.202           |          |
|  AP2A2 |  NECAP1 | 0.475 | 0.16           |
mutually_exclusive (P53680)        
|
|  ITSN2 |  AP1S1 | 0.471 | 0.074           |          |
|  SYNJ1 |  CLINT1 | 0.463 | 0.098           |          |
|  EPS15L1 |  NECAP1 | 0.43 | 0.158           |          |
|  AAGAB |  EPS15 | 0.427 | 0.038           |          |
|  ITSN1 |  SYNJ1 | 0.416 |            |          |
|  AAGAB |  EPS15L1 | 0.415 | 0.066           |          |
|  ITSN1 |  NECAP1 | 0.36 |            |          |
|  ITSN2 |  NECAP1 | 0.353 | 0.092           |          |
|  NECAP2 |  AP1S1 | 0.353 | 0.048           |          |
|  EPS15L1 |  SPAG6 | 0.343 |            |          |
|  SPAG6 |  EPS15 | 0.343 |            |          |
|  AP1B1 |  SPAG6 | 0.332 |            |          |
|  FCHO2 |  CLINT1 | 0.324 | 0.144           |          |
|  EPS15L1 |  AP1S1 | 0.322 | 0.068           |          |
|  CCDC32 |  STON2 | 0.305 | 0.06           |          |
|  AP2A2 |  SPAG6 | 0.262 |            |          |
|  AP2S1 |  SPAG6 | 0.262 |            |          |
|  AP2B1 |  SPAG6 | 0.255 |            |          |
|  SPAG6 |  AP2A1 | 0.255 |            |          |
|  AAGAB |  RALBP1 | 0.24 | 0.034           |          |
|  AP2M1 |  SPAG6 | 0.238 |            |          |
|  ITSN2 |  RALBP1 | 0.231 | 0.07           |          |
|  CCDC32 |  REPS1 | 0.209 | 0.094           |          |
|  AAGAB |  NECAP2 | 0.18 | 0.03           |
mutually_exclusive (P53680)        
|
|  CCDC32 |  NECAP2 | 0.172 | 0.086           |
mutually_exclusive (P53680)        
|
|  EPS15L1 |  CLINT1 | 0.17 | 0.228           |          |
|  CCDC32 |  RALBP1 | 0.164 | 0.128           |          |
|  AAGAB |  STON2 | 0.138 | 0.082           |          |
|  ITSN2 |  SYNJ1 | 0.131 | 0.112           |          |
|  ITSN2 |  AAK1 | 0.121 | 0.074           |          |
|  EPS15L1 |  SYNJ1 | 0.114 | 0.16           |          |
|  NECAP2 |  SYNJ1 | 0.105 | 0.134           |          |
|  AAGAB |  NECAP1 | 0.102 | 0.118           |
mutually_exclusive (P53680)        
|
|  AAGAB |  REPS1 | 0.096 | 0.044           |          |
|  REPS2 |  CLINT1 | 0.081 | 0.18           |          |
|  NECAP1 |  REPS2 | 0.07 | 0.104           |          |
|  REPS2 |  STON2 | 0.068 | 0.084           |          |
|  AP1S1 |  REPS2 | 0.068 | 0.074           |          |
|  FCHO2 |  REPS2 | 0.068 | 0.056           |          |
|  SYNJ1 |  REPS2 | 0.066 | 0.052           |          |
|  AP2B1 |  REPS2 | 0.063 | 0.14           |          |
|  AAGAB |  CLINT1 | 0.057 | 0.068           |          |
|  AP2A2 |  REPS2 | 0.054 | 0.182           |          |
|  AP1B1 |  REPS2 | 0.043 | 0.164           |          |
|  CCDC32 |  AP1S1 | 0.043 | 0.06           |          |
|  ITSN2 |  REPS1 | 0.037 | 0.042           |          |
|  REPS2 |  EPS15 | 0.036 | 0.186           |          |
|  ITSN1 |  REPS2 | 0.031 |            |          |
|  ITSN2 |  NECAP2 | 0.029 | 0.07           |          |
|  REPS2 |  AP2A1 | 0.028 | 0.15           |          |
|  ITSN2 |  CCDC32 | 0.024 | 0.05           |          |
|  ITSN2 |  ARFGAP1 | 0.023 | 0.172           |          |
|  ITSN1 |  CLINT1 | 0.022 |            |          |
|  ITSN2 |  AAGAB | 0.02 | 0.042           |          |
|  SYNJ1 |  ARFGAP1 | 0.02 | 0.176           |          |
|  ITSN2 |  REPS2 | 0.019 | 0.126           |          |
|  NECAP2 |  REPS2 | 0.018 | 0.076           |          |
|  ARFGAP1 |  EPS15 | 0.018 | 0.09           |          |
|  ITSN1 |  ARFGAP1 | 0.016 |            |          |
|  EPS15L1 |  REPS2 | 0.015 | 0.202           |          |
|  EPS15L1 |  ARFGAP1 | 0.015 | 0.077           |          |
|  NECAP2 |  CLINT1 | 0.015 | 0.084           |          |
|  ARFGAP1 |  CLINT1 | 0.013 | 0.116           |          |
|  REPS1 |  ARFGAP1 | 0.009 | 0.062           |          |
|  NECAP2 |  ARFGAP1 | 0.007 | 0.018           |          |
|  ARFGAP1 |  AAK1 | 0.007 | 0.048           |          |
|  REPS2 |  ARFGAP1 | 0.006 | 0.132           |          |
|  AP1S1 |  ARFGAP1 | 0.005 | 0.036           |          |
|  FCHO2 |  ARFGAP1 | 0.005 | 0.09           |          |
|  RALBP1 |  ARFGAP1 | 0.005 | 0.056           |          |
|  ARFGAP1 |  STON2 | 0.005 | 0.168           |          |
|  ITSN2 |  CLINT1 | 0.003 | 0.074           |          |
Related Complexes